229 research outputs found
The theses for MD degree
No full textO.I. Malomuzh – Chronic liver diseases: indications and optimal terms for transplantation.Ye.V. Stepanova – Clinical and genetic aspects of a Crohn’s disease
Folklore images in the story of O.I. Senkovsky's "Notes of the House"
No full textFolklore images in O.I. Senkovsky's "Notes of the Brown Man." The author analyzes the corpus of texts on folklore studies and based on these works an analysis of the work of art is made. It is proved that the use of both traditional folklore images and images modified by the author directly speaks about the idea and idea of the work.</jats:p
Protection against multiple influenza a virus strains induced by candidate recombinant vaccine based on heterologous m2e peptides linked to flagellin
No full textMatrix 2 protein ectodomain (M2e) is considered a promising candidate for a broadly protective influenza vaccine. M2e-based vaccines against human influenza A provide only partial protection against avian influenza viruses because of differences in the M2e sequences. In this work, we evaluated the possibility of obtaining equal protection and immune response by using recombinant protein on the basis of flagellin as a carrier of the M2e peptides of human and avian influenza A viruses. Recombinant protein was generated by the fusion of two tandem copies of consensus M2e sequence from human influenza A and two copies of M2e from avian A/H5N1 viruses to flagellin (Flg-2M2eh2M2ek). Intranasal immunisation of Balb/c mice with recombinant protein significantly elicited anti-M2e IgG in serum, IgG and sIgA in BAL. Antibodies induced by the fusion protein Flg-2M2eh2M2ek bound efficiently to synthetic peptides corresponding to the human consensus M2e sequence as well as to the M2e sequence of A/Chicken/Kurgan/05/05 RG (H5N1) and recognised native M2e epitopes exposed on the surface of the MDCK cells infected with A/PR/8/34 (H1N1) and A/Chicken/ Kurgan/05/05 RG (H5N1) to an equal degree. Immunisation led to both anti-M2e IgG1 and IgG2a response with IgG1 prevalence. We observed a significant intracellular production of IL-4, but not IFN- ã, by CD4+ T-cells in spleen of mice following immunisation with Flg-2M2eh2M2ek. Immunisation with the Flg-2M2eh2M2ek fusion protein provided similar protection from lethal challenge with human influenza A viruses (H1N1, H3N2) and avian influenza virus (H5N1). Immunised mice experienced significantly less weight loss and decreased lung viral titres compared to control mice. The data obtained show the potential for the development of an M2e-flagellin candidate influenza vaccine with broad spectrum protection against influenza A viruses of various origins. © 2015 Stepanova et al
The synthesis of monodisperse alkanes with long chains
No full textThis thesis discusses reasons for the interest in monodisperse long chain alkanes and describes attempts, past and present, to synthesise such molecules. Chapter 1 discusses why the synthesis of such molecules are important and the objectives of this project. Chapter 2 reviews the methods previous groups have devised to prepare pure samples of long chain alkanes. In particular, work carried out by Whiting et al. at Bristol, whose scheme formed the basis of the early work in Durham. Chapter 3 describes the work in Durham and improvements which were made to Whiting's method, allowing the synthesis of longer chain lengths and greater quantities of materials to be achieved. Chapter 4 provides a summary of the practical work carried out by the author. Chapter 5 gives experimental details of the work described in Chapter 4
Clinical experience with cyclosporine eye drops for severe dry eye
No full text
O.I. Lebedev1, A.V. Surov1, E.V. Akentieva2
1Omsk State Medical University, Omsk, Russian Federation
2Clinical Ophthalmologic Hospital named after V.P. Vykhodtsev, Omsk, Russian Federation
Dry eye disease provokes inflammation of autoimmune origin. Therefore, immunosuppressants are pathogenetically reasonable for this disorder. Topical 0.05% cyclosporine emulsion may provide good treatment outcomes when tear replacement drops and corneal protective remedies are ineffective. Cyclosporine is a calcineurin inhibitor which blocks T cells thus decreasing pro-inflammatory cytokine release and preventing goblet cell apoptosis. This paper describes clinical experience with cyclosporine in a woman with severe dry eye who received long-term treatment without stable favorable outcomes. Topical 0.05% cyclosporine emulsion (eye drops) improves subjective signs and functional test results as well as provides corneal infiltrate epithelialization. The analysis of clinical sings and functional test results demonstrates that cyclosporine is highly effective for severe dry eye which manifests with corneal and conjunctival inflammation and degeneration (especially considering autoimmune origin of the inflammation). In addition, this agent provides favorable outcomes when standard tear replacement and anti-inflammatory treatment is ineffective.
Key words: dry eye, xerosis, autoimmune inflammation, apoptosis, goblet cells, anti-inflammatory treatment, cyclosporine.
For citation: Lebedev O.I., Surov A.V., Akentieva E.V. Clinical experience with cyclosporine eye drops for severe dry eye. Russian Journal of Clinical Ophthalmology. 2019;19(1):50–53.
About the authors:
1Оleg I. Lebedev — MD, PhD, Professor, Head of Ophthalmological Department;
1Aleksandr V. Surov — MD, PhD, Associate Professor of Ophthalmological Department;
2Yevgeniya V. Akentyeva — ophthalmologist.
1Omsk State Medical University. 12, Lenin str., Оmsk, 644099, Russian Federation.
2Clinical Ophthalmologic Hospital named after V.P. Vykhodtsev. 60, Lermontov str., Оmsk, 644024, Russian Federation.
