188 research outputs found
Gut Microbiome as a Novel Treatment Strategy for Psoriasis
No full textZając Marlena, Borowiecka Monika, Gruca Dariusz, Buksak Dagmara, Wróblewski Wiktor. Gut Microbiome as a Novel Treatment Strategy for Psoriasis. Journal of Education, Health and Sport. 2022;12(9):407-421. eISSN 2391-8306. DOI http://dx.doi.org/10.12775/JEHS.2022.12.09.046
https://apcz.umk.pl/JEHS/article/view/39692
https://zenodo.org/record/7046427
The journal has had 40 points in Ministry of Education and Science of Poland parametric evaluation. Annex to the announcement of the Minister of Education and Science of December 21, 2021. No. 32343.
Has a Journal's Unique Identifier: 201159. Scientific disciplines assigned: Physical Culture Sciences (Field of Medical sciences and health sciences); Health Sciences (Field of Medical Sciences and Health Sciences).
Punkty Ministerialne z 2019 - aktualny rok 40 punktów. Załącznik do komunikatu Ministra Edukacji i Nauki z dnia 21 grudnia 2021 r. Lp. 32343. Posiada Unikatowy Identyfikator Czasopisma: 201159.
Przypisane dyscypliny naukowe: Nauki o kulturze fizycznej (Dziedzina nauk medycznych i nauk o zdrowiu); Nauki o zdrowiu (Dziedzina nauk medycznych i nauk o zdrowiu).
© The Authors 2022;
This article is published with open access at Licensee Open Journal Systems of Nicolaus Copernicus University in Torun, Poland
Open Access. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author (s) and source are credited. This is an open access article licensed under the terms of the Creative Commons Attribution Non commercial license Share alike.
(http://creativecommons.org/licenses/by-nc-sa/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited.
The authors declare that there is no conflict of interests regarding the publication of this paper.
Received: 15.08.2022. Revised: 20.08.2022. Accepted: 01.09.2022.
Gut Microbiome as a Novel Treatment Strategy for Psoriasis
Marlena Zając1, Monika Borowiecka1, Dariusz Gruca1, Dagmara Buksak1,
Wiktor Wróblewski1
1Medical University of Lublin, Aleje Racławickie Street 1, 20-059 Lublin, Poland
Marlena Zając; [email protected]; ORCID: 0000-0002-6251-0175;
Monika Borowiecka; [email protected]; ORCID: 0000-0003-2612-7838;
Dariusz Gruca; [email protected]; ORCID: 0000-0002-5583-1229;
Dagmara Buksak; [email protected]; ORCID: 0000-0003-4008-5611;
Wiktor Wróblewski: [email protected]; ORCID: 0000-0003-4740-9455
Summary:
Introduction and purpose: Psoriasis is a skin disease that develops following chronic inflammatory signaling and keratinocyte hyperproliferation. The pathogenesis of psoriasis is compound and not yet fully understood. Several studies concerning the gut microbiota composition and its role in disease pathogenesis recently demonstrated significant alterations among psoriatic patients. This study aims to highlight the latest scientific evidence regarding the gut microbiome alterations of psoriatic patients, as well as the state of knowledge in terms of microbiome-targeted therapies as promising preventive and therapeutic tools for psoriasis.
Brief description of the state of knowledge: The current state of knowledge indicates that the main causes of psoriasis may be genetic predisposition, as well as many immunological and environmental factors, including dysbiosis of the intestinal microflora. The article covers clinical and experimental studies which indicate that gut microbiota dysbiosis concerning diversity as well as composition of microbiome is the potential causal factor of psoriasis and the gut microbiota may serve as promising prevention/therapy target for psoriasis patients.
Conclusions: This review highlighted a strong link between psoriasis and the gut microbiota, with the purpose of adding new knowledge for discovering the relationship between the altered intestinal microbiota in psoriasis patients. Despite all of these interesting findings, there are a lot of limitations and challenges that future studies should face. More precise and greater studies need to be done to fully understand the potential of microbiota-aimed therapies.
Key words: psoriasis; microbiome; gut; dysbiosis; probiotics
The relation between adipose-derived stem cells and wound healing process - the review
No full textGruca Dariusz, Zając Marlena, Wróblewski Wiktor, Borowiecka Monika, Buksak Dagmara. The relation between adipose-derived stem cells and wound healing process - the review. Journal of Education, Health and Sport. 2022;12(4):87-93. eISSN 2391-8306. DOI http://dx.doi.org/10.12775/JEHS.2022.12.04.007
https://apcz.umk.pl/JEHS/article/view/JEHS.2022.12.04.007
https://zenodo.org/record/6427438
The journal has had 40 points in Ministry of Education and Science of Poland parametric evaluation. Annex to the announcement of the Minister of Education and Science of December 21, 2021. No. 32343.
