3,163 research outputs found
Bluedesign
No full textOltre quindici anni fa, la comunità scientifica italiana del Design già si interrogava sull’identità del «design medi-terraneo come momento di confronto tra luoghi e culture diverse, spesso contraddittorie e a volte ostili» e sulla sua eredità culturale (Spadolini, 2004).
Nell’occasione Genova, Capitale della cultura, si offrì come sede privilegiata per convegni, mostre, attività di confronto e ricerca legate al tema Mediteranneo e Design
WOMEN WITH LYMPANGIOLEIOMYOMATOSIS: FROM RESPIRATORY FUNCTION TO SERUM BIOMARKERS ANALYSIS. PHENOTYPING OF A RARE DISEASE.
No full textLymphangioleiomyiomatosis (LAM) is a rare progressive cystic lung disease that affects almost exclusively women. LAM can occur sporadically, or can be associated with tuberous sclerosis complex (TSC); a rare disorder with multiorgan involvement effecting the brain, kidneys, heart, liver, skin and eyes and is associated with intellectual disability, epilepsy and autism spectrum disorders. Dr.Terraneo PhD project was developed with the aim to expand clinical knowledge about diagnosis and follow up as well as to analyze pathogenic aspect of the development of the disease.
As a first step of the PhD project, the association between LAM and other features of TSC (e.g. demography, extrapulmonary manifestations, genetic mutations..) was investigated as well as the role of pulmonary function tests (PFTs) for LAM diagnosis. Our results demonstrate that age, but not PFTs, is independently associated with LAM development in patients with TSC. PFTs, even if indicated to assess impairment in lung function, result feasible in a limited number of patients due to cognitive impairment, and are not significantly useful for LAM diagnosis in women with TSC. Successively, the case of a patients with coexistence of three rare diseases (autoimmune hepatitis/primary biliary cirrhosis overlap syndrome, lymphangioleiomyomatosis/tuberous sclerosis complex (LAM-TSC), and sarcoidosis) was described. We speculated that the dysregulation of the pathway involving mTOR and MAPK and their interaction might play a role in the pathogenesis of diseases other than TSC, including sarcoidosis.
In the last part of PhD project, the serum levels of VEGF-D, VEGF-C, MMP-2 and MMP-7 were assessed in a cohort of patients affected with S-LAM and TSC with and without LAM.
Our results showed that VEGF-D, MMP-2 and MMP7 were higher in patients with LAM than in patients without. VEGF-D was confirmed as the biomarkers with the highest accuracy for LAM diagnosis. MMP-2 and MMP-7 could be a promising biomarker of LAM
Eloge
No full textOverview of the typology of the encomiastic epigram, from the archaic to the Byzantine period. Silvia Barbantani is author of the section on Greek epigram Rosario Moreno Soldevila is author of the section on the latin epigram
Dynamic hyperinflation during the 6-min walk test in severely asthmatic subjects
No full textWe tested the hypothesis that dynamic hyperinflation develops in severe asthmatic subjects during exercise. Changes in inspiratory capacity (IC) were measured during the 6-min walk test (6MWT) in severe asthmatic subjects compared with chronic obstructive pulmonary disease (COPD) subjects with a similar degree of bronchial obstruction. We assessed whether changes in IC were associated with changes in dyspnoea perception. 27 severe asthmatic subjects (10 males and 17 females) and 43 COPD subjects (35 males and eight females) were recruited. The two groups performed similarly in the 6MWT (p=0.90). At the end of the test, the Borg score increased significantly in both groups (mean difference: for asthmatic subjects 1.7±1.6; p<0.0001; for COPD subjects 3.1±1.9; p<0.0001). IC measured at the beginning of 6MWT was not different between groups (2.25±0.47 L in asthmatic subjects versus 2.38±0.60 L in COPD subjects; p=0.32) and decreased in both groups (mean difference: for asthmatic subjects 0.160 L; p=0.02; for COPD subjects 0.164 L; p<0.0001). However, changes in IC were significantly associated with changes in the Borg score in the COPD group (r2=0.17; p=0.006), but not in the asthma group (r2=0.06; p=0.20). In severe asthmatic subjects, IC significantly drops during the 6MWT to the same extent as COPD subjects with a similar degree of lung impairment, indicating the development of dynamic hyperinflation. Contrary to COPD, in asthmatic subjects the occurrence of dynamic hyperinflation was not associated with changes in dyspnoea perception
The National Labour Policies in the context of the Europe 2020 strategy and of the European Economic Governance
No full textThe National Labour Policies in the context of the Europe 2020 strategy and of the European Economic Governance, by Silvia Borelli
The author presents the main priorities of the Europe 2020 strategy and the different steps of the European Semester of the European Economic Governance. The system of the European measures to solve the economic crisis is completed by the analysis of the “Six Pack”, the EuroPlus Pact and the Treaty on Stability, Coordination and Governance. The author clarifies how the European Employment Strategy has been fully absorbed by the European Economic Governance. After considering some of the new European economic framework’s consequences on Member States’ labour policies and on social dialogue, the author focuses on the recent review of Italian labour policies, performed by European Commission as part of the European Semester
Medical thoracoscopy treatment for pleural infections: a systematic review and meta-analysis
