4,923 research outputs found
A multi-stage genome-wide association study of bladder cancer identifies multiple susceptibility loci.
Get PDFWe conducted a multi-stage, genome-wide association study of bladder cancer with a primary scan of 591,637 SNPs in 3,532 affected individuals (cases) and 5,120 controls of European descent from five studies followed by a replication strategy, which included 8,382 cases and 48,275 controls from 16 studies. In a combined analysis, we identified three new regions associated with bladder cancer on chromosomes 22q13.1, 19q12 and 2q37.1: rs1014971, (P = 8 × 10⁻¹²) maps to a non-genic region of chromosome 22q13.1, rs8102137 (P = 2 × 10⁻¹¹) on 19q12 maps to CCNE1 and rs11892031 (P = 1 × 10⁻⁷) maps to the UGT1A cluster on 2q37.1. We confirmed four previously identified genome-wide associations on chromosomes 3q28, 4p16.3, 8q24.21 and 8q24.3, validated previous candidate associations for the GSTM1 deletion (P = 4 × 10⁻¹¹) and a tag SNP for NAT2 acetylation status (P = 4 × 10⁻¹¹), and found interactions with smoking in both regions. Our findings on common variants associated with bladder cancer risk should provide new insights into the mechanisms of carcinogenesis
Fine-Tuning Mesochannel Orientation of Organically Functionalized Mesoporous Silica Nanoparticles
No full textUp-regulation of vascular endothelial growth factor C in breast cancer cells by heregulin-beta1. A critical role of p38/NF-kB signaling pathway.
No full textExperimental study of the brittle–ductile transition in hot cutting of SG iron specimens
Get PDFhttp://www.sciencedirect.com/science/article/pii/S0924013612002579The present paper investigates the brittle-ductile transition (BDT) of the primary shear zone during cutting of spheroidal graphite (SG) iron in the austenitization temperature range (around 1000 °C). The experimental tests were performed using a cutting test bench in the cutting speed range of 0.8 to 1.6m.s-1. The cut surfaces were studied using optical microscopy and Scanning Electron Microscope (SEM) analysis techniques. The obtained results revealed either consequent deep fractured regions governed by a brittle-cracking regime (BCR) or a crack-free cut surface governed by a ductile-shear regime (DSR) with large plastic deformations. When cutting data were discussed with respect to the influences of cutting parameters and obtained cut surface, the correlation is significantly rich. Both cut surface integrity, cutting force curves and metallographic results show a BDT indicating a change in the dominating hot cutting process mechanism. Such a transition is associated with the dynamic recrystallization promoting strain softening and hot cutting by ductile shearing
Absorption spectra of SG.
No full text<p>(A) UV-Vis absorption spectra of SG (5 µM) in the absence and presence of 5 µM DNA1-Ys. The corresponding fully matched DNAs (FM-DNA) were used as controls. (B) UV-Vis absorption spectra of SG (5 µM) alone at pH 8.3 (a) and pH 6.0 (b).</p
Experimental investigation of the temperature effect on the structural response of SG-laminated reinforced glass beams
No full textTo generate high-level redundancy for structural glass beams, a novel concept of laminating a metal reinforcement to a structural glass beam has been developed at Delft University of Technology (TU Delft). This concept makes use of the relatively stiff polymer interlayer material SentryGlas (SG) to bond the metal to the glass. However, due to the visco-elastic properties of the SG, its stiffness varies at different temperature levels. To what extent this temperature dependency has an effect on the structural response of the beam composite has been experimentally investigated in cooperation with Ghent University (UGent) and is the subject of current publication. Two separate series of pull-out tests, to investigate the bond strength, and beam tests, to investigate the post-breakage response, have been conducted at -20, 23 and 60 degrees C. The pull-out tests revealed a high temperature dependency of the bond strength of SG. This temperature dependency also had an effect on the structural response of the beams. However, regardless of temperature level all beams showed high-level plastic response and high redundancy. It is therefore concluded that temperature levels of -20 to 60 degrees C do not endanger the structural safety of SG-laminated reinforced glass beams.RESSLA
pH dependence of SG fluorescence.
No full text<p>(A) emission spectra and (B) the relative intensity alterations of SG (5 µM). λ<sub>ex</sub> = 336 nm.</p
Blocking TLR-TICAM-1 pathway by RSV sG
Get PDFMonocyte-derived dendritic cells (mDCs) recognize viral RNA extrinsically by TLR3 on the membrane and intrinsically RIG-I/MDA5 in the cytoplasm to induce type I interferons (IFNs) and mDC maturation. When mDCs were treated with live or UV-irradiated respiratory syncytial virus (RSV), early (~4 h) induction of IFN-β detected in other virus infections was barely observed. Live RSV subsequently replicated to activate the cytoplasmic IFN-inducing pathway leading to robust type I IFN induction. We found that RSV initial attachment to cells blocked polyI:C-mediated IFN-β induction, and this early IFN-β-modulating event was abrogated by Abs against envelope proteins of RSV, demonstrating the presence of a IFN-regulatory mode by early RSV attachment to host cells. By IFN-stimulated response element (ISRE) reporter analysis in HEK293 cells, polyI:C- or LPS-mediated ISRE activation was dose-dependently inhibited by live and inactive RSV to a similar extent. Of the RSV envelope proteins, simultaneously-expressed or exogenously-added RSV G or soluble G (sG) proteins inhibited TLR3/4-mediated ISRE activation in HEK293 cells. sG proteins expressed in cells did not affect the RIG-I/MDA5 pathway but inhibited the TLR adaptor TRIF/TICAM-1 pathway for ISRE activation. Finally, extrinsically-added sG protein suppressed the production of IFN-β in mDCs. Although the molecular mechanism of this extrinsic functional mode of the RSV G protein remains undetermined, G proteins may neutralize the F protein function that promotes IFN-mediated mDC modulation via TLR4 and may cause insufficient raising cell-mediated immunity against RSV
Structures of SG and DNA sequences.
No full text<p>(A) SG at the variable forms and schematic representation of the AP site-targeted association of SG with a large emission shift. (B) For AP site-containing DNAs, X = AP site (dSpacer, tetrahydrofuran residue) that is opposed by base Y and flanked by base Fs. Fully matched DNAs (FM-DNA) with X/Y = A/T, C/G, G/C, and T/A were used as controls.</p
SG-Net: Syntax-Guided Machine Reading Comprehension
No full textFor machine reading comprehension, the capacity of effectively modeling the linguistic knowledge from the detail-riddled and lengthy passages and getting ride of the noises is essential to improve its performance. Traditional attentive models attend to all words without explicit constraint, which results in inaccurate concentration on some dispensable words. In this work, we propose using syntax to guide the text modeling by incorporating explicit syntactic constraints into attention mechanism for better linguistically motivated word representations. In detail, for self-attention network (SAN) sponsored Transformer-based encoder, we introduce syntactic dependency of interest (SDOI) design into the SAN to form an SDOI-SAN with syntax-guided self-attention. Syntax-guided network (SG-Net) is then composed of this extra SDOI-SAN and the SAN from the original Transformer encoder through a dual contextual architecture for better linguistics inspired representation. To verify its effectiveness, the proposed SG-Net is applied to typical pre-trained language model BERT which is right based on a Transformer encoder. Extensive experiments on popular benchmarks including SQuAD 2.0 and RACE show that the proposed SG-Net design helps achieve substantial performance improvement over strong baselines
- …
