17 research outputs found
Psychometric Properties of Turkish versions of the Leyton Obsessional Inventory-Child Version (LOI-CV) and Obsessive Beliefs Questionnaire-Child Version (OBQ-CV)
No full textObjective: Juvenile obsessive-compulsive disorder has been increasingly recognized in the literature. However, the developmentally sensitive screening tools for obsessive-compulsive disorder (OCD) in children and adolescents still lag behind psychometric tools developed for adult OCD. The Leyton Obsessional Inventory-Child Version is the most widely utilized screening tool for juvenile OCD assessment. Our aim was to assess psychometric properties of the Leyton Obsessional Inventory-Child Version (LOI-CV) and Obsessive Beliefs Questionnaire-Child Version (OBQ-CV)
The commentary methodology in the commentary on Musnad Abi hHanifah by Ali al-Qari
No full textYüksek Lisans TeziBu çalışmada, Ali el-Kârî'nin Şerhu Musnedi Ebî Hanîfe isimli eserinin muhteva ve metodu tesbit edilmeye çalışılmış, Ebû Hanîfe'ye yöneltilen bazı tenkidlere müellifin verdiği cevaplar ortaya konmuştur. Netice itibarıyla bu şerh özelinde Ali el-Kârî'nin hadisçiliği hakkında fikir edinmeye çalışılmıştır. Bununla birlikte çalışmada Ali el-Kârî'nin şerhini ilim dünyasında farklı yönleriyle gündeme taşımak hedefi güdülmüştür. İslâmî ilimlerde önde gelen âlimlerden biri olan Ali el-Kârî, Afganistan'ın Herat şehrinde dünyaya gelmiş, Şah İsmail'in şîîleştirme siyasetinden dolayı Herat'ı terkedip Mekke'ye yerleşmiş ve orada 1014/1605 senesinde vefat etmiştir. İslâmî ilim dallarının hemen hemen tamamında eser yazmıştır. Eserlerinden bugün de istifâde edilmektedir. Ali el-Kârî, Musnedu Ebî Hanîfe'nin Hârisî (340/952) tarafından cem edilen ve Haskefî'nin (650/1252) ihtisar ettiği Musned üzerine şerh yazmıştır. İşte bugün Musnedu Ebî Hanîfe ismi ile meşhur olan ve Ali el-Kârî'nin şerh ettiği Musned budur. Çalışma iki bölümden müteşekkildir. Birinci bölümde Ali el-Kârî'nin hayatı, ilmî şahsiyeti, hadisçiliği ve Musned hakkında bazı bilgilere yer verilmiştir. İkinci bölümde ise Şerhu Musnedi Ebî Hanîfe'nin tanıtımı, şerhte kullanılan kaynaklar, şerhin muhteva ve metodu, Ebî Hanîfe'ye yöneltilen bazı tenkidler ve Ali el-Kârî'nin cevabı incelenmiş ve misallerle îzah edilmeye çalışılmıştır. Ali el-Kârî, genel olarak bu şerhi anlaşılır ve kolay ibarelerle, okuyan kimsenin rahatlıkla anlayabileceği bir üslûp benimseyerek, rivâyetleri kısa ifâdelerle şerh etmiştir. Hadisleri Hanefî mezhebi doğrultusunda şerh etmiş ve yer yer diğer mezheplerin görüşlerine de yer vermiştir. Hadisler arasındaki tearuzda genelde cem' ve te'lif, nesih ve haml yöntemlerini kullanmıştır.In this study, the content and method of Ali Al-Qari's work named Sharh Musnad Abî Hanîfah was tried to be determined, and the answers of the author to some of the criticisms directed to Abu Hanîfah were revealed. As a result, it's been tried to get an idea of the Hadith aspect of Ali Al-Qari in this commentary work. However, in this study, the major goal was to bring Ali Al-Qari's work to the world of science with its different aspects. Ali Al-Qari, one of the leading scholars in Islamic Sciences, was born in the city of Herat in Afghanistan. Due to Shah Ismail's policy of converting people to shiism, he has left Herat and settled in Mecca. He died there in 1014/1605. He wrote works in almost all branches of Islamic Science. His works are also being used today. Ali Al-Qari wrote an commentary on Musnad which was compilated and collected by Harisi (340/952) and then was shortened by Haskafi (650/1252). This is the same work which is known today as Musnad Abî Hanîfah with its commentary made by Ali al-Qari. The study is composed of two parts. The first section deals with some information about Ali Al-Qari's life, his