281 research outputs found
Pengaruh Finger Painting Terhadap Kemampuan Menulis Permulaan Peserta Didik Autis Di Slb Autis Laboratorium Universitas Negeri Malang
No full textUlandary, Yury. 2019. Pengaruh Finger Painting Terhadap Kemampuan Menulis Permulaan.Skripsi, Jurusan Pendidikan Luar Biasa, Fakultas Ilmu Pendidikan, Universitas Negeri Malang. Pembimbing (1) Drs. M. Shodiq AM, M.Pd, (II) Drs. H. Ahmad Samawi, M.Hum. Kata Kunci:Menulis Permulaan, Autis, Finger Painting.Autis memiliki hambatan dalam motorik halus sehingga mengalami kesulitan dalam menulis permulaan. Keterampilan menulis harus dikuasai oleh semua anak. Menulis harus dilakukan secara bertahap diantaranya adalah menulis permulaan. Oleh karena itu dilakukan pembelajaran yang dapat membantu anak dalam meningkatkan keterampilan menulis permulaan.Tujuan penelitian ini adalah mendeskripsikan kemampuan menulis permulaan peserta didik autisdi SLB Autis Laboratorium UM sebelum diterapkan metode finger painting, kemampuan menulis permulaan peserta didik autisdi SLB Autis Laboratorium UM setelah diterapkan metode finger painting dan pengaruh metode finger painting terhadap kemampuan menulis permulaan peserta didik autispeserta didik autis di SLB Autis Laboratorium UM.Penelitian ini menggunakan metode eksperimen Single Subject Research (SSR) desain A-B-A. subjek penelitian ini yaitu Z peserta didik penyandang Autis kelas III di SLB Autis Laboratorium UM yang mengalami kesulitan dalam menulis. Variabel terikat dala penelitian ini adalah menulis permulaan, variabel bebas dalam penelitian ini adalah finger painting.Hasil penelitian ini menunjukkan adanya pengaruh finger painting terhadap kemampuan menulis permulaan. Keadaan ini ditunjukkan pada penilaian kemampuan menulis permulaan peserta didik autis pada kondisi baseline memperoleh hasil 75%, pada intervensi diperoleh hasil tertinggi 90% dan pada baseline-2 diperoleh hasil tertinggi 85% yang menunjukan peningkatan antara baseline-1 dan baseline-2. Kesimpulan dari penelitian ini adalah finger painting dilaksanakan dengan menggunakan cat sebagai dasar pengembangan bahan menulis memiliki pengaruh terhadap kemampuan menulis permulaan
KEEFEKTIFAN METODE KALIMAT KONTEKSTUAL DAN FUNGSIONAL UNTUK MENINGKATKAN KEMAMPUAN MEMBACA PERMULAAN ANAK DOWN SYNDROME
Full text linkEarly reading is a fundamental reading ability that indicates that the child can understand letters, syllables, words, and sentences in written into spoken form. Limitations in intellectual make children with Down Syndrome have difficulty in the early reading stage, because the methods are used today are not based on the learning principles of children with Down Syndrome. So, we need a method that is expected to allow children to understand writings that can provide useful information in their environment. Based on the research problems, the purpose of this study was to determine 1) The objective condition of the reading ability of Children with Down Syndrome before being given treatment; 2) Formulate the contextual and functional sentence method draft to improve the early reading ability of Children with Down Syndrome; 3) recognize the effectiveness of the contextual and functional sentence method to improve the early reading ability of children with Down Syndrome. This study uses a quantitative approach with an experimental Single Subject Research (SSR) design method. The subjects in this study are two children with Down Syndrome on grade fifth at SLBN A Citeureup. The obtained data are the result from the test using descriptive percentage analysis. The results showed that the application of contextual and functional sentence methods effectively improved the early reading ability of children with Down Syndrome. So, it is recommended to teachers as an alternative for early reading learning of children with Down Syndrome
Synergestic induction of NRF-2 gene by curcumin and sulforaphane and pharmacokinetics/metabolism of 13C/Dim in rats by UPLC/MS
No full textCurcumin (CUR) and Sulforaphane (SFN) have shown remarkable cancer chemopreventive effects in numerous studies and combinations of low doses of chemopreventive agents can reduce toxicity while augmenting efficacy. The first part of the thesis investigated the chemotherapeutic effects elicited by a combination of CUR and SFN on human hepatocarcinoma
cells. The combination treatment- mediated effects on phase II/antioxidant enzymatic induction and antioxidant response element (ARE) was investigated. It was proposed that the combination of CUR and SFN could synergistically enhance the induction of ARE and the nuclear E2-factor related factor 2 (Nrf2)-mediated enzymes. Low doses of CUR and SFN significantly induced the expression of Nrf2-mediated enzymes, HO-1 and UGT1A1, promoted nuclear translocation of
