126,589 research outputs found
Evaluation of the sums
No full textsummary:The convolution sum is evaluated for and all . This completes the partial evaluation given in the paper of J. G. Huard, Z. M. Ou, B. K. Spearman, K. S. Williams
Measurement of the isospin asymmetry in B -> K(*) mu+mu- decays
No full textThe isospin asymmetries of B → K (∗) μ + μ − decays and the partial branching fractions of B 0 → K 0 μ + μ − and B + → K ∗+ μ + μ − are measured as a function of the di-muon mass squared q 2 using an integrated luminosity of 1.0 fb−1 collected with the LHCb detector. The B → Kμ + μ − isospin asymmetry integrated over q 2 is negative, deviating from zero with over 4 σ significance. The B → K ∗ μ + μ − decay measurements are consistent with the Standard Model prediction of negligible isospin asymmetry. The observation of the decay B 0 → K S μ + μ − is reported with 5.7 σ significance. Assuming that the branching fraction of B 0 → K 0 μ + μ − is twice that of B 0 → K S μ + μ −, the branching fractions of B 0 → K 0 μ + μ − and B → K ∗+ μ + μ − are found to be (0.31−0.06) × 10−6 and (1.16 ± 0.19) × 10−6, respectively
Decisions made on scant information: overview
No full textThis chapter brings an overview to an edited book that looks at how decisions can be made at the front-end of major projects, in circumstances where information is usually scant. The book examines how projects can be successfully aligned with the desired direction; how sufficient, appropriate and valid information can be gathered at the front-end; how information can be analysed; and finally how decisions can be made. Each chapter of the book is written by an expert in the field, and each chapter speaks for itself. However, some key themes run throughout the book. These include the need for alignment between organisational strategy and the project concept; dealing with complexity, in particular the systemicity and interrelatedness within project decisions; consideration of the ambiguity implicit in all major projects; taking into account psychological and political biases within estimation of benefits and costs; consideration of the social geography and politics within decision-making groups; and preparation for the turbulence within the project environment, including the maintenance of strategic alignment
The development of metaphorical language comprehension in typical development and in Williams syndrome
No full textThe domain of figurative language comprehension was used to probe the developmental relation between language and cognition in typically developing individuals and individuals with Williams syndrome. Extending the work of Vosniadou and Ortony, the emergence of nonliteral similarity and category knowledge was investigated in 117 typically developing children between 4 and 12 years of age, 19 typically developing adults, 15 children with Williams syndrome between 5 and 12 years of age, and 8 adults with Williams syndrome. Participants were required to complete similarity and categorization statements by selecting one of two words (e.g., either “The sun is like ___” or “The sun is the same kind of thing as ___”) with word pairs formed from items that were literally, perceptually, or functionally similar to the target word or else anomalous (e.g., moon, orange, oven, or chair, respectively). Results indicated that individuals with Williams syndrome may access different, less abstract knowledge in figurative language comparisons despite the relatively strong verbal abilities found in this disorder
A comparison of the chemical analyses of cell lipids with their complete proton NMR spectrum
No full textWhole cells are made up of molecules in different environments to which NMR spectroscopy is sensitive. In particular, malignant and transformed cells contain lipids not only in bilayers but in isotropically tumbling domains which give rise to high-resolution spectra. We have recently developed a technique for simultaneously analyzing broadline and high-resolution signals (M. Bloom, K. T. Holmes, C. E. Mountford, and P. G. Williams, <i>J. Magn. Reson</i>., in press) and we report here its application to a range of rat, mouse, and human cell lines. Some selected features of the NMR spectra were compared with the chemical analysis of the whole-cell lipid. We found that in general the proportion of protons in the narrow methylene resonance at 1.3 ppm increased with the neutral lipid content of the cells. This peak was chosen because its <i>T<sub>2</sub></i> relaxation behavior correlates with metastatic potential in a rat model system. This new technique could be applied to other high-resolution components both in healthy and in diseased states
Measurement of the ratio of branching fractions B(B0→K∗0γ )/B(B0s→φγ ) and the directCP asymmetry inB 0→K∗0γ
No full textThe ratio of branching fractions of the radiative B decays B0→K⁎0γ and B0s→ϕγ has been measured using an integrated luminosity of 1.0 fb−1 of pp collision data collected by the LHCb experiment at a centre-of-mass energy of s√=7TeV. The value obtained is
B(B0→K⁎0γ)B(B0s→ϕγ)=1.23±0.06(stat.)±0.04(syst.)±0.10(fs/fd),
where the first uncertainty is statistical, the second is the experimental systematic uncertainty and the third is associated with the ratio of fragmentation fractions fs/fd. Using the world average value for B(B0→K⁎0γ), the branching fraction B(B0s→ϕγ) is measured to be (3.5±0.4)×10−5.
