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Lipemia retinalis following FLAG-Ida protocol in an 11-year-old patient with acute myeloid leukemia
No full textIntroduction: We report a case of early-onset lipemia retinalis secondary to the FLAG-Ida protocol in the treatment of acute myeloid leukemia (AML) in an 11-year-old girl. Case Report: An 11-year-old patient, diagnosed with AML at four months old, experienced a relapse and was treated with the FLAG-Ida protocol (fludarabine, idarubicin, granulocyte-colony stimulating factor, and high-dose cytarabine). Prior to allogeneic stem cell transplantation, she underwent a pre-transplantation eye examination. The patient exhibited normal visual acuity in both eyes. Fundus examination revealed cream-white retinal vessels and a salmon-pink retina, indicative of grade 3 lipemia retinalis. Laboratory tests, normal before treatment initiation, showed significantly elevated serum cholesterol (727.6 mg/dL) and triglyceride (6015.6 mg/dL) levels post-treatment. After receiving fenofibrate, these levels decreased markedly, and the retinal vessels normalized on follow-up fundus examination. Conclusion: Lipemia retinalis, characterized by creamy-white retinal vessels resulting from hypertriglyceridemia, can develop as a secondary condition to chemotherapy. Early detection and treatment of hyperlipidemia are crucial to prevent severe ocular and systemic complications. This case highlights the importance of monitoring lipid levels and conducting thorough ophthalmologic examinations in patients undergoing chemotherapy
A novel ofdm-fmcw waveform for low-complexity joint sensing and communication
No full textWith the advent of 6th Generation (6G) wireless networks, integrating Orthogonal Frequency Division Multiplexing (OFDM) and Frequency Modulated Continuous Wave (FMCW) waveforms presents a promising solution for simultaneous communication and sensing. While OFDM offers high communication performance, it requires complex transceivers for sensing applications. Conversely, FMCW is easily implemented for sensing but provides low data rates for communication. This letter derives the mathematical relationship between OFDM and FMCW, showing how FMCW can be generated from the diagonal elements of the OFDM modulator (i.e.ifnextchar.gobble, the Discrete Fourier Transform (DFT) matrix). We propose a novel approach that leverages the DFT matrix to seamlessly integrate these two waveforms, minimizing interference and enabling high data rate communication alongside low-complexity sensing receiver design. Extensive simulations demonstrate the effectiveness of our technique in achieving simultaneous sensing and communication.Turkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK
Reduced resting and task-related alpha activity in mine workers: Implications for occupational health and neurodegenerative risk
No full textUnderground mine workers face many risk factors at work sites that are known to affect the neural system. Observational studies report that these risk factors precede neuromuscular and neurodegenerative disorders, especially in old-age miners. Neurodegenerative disorders have electrophysiological, anatomical, and functional changes long before symptoms are seen in older adults. Therefore, this study investigated whether risks faced by miners at young ages were reflected in electrophysiological signals. Twenty-one underground miners and twenty-two above-ground workers matched with them in terms of age, education, and working duration were included in this study. Participants were recorded with a 20-channel EEG during the resting-state (eyes open and closed; EO-EC) and the perception of the International Affective Picture System Paradigm (IAPS). Time-frequency analyses were performed for alpha frequency. Rs-EEG results showed a statistically significant difference in alpha power between the EO and EC states in the control group. However, there was no statistical difference in alpha power between these two conditions in the miners. Additionally, we noted a more pronounced decrease in alpha responses in the posterior region during EC in the miners. The group's main effects were statistically significant in event-related alpha responses during emotional responses. Accordingly, event-related alpha responses of the miner group were lower than the control group in terms of both power spectrum and phase-locking. Underground mine workers are cognitively and emotionally affected by risks in the work environment. Electrophysiological changes seen in young underground workers may be a harbinger of neurodegenerative disorders in miners' old age. Our research findings may lead to the development of occupational neuroscience, social policies, and worker health, which are necessary to improve working conditions for mineworkers.Türkiye Bilimsel ve Teknolojik Araştırma Kurumu (TÜBİTAK
Liver transplantation for autoimmune hepatitis 20 years of tertiary centre experience