scientific personality, his proficiency in terms of hadith, and some details about Musnad. In the second part, the introduction of Sharh Musnad Abî Hanîfah, the sources used in it, the content and method of the sharh, some strictures directed to Abu Hanifah, and the answers of Ali al-Qari to those strictures were examined and tried to be explained with examples. Ali Al-Qari, wrote his sharh with open-and-shut inscriptions, in a manner that is easily understood to every reader and made his commentaries about the narrations with short and brief phrases, in general. He has made his commentary in accordance with the Hanafi school, and occasionally presented the opinions of other schools also. In contradicting cases between the hadiths, he generally used the methods of jam' and ta'leef, naskh and haml
Low Serum Level alpha-Synuclein and Tau Protein in Autism Spectrum Disorder Compared to Controls
No full textalpha-Synuclein (alpha-syn) and tau proteins are thought to be related with the synaptic loss and cell death underlying several important neurodegenerative diseases. The aim of our study was to investigate serum alpha-syn and tau levels in autism. Serum levels of alpha-syn and tau were measured, and autism spectrum disorder (ASD) severity was assessed at admission using the Childhood Autism Rating Scale (CARS) total score. The mean CARS score of the autism group on admission was 47.91 points (SD: 5.97). The results indicated that the mean serum alpha-syn and serum tau levels were significantly (p < 0.001) lower in children with ASD as compared with normal cases (33.01 +/- 20.78 and 55.19 +/- 15.34 ng/mL and 241.23 +/- 290.5 and 509.78 +/- 269.25 ng/mL, respectively). There was a significant positive correlation between seruma-syn levels and serum levels of tau identified by Pearson correlation analysis (r = 0.922, n = 28, p < 0.001). Synaptic abnormality in autism may result from microglial activity. Furthermore, alpha-syn and tau aggregation may lead to synaptic dysfunction, and this may contribute to either neuronal or synaptic dysfunction or neurodegeneration. Our preliminary study suggests that low levels of serum alpha-syn and tau may be implicated in the relationship between synaptic activity and autism
P38 Assessment of neurodevelopment and school performance of late and moderate preterms at 11–12 years of age
No full text
Should We Continue Methylphenidate Treatment Despite Orofacial or Extremity Dyskinesias?
No full textAliyyul-Kârî and method of commentary (Example on The Mirkatu`l-Mefatih)
No full textDoktora TeziAraştırmanın konusu 16. Yüzyıl alimlerinden biri olan Aliyyu'l-Kârî'nin hayatını "Mirkâtu'l-Mefâtîh Şerhu Mişkâti'l-Mesâbîh" adlı eserini ve bu şerh eserinde kullandığı metodunu incelemektir. Aliyyu'l-Kârî'nin bu eseri hadis ilminde cem niteliği olarak kabul edilen eserlerden biri olan "Mişkâtu'l-Mesâbîh" eserine yazılmış en kapsamlı eser olarak kabul edilmiştir. Müellif şerhini kaleme alma sebebi olarak dönemin halkının sünnet ve hadise olan ilginin azalması ve hanefi mezhebinin hadis ilmine olan ilgisini ortaya koymak olduğunu vurgulamıştır. Araştırmamız üç bölümden oluşmaktadır. Müellifin hayatı ile ilgili malumat ve eserleri giriş bölümünde ele alınmıştır. Birinci bölümde, Mirkâtu'l-Mefâtîh'in her yönü ile tanıtımı yapılarak hem eserin ana kaynakları hem de Aliyyu'l-Kârî'nin hadislerin şerhinde kullandığı kaynakların tanıtımı yapılmıştır. İkinci bölümde Aliyyu'l-Kârî'nin hadisleri şerh etme metodu örneklendirme yolu ile izah edilmiştir. Bu bölümde genel itibariyle müellif hadislerin bab başlıklarının izah edildiği daha sonra muhteva değerlendirilmesinin ele alındığı tespit edilmiştir. Genel nitelikli tez olarak kabul edilebilecek eserde şerh alanında gerekli görülen temel noktalara temas edilmiştir. Üçüncü