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    The protective effect of adipose-derived stromal vascular fraction on ovarian function in rats with cyclophosphamide-induced ovarian damage

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    Objective: The aim of this study was to investigate if adipose-derived stromal vascular fraction (SVF) treatment has any protective effect on ovarian function in rats with cyclophosphamide (CP) induced ovarian damage. Design: This was an experimental animal study. Participants/Materials, Setting, Methods: 25 mature cycling Wistar-Albino rats were randomized into four groups (n = 5 per group). Rats in groups 1 and 2 received single dose of intraperitoneal (i.p.) 1 mL/kg sodium chloride 0.9% (NaCl). Groups 3 and 4 received single dose of 75 mg/kg i.p. CP. On seventh day, SVF was prepared from adipose tissues of 5 additional rats and groups 1 and 3 received 0.9% NaCl i.p. injections while groups 2 and 4 received 0.2 mL i.p. injections of SVF. On day 21 all rats were euthanized, and serum anti-mullerian hormone (AMH) levels, primordial, primary, secondary, antral, and atretic follicle counts, AMH positive staining follicle counts along with AMH staining intensity of the follicles were evaluated. Results: Among two CP induced ovarian damaged groups, SVF treated group showed significantly higher secondary and antral follicle and lower atretic follicle counts, significantly higher mean serum AMH levels, AMH positive antral follicle count and higher intensity of AMH positive follicle scores for primary, secondary, and antral follicles when compared to untreated group. Moreover, group 1 showed no significant difference for all parameters except antral follicle count and AMH positive staining intensity scores for antral follicles when compared to group 4. Limitations: This study was conducted on experimental rat model. Conclusion: Our study demonstrated a significant protective effect of SVF against CP-induced ovarian damage which reveals the apparent need for further investigation of its precise mechanisms of action as it may provide a new treatment approach for women with premature ovarian failure

    Are nutrition literacy and sustainable dietary habits associated with cardiovascular disease and diabetes developmental risks?

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    Objective: This study aimed to examine the association of nutritional literacy levels and sustainable nutritional behaviors with the risk of developing cardiovascular diseases and diabetes in the Turkish adult population. Methods: Sociodemographic information, disease history, nutritional habits, and physical activity levels of 3146 volunteer individuals (male = 1590, female = 1556) between the ages of 40–75 were collected using a questionnaire form and face-to-face interviews. The sustainable nutritional behaviors of the participants were evaluated using Turkish validated scales for Sustainable and Healthy Eating Behavior (SHE) and nutritional literacy levels with the Evaluation Instrument of Nutrition Literacy on Adults (EINLA). Cardiovascular disease risks of the participants were assessed with the Atherosclerotic Cardiovascular Disease (ASCVD) Risk Estimator program and the Heart Score (SCORE) scale and type-2 diabetes risk with the Finnish Diabetes Risk Score (FINDRISC). Each participant’s 24-h food consumption record was obtained using the retrospective recall method. Results: It was determined that ASCVD and SCORE levels were significantly higher in males compared to females. It was observed that individuals with lower cardiovascular and diabetes risk scores had higher educational levels, and the risks increased significantly with age (p < 0.05). Anthropometric measurements such as body mass index, and waist hip circumference were significantly higher in those with higher cardiovascular and diabetes risk scores. Furthermore, in individuals with higher SCORE and FINDRISC levels, SHE and EINLA scores were significantly lower (p < 0.05). It was also observed that SCORE and diabetes risk scores increased with higher energy and macronutrient intakes. Conclusion: The risk of developing cardiovascular disease and diabetes was associated with sustainable nutritional behaviors and nutritional literacy. It may be suggested that increasing nutritional literacy and encouraging sustainable nutritional behaviors may be effective strategies in the management and reduction of the prevalence of certain chronic diseases. KEY TEACHING POINTS Cardiovascular diseases and diabetes are two major chronic conditions that can be managed and treated through proper nutrition. Increased nutritional literacy levels and sustainable dietary habits may result in reduced risk of cardiovascular diseases and diabetes. Nutritionists should assess the patients’ nutrition literacy levels and implement sustainable, health-focused nutrition education programs to enhance their understanding of nutrition

    Content analysis of the top 25 most cited articles of the journal of craniofacial surgery with chatgpt-4o