Contact information: Aleksandr V. Surov, e-mail: [email protected]. Financial Disclosure: no author has a financial or property interest in any material or method mentioned. There is no conflict of interests. Received: 18.09.2018.<br
Archaeologic research of O.I. Terenozhkin in the Central Asia (1929—1941)
No full textВисвітлено процес становлення визначного археолога О.І. Тереножкіна та його внесок у середньоазійську археологію.В статье рассматриваются исследования А.И. Тереножкина в Средней Азии в 1929—1941 гг. Этому периоду его
деятельности уделялось недостаточно внимания, чем и обусловлены актуальность и новизна. Исследованный ма-териал позволяет проследить становление ученого, а также выделить круг его научных интересов. Рассмотрено три основных этапа: разведки в Киргизии, Казахстане, Узбекистане, главным итогом которых стало введение в научный оборот новых материалов. «Хорезмийский» этап — открытие ученым ряда памятников древнего Хорез-ма, изучение средневековой архитектуры региона, вопросов искусства, гончарного производства, периодизации; «ташкентский» — изучение особенностей средневековой архитектуры региона по материалам крепости Ак-тепе; археологические исследования ученого при строительстве Большого Ташкентского канала, в ходе которых была
открыта бургулюкская культура, найдены и описаны памятники от каменного века до средневековья. В целом, А.И. Тереножкин внес значительный вклад в изучение древней истории стран Средней Азии, а его исследования, источниковая база и идеи послужили основой для научных разработок следующими поколениями специали-стов.The article views the research by O.I. Terenozhkin in the Central Asia since 1929 to 1941. This period of his activity has received insufficient attention which causes topicality and novelty. The material researched allows the author to trace the development of a scholar, and also to define a circle of his interests. Three main stages are viewed: archaeological prospectin gin Kyrgyzstan, Kazakhstan, and Uzbekistan, the main result of which was presenting the new materials to the scientific circles. On the «Chorasmian» stage the researcher discovered a number of sites of the Ancient Choresm, studied mediaeval architecture of a region, issues of art, ceramics, and division into periods. On the «Tashkent» stage he studied the peculiarit ies of mediaeval architecture of a region based on the materials of Ak-Tepe fortress. The last stage is the archaeological research of the scholar during the construction of the Great Tashkent canal, when Burguluk culture was discovered, and the sites dating from the Stone Age to the Mediaeval period were found and described. In general, O.I. Terenozhkin contributed a lot to the study of the ancient history of countries of the Central Asia, and his research, source base and ideas became the base for the scientific developments of the successing generations of scholars
Archaeologic research of O.I. Terenozhkin in the Central Asia (1929—1941)
No full textВисвітлено процес становлення визначного археолога О.І. Тереножкіна та його внесок у середньоазійську археологію.В статье рассматриваются исследования А.И. Тереножкина в Средней Азии в 1929—1941 гг. Этому периоду его
деятельности уделялось недостаточно внимания, чем и обусловлены актуальность и новизна. Исследованный ма-териал позволяет проследить становление ученого, а также выделить круг его научных интересов. Рассмотрено три основных этапа: разведки в Киргизии, Казахстане, Узбекистане, главным итогом которых стало введение в научный оборот новых материалов. «Хорезмийский» этап — открытие ученым ряда памятников древнего Хорез-ма, изучение средневековой архитектуры региона, вопросов искусства, гончарного производства, периодизации; «ташкентский» — изучение особенностей средневековой архитектуры региона по материалам крепости Ак-тепе; археологические исследования ученого при строительстве Большого Ташкентского канала, в ходе которых была
открыта бургулюкская культура, найдены и описаны памятники от каменного века до средневековья. В целом, А.И. Тереножкин внес значительный вклад в изучение древней истории стран Средней Азии, а его исследования, источниковая база и идеи послужили основой для научных разработок следующими поколениями специали-стов.The article views the research by O.I. Terenozhkin in the Central Asia since 1929 to 1941. This period of his activity has received insufficient attention which causes topicality and novelty. The material researched allows the author to trace the development of a scholar, and also to define a circle of his interests. Three main stages are viewed: archaeological prospectin gin Kyrgyzstan, Kazakhstan, and Uzbekistan, the main result of which was presenting the new materials to the scientific circles. On the «Chorasmian» stage the researcher discovered a number of sites of the Ancient Choresm, studied mediaeval architecture of a region, issues of art, ceramics, and division into periods. On the «Tashkent» stage he studied the peculiarit ies of mediaeval architecture of a region based on the materials of Ak-Tepe fortress. The last stage is the archaeological research of the scholar during the construction of the Great Tashkent canal, when Burguluk culture was discovered, and the sites dating from the Stone Age to the Mediaeval period were found and described. In general, O.I. Terenozhkin contributed a lot to the study of the ancient history of countries of the Central Asia, and his research, source base and ideas became the base for the scientific developments of the successing generations of scholars
Determination of wind chill on a life-sized clothed Copper Man
No full textCER47/52-49.June, 1952.Final report.Includes bibliographical references.Prepared for the Environmental Research Section, Protection Branch, Research and Development Division, Department of the Army, Office of the Quartermaster General under Contract No. DA44-109-QM-584; O.I. no. 5967 (GFP-839); Reqn. no. 49-106-653-51
РОЛЬ МУЗИЧНОГО ВИКОНАВСТВА У ПРОЦЕСІ РОЗВИТКУ ДУХОВНОСТІ
No full textThe author presents a social-philosophical model for understanding the substantial value of musical performance experience and its specific role in the process of the spiritual development
ХУДОЖНІЙ ДОСВІД ЯК ЦІЛІСНИЙ ШЛЯХ ОСЯГНЕННЯ ІСТИНИ
No full textEsihencal experience as a integral way comprehension of truth. By specifying the notion of essential unity and peadianty af the philosophical and aesthetic thinking, the author considers esthetical experience as a harmonically united logic-rational and miagmalmluitive comprehension of truth
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