bölümde ise Mirkâtu'l-Mefâtîh'in İslâm ilimleri bakımından değeri ve kendisinden sonraki çalışmalara hangi ölçüde kaynaklık ettiği tespit edilmiştir. Eserin etkisi hem arapça hem de Türkçe yazılmış eserler çerçevesinde ele alınarak örneklendirme yapılmıştır. Yazıldığı dönemde olduğu gibi hala günümüzde de ilgi gören eserlerin başında gelir.The subject of the study is to examine the life of Aliyyul-Kari, one of the 16th century scholars, and his method used in this annotation work. This work of Aliyyul-Kârî is considered to be the most comprehensive work on " Mişkâtul-Mesâbîh" one of the works considered to be an inclusive characteristic in the science of hadith. The author explained his reason for writing the annotation as reducing the interest of the people in that period to Sunna and the Hadis, and he also wanted to emphasize the interest of the Hanafi sect in the hadith science. Our research consists of three parts. Information about the life of the author and his works are discussed in the introduction. In the first chapter, "Mirkâtul-Mefâtîh" was introduced in every aspect, simultaneously the main sources of this work are explained. In the same time, the sources used by Aliyyul-Kârî in the explanations of the hadiths were introduced. In the first chapter, the main sources of the work and the sources used by Aliyyul-Kârî in the commentary of the hadiths were introduced. In the second chapter, Aliyyul-Kârî's method of commentary on the hadiths is explained by sampling. In this section, it is determined that the headings of the hadiths are explained and then the content evaluation is discussed. In the work which can be accepted as a general qualified thesis, the essential points in the field of commentary have been touched. In the third chapter, the value of Mirkâtul-Mefâtîh in terms of Islamic sciences and the extent to which it was the source of the studies after him were determined. The effect of the work was examined by sampling and also in the frame of both in Arabic and Turkish scientific works. As it was in the period of writing, it is still one of the most popular works on this subject today
Düşük serum UCH-L1 ve TDP-43 düzeyleri otizmde bozulmuş ubikuinasyon sürecini yansıtabilir mi?
No full textWOS: 000412669100014PubMed ID: 29033641Introduction: The mechanism of ubiquitination-related abnormalities causing neural development problems is still unclear. We examined the association between autism and serum transactive response DNAbinding protein-43 (TDP-43) and ubiquitin c-terminal hydrolase-L1 (UCH-L1) levels, both of which are members of the ubiquitinproteosome system. Methods: We measured serum levels of TDP-43 and UCH-L1 in 24 children with autism and 24 healthy children. Childhood Autism Rating Scale (CARS) was used to assess symptom severity at admission. Results: The mean serum TDP-43 and UCH-L1 levels in children with autism spectrum disorder (ASD) were found to decrease compared to healthy controls (p< 0.001, 506.21 +/- 780.97 ng/L and 1245.80 +/- 996.76 ng/L, respectively; 3.08 +/- 5.44 ng/mL and 8.64 +/- 6.67 ng/mL, respectively). A positive correlation between serum TDP-43 levels and UCH-L1 levels was found in the ASD group (r= 0.947, n= 24, p< 0.001). The CARS score of children with ASD was 48.91 points (standard deviation [SD]: 5.82). Conclusion: Low serum levels of UCH-L1 and TDP-43 may reflect disturbed ubiquitination in autism.Amaç: Protein ubikitinlenme ile ilgili bozuklukların nöronal gelişim sorunlarına nasıl yol açtığı açıklanamamıştır. Bu çalışmada, ubikuitin proteozom sistemine üye olan ubikuitin c-terminal hidrolaz-L1 (UCH-L1) ve transaktif yanıtlı DNA-bağlayıcı protein (TDP-43) düzylerinin otizm ile ilişkisi araştırılmıştır.Yöntemler: Bu bağlamda 24 otizm tanılı çocuk ve 24 sağlıklı