Has a Journal's Unique Identifier: 201159. Scientific disciplines assigned: Physical Culture Sciences (Field of Medical sciences and health sciences); Health Sciences (Field of Medical Sciences and Health Sciences).
Punkty Ministerialne z 2019 - aktualny rok 40 punktów. Załącznik do komunikatu Ministra Edukacji i Nauki z dnia 21 grudnia 2021 r. Lp. 32343. Posiada Unikatowy Identyfikator Czasopisma: 201159.
Przypisane dyscypliny naukowe: Nauki o kulturze fizycznej (Dziedzina nauk medycznych i nauk o zdrowiu); Nauki o zdrowiu (Dziedzina nauk medycznych i nauk o zdrowiu).
© The Authors 2022;
This article is published with open access at Licensee Open Journal Systems of Nicolaus Copernicus University in Torun, Poland
Open Access. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author (s) and source are credited. This is an open access article licensed under the terms of the Creative Commons Attribution Non commercial license Share alike.
(http://creativecommons.org/licenses/by-nc-sa/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited.
The authors declare that there is no conflict of interests regarding the publication of this paper.
Received: 25.03.2022. Revised: 25.03.2022. Accepted: 07.04.2022.
The relation between adipose-derived stem cells and wound healing process - the review
Dariusz Gruca https://orcid.org/0000-0002-5583-1229 [email protected]
Uniwersytet Medyczny w Lublinie
Marlena Zając https://orcid.org/0000-0002-6251-0175
Uniwersytet Medyczny w Lublinie
Wiktor Wróblewski https://orcid.org/0000-0003-4740-9455
Uniwersytet Medyczny w Lublinie
Monika Borowiecka https://orcid.org/0000-0003-2612-7838
Uniwersytet Medyczny w Lublinie
Dagmara Buksak https://orcid.org/0000-0003-4008-5611
Uniwersytet Medyczny w Lublinie
Abstract
Introduction and purpose: Wound healing is a process including complex overlapping stages requiring many components. Adipose tissue is an organ that is responsible for maintaining homeostasis through inflammatory responses, signal transmission, energy expenditure connected with different organs. Fat tissue is a rich and readily available source of multipotent stem cells. Adipose-derived stem cells (ADSCs) have the potential in tissue regeneration because of their self-renewal and ability to differentiate in various types of cells. This review discusses ADSCs in terms of basic knowledge, methods of acquisition, prospects for use in healthcare, focusing mainly on the potential application in the wound healing process.
Brief description of the state of knowledge: The article contains current knowledge about biology, specific properties of adipose-derived stem cells and also shows the relationship to the wound healing process. The review presents research that points to the possibility of using ADSCs in future medicine.
Conclusions: Adipose-derived stem cells may constitute a prominent role in tissue regeneration owing to the secretion of various cytokines, the ability to differentiate into multiple lineages, their immunomodulatory effects, and the ease of cell obtaining. Further studies are required to explore the accurate mechanism of ADSCs action and their long-term safety in clinical application. Stem cell therapy brings new hope for the repair of chronic and refractory wounds and skin defects.
Key words: adipose tissue; stem cells; regeneration; wound healin
Łukasz Wróblewski – Aranżowanie nie-miejsc. Od ekspozycji afektu do medium zmiany
No full textThe text discusses the theory of Marc Augé’s non-places. In this article the author
focuses on the relation between non-places and identity, and answers the question of to what
extent it is possible to transform non-places to places – one of the Augé’s theses is that there
are close relations between these two categories. According to the author, this change can
be made thanks to the external media. The websites such as Facebook and YouTube, allow
a symbolic transformation of a status of non-places, their rearrangement. In the study the
author also proposes to expand Augé’s dictionary to include a category of analgetic places
and non-places of affect.
