454,883 research outputs found
[Report to W. F. Dyson by C. T. Burnley, March 10, 1967 #1]
No full textReport to W. F. Dyson by detective C. T. Burney. Burnley states that he has attached newspaper clippings to the report. The clippings appeared in the Dallas Morning News. The articles featured are titled "Man Claims Ferrie, Ruby, Oswald Link" and "Lawyer Testifies In Garrison Probe.
[Report to W. F. Dyson by C. T. Burnley, March 10, 1967 #2]
No full textReport to W. F. Dyson by detective C. T. Burney. Burnley states that he has attached newspaper clippings to the report. The clippings appeared in the Dallas Morning News. The articles featured are titled "Man Claims Ferrie, Ruby, Oswald Link" and "Lawyer Testifies In Garrison Probe.
Participation of c-FLIP in NLRP3 and AIM2 inflammasome activation
No full textCellular FLICE-inhibitory protein (c-FLIP) is an inhibitor of caspase-8 and is required for macrophage survival. Recent studies have revealed a selective role of caspase-8 in noncanonical IL-1 beta production that is independent of caspase-1 or inflammasome. Here we demonstrated that c-FLIPL is an unexpected contributor to canonical inflammasome activation for the generation of caspase-1 and active IL-1 beta. Hemizygotic deletion of c-FLIP impaired ATP-and monosodium uric acid (MSU)-induced IL-1 beta production in macrophages primed through Toll-like receptors (TLRs). Decreased IL-1 beta expression was attributed to a reduced activation of caspase-1 in c-FLIP hemizygotic cells. In contrast, the production of TNF-alpha was not affected by downregulation in c-FLIP. c-FLIPL interacted with NLRP3 or procaspase-1. c-FLIP is required for the full NLRP3 inflammasome assembly and NLRP3 mitochondrial localization, and c-FLIP is associated with NLRP3 inflammasome. c-FLIP downregulation also reduced AIM2 inflammasome activation. In contrast, c-FLIP inhibited SMAC mimetic-, FasL-, or Dectin-1-induced IL-1 beta generation that is caspase-8-mediated. Our results demonstrate a prominent role of c-FLIPL in the optimal activation of the NLRP3 and AIM2 inflammasomes, and suggest that c-FLIP could be a valid target for treatment of inflammatory diseases caused by over-activation of inflammasomes
All officers look out for and arrest the following described negro: He calls himself Prof. Howard.
No full textLIBERAL REWARD
All officers look out for and arrest the following described negro: He calls himself Prof. Howard. Will be apt to have a good deal of money on him. He stole $600 on the night of the 21st inst.; four 1OO dollar bills marked First National Bank of Sioux City, Iowa. Description of negro: 28 years old, 6 feet high, weighs 160 or 170 pounds, A
very light brown or yellow negro, clean shaved, with mustache; has scar in forehead; a small black spot in white of eyes. He claims to be working for the government, also a faith doctor. When he left here he had on black hat, light coat, pants with large stripes, pair of boots.
Wire all information to
T. C. NUNN. Sheriff
The Role of c-FLIP in the Regulation of Apoptosis, Necroptosis and Autophagy in T Lymphocytes
No full textTo maintain homeostasis, T lymphocytes die through caspase–dependent apoptosis. However, blockage of caspase activity in T lymphocytes does not increase cell survival. The loss of caspase 8 activity leads to programmed necrosis (necroptosis) upon T cell receptor (TCR) stimulation in T lymphocytes. Necroptosis is correlated with excessive macroautophagy, an intracellular catabolic process characterized by the sequestration of cytoplasmic compartments through double–membrane vacuoles. Meanwhile, the proper induction of macroautophagy is required for T lymphocyte survival and function. Cellular caspase 8 (FLICE)–like inhibitory protein (c–FLIP) promotes survival in T lymphocytes. c–FLIP suppresses death receptor–induced apoptosis by modulating caspase 8 activation. Whether this modulation plays a role in the regulation of necroptosis has yet to be studied. Additionally, overexpression of c–FLIP reduces autophagy induction and promotes cell survival in cell lines. It remains unclear whether c–FLIP protects primary T lymphocytes by regulating the threshold at which autophagy occurs. In this study, c–FLIP isoform–specific conditional deletion models were used to study the role of c–FLIP in necroptosis and autophagy in primary T lymphocytes.Our results showed that the long isoform of c–FLIP (c– FLIPL) regulates necroptosis by inhibiting receptor interacting protein 1 (RIP–1). Upon TCR stimulation, c–FLIPL–deficient T cells underwent RIP–1–dependent necroptosis. Interestingly, though previous studies have generally described necroptosis in the absence of caspase 8 activity and apoptosis, pro–apoptotic caspase 8 activity and the rate of apoptosis were also increased in c–FLIPL–deficient T lymphocytes. Moreover, c– FLIPL–deficient T cells exhibited enhanced autophagy, which served a cytoprotective function. Apoptosis can be induced by either death receptors on the plasma membrane (extrinsic pathway), or the damage of the genome and/or cellular organelles (intrinsic pathway). Previous studies in c–FLIP–deficient T lymphocytes suggested that c–FLIP promotes cell survival in the absence of death receptor signals. Independent of death receptor signaling, mitochondria sense apoptotic stimuli and mediate the activation of caspases. Whether c–FLIP regulates mitochondrion–dependent apoptotic signaling remains unknown. Here, by deleting the c–Flip gene in mature T lymphocytes, we showed a role for c–FLIP in the intrinsic apoptosis pathway. In naïve T cells stimulated with the apoptosis inducer, c–FLIP suppressed cytochrome c release from mitochondria. Bim–deletion rescued the enhanced apoptosis in c–FLIP–deficient T cells, while inhibition of caspase 8 did not. Different from activated T cells, there were no signs of necroptosis in c–FLIP–deficient naïve T cells. Together, our findings indicate that c–FLIP is a key regulator of apoptosis, necroptosis and autophagy in T lymphocytes.</p
