50,311 research outputs found
sj-docx-1-tai-10.1177_20499361231161157 – Supplemental material for Anti-G protein antibodies targeting the RSV G protein CX3C chemokine region improve the interferon response
No full textSupplemental material, sj-docx-1-tai-10.1177_20499361231161157 for Anti-G protein antibodies targeting the RSV G protein CX3C chemokine region improve the interferon response by Harrison C. Bergeron, Lawrence M. Kauvar and Ralph A. Tripp in Therapeutic Advances in Infectious Disease</p
Dimensions of test anxiety: Relations to ways of coping with pre-exam anxiety and uncertainty.
Full text linkCumulative evidence has shown that four dimensions can be differentiated in the experience of test anxiety:
worry, emotionality, interference, and lack of confidence. To investigate whether these dimensions show
specific relationships with ways of coping, a study with 162 students (75 male, 87 female) examined how
students cope with anxiety and uncertainty in the run-up to important exams. Coping strategies included task orientation and preparation, seeking social support, and avoidance. Results showed that overall test anxiety
was related to seeking social support. When dimensions of test anxiety were inspected individually while
controlling for interdimensional overlap, however, results showed a specific pattern of relationships: (a) worry
was related to task-orientation and preparation and inversely related to cognitive avoidance, (b) emotionality
was related to task-orientation and preparation and seeking social support, and (c) interference was related to
avoidance and inversely related to task-orientation and preparation, whereas (d) lack of confidence was
related to avoidance only. Although some gender differences emerged, the findings indicate that the main
components of test anxiety display different relationships with coping. Moreover, they confirm that it is
important to differentiate between worry and interference because these dimensions, albeit closely related,
may show opposite relationships with ways of coping
Evolution of the G+C content frontier in the rat cytomegalovirus genome
Full text linkWithin the 230138 bp of the rat cytomegalovirus (RCMV) genome, the G+C content changes abruptly at position 142644, constituting a G+C content frontier. To the left of this point, overall G+C content is 69.2%, and to the right it is only 47.6%. A region of extremely low G+C content (33.8%) is found in the 5 kb immediately to the right of the frontier, in which there are no predicted coding sequences. To the right of position 147501, the G+C content rises and predicted coding sequences reappear. However, these genes are much shorter (average 848bp, 50% G+C) than those in the left two-thirds of the genome (average 1462bp, 70% G+C). Whole genome alignment of several viruses indicates that the initial ultra-low G+C region appeared in the common ancestor of the genera Cytomegalovirus and Muromegalovirus, and that the lowering of G+C in the right third has been a subsequent process in the lineage leading to RCMV. The left two-thirds of RCMV has stop codon occurrences at 67.5% of their expected level, based on a modified Markov chain model of stop codon distribution, and the corresponding figure for the right third is 78%. Therefore, despite heavy mutation pressure, selective constraint has operated in the right third of the RCMV genome to maintain a degree of gene length unusual for such low G+C sequences
Comparison of electrical activity of lateral and medial stabilizers of the patella and further diagnostically relevant risk factors in athletes with and without patellofemoral pain and in a Tai Chi group
Full text linkKhoshraftar Yazdi N. Comparison of electrical activity of lateral and medial stabilizers of the patella and further diagnostically relevant risk factors in athletes with and without patellofemoral pain and in a Tai Chi group. Bielefeld (Germany): Bielefeld University; 2010.Patellofemoral pain syndrome (PFPS) is a term for a variety of pathologies or anatomical abnormalities leading to a type of anterior knee pain and is the most common single diagnosis among runners and in sport medicine centers. Despite this high incidence, the exact cause of these disorders remains enigmatic.
The major complain of patients with PFPS is retropatellar pain during activities such as running, squatting, going up and down stairs, prolonged sitting, cycling, and jumping.
Some of risk factors in athletes with PFPS were considered and compared with athletes without PFPS in the present study. In addition, since Tai Chi (TC) helps or reduces the load on the lower limbs joints, particularly in knee, a TC group was chosen to compare with the two other groups
Economic analysis of Tai Chi as a means of preventing falls and falls related injuries among older adults, CHERE Working Paper 2006/4
Full text linkThis study has examined the costs and consequences of a randomised controlled trial of a community based Tai Chi program for people over 60 years of age. The hypothesis for the trial was that compared to non-participants, participants in the Tai Chi program would have fewer falls and may experience additional health and other benefits. In terms of resource use it was anticipated that the Tai Chi program would use additional resources in terms of running costs but was expected to save resources as a result of falls prevented. Data for this economic evaluation were collected prospectively alongside the randomised controlled trial. The aim of this evaluation was to investigate the cost-effectiveness of Tai Chi as means of preventing falls in elderly people living in the community. Costs included were those of the Tai Chi trial and health service utilisation (including GP and specialist and other consultations, tests, hospitalisations and medications). Effectiveness was measured as the number of participants in the intervention and control groups, all participants and the number of falls avoided. SPSS was used to analyse the data; Fisher?s exact and the student?s t-test were used to test differences between the intervention and control groups. From the