Nrf2– a key regulator of phase II detoxifying /antioxidant enzymes – and synergistically induced the ARE luciferase activity. Chemical inhibitors of mRNA and protein synthesis affected the combination therapy- mediated transcriptional regulation of both HO-1 and UGT1A1. Synergism of CUR and SFN was evident at low concentrations. Such synergism in ARE-luciferase activity may partly explain the significant induction in the expression of Nrf2- mediated expression of HO-1 and UGT1A1 and the nuclear translocation of Nrf2, suggesting that a combination of low doses may be a promising strategy for cancer chemoprevention. For the second part of this thesis, a liquid chromatographic method was validated for the simultaneous analysis and pharmacokinetic evaluation of Indole-3-Carbinol (I3C), Diindolylmethane (DIM), and several I3C metabolites. I3C and DIM are naturally derived phytochemicals with promising in-vitro and
in-vivo anticarcinogenic properties. Using reversed-phase ultra performance liquid
chromatography (UPLC) coupled with mass spectrophotometry (MS), a rapid, specific, and high
throughput method was developed and validated for the quantification and identification of I3C, DIM, and other I3C metabolites in plasma. Recovery, linearity, precision, accuracy, and stability analysis fulfilled the CDER guidelines criteria. The method was successfully applied to the determination of the pharmacokinetic parameters and elucidation of metabolites of I3C or DIM
after oral, intravenous, or intraperitoneal administration to Sprague- Dawley rats.M.S.Includes bibliographical referencesIncludes vitaby Yury Y. Gome
UDP-glucose glycoprotein glucosyltransferase (uggt-1) and UPR genes modulate C. elegans necrotic cell death:
No full textContrary to an initial understanding of necrosis as a chaotic, non-regulated type of cell death, recent studies suggest that necrotic cell death (NCD) is a consequence of a complex and lethal cascade of genetically-encoded events. Necrosis underlies the pathology of many neurodegenerative diseases, stroke, and traumatic injury. In the Driscoll Lab, NCD mechanisms have been addressed for several years taking advantage of unique genetic and molecular biology tools developed in the model organism Caenorhabditis elegans. The necrotic paradigm we study the most involves initiation of cell death by hyperactivated ion channels expressed in six touch-sensory neurons and requires elevation of intracellular Ca2+, which activates calpain and cathepsin proteases.
I exploited the unique features of our model system to uncover novel genetic factors influencing this process. To this end, I conducted a high-throughput forward genetic screen to identify mutations that block or delay necrotic cell death induced by MEC-4(d) channel hyperactivation, and genetically mapped novel mutations capable of blocking or slowing the death process. I exploited an automated mutational screening capacity that allows sorting of individual animals based on detection of fluorescent signals that, in our particular case, had been engineered to indicate neuronal viability. I focused on the cloning of two novel mutant loci and dissected molecular mechanisms responsible for death suppression. In addition, I studied the impact of a major subset of calcium homeostasis genes in a C. elegans model of Aβ toxicity.
My research adds a new component to the current understanding of NCD, suggesting that inability to cope with endoplasmic reticulum stress (presumably induced by calcium depletion inside the ER, which affects chaperone functionality) plays an important role in progression through necrosis. I discovered that mild activation of an intact unfolded protein response (UPR), e.g., as induced by downregulation of UDP-glucose:glycoprotein glucosyltransferase (UGGT, an ER-resident enzyme involved in high-fidelity protein folding quality control) or mild increments in ambient temperature, can partially suppress necrosis in our C. elegans model, reminiscent of beneficial preconditioning effects in mammals. Additionally I found that several UPR transducers contribute to such modulation of cell death in a “tug-of-war” fashion. Our refined model of molecular mechanisms contributing and modulating necrosis suggests new strategies that could eventually limit the devastating effects of necrosis in human injury and disease.Ph.D.Includes bibliographical references (p. 154-174)by Yury Orlando Nunez Lope
Absorbing new subjects: holography as an analog of photography
Full text linkI discuss the early history of holography and explore how perceptions, applications, and forecasts of the subject were shaped by prior experience. I focus on the work of Dennis Gabor (1900–1979) in England,Yury N. Denisyuk (b. 1924) in the Soviet Union, and Emmett N. Leith (1927–2005) and Juris Upatnieks (b. 1936) in the United States. I show that the evolution of holography was simultaneously promoted and constrained by its identification as an analog of photography, an association that influenced its assessment by successive audiences of practitioners, entrepreneurs, and consumers. One consequence is that holography can be seen as an example of a modern technical subject that has been shaped by cultural influences more powerfully than generally appreciated.