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    Objective:Since 1990, the Journal of Craniofacial Surgery has been an important resource for clinicians and basic scientists. The journal addresses clinical practice, surgical innovations, and educational issues. This study aims to evaluate the contribution of these articles to clinical practice innovations and surgical procedures by analyzing the content of the 25 most cited articles published in the journal. It also aims to demonstrate the potential of artificial intelligence tools in academic content analysis.Methods:All articles published in the Journal of Craniofacial Surgery on June 13, 2024, were searched using the Web of Science Database, and the 25 most cited articles were identified. The full texts of these articles were saved in PDF format and metadata were saved as plain text files. Content analysis of these 25 articles was performed using ChatGPT-4o.Results:As a result of the analysis, some articles stood out in terms of clinical importance. It also appeared that ChatGPT could be used to compare multiple articles.Conclusion:In this study, the authors analyzed the content of the 25 most cited articles published in the Journal of Craniofacial Surgery using ChatGPT-4o. These articles were evaluated according to the criteria of innovations in clinical practice and compliance with surgical procedures. This study presents interesting findings in terms of the use of artificial intelligence tools in academic content analysis. The authors thought that this study could be a source of inspiration for future studies

    Does the healthy plate model workshop improve nutrition knowledge, behaviors, and habits in school-age children? the impact of workshop on dietary habits: original article

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    Background: This study was conducted to identify the impacts of the healthy plate model workshop on 4th-graders nutrition knowledge, behaviors, and habits. Methods: The study was conducted from March to June 2023 in the Uskudar district of Istanbul, involving 102 children (50% girls) with a mean age of 10.2 ± 0.45 years. A pretest-intervention-posttest design was used for the research. Before and after the training, a questionnaire was administered to measure students’ demographic characteristics, physical activity status, adherence to the Mediterranean Diet, frequencies of food group consumption, and nutritional knowledge. Results: The number of students consuming eggs, legumes, vegetables, fruits, and oilseeds daily increased after the training (p > 0.05). Increases were observed in daily consumption of meat group and water (p < 0.05). While the proportion of students who consumed whole fruit with skin was 35.3% before the training, this rate increased to 47.1% after the training (p < 0.05). The mean nutritional knowledge score (before: 71.37 ± 11.8; after: 80.45 ± 1.6, p < 0.05) and the Mediterranean Diet Quality Index (KIDMED) score (before: 4.77 ± 2.41; after: 5.50 ± 2.45, p < 0.05) increased significantly after the training. A weak positive correlation was identified between pre-training nutritional knowledge scores and KIDMED index scores (r = 0.19; p = 0.045). Furthermore, a negative weak relationship was observed between post-training nutritional knowledge scores and meal-skipping status (r=-0.231; p = 0.019). Conclusions: Structured nutrition education for school-age children can positively impact their nutritional knowledge and dietary habits

    Prevalence of depressive symptoms and related factors in Türkiye: results of the 2016 and 2019 Turkish health survey

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    Objective: We investigated the prevalence and distribution of depressive symptoms in individuals aged 15 and older, as well as the relationship between depressive symptoms and sociodemographic characteristics, chronic diseases, health status and health behaviors. Method: The analysis of data collected from the Türkiye Health Surveys conducted by Turkish Statistical Institute (TURKSAT) in 2016 and 2019 involved using the Chi-Square independence test. Effect sizes were evaluated using Phi or Cramer’s V coefficients. Patient Health Questionnaire-8 (PHQ-8) module was used to scan the depressive symptoms. Results: The adult population’s point of prevalence of depressive symptoms was 4.7%±0.24 in males and 8%±0.19 in females, with a population total of 6.3%±0.21. The yearly prevalence of depressive symptoms was 6.1%±0.45 in males, 13.2%±0.53 in females and a population total of 10%±0.49. Age, gender, income, education, social support, health status, disability, and chronic illnesses were found to be significant predictors of the incidence of depressive symptoms (p<0,05). The results indicated that the rate of people with depression getting help from psychologists, psychotherapists, and psychiatrists was low. Conclusion: Age, gender, income, education, marital status, self-rated health status, social support, number of chronic illnesses, and disability were the most important risk factors for depressive episodes. In addition to such self-reported research completed before the pandemic and Kahramanmaraş earthquakes in Türkiye, further studies based on structured diagnostic interviews are required

