117,314 research outputs found
Il mausoleo di Lucio Canuleio a Bolsena
No full textAngelo Timperi, Il mausoleo di Lucio Canuleio a Bolsena, p. 609-620.
Dal 1984 la Soprintendenza archeologica per l'Etruria meridionale effettua interventi miranti a «riscoprire» il mausoleo di L. Canuleio in loc. S. Arcangelo a Bolsena, sia liberandolo dalla fitta vegetazione di sottobosco sia indagandolo con opportuni scavi archeologici.
La composizione del mausoleo segue lo schema basamento-tamburo-tumulo all'esterno; all'interno, cella con piana a croce greca e cupola, sottostante cripta ed altre celle minori. L'attribuzione alla famiglia dei Canulei sembra ben fondata, essendoci testimoniato dall'Adami il recupero dell'urna di L. Canuelio dal monumento.Timperi Angelo. Il mausoleo di Lucio Canuleio a Bolsena. In: Mélanges de l'École française de Rome. Antiquité, tome 99, n°2. 1987. pp. 609-620
Nivolumab plus chemoradiotherapy in locally-advanced cervical cancer: the NICOL phase 1 trial
No full textConcurrent chemoradiotherapy (CRT) with blockade of the PD-1 pathway may enhance immune-mediated tumor control through increased phagocytosis, cell death, and antigen presentation. The NiCOL phase 1 trial (NCT03298893) is designed to determine the safety/tolerance profile and the recommended phase-II dose of nivolumab with and following concurrent CRT in 16 women with locally advanced cervical cancer. Secondary endpoints include objective response rate (ORR), progression free survival (PFS), disease free survival, and immune correlates of response. Three patients experience grade 3 dose-limiting toxicities. The pre-specified endpoints are met, and overall response rate is 93.8% [95%CI: 69.8–99.8%] with a 2-year PFS of 75% [95% CI: 56.5–99.5%]. Compared to patients with progressive disease (PD), progression-free (PF) subjects show a brisker stromal immune infiltrate, higher proximity of tumor-infiltrating CD3+ T cells to PD-L1+ tumor cells and of FOXP3+ T cells to proliferating CD11c+ myeloid cells. PF show higher baseline levels of PD-1 and ICOS-L on tumor-infiltrating EMRA CD4+ T cells and tumor-associated macrophages, respectively; PD instead, display enhanced PD-L1 expression on TAMs, higher peripheral frequencies of proliferating Tregs at baseline and higher PD-1 levels at week 6 post-treatment initiation on CD4 and CD8 T cell subsets. Concomitant nivolumab plus definitive CRT is safe and associated with encouraging PFS rates. Further validation in the subset of locally advanced cervical cancer displaying pre-existing, adaptive immune activation is warranted
Going Beyond Counting First Authors in Author Co-citation Analysis
No full textThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Square Dancing with the Stars to Enhance Dynamic Hirschman Linkages?
No full textIn this Presidential Address, the author takes the reader on a reconnaissance of his life and time as a regional scientist. He points out scenery he found scintillating along the way, hoping that some may pick up the banner and chew on a few of the ideas for a while. He suggests a revisit to Albert O. Hirschman’s notion of key sectors and more empirical analysis related to Marcus Berliant’s and Masahisa Fujita’s notion of knowledge creation and transfer.Presidential Address, San Antonio, Texas, March 29, 2014 (53rd Meetings of the Southern Regional Science Association
Appropriate Similarity Measures for Author Cocitation Analysis
No full textWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Circulating neutrophils of nonalcoholic steatohepatitis patients show an activated phenotype and suppress T lymphocytes activity
No full textNeutrophils or PolyMorphonuclear Neutrophils (PMNs) are key effector cells of the innate immune system and thanks to their remarkable plasticity, establish a cross talk with T cells modulating their survival and effector functions. During Nonalcoholic Steatohepatitis (NASH), the advanced form of hepatic steatosis or NAFL, PMNs infiltrate liver tissue, becoming a histological feature of NASH. Our aim was to evaluate the frequency of PMNs in NAFL and NASH patients in order to understand how they modulate the activity of circulating CD4+ and CD8+ T cells. In our cohort of patients, NASH patients displayed a higher frequency of circulating PMNs that was strongly correlated to liver enzymes, grade of steatosis, inflammation and fibrosis, the hepatocellular ballooning, and NAFLD Activity Score (NAS). Furthermore, even if ex vivo, in both groups of patients, PMNs shared the same phenotype of resting cells, after 24 hours of coculture with autologous CD4+ and CD8+ T cells, PMNs of NASH patients acquired a more active phenotype, becoming able to strongly inhibit proliferation and activation of CD4+ and CD8+ T cells. The higher ability of PMNs of NASH patients in suppressing CD4+ and CD8+ T cells, over time, might contribute in reducing the immunological defense of liver tissue against damages thus taking part in the progression of the NAFL disease toward NASH