No full textBackground/Aims: We analyzed the frequency of complications and survival rates in patients with autoimmune hepatitis (AIH) who underwent liver transplantation at a high-volume transplant center. Materials and Methods: Patients who underwent transplantation for AIH at the İnönü University Liver Transplantation Institute between January 2002 and December 2021 were included. Patients with a confirmed diagnosis of AIH, without concomitant chronic liver disease, were included in the study. Results: We included 51 patients (31 female) with a median age of 38.5 years (18-65 years). The 12-month and 60-month survival rates were 86.3% and 80.9%, respectively. During a median 2.22 years follow-up, 9 patients died. Six patients died due to systemic infection, 1 due to biliary complications, and 2 patients due to graft rejection. Autoimmune hepatitis recurrence developed in 6 (11%) patients. Overall, biliary complications developed in 56% (28/51) of patients following liver transplantation, and graft rejection occurred in 22% (11/51) of patients. Conclusion: Our results suggest that the outcome of AIH following liver transplantation is good, with a survival rate of up to 80%. Post-transplant biliary complications are common; therefore, close follow-up is necessary
Acute effects of myofascial release technique on flexibility and pain: outcome for chronic low back pain
No full textBackground: Myofascial release technique (MFR) is frequently used in the treatment of patients with chronic low back pain (CLBP), but there are limited studies on the acute effects of this technique. It was aimed to determine the acute effect of MFR technique on pain and flexibility in CLBP. Methods: Forty CLBP patients (19 female; 21 male) with an average age of 40 years were randomized as MFR technique and classical massage groups. A single session of technique was applied to each group. Outcome measurements consisted of the Visual Analogue Scale (VAS), Sit and Reach Test (SRT), Straight Leg Raise Test (SLRT), and Modified Schober Test. Results: In within-group comparisons, all outcome measures (except right-SLRT) improved statistically significantly in both groups after interventions (p˂0.05). ANCOVA was conducted to determine whether there were significant differences in between groups after intervention while controlling for age. The analysis showed that VAS, SRT and left-SLRT results were significantly more improved after the MFR technique compared with classical massage (p˂0.05). Conclusion: In conclusion, the MFR technique is a safe and effective method for the immediate relief of pain and the enhancement of flexibility. Furthermore, it demonstrates superior efficacy in pain relief and flexibility improvement compared to classical massage, which is another manual therapy technique
Effect of a novel irrigation regimen and root canal filling material versus conventional endodontic protocols on dentin wettability
No full textThe purpose of this study was to compare the effect of different irrigation regimens on the dentin wettability of root canal sealers. The occlusal surfaces of human molar teeth (N = 90) were removed, polished, and divided into three groups (n = 30) based on the irrigation regimen: control group (SAL), standard irrigation group (NES), and test group (ODC). Each group was randomly divided into three subgroups according to the root canal sealer: AH Plus (AHP), Total Fill BC Sealer HiFlow (TOT), and OdneFill (ODF). The contact angle was determined using the sessile drop technique. The pendant droplet method assessed the work of adhesion. Surface roughness was measured using atomic force microscopy. Data were analyzed using non-parametric tests (p .05) while both groups presented significantly lower results than TOT (p .05), whereas ODF presented significantly lower results compared to both (p .05). This study highlights the wettability of a new root canal sealer and the effect of a new irrigation activation system on the wettability of different root canal sealers. OdneFill showed superior wettability compared to other sealers while exhibiting a synergistic effect with OdneClean.nnosuisse-Swiss Innovation Agency, Zurich, Switzerlan
Validity and reliability of the Turkish version of the Düsseldorf orthorexia scale (tr-dos) and the prevalence of orthorexia nervosa among Turkish university students
No full textOrthorexia Nervosa (ON) is characterized by an excessive preoccupation with healthy foods accompanied by the avoidance of self-declared unhealthy options, yet it remains unrecognized in major diagnostic guidelines. The Düsseldorf Orthorexia Scale (DOS), a 10-item self-report questionnaire using a four-point Likert scale, assesses the obsession with healthy eating. This study evaluates the reliability and validity of the TR-DOS in the Turkish context and estimates the prevalence of ON among university students. Several studies have shown that translating the DOS into various linguistic groups may exhibit different models of DOS scores. However, the psychometric properties and model fit of the DOS have not yet been investigated in Turkish-speaking populations; to address this gap, we assessed the psychometric properties of a Turkish translation of DOS (TR-DOS) in a sample of 425 university students in Türkiye. The TR-DOS revealed a 7.3% ON prevalence and a 9.0% risk of development. Weak positive associations were observed between TR-DOS total scores and BMI (r = 0.152, p =.002). Exploratory Factor Analysis confirmed the validity of TR-DOS (KMO = 0.867) with satisfactory reliability (Cronbach’s alpha = 0.854). Confirmatory Factor Analysis indicated an acceptable fit for the TR-DOS model (χ2/df = 3.127, RMSEA = 0.071, SRMR = 0.046, IFI = 0.955, CFI = 0.955, GFI = 0.956, TLI = 0.932). Moderate positive correlations were found between TR-DOS and eating disorder measures (EAT-26: r = 0.428, p <.001; EDE-Q-13: r = 0.430, p <.001). The findings demonstrated that the TR-DOS is both culturally appropriate and psychometrically adequate for Turkish university students. It is a reliable and valid instrument for assessing obsessive healthy eating behaviors in this population