    New graduate nurses' approaches to death and dying patients and the relationship between death anxiety and death awareness a cross-sectional study

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    Background: One of the challenges experienced by new graduate nurses during the transition into practice is caring for dying patients. This study aimed to determine new graduate nurses’ approaches to death and dying patients and the relationship between death anxiety and death awareness. Methods: This descriptive, cross-sectional study was conducted with 226 new graduate nurses in Istanbul, Türkiye. A personal and work environment characteristics form, the Approach to Death and Dying Patients Attitude Scale, Templer’s Death Anxiety Scale, and Multidimensional Mortality Awareness Measure were used to collect data. Results: Hardness in communicating with the dying patients (hardness: meaning difficulty) and their relatives and avoiding death and dying patients were considered moderate, with mean scores of 2.64 ±.63 and 2.45 ±.40, out of 4. Death anxiety accounted for approximately 7% of the variance of hardness in communicating with dying patients and their relatives, which is statistically significant. Death awareness statistically significantly explained 9.7% of avoiding death and dying patients. Conclusion: For new graduate nurses, besides simulation-based training on end-of-life care, approaches to sharing their experiences about death and programs to determine a value system related to death may be recommended

    Surface roughness on cementoenamel junction after rubber-dam clamp application

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    Objective: To investigate the surface roughness on cementoenamel junction after application of various rubber-dam retraction clamps for different durations. Materials and Methods: Fifty-four extracted human molar teeth were used. Various retraction clamps were placed on the cementoenamel junction. There are three main examination groups in the study. Group 1 (n = 6) included a polymer clamp (SoftClamp, Kerr Hawe, Switzerland), Group 2 (n = 6) included a metal clamp with a flat edge (Black Line RDCM7X, Hu-Friedy Group, USA), and Group 3 (n = 6) included a metal clamp with a serrated edge (Fiesta Color Coded, Coltene, USA). All clamps were applied for 30 min, 1, and 2 h. Surface roughness measurements were performed using a profilometer before and after the clamp application and surface morphology was assessed through the SEM images. One-way ANOVA was used to compare three or more groups. Percentage changes were evaluated using the Kruskal–Wallis test, followed by Dunn's test for post hoc analyses. The deemed significance was set at p < 0.05. Results: Between the initial and the final roughness measurements, after 30 min of clamp application, only Group 3 showed significant increases in roughness (p = 0.001). After 1 and 2 h of clamp application, there were significant increases in roughness for all groups. No significant differences in percentage changes for all groups in 30 min and 2 h of application (p = 0.220 and p = 0.091, respectively). However, Group 1 presented significantly lower surface roughness in percentage after the 1 h of application (p = 0.040). No significant differences in the percentage changes in roughness were observed within the groups for 30 min, 1, and 2 h applications (p = 0.220, p = 0.884, and p = 0.755 for Groups 1, 2, and 3, respectively). In SEM analysis, deep point microstructure defects were seen as the clamp application time increased. Conclusions: Rubber-dam clamp application may cause damage to the cementoenamel junction area. However, the level of damage is clamp-type-dependent. Slight scratch-type damages were observed on teeth with plastic clamps, while metal clamps generally caused cracks. The increase in the duration of the same rubber-dam clamp application was not considered an effective factor regarding the damage. Clinical Significance: During rubber-dam isolation, clamp type and duration of the application may cause damage to the tooth surface or progress an existing defect. Examining the teeth before selecting the clamp might be beneficial for minimizing dental tissue damage.Istanbul Kent University Scientific Research Committe

    Visibility region exploitation for phy authentication in xl-mimo systems

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    Wireless networks are open to identity spoofing attacks because of their broadcast nature, emphasizing the need for strong security. Physical layer authentication (PLA) is a crucial strategy for securing wireless networks against such threats. Extra-large multiple-input multiple-output (XL-MIMO) technology, with its unique visibility region (VR) concept due to the near-field effect, offers a promising way to enhance network performance. This letter proposes a PLA approach using VR to create unique and robust signatures from the power and beamspace domain of XL-MIMO. Simulation results confirm the effectiveness of the proposed method in detecting attacks with high accuracy and low false alarm rates.Türkiye Bilimsel ve Teknolojik Araştırma Kurumu (TÜBİTAK

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