çocukta serum TDP-43 ve UCH-L1 düzeylerine bakılmıştır. Otizm şiddet derecesi Çocukluk Otizm Derecelendirme Ölçeği (ÇODÖ) ile değerlendirilmiştir. Bulgular: Otizm tanılı çocukların başvuru sırasında ortalama ÇODÖ puanları 48.91 (SD: 5.82) idi. Sağlıklı gruba göre otizmli grupta serum TDP-43 ve Serum UCH-L1 düzeyleri anlamlı olarak düşüktü (sırasıyla 506,21±780,97 ng/L ve 1245,80±996,76 ng/L; 3,08±5,44 ng/mL ve 8,64±6,67 ng/mL; p<0.001). Serum TDP-43 and UCH-L1 düzeyleri arasında pozitif korelasyon anlamlı olarak tespit edildi (r=0.947, n= 24, p<0.001).Sonuç: Sonuç olarak, düşük UCHL-L1 ve TDP-43 düzeylerinin, otizmde bozulmuş ubikitinlenme sürecini yansıtabileceği düşünülmüştür.Batman University Scientific Research Project Coordination Center [BTUBAP-2015-YL1]This research was supported by Grants from Batman University Scientific Research Project Coordination Center (BTUBAP-2015-YL1
Biological Rhythm Disturbances in Drug-Free Adult ADHD Patients
No full textObjective: The aim of study was to examine the biological rhythms in drug-free ADHD patients with healthy controls in a cross-sectional study. Methods: 50 adult ADHD patients %26 female) between 17 and 42 years old (M=27.76 SD:6.80) and healthy controls (%56.6 female) between 18 and 63 years old (M=31.39 SD:8.12) were recruited from Health Sciences University's Bakirkoy Mental Health Training and Research Hospital. Participants were assessed with clinical interview, Wender-Utah Adult ADHD Rating Scale and the Biological Rhythms Interview of Assessment in Neuropsychiatry (BRIAN). Results: Adult ADHD patients scored higher on total scores (t=8.75, p<0.001), eating patterns (t=2.55, p<0.001), sleep patterns-social rhythm (t=3.41, p=0.001) and activity levels (t=3.0, p<0.001) in regarding to biologic rhythms. In the BRIAN subdomains; activity levels (t=4.59, p<0.001) and sleep-eating patterns (t=3.62, p<0.001) were also significantly different between the two groups. Conclusions: Our findings suggested that there was a significant difference between ADHD patients and healthy controls in most dimensions of biorhythm.</p
Association of Dissociation with Suicide Attempt and Non-Suicidal Self Injury in Adolescents with a History of Sexual Abuse
No full text© 2022 The Washington School of Psychiatry.Objective: Dissociative symptoms are considered risk factors for suicide and non-suicidal self-injury (NSSI). In this study, the relationship between suicidal behaviors and NSSI with dissociative symptoms in adolescents with a history of Child Sexual Abuse (CSA) was investigated. Methods: A total of 100 adolescents with a history of CSA were evaluated with a detailed forensic psychiatric interview. Dissociative symptoms were measured with the self-report Adolescent Dissociative Experiences Scale (A-DES) and the parent-reported Child Dissociative Checklist (CDC). Results: While dissociative symptoms did not differ between adolescents with and without suicide attempts (CDC; p = .068 and A-DES; p = .060), they were significantly higher in adolescents with non-suicidal self-harming behavior (CDC; p < .001 and A-DES; p = .001). Suicide attempts and NSSI were more common in those who reported genital touching as a type of sexual abuse (respectively, p = .003; p = .048). In regression analysis; history of psychiatric treatment (OR = 9.09 [95% CI = 1.52, 54.29]) and NSSI (OR = 8.18 [95% CI = 2.01, 33.23]) were independently associated with suicide attempts. In addition, parent-reported dissociative symptoms (CDC scores) (OR = 1.27 [95% CI = 1.06, 1.53] and suicide attempt (OR = 8.09 [95%CI = 1.96,33.42] showed independent association with NSSI. Conclusions: Dissociative symptoms may be predictive factors for NSSI and should be considered in risk assessment of adolescents with a history of CSA
