818 research outputs found
Angiography and Polarimetry of the Posterior Eye with Functional Optical Coherence Tomography
Get PDFBoer, J.F. de [Promotor
Imaging the structure and the movement of the retina with scanning light ophthalmoscopy
Get PDFBoer, J.F. de [Promotor
Reconstructive imaging based on indirect measurements: From lensless imaging to waveguide analysis
Get PDFBoer, J.F. de [Promotor]Witte, S.M. [Copromotor
Temporal and spatial dynamics of corticosteroid receptor down-regulation in rat brain following social defeat
Get PDFThe experiments explored the nature and time course of changes in glucocorticoid receptor (GR) and mineralocorticoid receptor (MR) binding in homogenates of various brain regions and pituitary of male Wistar rats following social defeat stress. One week after defeat, the binding capacity of GRs was decreased in the hippocampus and the hypothalamus while no changes were observed in the parietal cortex and the pituitary. The number of MRs remained at the same level as in undefeated rats. Three weeks postdefeat, the initially down-regulated GR returned to baseline level in the hippocampus and the hypothalamus. However, GR binding was now decreased in the parietal cortex. Severe down-regulation of MRs was detected in the hippocampal and septal tissue. The results show that brief but intense stress like social defeat induces a long-lasting down-regulation of corticosteroid receptors and that the temporal dynamics of these changes are not only differential for GRs and MRs but also for brain sites.
In vivo depth resolved birefringence measurement of the human retinal nerve fiber layer by polarization sensitive OCT
No full textPurpose: To measure the depth resolved retinal nerve fiber layer (RNFL) birefringence using a new Polarization Sensitive Optical Coherence Tomography (PS-OCT) machine that was developed by the authors [1]. Measurement of RNFL optical birefringence enhances specificity in determining RNFL thickness in structural Optical Coherence Tomography (OCT) images. A decrease in birefringence may also be an early sign of glaucomatous atrophy of the RNFL, and therefore PS-OCT may be particularly helpful in the early diagnosis of glaucoma. Methods: With OCT, cross-sectional structural images of the retina can be made in vivo, allowing determination of the RNFL thickness. From light reflected back from the retina, Scanning Laser Polarimetry (SLP) can measure polarization state changes, which are attributed to the birefringence of the RNFL. We have developed a PS-OCT instrument that combines the depth resolution of OCT with the polarization sensitivity of SLP to image the depth resolved optical birefringence of the human RNFL in vivo. By measuring the OCT interference fringes simultaneously in orthogonal polarization channels, the polarization state of light reflected from a structure within the retina can be determined completely. By modulating the input polarization over two states, the optic axis and birefringence of the RNFL can be uniquely determined. The PS-OCT scan location is co-registered by a video camera during data acquisition. Results: Measurements on one volunteer show that the average double pass phase retardation in the RNFL in near the optic nerve head is equal to 0.29 ± 0.02° / mm. Conclusions: For the first time the depth resolved birefringence of the human retinal nerve fiber layer in vivo was measured using Polarization Sensitive Optical Coherence Tomography. [1] B. Cense, T.C. Chen, B.H. Park, M.C. Pierce, J.F. de Boer, "In vivo depth-resolved birefringence measurements of the human retinal nerve fiber layer by polarization-sensitive optical coherence tomography" Optics Letters 27, 1610 (2002
Avaliação de custos em epilepsia: um estudo de custos da doença sob a perspectiva da população usuária do Sistema Único de Saúde (SUS) região metropolitana de Florianópolis, Santa Catarina, 2009
Get PDFTrabalho de Conclusão de Curso - Universidade Federal de Santa Catarina. Curso de Medicina. Departamento de Pediatria
6-thioguanine treatment in inflammatory bowel disease: A critical appraisal by a European 6-TG working party
Get PDFRecently, the suggestion to use 6-thioguanine (6-TG) as an alternative thiopurine in patients with inflammatory bowel disease (IBD) has been discarded due to reports about possible (hepato) toxicity. During meetings arranged in Vienna and Prague in 2004, European experts applying 6-TG further on in IBD patients presented data on safety and efficacy of 6-TG. After thorough evaluation of its risk-benefit ratio, the group consented that 6-TG may still be considered as a rescue drug in stringently defined indications in IBD, albeit restricted to a clinical research setting. As a potential indication for administering 6-TG, we delineated the requirement for maintenance therapy as well as intolerance and/or resistance to aminosalicylates, azathioprine, 6-mercaptopurine, methotrexate and infliximab. Furthermore, indications are preferred in which surgery is thought to be inappropriate. The standard 6-TG dosage should not exceed 25 mg daily. Routine laboratory controls are mandatory in short intervals. Liver biopsies should be performed after 6-12 months, three years and then three-yearly accompanied by gastroduodenoscopy, to monitor for potential hepatotoxicity, including nodular regenerative hyperplasia (NRH) and veno-occlusive disease (VOD). Treatment with 6-TG must be discontinued in case of overt or histologically proven hepatotoxicity. Copyright (c) 2006 S. Karger AG, Basel
Cirurgia para epilepsia do lobo temporal secundária à esclerose mesial temporal
Get PDFTrabalho de Conclusão de Curso - Universidade Federal de Santa Catarina. Curso de Medicina. Departamento de Clínica Médica
Alterações retinianas na doença hipertensiva específica da gestação.
Get PDFTrabalho de Conclusão de Curso - Universidade Federal de Santa Catarina, Centro de Ciências da Saúde, Departamento de Tocoginecologia, Curso de Medicina, Florianópolis, 200
Genetic variants in lipid metabolism are independently associated with multiple features of the metabolic syndrome
Get PDFAbstract Background Our objective was to find single nucleotide polymorphisms (SNPs), within transcriptional pathways of glucose and lipid metabolism, which are related to multiple features of the metabolic syndrome (MetS). Methods 373 SNPs were measured in 3575 subjects of the Doetinchem cohort. Prevalence of MetS features, i.e. hyperglycemia, abdominal obesity, decreased HDL-cholesterol levels and hypertension, were measured twice in 6 years. Associations between the SNPs and the individual MetS features were analyzed by log-linear models. For SNPs related to multiple MetS features (P Results Two SNPs, CETP Ile405Val and APOE Cys112Arg, were associated with both the prevalence of low HDL-cholesterol level (Ile405Val P = Cys112Arg P = 0.001) and with the prevalence of abdominal obesity (Ile405Val P = 0.007; Cys112Arg P = 0.007). For both SNPs, the association with HDL-cholesterol was partly independent of the association with abdominal obesity and vice versa. Conclusion Two SNPs, mainly known for their role in lipid metabolism, were associated with two MetS features i.e., low HDL-cholesterol concentration, as well as, independent of this association, abdominal obesity. These SNPs may help to explain why low HDL-cholesterol levels and abdominal obesity frequently co-occur.</p
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