Conversely, the understanding of this new science and technology in terms of an older one helps
to explain why the cultural effects of holography have been more muted than anticipated by forecasters
between the 1960s and 1990s
Украинская духовная атмосфера за интеллектуальным барометром Юрия Шевелёва
Full text linkСтаття написана до столітнього ювілею Ю.Шевельова (1908–2002), розкрито тему “Юрій Шевельов
(Шерех) й Україна”. Проаналізовано літературознавчу спадщину, зокрема й завершальний двотомник
(2001) “Я–мене–мені... (і довкруги)”.This article was written on the occasion of the 100th annivesary of Yury Shevelev (Sherekh) (1908–2002).
The author investigates the relations between Yury Shevelev (Sherekh) and Ukraine, analysing the writer’s
literary criticism, in particular his last book (in two volumes) “Me–myself–I... (and around)” (2001).Статья написана к столетнему ювилею
Ю.Шевелёва (1908–2002), раскрыто тему “Юрий Шевелёв (Шерех) и Украина”. Проанализировано
литературоведческое наследие, в том числе и окончательный двухтомник (2001) “Я–меня–мне… (и вокруг)”
Украинская духовная атмосфера за интеллектуальным барометром Юрия Шевелёва
No full textСтаття написана до столітнього ювілею Ю.Шевельова (1908–2002), розкрито тему “Юрій Шевельов
(Шерех) й Україна”. Проаналізовано літературознавчу спадщину, зокрема й завершальний двотомник
(2001) “Я–мене–мені... (і довкруги)”.This article was written on the occasion of the 100th annivesary of Yury Shevelev (Sherekh) (1908–2002).
The author investigates the relations between Yury Shevelev (Sherekh) and Ukraine, analysing the writer’s
literary criticism, in particular his last book (in two volumes) “Me–myself–I... (and around)” (2001).Статья написана к столетнему ювилею
Ю.Шевелёва (1908–2002), раскрыто тему “Юрий Шевелёв (Шерех) и Украина”. Проанализировано
литературоведческое наследие, в том числе и окончательный двухтомник (2001) “Я–меня–мне… (и вокруг)”
Украинская духовная атмосфера за интеллектуальным барометром Юрия Шевелёва
No full textСтаття написана до столітнього ювілею Ю.Шевельова (1908–2002), розкрито тему “Юрій Шевельов
(Шерех) й Україна”. Проаналізовано літературознавчу спадщину, зокрема й завершальний двотомник
(2001) “Я–мене–мені... (і довкруги)”.This article was written on the occasion of the 100th annivesary of Yury Shevelev (Sherekh) (1908–2002).
The author investigates the relations between Yury Shevelev (Sherekh) and Ukraine, analysing the writer’s
literary criticism, in particular his last book (in two volumes) “Me–myself–I... (and around)” (2001).Статья написана к столетнему ювилею
Ю.Шевелёва (1908–2002), раскрыто тему “Юрий Шевелёв (Шерех) и Украина”. Проанализировано
литературоведческое наследие, в том числе и окончательный двухтомник (2001) “Я–меня–мне… (и вокруг)”
Yury Tynyanov. Energy of the Form.pdf
No full text This book contains articles published at different times, the theme of which is being determined by the innovation of Tynyanov-theorist. Collected under one cover they express, according to the author, the essence of the book’s title. The first theoretical article serves as an introduction to the general theme. And it also is a kind of pretext to the main “Onegin” block of the book, which represents the dynamic concept of literature and the Pushkin’s novel. The article on renewal and development of the Tynyanov's concept of “Eugene Onegin” in the 1960s, which revolutionized the understanding of the poetic novel, closes the Pushkin theme. The Pushkin’s novel in poetry became the reservoir of the theoretical energy of Yu. Tynyanov. Therefore, it is obvious that the language of the novel description and the scientific text of Tynyanov could have the correlative relationships. There is an article about it, devoted to the poetics of Tynyanov’s scientific prose. In two articles completing the book, Tynyanov is mentioned in the context of the main representatives of Russian formalism – Viktor Shklovsky and Boris Eichenbaum. The involvement of the two pillars of the formal method has no opposition significance, same as significance in the similarity of their research positions. Here was important to comprehend the difference in themes, “methods” and approaches of the famous formalists – V. Shklovsky, B. Eichenbaum and Yu. Tynyanov, and also to show that the literary centrism of formalists is far from a self-evident fact. The author did not set himself the task of recalling Tynyanov by praising his ideas in the existing cultural paradigm. According to the author, the main events of the book should be both – the energetic nature of Tynyanov’s theoretical constructions and the energy of the meta text offered to the book’s readers. The book is plump with quotations and citation exchange (for which we apologize to the readers), but which the author did not neglect, so as not to violate the integrity of the narration. Also, here is a technical clarification: all emphasized citations belong to the authors of the quoted texts. The author of the book intentionally tried to avoid the interpretation scheme, following the methodological installation, which Sergei Georgievich Bocharov in the preface to his book «Subjects of Russian Literature» outlined with a notable formula: «Literary criticism is also literature and a philologist is a writer».</p
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