perspective of NSW Health, the cost of providing Tai Chi as part of this trial (24795). Only a small proportion used health services and this mostly involved the use of over-the-counter pain relieving medication and GP consultations. Only 3 people were admitted to hospital. There were no significant differences between the study and control groups in terms of utilisation and costs except in terms of overall costs where the control group costs were significantly more than the study group (p=0.43). However, this difference was driven by the cost of one admission to hospital. In the trial 3/216 falls resulted in hospitalisation. This means that for every 100 falls avoided, 1.4 serious falls were prevented. Assuming that Tai Chi would continue to prevent falls at the same rate as the trial, 740 individuals would need to participate in Tai Chi to avoid 100 falls and 1.4 serious falls. The value of avoiding a small number of serious falls must be weighed against the high cost of treating and managing the consequences of such falls.Tai chi, economic aspects, Australia
Test anxiety, working memory, and cognitive performance: Supportive effects of sequential demands
Full text linkSubstantial evidence suggests that test anxiety is associated with poor performance in complex tasks. Based on the differentiation of coordinative and sequential demands on working memory (Mayr & Kliegl, 1993), two studies examined the effects of sequential demands on the relationship between test anxiety and cognitive performance. Both studies found that high sequential demands had beneficial effects on the speed and accuracy of the performance of test-anxious participants. It is suggested that the more frequent memory updates associated with high sequential demands may represent external processing aids that compensate for the restricted memory capacity of individuals with high test anxiet
Erratum to: Effect of moderate red wine intake on cardiac prognosis after recent acute myocardial infarction of subjects with Type 2 diabetes mellitus (Diabetic Medicine, (2006), 23, 9, (974-981), 10.1111/j.1464-5491.2006.01886.x)
No full textIn an article by Marfella et al, the author name C. Saron is incorrect and should be listed as C. Sardu. Therefore the correct author list is: R. Marfella, F. Cacciapuoti, M. Siniscalchi, F. C. Sasso, F. Marchese, F. Cinone, E. Musacchio, M. A. Marfella, L. Ruggiero, G. Chiorazzo, D. Liberti, G. Chiorazzo, G. F. Nicoletti, C. Sardu, F. D'Andrea, C. Ammendola, M. Verza and L. Coppola.In an article by Marfella et al, the author name C. Saron is incorrect and should be listed as C. Sardu. Therefore the correct author list is: R. Marfella, F. Cacciapuoti, M. Siniscalchi, F. C. Sasso, F. Marchese, F. Cinone, E. Musacchio, M. A. Marfella, L. Ruggiero, G. Chiorazzo, D. Liberti, G. Chiorazzo, G. F. Nicoletti, C. Sardu, F. D'Andrea, C. Ammendola, M. Verza and L. Coppola
Opposing regulatory effects of protein kinase C on the cAMP cascade in human HL-60 promyelocytic leukemia cells
No full textThe functional role of protein kinase C in the cAMP signaling cascade was investigated in human promyelocytic leukemia (HL-60) cells. Protein kinase C activation after short exposure to 100 nM phorbol 12-myristate 13-acetate (PMA) increased the intracellular cAMP level up to 3- to 5-fold after 30 min. Such enhancement was almost completely blocked by the selective protein kinase C inhibitor bisindolylmaleimide (GF 109203X). In addition, PMA, but not 4-alpha-PMA, synergistically elevated cAMP levels when adenylyl cyclase was activated directly by forskolin or indirectly by G protein activation after cholera toxin treatment or guanosine 5'-O-(3-thiotriphosphate) (GTP gamma S) treatment in digitonin-permeabilized cells. The results indicate that protein kinase C directly increases adenylyl cyclase activity and synergistically enhances it, when it is simultaneously activated otherwise. On the other hand, a 10-min treatment with PMA cut the cAMP accumulation induced by histamine, prostaglandin E-2, or isoproterenol by 50-70%. However, the binding affinity and total binding of [H-3]histamine to membrane receptors was not effected by PMA, suggesting that the site of protein kinase C's action is not at the receptor level. Western blot analysis of protein kinase C isozymes revealed that PMA (100 nM) caused translocation of cytosolic protein kinase C such as alpha, beta and epsilon to the particulate/membrane fraction. Treatment with a lower concentration of PMA (10 nM) translocated the protein kinase C-epsilon within 2 min, while it had little effect on the translocation of protein kinase C-alpha and -beta up to 20 min. However, simultaneous treatment with 10 nM PMA plus histamine for 5 min significantly inhibited the histamine-mediated cAMP generation indicating that the protein kinase C-epsilon could be involved in the inhibition of receptor-mediated cAMP generation. Taken together, we conclude that PMA, through the activation of protein kinase C, has two opposite effects on the cAMP signaling cascade in HL-60 cells: a direct activation of adenylyl cyclase and an inhibition of receptor-mediated signal transduction. (C) 1998 Elsevier Science B.V. All rights reserved.X115sciescopu
Measurement of the ratio of prompt χ c to J / ψ production in pp collisions at √s = 7 TeV
Full text linkThe prompt production of charmonium χ c and J / ψ states is studied in proton-proton collisions at a centre-of-mass energy of √s = 7 TeV at the Large Hadron Collider. The χ c and J / ψ mesons are identified through their decays χ c → J / ψ γ and J / ψ → μ + μ - using 36 pb - 1 of data collected by the LHCb detector in 2010. The ratio of the prompt production cross-sections for χ c and J / ψ, σ (χ c → J / ψ γ) / σ (J / ψ), is determined as a function of the J / ψ transverse momentum in the range 2 < p T J / ψ < 15 GeV / c. The results are in excellent agreement with next-to-leading order non-relativistic expectations and show a significant discrepancy compared with the colour singlet model prediction at leading order, especially in the low p T J / ψ region
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