Detrital zircon and apatite (U‐Th)/He geochronology of intercalated baked sediments: a new approach to dating young basalt flows
No full textSimple numerical models suggest that many basaltic lava flows should sufficiently heat the sediments beneath them to reset (U‐Th)/He systematics in detrital zircon and apatite. This result suggests a useful way to date such flows when more conventional geochronological approaches are either impractical or yield specious results. We present here a test of this method on sediments interstratified with basalt flows of the Taos Plateau Volcanic Field of New Mexico. Nineteen zircons and apatites from two samples of baked sand collected from the uppermost 2 cm of a fluvial channel beneath a flow of the Upper Member of the Servilleta Basalt yielded an apparent age of 3.487 ± 0.047 Ma (2 SE confidence level), within the range of all published 40Ar/39Ar dates for other flows in the Upper Member (2.81–3.72 Ma) and statistically indistinguishable from the 40Ar/39Ar dates for basal flows of the Upper Member with which the studied flow is broadly correlative (3.61 ± 0.13 Ma). Given the high yield of 4He from U and Th decay, this technique may be especially useful for dating Pleistocene basalt flows. Detailed studies of the variation of (U‐Th)/He detrital mineral dates in sedimentary substrates, combined with thermal modeling, may be a valuable tool for physical volcanologists who wish to explore the temporal and spatial evolution of individual flows and lava fields.</p
Measurement of the ratio of prompt χ c to J / ψ production in pp collisions at √s = 7 TeV
No full textThe prompt production of charmonium χ c and J / ψ states is studied in proton-proton collisions at a centre-of-mass energy of √s = 7 TeV at the Large Hadron Collider. The χ c and J / ψ mesons are identified through their decays χ c → J / ψ γ and J / ψ → μ + μ - using 36 pb - 1 of data collected by the LHCb detector in 2010. The ratio of the prompt production cross-sections for χ c and J / ψ, σ (χ c → J / ψ γ) / σ (J / ψ), is determined as a function of the J / ψ transverse momentum in the range 2 < p T J / ψ < 15 GeV / c. The results are in excellent agreement with next-to-leading order non-relativistic expectations and show a significant discrepancy compared with the colour singlet model prediction at leading order, especially in the low p T J / ψ region
Letter from T. C. Tang to Josephine Rathbone (March 18, 1949)
No full textA four-page letter written by T. C. Tang to Josephine Rathbone. The letter is dated March 18, 1949. He was the treasurer for the preparatory committee for the proposed Research and Training Institute for Physical and Health Education in China. In the letter he talks about the future of the proposed institute.For more information about Lu Hui-chʻing, see:https://springfield.as.atlas-sys.com/agents/people/97
A Dynamic Analysis of the Microstructure of Moving Average Rules in a Double Auction Market
No full textInspired by the theoretically oriented dynamic analysis of moving average rules in Chiarella, He and Hommes (CHH) (2006a) model, this paper conducts a dynamic analysis of a microstructure model of continuous double auctions in which the probability of heterogeneous agents to trade is determined by the rules of either fundamentalists mean-reverting to the fundamental or chartists choosing moving average rules based their relative performance. With such a realistic market microstructure, the model is able not only to obtain the results of the CHH model but also to characterise most of the stylized facts including the power-law behaviour of volatility. The results seem to suggest that a comprehensive explanation of several statistical properties of returns is possible in a framework where both behavioral traits and realistic microstructure have a role
Excitation function measurements of C-12(He-4,Be-8)Be-8, C-12(He-4,C-12[7.65, 0(+)])He-4, and C-12(He-4,C-12[9.64, 3(-)])He-4 reactions
No full textIn the present measurements a C-12 target was bombarded by a He-4 beam with energies from 14 to 21 MeV and the excitation function measurements for the reactions of the C-12(He-4, Be-8)Be-8, C-12(He-4, C-12[7.65, 0(+)])He-4, and C-12(He-4, C-12[9.64, 3(-)])He-4 were obtained using an array of 6 double-sided silicon strip detectors. The excitation functions are used to gain an insight into possible a-cluster structures in O-16.TUBITAK-BIDEB; Nigde University; Science and Technology Facilities Council [ST/E500651/1, ST/J000140/1]One of the authors (A.S.) would like to thank TUBITAK-BIDEB and Nigde University for financial support as well as Prof. Dr. S. Erturk and Prof. Dr. I. Boztosun for useful comments and discussions
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