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Effect of Diplotenia turcica Root Extraction on Biochemical and Hematological Parameters
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Carbon supported Pt-M (M=Ag, Ca, Cd, Cs, Cu, Fe, Ir, Mg, Pd, Ru, Zr) nanocatalysts: A Novel approach for alcohol elec-trooxidation by using EIS
No full textTerfezia claveryi'nin Morfolojik ve Moleküler Karakterizasyonu ve Türkiye'deki Dağılımı
No full textÖrnekler, Türkiye'nin Ankara, Gaziantep, Konya, Niğde ve Şanlıurfa illerinden 2020 ile 2023 yılları arasında toplanmıştır. Örneklerin incelenmesinde morfolojik analizler ve nrITS rDNA dizisine dayalı filogenetik yöntemler kullanılmıştır. Yirmi bir örnek, makro ve mikro seviyede Terfezia claveryi Chatin ile uyumlu morfolojik özellikler sergilemiştir. Genetik analiz, bu türle %99'dan fazla dizi benzerliği olduğunu ortaya koymuştur. Detaylı dokümantasyon kapsamında habitat tanımları, coğrafi koordinatlar, toplama tarihleri ve makroskobik ile mikroskobik yapıların fotoğrafik kayıtları yer almıştır. Bu bulgular, Türkiye'deki T. claveryi'nin dağılımı ve taksonomisi hakkında değerli bilgiler sunmaktadır.The samples were collected from Ankara, Gaziantep, Konya, Niğde, and Şanlıurfa (Türkiye), between 2020 and 2023. Morphological analyses and nrITS rDNA sequence-based phylogenetic methods were used to examine the samples. Twenty-one specimens displayed morphological features consistent with Terfezia claveryi Chatin at both macro and micro levels. Genetic analysis revealed over 99% sequence similarity with this species. Detailed documentation included habitat descriptions, geographical coordinates, collection dates, and photographic records of macroscopic and microscopic structures. These findings contribute valuable insights into the distribution and taxonomy of T. claveryi in Türkiye
Examining Users Intentions to Use Cryptocurrency in Türkiye
No full textThis study aims to test a research model forcryptocurrencies based on integrated theoretical foundations of the TAM, trusttheory and flow theory. Data were obtained from 280 people through an onlinesurvey. Structural equation modeling was used to test the research model.Process macro was performed to test mediating roles. According to the findings,perceived trust (PT), perceived enjoyment (PE) and perceived usefulness (PU)directly affect the intention to use (IU). In contrast, the direct effect ofperceived ease of use (PEOU) on IU is not significant. However, as expected,PEOU directly affects PT, PE, and PU. PT directly affects PE and PU. PEdirectly effects PU. In addition, PEOU, PT, and PE have indirect effects on IU.PEOU also has an indirect effect on PE and PU. PT has an indirect effect on PU.Consequently, all mediating roles of PT, PE, and PU are significant.Recommendations are provided.</p
Synthesis of New Pyrazolo[1,5-a]Pyrazin-4(5H)-One Derivatives and Effects on PI3K Protein Levels in A549 Lung Adenocarcinoma Cell Line
No full textMolecular targeted therapies have significantly advanced non-small cell lung cancer (NSCLC) treatment; however, acquired resistance in advanced stages remains a critical challenge. To overcome this, novel therapeutic targets or combination strategies are urgently needed. In this study, a new series of pyrazolo[1,5-a]pyrazin-4(5H)-one derivatives (compounds 12–41) was designed and synthesized. Their antiproliferative activities were assessed in the A549 NSCLC cell line. Compounds 15, 16, 21, and 26–28 showed strong cytotoxicity, with IC50 values of 8.19 µM (compound 27) and 7.01 µM (compound 28). Notably, compounds 21 and 26–28 significantly reduced phosphoinositide 3-kinase (PI3K) protein levels in A549 cells. To better understand their mode of action, molecular docking studies were performed using the crystal structure of PI3K (PDB ID: 4XE0), revealing favorable binding affinities and conserved interactions within the active site. Compounds 27 and 28, which showed the strongest in vitro activity, also exhibited the most stable binding modes and docking scores, consistent with the biological data. Structure–activity relationship (SAR) analysis indicated that a high electron-density benzene ring on the pyrazole moiety and a low electron-density ring on the pyrazine enhanced cytotoxic activity. Drug-likeness and pre–absorption, distribution, metabolism, excretion, and toxicity (ADMET) evaluations suggested favorable pharmacokinetic properties