No full textBACKGROUND: Complicated parapneumonic effusions and empyema represent advanced stages of pleural infections and are characterized by a high mortality. Medical thoracoscopy is a safe and minimally invasive endoscopic technique prescribed to treat severe pleural infections. However, only a few studies evaluated its success rate. A systematic review of observational studies was performed to assess the efficacy of medical thoracoscopy in patients with complicated parapneumonic effusions and empyema, as well as its predictive factors.METHODS: A search of the scientific evidence was carried out using PubMed, EMBASE, and Cochrane Central Register of Controlled Trials. Articles describing observational studies on medical thoracoscopy in patients with parapneumonic effusions and empyema were selected.RESULTS: Eight studies met the inclusion criteria. The pooled treatment success rate of thoracoscopy was 85% (95% CI 80.0-90.0%; I2: 61.8%) when used as first-line intervention or after failure of chest tube. The pooled complication rate was 9.0% (95% CI 6.0-14.0%; I2: 58.8%). A pooled difference of treatment success of 9.0% (95% CI 1.0-18.0%) was found when post-thoracoscopy intra-pleural fibrinolysis was prescribed. Pooled success rate was higher in cases with pleural fluid culture negativity (pooled difference: 14.0%; 95% CI 4.0-24.0%).CONCLUSIONS: Medical thoracoscopy is effective and safe when prescribed for complicated parapneumonic effusions and empyema. Bacteriological negativity of pleural effusion specimens and administration of adjuvant intra-pleural fibrinolysis after the procedure are associated with a higher success rate
Lavorare per la rivoluzione. Un'impresa commerciale tra Italia e Cina
No full textThe volume collects the biographical testimony of Fabio Matteini who, starting from the ’60s, undertook an import activity of Chinese handcra products with the aim of supporting the political and cultural initiative of the Edizioni Oriente of Milan, the main center for the spread of Maoism in Italy. The testimony is accompanied by a prefatory essay by Gilda Zazzara on Matteini work culture and by a selection of photographs taken by the author during the years of the Cultural Revolution, chosen and introduced by Silvia Calamandrei
Experiential verbs in Homeric Greek
No full textIn Experiential verbs in Homeric Greek. A constructional approach Silvia
Luraghi offers a comprehensive account of construction variation with
two-place verbs belonging to different sub-domains of experience
(including bodily sensation, perception, cognition, emotion and
volitionality) in the Homeric language. Traditionally, variation is
ascribed to the independent meaning of cases that mark the second
argument, and explanations have focused on properties of the latter.
By taking a constructional approach, the author shows that construction
variation also brings about differences in the conceptualization of the
subject/experiencer by pointing to different degrees of control and
awareness. Variation is then shown to refl ect the embodied construal
of experience along with the social dimension of emotion
Does strict employment protection discourage job creation? Evidence from Croatia
No full textEmployment protection legislation in Croatia is among the most strict in Europe. Firing is difficult and costly, and flexible forms of employment are limited. Is this apparent rigidity reflected-as one would expect based on standard economic theory-in low labor market dynamics? Is job creation low and hiring limited? Is the job security of insiders achieved at the cost of outsiders not being able to enter thelabor market? The author attempts to answer these questions by examining job flows. If the employment protection legislation is binding, then job and worker turnover should be low. He shows that this is indeed the case. Hiring is limited and the average job tenure is very long in Croatia. Job destruction is low, however job creation is still lower. The result is accumulation of unemployment, in large part due to new labor market entrants not being able to find a job. The high degree of job protection also seems to strengthen the bargaining position of insiders and results in relatively high wages. So, wages in Croatia are higher than among its competitors, even after adjusting for productivity. These high labor costs are likely to contribute to limited job creation in existing firms, but also are likely to discourage the entry of-and thus job creation in-new firms. The author presents evidence that firm growth has been indeed limited in Croatia, contributing to the low employment level. The author examines other potential causes of high unemployment in Croatia (the unemployment benefit system, labor taxation, the wage structure, and skill and spatial mismatches). He argues that they do not play a substantial part in accounting for poor labor market outcomes in Croatia. The author concludes that the stringent employment protection legislation is the key labor market institution behind low job creation and high unemployment. Based on this he recommends specific measures aimed at liberalizing the labor market to foster job creation and employment.Labor Management and Relations,Labor Policies,Labor Markets,Environmental Economics&Policies,Trade Finance and Investment,Labor Markets,Labor Management and Relations,Labor Standards,Banks&Banking Reform,Environmental Economics&Policies
A interação texto/imagem em duas traduções de Flicts para o inglês
No full textDissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Comunicação e Expressão, Programa de Pós-Graduação em Estudos da Tradução, Florianópolis, 2013.Abstract : This study aims to investigate two translations of FLICTS, first children's book written by Ziraldo and first full-colored album for children produced in Brazil, with a view to discussing the different interactions between text and image that might occur within the translation of children's literature. Considered a landmark in Brazilian Children's Literature since its launch in 1969, its British version was translated by Silvia Caruana and published by the publishing house Roger Schlesinger in 1973 and its American English version was translated by Daniela Pinto, originally published by Melbooks in 1984 - subsequently also published by Editora Melhoramentos and commercialized in Brazil. The theoretical framework informing the study is based on the interface of Descriptive Translation Studies, Translation of Children's Literature and the Grammar of Visual Design. By the analyses of a multimodal corpus and a dossier about the history of this printed book, it was possible to note that the several changes along FLICTS publishing history have made up other possible readings on this work
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