Impact of cooking on nutritional contents of kenger in terms of antioxidants
No full textKenger (Gundelia tournefortii) grown in Sanliurfa and neighbouring provinces in Turkiye, is known for its health promoting potential due to the presence of bioactive compounds as phenolics and antioxidant vitamins. However, such compounds in food may be affected by thermal treatment as cooking. This study investigated the impact of common cooking techniques (boiling and stir-frying in oil) on phenolics, vitamin C content and antioxidant activity of kenger. Phenolic compounds were analysed using LC–MS/MS and DPPH inhibition. Vitamin C was quantified using HPLC and antioxidant activities were assessed by DPPH inhibition, ABTS and FRAP methods. Major phenolic compounds in raw samples were vanillic (18.755 ± 0.606 µg/g) and fumaric (16.211 ± 0.524 µg/g) acids. In boiled kenger, significant loss of fumaric (5.789 ± 0.187 µg/g), in stir-fried kenger, loss of vanillic (15.604 ± 0.504 µg/g) and fumaric (8.113 ± 0.262 µg/g) acids were noted (p 0.05) in terms of phenolic compounds and vitamin C. Correlation between antioxidant activity assessing methods were only significant for 75 and 100 mg/mL sample concentration (rho = -0.90 p < 0.05). In conclusion, boiled and stir-fried kenger is suggested as optional consumption methods. Inclusion of condiments, herbs, olive oil, yoghurt during service would not only increase palatibility but also add to the health benefits
Regulatory issues related to the use of sodium hypochlorite solutions in endodontics
No full textAim: To assess the regulation of sodium hypochlorite (NaOCl) solutions for endodontic usage in some of the world's main dental markets, in view of the European Union's recent move to classify antimicrobial root canal irrigants as high-risk devices under their Medical Device Regulation (MDR). Methodology: The authors consulted legal texts available online and communicated with local health authorities wherever necessary to assess into which medical device category NaOCl solutions intended for endodontic application were subsumed. Furthermore, it was investigated whether there were sources outside the dental market to obtain NaOCl solutions for root canal treatments. Results: Upon completion of this text (mid 2024), NaOCl solutions for root canal irrigation had not been classified in the US and Canada, whilst in the European Union, they had just been upgraded to high-risk medical devices, with all the consequences for the dental supply market. This MDR rule was adopted by the EU's close trading partners, the United Kingdom, Switzerland and Turkey. In Japan, the legal hurdles were already high for manufacturers and importers of endodontic NaOCl solutions. Conversely, in China, these solutions were down-graded from a high-risk to a medium-risk status in 2017. A low-medium risk category was applied in the other countries under investigation, that is, Australia, India and Brazil. In some countries there was a possibility for dentists to procure plain NaOCl solutions from pharmacies. An alternative route to avoid buying NaOCl from dental suppliers was to use (household) bleach solutions for root canal irrigation wherever this practice was not prohibited explicitly. Conclusions: The legal situation to produce, import and use NaOCl solutions for root canal irrigation differs vastly around the globe. A sensible approach to regulate (yet not over-regulate) endodontic NaOCl solutions appears to be timely and necessary
Baseline characteristics, management patterns and outcome in patients with pulmonary embolism and malignancy: insights from a single-centre study
No full textBackground and aim: Acute pulmonary embolism (PE) is one of the main causes of death in patients with active cancer. In this study, we evaluated the impact of malignancy on the treatment choices, and short- and long-term clinical outcomes in patients with acute PE. Methods: In this study, 872 acute PE patients (age 61.6 ± 16.8 years, female 57.5 %) from different risk and treatment categories were retrospectively analyzed and divided into two groups according to the presence of active malignancy. Results: Active malignancy was documented in 129 (14.8 %) out of the 872 patients. Ultrasound-assisted-thrombolysis (USAT), rheolytic-thrombectomy (RT), systemic-thrombolysis (ST) and anticoagulation-alone therapies were noted in 27.3 %, 6.4 %, 16.6 % and 49.7 % of overall PE patients. RT and anticoagulation therapies were more frequent in patients with malignancy whereas ST and USAT were more frequently used in the other group. Regardless of the presence of malignancy and the treatment modality chosen, significant improvements were achieved in all treatment targets (p < 0.001 for all). Bleeding rates were similar in both groups, while in-hospital and long-term mortality was higher in the malignancy cohort. Active malignancy was found to be an independent predictor for composite of 60-day mortality and PE-related rehospitalization (adjusted OR: 2.43; 95 % CI: 1.32–4.47, p = 0.04) and long-term mortality (adjusted HR: 2.25, 95 % CI: 1.29–3.91, p = 0.004). Conclusion: Concomitant malignancy adversely affects both short- and long-term outcomes in patients with acute PE. Although these patients are more vulnerable, it is possible to achieve satisfactory treatment success with acceptable bleeding rates with the inclusion of catheter-based methods as treatment option