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Augustyn Wróblewski – prekursor lewackiego anarchizmu
No full textAugustyn Wróblewski was the author of the nowadays forgotten idealistic syndicalistic conception, which could be put in the wide comprehended leftish and revolutionary trend. At the turn of the nineteenth and twentieth century he got interested in the socialist direction in the course of his studies in Petersburg and Riga, where he met Russian activists of the Russian Narodnaya Volya propagating messianic terrorism. This direction was propagated by Wróblewski in the course of his so-called second proletariat affiliation. Subsequently he went away to start further studies in the Western Europa and occupied oneself with chemistry and aft er his return he became a lecturer at the Jagiellonian University in Cracow. Forming his own thoughts, he referred to the Russian anarchism and French anarchistic syndicalism. Despite apathy, which became prevalent aft er the suppression of revolution in 1905, he propagated ideas calling for the opposition to invasive rule and winning freedom in a stateless society among Polish inhabited in Galicia and indirectly in the Polish Kingdom. He declined legal and parliamentary methods replacing them with radical and anarchistic demands of common liberation in classless society professing its own and authentic „above religious religion of humanity”. That is why Wróblewski paid a great attention to the ethical aspect of preparations for the upcoming revolution. He desired to rebuild the lasting social economic order in a mystical. A new newspaper was designed for this, entitled „Working Affair” and being published in Cracow in years 1912 – 1913. However, this idea did not manage to gain common recognition in the course of the great world war and at the juncture of the revival of Polish statehood
AHP and TOPSIS as methods assessing the attractiveness of urban parks: The case of Lodz, Poland
No full textUrban parks are significant elements that improve the quality of life in built-up areas. This research aims to identify the most attractive park in Lodz, Poland, using a set of assessment indicators. In our opinion, the decision-making process in assessing the attractiveness of urban parks may be assisted by Multiple Criteria Decision Analysis (MCDA). Two methods were chosen from the MCDA group, namely the Analytic Hierarchy Process (AHP) and the Technique for Order Preference by Similarity to Ideal Solution (TOPSIS). The research shows that the proposed methods reveal which park needs support and calls for investment
The process of formation of the Polish local community in Siciny in the Lower Silesia within the years 1945–1956
No full textNowe społeczności lokalne, powstałe po II wojnie światowej na tzw. Ziemiach Odzyskanych, potrzebowały wielu lat, by wytworzyć więzi i zagospodarować obce im zupełnie środowiska. Artykuł omawia zachodzące wówczas zjawiska. Publikację Autor podzielił na dziewięć rozdziałów, w których opisuje najistotniejsze zagadnienia i procesy przejmowania Ziem Odzyskanych przez polskich osadników. Autor uwzględnił m. in. dramat ucieczki i wysiedlania ludności niemieckiej, rządy sowieckich komendantów wojennych, katastrofalny w skutkach szaber, niezwykle istotny społecznie proces polonizacji nazewnictwa, podziemną działalność niepodległościową oraz tworzenie pierwszych organów administracji lokalnej. Artykuł wieńczy obfita bibliografia oraz wykaz źródeł archiwalnych i wspomnień bezpośrednich świadków historii.It took many years for the new local communities that were formed after the World War II on so called Recovered Territories to form bonds between one another and develop the environment that used to be completely unfamiliar for them. The article ‟The formation process of Polish local community in Siciny in Lower Silesia in the years 1945–1956” written by Paweł Wróblewski, addresses the events occurring at that time. The publication is divided into nine chapters in which the author describes the most significant issues and processes of acquisition of the Recovered Territories by Polish settlers.
In his paper, Wróblewski included, among others, the tragedy connected with the escape and expulsion of the German inhabitants, the soviet war commendats’ reign, disastrous looting, extremely important in social context process of giving Polish place names, underground independence movement and the formation of first local administration authorities. The article ends with rich bibliography, a list of archives and memories of direct witnesses to history
Konflikty etniczne na Górze św. Anny. Polacy i mniejszość niemiecka
