459 research outputs found
Comorbidity in childhood asthma
No full textDit proefschrift heeft als focus comorbiditeit bij kinderen met astma en de impact hiervan op de astma. Comorbiditeiten in kinderen met astma zijn allergische rhinitis(AR), dysfunctioneel ademen(DA) en depressieve aandoeningen. De prevalentie van AR in kinderen met astma is 76.2%. AR was vastgesteld in maar 56.1%. Ongecontroleerd astma komt vaker voor bij kinderen met AR. De invloed op de astma controle verdwijnt wanner er behandeld wordt met intra-nasale steroïden. DA in kinderen met astma werd in 5.3% vastgesteld met de Nijmegen vragenlijst. DA heeft een associatie met minder astma controle. Er werden geen verschillen gevonden in de totale scores voor angst, depressie of in zelfbeeld tussen kinderen met of zonder astma. Het risico op angst of depressie stijgt met slechtere astma controle. Een oorzaak voor ongecontroleerd astma werd gevonden in 97.2%. De oorzaken waren: slechte therapietrouw(37%), persisterende blootstelling aan omgevingsprikkels(28%), comorbiditeiten(20%), (AR en DA zijn de meest voorkomende). Incorrecte inhalatie techniek(8%). Bij zes(4.2%) was er een andere diagnose dan astma. De prevalentie van therapie resistent astma was 2.8%. De conclusies zijn dat therapie resistent astma zeldzaam is. Comorbiditeiten hebben een belangrijke rol als oorzaak. AR is vaak onderkent maar is belangrijk en goed te behandelen. DA komt minder vaak voor, maar heeft invloed op de astma controle. In goed gecontroleerd astma zijn psychologische comorbiditeiten zeldzaam. Bij minder astma controle is er een associatie met een verhoogd risico op psychologische comorbiditeiten
Comorbidity in childhood asthma
No full textDit proefschrift heeft als focus comorbiditeit bij kinderen met astma en de impact hiervan op de astma. Comorbiditeiten in kinderen met astma zijn allergische rhinitis(AR), dysfunctioneel ademen(DA) en depressieve aandoeningen. De prevalentie van AR in kinderen met astma is 76.2%. AR was vastgesteld in maar 56.1%. Ongecontroleerd astma komt vaker voor bij kinderen met AR. De invloed op de astma controle verdwijnt wanner er behandeld wordt met intra-nasale steroïden. DA in kinderen met astma werd in 5.3% vastgesteld met de Nijmegen vragenlijst. DA heeft een associatie met minder astma controle. Er werden geen verschillen gevonden in de totale scores voor angst, depressie of in zelfbeeld tussen kinderen met of zonder astma. Het risico op angst of depressie stijgt met slechtere astma controle. Een oorzaak voor ongecontroleerd astma werd gevonden in 97.2%. De oorzaken waren: slechte therapietrouw(37%), persisterende blootstelling aan omgevingsprikkels(28%), comorbiditeiten(20%), (AR en DA zijn de meest voorkomende). Incorrecte inhalatie techniek(8%). Bij zes(4.2%) was er een andere diagnose dan astma. De prevalentie van therapie resistent astma was 2.8%. De conclusies zijn dat therapie resistent astma zeldzaam is. Comorbiditeiten hebben een belangrijke rol als oorzaak. AR is vaak onderkent maar is belangrijk en goed te behandelen. DA komt minder vaak voor, maar heeft invloed op de astma controle. In goed gecontroleerd astma zijn psychologische comorbiditeiten zeldzaam. Bij minder astma controle is er een associatie met een verhoogd risico op psychologische comorbiditeiten.This thesis focuses on comorbid conditions and its impact on asthma in children.Comorbidities in children with asthma are allergic rhinitis(AR), dysfunctional breathing(DB) and depressive disorders. The prevalence of AR in children with asthma is 76.2%. AR was diagnosed in only 56.1%. Uncontrolled asthma was more common in children with AR. The negative impact on asthma control disappeared in those treated with intranasal corticosteroids. DB in children with asthma using the Nijmegen questionnaire was identified in 5.3%. Asthma control was worse in children with DB. No significant differences were found on anxiety, depression or self-esteem between children with or without asthma. The risk of anxiety and depression increased with decreasing asthma control. An underlying cause of uncontrolled asthma could be identified in 97.2%. The causes were: poor adherence(37%), ongoing exposure to environmental triggers(28%), comorbidities(20%), AR and DB being the most common. Incorrect inhalation technique(8%). Six (4.2%) had an another diagnosis than asthma. The prevalence of true therapy resistant asthma was 2.8%. True therapy resistant asthma is very rare, in the majority of cases addressing the basics of asthma management led to well-controlled asthma. The overall conclusions are that true therapy resistant asthma is rare. Comorbidities are an important part of these causes. AR is frequently unrecognised but it is important and treatable. DB is less common, but it has an impact on asthma control. In well controlled asthma psychological comorbidities are rare, but less well controlled asthma seems to be associated with an increased risk of psychological comorbidities
Comorbidity in childhood asthma