The direct CP asymmetry in B0→K⁎0γ decays has also been measured with the same data and found to be
ACP(B0→K⁎0γ)=(0.8±1.7(stat.)±0.9(syst.))%.
Both measurements are the most precise to date and are in agreement with the previous experimental results and theoretical expectations
Spontaneous and cued gaze-following in autism and Williams syndrome
No full textBackground: From a young age the typical development of social functioning relies upon the allocation of attention to socially relevant information, which in turn allows experience at processing such information and thus enhances social cognition. As such, research has attempted to identify the developmental processes that are derailed in some neuro-developmental disorders that impact upon social functioning. Williams syndrome (WS) and Autism are disorders of development that are characterized by atypical yet divergent social phenotypes and atypicalities of attention to people. Methods: We used eye tracking to explore how individuals with WS and Autism attended to, and subsequently interpreted, an actor’s eye gaze cue within a social scene. Images were presented for three seconds, initially with an instruction simply to look at the picture. The images were then shown again, with the participant asked to identify the object being looked at. Allocation of eye-gaze in each condition was analyzed by ANOVA and accuracy of identification was compared with t-tests. Results: Participants with WS allocated more gaze time to face and eyes than their matched controls both with and without being asked to identify the item being looked at; while participants with Autism spent less time on face and eyes in both conditions. When cued to follow gaze, participants with WS increased gaze to the correct targets, while those with Autism looked more at the face and eyes but did not increase gaze to the correct targets, while continuing to look much more than their controls at implausible targets. Both groups identified fewer objects than their controls. Conclusions: The atypicalities found are likely to be entwined with the deficits shown in interpreting social cognitive cues from the images. WS and Autism are characterised by atypicalities of social attention that impact upon socio-cognitive expertise but importantly the type of atypicality is syndrome-specific
Social cognition in Williams Syndrome: genotype/phenotype insights from partial deletion patients
No full textIdentifying genotype/phenotype relations in human social cognition has been enhanced by the study of Williams syndrome (WS). Indeed, individuals with WS present with a particularly strong social drive, and researchers have sought to link deleted genes in the WS critical region (WSCR) of chromosome 7q11.23 to this unusual social profile. In this paper, we provide details of two case studies of children with partial genetic deletions in the WSCR: an 11-year-old female with a deletion of 24 of the 28 WS genes, and a 14-year-old male who presents with the opposite profile, i.e., the deletion of only four genes at the telomeric end of the WSCR. We tested these two children on a large battery of standardized and experimental social perception and social cognition tasks – both implicit and explicit – as well as standardized social questionnaires and general psychometric measures. Our findings reveal a partial WS socio-cognitive profile in the female, contrasted with a more autistic-like profile in the male. We discuss the implications of these findings for genotype/phenotype relations, as well as the advantages and limitations of animal models and of case study approaches
Jack K. Williams Library, 1975-2016
No full textDepartmental papers from the Jack K. Williams Library. Includes history of the library, library policies, and papers concerning the construction of the new library, finished in 1986. Also covers large exhibits displayed at the library and the meeting notes and correspondence of the library committee
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