No full textThe topic this article are ethnic conflicts occurring between the Polish majority and the German minority around St. Anna Hill. St. Anna Hill is a village in the nearby of Opole, which is historic capital of Upper Silesia. To analyze the case, author uses Lewis A. Coser’s theory of conflict and Claus Offe’s field of ethnic conflict. He takes into consideration the influence of local authorities and patronage state on the situation. Not only were inhabitant’s relations researched, but also tension during newcomers, who take part in various celebrations in the area (for example religious, patriotic, ethnic festivals). The institutions which regulate hostility between ethnic group were distinguished. Piotr Wróblewski describes types of conflicts, which arese/have been arising around St. Anna Hill, which is considered as Upper Silesia iconic sing.Tematem artykułu są konflikty etniczne występujące pomiędzy polską większością a niemiecką mniejszością wokół Góry Św. Anny. Góra Św. Anny to wieś w pobliżu Opola, historycznej stolicy Górnego Śląska. Do analizy przypadku autor wykorzystuje teorię konfliktu Lewisa A. Cosera oraz pole konfliktu etnicznego Clausa Offego. Bierze pod uwagę wpływ władz lokalnych i państwa patronackiego na sytuację. Badane są nie tylko relacje mieszkańców, ale także napięcia podczas przybyszów, którzy biorą udział w różnych uroczystościach na tym terenie (np. święta religijne, patriotyczne, etniczne). Wyróżniono instytucje regulujące wrogość między grupami etnicznymi. Piotr Wróblewski opisuje rodzaje konfliktów, które powstają wokół Góry Św. Anny, uważanej za symbol Górnego Śląska
Sources of disgust in the drama Dzień świra by Marek Koterski
No full textThe article is an analysis and interpretation of a drama Dzień świra (Day of the wacko) by Marek Koterski in the affective perspective. In this essay, the author proves that protagonist's behaviour
is determined by disgust. In the introduction author refers to some of theoretical conceptions of disgust (e.g. Darwin, Kant, Menninghaus, Rozin, Haidt and McCauley). Subsequently, the author describes the character of disgust in Dzień świra. According to the author, disgust is the effect of narcissistic personality of protagonist, the routine and protagonist's non-fulfillment. The author also discusses the influence of protagonist's mother on the shaping protagonist's character and his tendency to disgust. In conclusions, the author notices the correlation between repressed problems and emotions with disgust. As it turns out, the protagonist is not ready to confront with his problems and gain self-knowledge.ŁUKASZ WRÓBLEWSKI - absolwent filologii polskiej i kulturoznawstwa, doktorant w Katedrze Antropologii Literatury i Badań Kulturowych Wydziału Polonistyki UJ, stypendysta Ministra Nauki i Szkolnictwa Wyższego. Zajmuje się badaniem tekstów kultury w perspektywie afektywnej i antropologiczno kulturowej. Publikował m. in. w "Tekstach Drugich", "Postscriptum Polonistycznym" , "Przeglądzie Humanistycznym" , "Stanie Rzeczy", "Masce" oraz tomach zbiorowych. Jest autorem książki Masłowska: opowieść o wstręcie (2016) i współredaktorem monografii Rozkosz w kulturze (2016), W kulturze dotyku? Dotyk i jego reprezentacje w tekstach kultury (2016) oraz Nagość w kulturze (2017).Uniwersytet Jagielloński27328
Konflikty etniczne na Górze św. Anny. Polacy i mniejszość niemiecka
No full textThe topic this article are ethnic conflicts occurring between the Polish majority and the
German minority around St. Anna Hill. St. Anna Hill is a village in the nearby of Opole, which is
historic capital of Upper Silesia. To analyze the case, author uses Lewis A. Coser’s theory of conflict
and Claus Offe’s field of ethnic conflict. He takes into consideration the influence of local authorities
and patronage state on the situation. Not only were inhabitant’s relations researched, but also tension
during newcomers, who take part in various celebrations in the area (for example religious, patriotic,
ethnic festivals). The institutions which regulate hostility between ethnic group were distinguished.
Piotr Wróblewski describes types of conflicts, which arese/have been arising around St. Anna Hill,
which is considered as Upper Silesia iconic sing
Regarding Injurious Words. A Few Remarks on Immutable Mechanisms of Hate Speech
No full textW artykule przedstawiono koncepcję odróżnienia hejtu od języka propagandy
i mowy nienawiści poprzez wskazanie na łączące je bezpośrednio relacje. Kolejno,
z perspektywy różnych ujęć badawczych, omówione zostały społeczne i językowe
uwarunkowania hejtu. Następnie, dzięki zestawieniu trzech klasycznych tekstów
dotyczących mowy nienawiści, ukazano niezmienne mechanizmy rządzące zarówno
mową nienawiści oraz językiem propagandy, jak i językiem hejtu. W końcowej
części artykułu omówione zostały możliwości obrony przed krzywdzącymi
komentarzami lub wypowiedziami.In the article the author analyzes and interprets mechanisms of hate speech and
propaganda speech which have had a great impact on contemporary culture. In
order to understand the phenomenon of hate speech fully, the author tries to find
the processes and procedures that lead to creation of propaganda speech as well
as hate speech in modern society by considering the classic texts which regard
the problem of propaganda in the 20th century. The impact of mass media on perception
has resulted in constantly repetitive structures of thinking which create
stereotypical images.Udostępnienie publikacji Wydawnictwa Uniwersytetu Łódzkiego finansowane w ramach projektu „Doskonałość naukowa kluczem do doskonałości kształcenia”. Projekt realizowany jest ze środków Europejskiego Funduszu Społecznego w ramach Programu Operacyjnego Wiedza Edukacja Rozwój; nr umowy: POWER.03.05.00-00-Z092/17-00
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