No full textDit proefschrift heeft als focus comorbiditeit bij kinderen met astma en de impact hiervan op de astma. Comorbiditeiten in kinderen met astma zijn allergische rhinitis(AR), dysfunctioneel ademen(DA) en depressieve aandoeningen. De prevalentie van AR in kinderen met astma is 76.2%. AR was vastgesteld in maar 56.1%. Ongecontroleerd astma komt vaker voor bij kinderen met AR. De invloed op de astma controle verdwijnt wanner er behandeld wordt met intra-nasale steroïden. DA in kinderen met astma werd in 5.3% vastgesteld met de Nijmegen vragenlijst. DA heeft een associatie met minder astma controle. Er werden geen verschillen gevonden in de totale scores voor angst, depressie of in zelfbeeld tussen kinderen met of zonder astma. Het risico op angst of depressie stijgt met slechtere astma controle. Een oorzaak voor ongecontroleerd astma werd gevonden in 97.2%. De oorzaken waren: slechte therapietrouw(37%), persisterende blootstelling aan omgevingsprikkels(28%), comorbiditeiten(20%), (AR en DA zijn de meest voorkomende). Incorrecte inhalatie techniek(8%). Bij zes(4.2%) was er een andere diagnose dan astma. De prevalentie van therapie resistent astma was 2.8%. De conclusies zijn dat therapie resistent astma zeldzaam is. Comorbiditeiten hebben een belangrijke rol als oorzaak. AR is vaak onderkent maar is belangrijk en goed te behandelen. DA komt minder vaak voor, maar heeft invloed op de astma controle. In goed gecontroleerd astma zijn psychologische comorbiditeiten zeldzaam. Bij minder astma controle is er een associatie met een verhoogd risico op psychologische comorbiditeiten.This thesis focuses on comorbid conditions and its impact on asthma in children.Comorbidities in children with asthma are allergic rhinitis(AR), dysfunctional breathing(DB) and depressive disorders. The prevalence of AR in children with asthma is 76.2%. AR was diagnosed in only 56.1%. Uncontrolled asthma was more common in children with AR. The negative impact on asthma control disappeared in those treated with intranasal corticosteroids. DB in children with asthma using the Nijmegen questionnaire was identified in 5.3%. Asthma control was worse in children with DB. No significant differences were found on anxiety, depression or self-esteem between children with or without asthma. The risk of anxiety and depression increased with decreasing asthma control. An underlying cause of uncontrolled asthma could be identified in 97.2%. The causes were: poor adherence(37%), ongoing exposure to environmental triggers(28%), comorbidities(20%), AR and DB being the most common. Incorrect inhalation technique(8%). Six (4.2%) had an another diagnosis than asthma. The prevalence of true therapy resistant asthma was 2.8%. True therapy resistant asthma is very rare, in the majority of cases addressing the basics of asthma management led to well-controlled asthma. The overall conclusions are that true therapy resistant asthma is rare. Comorbidities are an important part of these causes. AR is frequently unrecognised but it is important and treatable. DB is less common, but it has an impact on asthma control. In well controlled asthma psychological comorbidities are rare, but less well controlled asthma seems to be associated with an increased risk of psychological comorbidities
Global Root Traits (GRooT) Database
No full textTrait data are fundamental to the quantitative description of plant form and function. Although root traits capture key dimensions related to plant responses to changing environmental conditions and effects on ecosystem processes, they have rarely been included in large‐scale comparative studies and global models. For instance, root traits remain absent from nearly all studies that define the global spectrum of plant form and function. Thus, to overcome conceptual and methodological roadblocks preventing a widespread integration of root trait data into large‐scale analyses we created the Global Root Trait (GRooT) Database. GRooT provides ready‐to‐use data by combining the expertise of root ecologists with data mobilization and curation. Specifically, we (a) determined a set of core root traits relevant to the description of plant form and function based on an assessment by experts, (b) maximized species coverage through data standardization within and among traits, and (c) implemented data quality checks
De Leidse koorboeken een ongehoorde schat
No full textGeschiedenis van de zes zestiende-eeuwse handschriften met liturgische koormuziek, bestemd voor diensten in de Leidse Pietersker
A naval travesty : the dismissal of Admiral Sir John Jellicoe, 1917
No full textThis dissertation relates to the dismissal of Admiral Jellicoe, First Sea Lord from November 1916 to December 1917, by Sir Eric Geddes, First Lord of the Admiralty, at the behest of the Prime Minister, David Lloyd George. The dismissal was peremptory and effected without rational explanation, despite Jellicoe having largely fulfilled his primary mission of combating the German U-boat threat to British merchant shipping. The outcome of the war may well have been affected if the level of shipping losses sustained through U-boat attack in April 1917 had continued unabated.
The central argument of the dissertation is that the dismissal was unjustified. As an adjunct, it argues that the received view of certain historians that Jellicoe was not successful as First Sea Lord is unwarranted and originates from severe post war critism of Jellicoe by those with a vested interest in justifying the dismissal, notably Lloyd George.