EPIDERMIS AND HAIR FOLLICLE IN BOVINE SKIN EXPRESS THE LEPTIN HORMONE AND ITS RECEPTOR
No full textLeptin (Ob) is a hormone that acts through the activation of the specific receptor Ob-R. It is mainly secreted by visceral and subcutaneous adipose tissue and represents the first known adipokine [1]. Ob is a pleiotropic molecule and plays an important role in the skin, where it stimulates keratinocytes to proliferate and intervenes in the regulation of wound healing processes. It also participates in the control of hair follicle morphogenesis and its cycles of growth, regression, and rest [2]. Ob may act through endocrine, paracrine and autocrine mechanisms. While it is secreted by skin structures including epidermis and hair follicles, intradermal adipose tissue also seems to have a role in Ob secretion and accordingly in the control of the hair follicle cycle in mice and humans [3]. In this work, the morphological characteristics of the skin in bovine species were evaluated by Hematoxylin-Eosin and Oil Red O stainings to investigate the presence and extension of intradermal adipose tissue that may be invoved in Ob secretion. Moreover, Ob and Ob-R expression were analized by means of RT-PCR and immunohistochemistry. Through the morphological analysis, a high and thick dermis without adipocytes was observed. Hair follicles and glands were located in the prossimal part of the skin, beneath the epidermis, while a thick layer of connective tissue, lacking adipose cells, separated these structures by subcutis. RT-PCR gave a positive outcome, evidencing the transcripts for both molecules in the bovine skin samples examined By immunohistochemistry, Ob and its receptor were observed in the epidermis and in the outer root sheath of hair follicles during the follicular cycle. The epidermis abundantly expressed Ob; while all layers of cells were involved, the suprabasal layers expressed a stronger signal. Ob-R was observed in the cells of the basal layer. As regards hair follicles, both Ob and Ob-R were expressed by the outer root sheath of hair follicles. Staining mainly extended into the regions of the infundibulum and isthmus while the bulb was negative. Immunostaining persisted in all stages of hair follicles. The expression of Ob-R in the bovine skin proves that Ob acts on this peripheral organ. The identification of Ob in the epidermis and hair follicle epithelium attests that Ob may act through a paracrine and autocrine mechanism on these structures even if an endocrine mechanism cannot be excluded. The absence of adipocytes around hair follicles and, broadly, in all the dermis indicates that the intradermal adipose tissue does not exist in bovine and accordingly cannot exert paracrine control on the hair follicle. The identification of the Ob system in bovine skin provides important information for properly understanding the biological mechanisms that regulate skin structures, and well as for comparing animal species and highlighting their differences
Letter from unknown writer to Jesse L. Boyce
No full textLetter to Jesse L. Boyce from unknown author (possibly Jack) about the investigation into the powder magazine located in the Grand Canyon. Some personal news is included in the letter such as the writer's marriage to the daughter of C.A. Taylor, former Supervisor of Cochise County
Dispelling the Myths Behind First-author Citation Counts
No full textWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
Sarah L. Blum Author Visit - Warrior Nurse: PTSD and Healing
No full textHear Sarah L. Blum, author of Women Under Fire: Abuse in the Military, discuss her newest book, Warrior Nurse: PTSD and Healing followed by a Q&A and book signing.
Sarah L. Blum is a decorated Vietnam veteran who served as an operating room nurse during the intense fighting of 1967. In recognition of her service, she was awarded the Army Commendation Medal.
Sponsored by CWU Veterans Center and CWU Libraries.https://digitalcommons.cwu.edu/libraryevents/1252/thumbnail.jp
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