Supporting these arguments, the following assertions are made. Firstly, given the legacy Jellicoe inherited when joining the Admiralty, through the strategies adopted, organisational changes made and initiatives undertaken in anti-submarine weapons development, the progress made in countering the U-boat threat was notable. Secondly, the universal criticism directed at the Admiralty over the perceived delay in introducing a general convoy system for merchant shipping is not sustainable having regard to primary source documentation. Thirdly, incidents that occurred during the latter part of 1917, and suggested as being factors which contributed to the dismissal, can be discounted. Fourthly, Lloyd George conspired to involve General Haig, Commander of the British Forces France, and the press baron, Lord Northcliffe, in his efforts to mitigate any potential controversy that might result from Jellicoe’s removal from office. Finally, the arguments made by a number of commentators that the Admiralty performed better under Jellicoe’s successor, Admiral Wemyss, is misconceived
Psychological Sentiments and Economic Behavior.
No full textThis thesis is a contribution to the field of psychology and economics. The two central themes are gift-giving and the effects of rewards. Within these themes, it studies questions like: Why do people donate to charity funds? Why are people sometimes less motivated when they get rewarded for their behavior? Why does the value of a product increase after they have bought it? And why does the market not completely crowd-out gift-giving? Answers to the above and other questions are given by extending economic models with psychological sentiments. The broad message is that taking such sentiments into account often offers insights into why and how institutions should be designed accordingly. Disregarding these effects leads to unintended consequences of incentive schemes.
Service not self : the British Legion, 1921-1939
No full textThe organisation of ex-service men into a mass membership movement was a
new departure in British life. Four main groups came together in 1921 to form the
British Legion. On its establishment, the leadership, who were predominantly high-
ranking ex-officers, had high hopes of forming an extremely powerful and influential
organisation. Due to a number of inherent flaws in the Legion's ideology,
composition and character, the organisation never became a truly mass movement of
all ex-service men. This work looks at the dynamics of the movement and provides
insights into the motivations of its leaders and their impact upon the organisation. It
provides a detailed account of the structure of the Legion and explores the strengths
and weaknesses of the movement. The existence of a semi-autonomous Officer's
Benevolent Department, a subordinate Women's Section, and an independent Legion
in Scotland reveal the serious rifts within this superficially unified movement. The
paradox of low officer involvement combined with an almost exclusively officer
leadership contributed to low membership and other factors such as geography,
unemployment and finance are considered in the discussion of Legion membership.
Divisions between leaders and led on policy and methods are explored in an
examination of Legion democracy. A full examination of the Legion's practical work
and the attitudes which underpinned that activity confirms the Legion's position as a
voluntary society with traditional charitable views. A detailed examination of the
Legion's struggles over pension legislation gives an insight into Government attitudes
towards ex-service men and also reveals the inherent weakness of the Legion's
position when dealing with politicians. An analysis of the Legion's contacts with
foreign ex-service men penetrates the Legion's rhetoric and reveals the real
motivations and attitudes of the Legion leaders who developed and executed the
Legion's foreign policy. Ultimately, this study provides important conclusions about
the nature of the British ex-service movement
Corporate Investment under Uncertainty and Competition: A Real Options Approach.
No full textAbstract: Corporate investment opportunities can be represented as a set of (real) options to acquire productive assets. Identification of the optimal exercise strategies for these options plays a crucial role in improving the quality of capital budgeting decisions and, as a consequence, in maximizing shareholders¿ wealth. Structural changes in the economic environment, imperfect product market competition and agency conflicts across different groups of the firm¿s stakeholders make the standard option theory alone often insufficient for analyzing real investment decisions. This thesis combines option theory with non-cooperative game theory to establish some new results concerning the impact of policy uncertainty, product market interactions, and debt financing on the firm¿s optimal investment strategy.
Electrodeposited Ni/Ge and germanide schottky barriers for nanoelectronics applications
No full textIn recent years metal/semiconductor Schottky barriers have found numerous applications in nanoelectronics. The work presented in this thesis focuses on the improvement of a few of the relevant devices using electrodeposition of metal on Ge for Schottky barrier fabrication. This low energy metallisation technique offers numerous advantages over the physical vapour deposition techniques. Electrical characteristics of the grown diodes show a high quality rectifying behaviour with extremely low leakage currents even on highly doped Ge. A non-Arrhenius behaviour of the temperature dependence is observed for the grown Ni/Ge diodes on lowly doped Ge that is explained by a spatial variation of the barrier heights. The inhomogeneity of the barrier hights is explained in line with an intrinsic surface states model for Ge. The understanding of the intrinsic surface states will help to create ohmic contacts for doped n-MOSFETs. NiGe were formed single phase by annealing. Results reveal that by using these high-quality germanide Schottky barriers as the source/drain, the subthreshold leakage currents of a Schottky barrier MOSFET could be minimised, in particular, due to the very low drain/body junction leakage current exhibited by the electrodeposited diodes. The Ni/Ge diodes on highly doped Ge show negative differential conductance at low temperature. This effect is attributed to the intervalley electron transfer in Ge conduction band to a low mobility valley. The results show experimentally that Schottky junctions could be used for hot electron injection in transferred-electron devices. A vertical Co/Ni/Si structure has been fabricated for spin injection and detection in Si. It is shown that the system functions electrically well although no magnetoresistance indicative of spin injection was observed
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