35 research outputs found
Paradossi della conoscenza divina nel De scientia Christi di Bonaventura da Bagnoregio
No full textAttraverso un esame delle questioni I-III del De scientia Christi di Bonaventura da Bagnoregio vengono messi in luce i tratti paradossali e controintuitivi della conoscenza divina
Understanding the Impact of High-Pressure Treatment on Physico-Chemical, Microstructural, and Microbiological Aspects of Pumpkin Cubes
No full textIn this study color, texture, starch–pectin, total antioxidant capacity, microbial count, and microstructure of HPP-treated Violina pumpkin cubes were evaluated. Samples were treated at six different pressures (100 to 600 MPa–HPP100 to HPP600) for 3 min. Moisture, total soluble solids, and pH showed no significant differences between untreated (UNTR) and treated samples. Pumpkin tissue showed great structural modifications as changes in cell size and shape, cell wall damage, increased cell wall thickness, cell detachment and dehydration, and calcium ions deposition mainly from HPP300 to 600. UNTR samples showed the highest value of maximum and minimum cell elongation, perimeter segment, and a more regular cell wall thickness whereas HPP600 showed the lowest values for all these parameters. A noticeable difference was observed in HPP600 samples, with a difference in terms of color (ΔE 11.3 ± 1.9) and hardness (87.4 ± 27.8 N) compared to the UNTR ones (194.9 ± 37.9 N) whereas treatments at other pressures changed less markedly the color and texture. HPP200 could ensure a higher amount of starch and pectin availability while HPP200 and HPP400 showed the highest total antioxidants capacity. High-pressure treatment from HPP400 to 600 gave the highest destruction of microorganisms but negatively influenced the structural quality as well as texture and microstructure
Clotting Factors in COVID-19: Epidemiological Association and Prognostic Values in Different Clinical Presentations in an Italian Cohort
No full textIntroduction: A novel highly pathogenic human coronavirus able to induce severe acute respiratory syndrome (SARS) has been recently recognized as the cause of the coronavirus disease 2019 (COVID-19) outbreak, which has spread rapidly from China to other countries. Little is known about laboratory prognostic markers in COVID-19 patients. The aim of our study was to describe the basic clotting parameters in COVID-19 patients and their prognostic role in different clinical forms of the disease. Material and Methods: We enrolled 67 COVID-19 patients admitted to the Emergency Department. A cohort of 67 age- and sex-matched non-COVID-19 patients with acute respiratory illness was used as a control group. For all patients, platelet count (PLT), prothrombin time (PT), activated thromboplastin time (aPTT), C-reactive protein (PCR), fibrinogen, and D-dimer were determined. The COVID-19 population was divided in two groups according to the presence or absence of SARS. The clotting factors values were compared between the groups. Results: At admission, the COVID-19 patients showed statistically significant increased levels of fibrinogen (601.5 (480-747) vs. 455 (352.5-588.5) mg/dL; p = 0.0000064), and a higher percentage of patients had fibrinogen levels >400 mg/dL (86% vs.58%; p = 0.0054) compared to the control group. The levels of fibrinogen were higher in COVID-19 patients with SARS compared to those without SARS (747 (600.0-834.0) vs. 567 (472.5-644.50); p = 0.0003). Conclusion: Fibrinogen seems to increase early in COVID-19 patients and may be used as a risk stratification marker for the early detection of a subgroup of COVID-19 patient at increased risk to develop SARS, who might benefit from a different and thorough clinical surveillance and treatment
Prophecy, prophets and the problem of truth in Latin late Antiquity and the early Middle Ages
No full textBetween the 4th and 9th century AC, many Latin Christian thinkers explore the nature and possible definitions of ‘prophecy’ from a philosophical point of view. The two main theories are found in the works of Augustine of Hippo and Gregory the Great, who agree on the idea of prophecy as «divine message», but diverge on the role of the prophet, who for the former is an interpreter with an active role, for the latter is a medium of the message rather than its author. Gregory’s theory seems to be more common – being more easily understandable – in the Early Middle Ages.
All thinkers quoted in the essay (apart from Augustine and Gregory, Cassiodorus, Isidore of Seville, Alcuin of York and Rabanus Maurus) also deal with the problem of truth in relation to prophecy and prophets: is there a criterion with which to establish with certainty who is a real prophet and who is a false one? This article attempts to demonstrate, on the basis of the De doctrina christiana of Augustine and of the Liber visionum of Othlo of Sankt Emmeram, that one of the signs of the truthfulness of a true prophet could well be the nature and form of language he uses
Cardiovascular autonomic dysfunction, altered sleep architecture, and muscle overactivity during nocturnal sleep in pediatric patients with narcolepsy type 1
No full textSTUDY OBJECTIVES: arterial blood pressure (ABP) decreases during sleep compared to wakefulness and this change is blunted in mouse models of and adult patients with narcolepsy type 1 (NT1). We tested whether: 1) pediatric patients with NT1 have similar cardiovascular autonomic abnormalities during nocturnal sleep; and 2) these abnormalities can be linked to hypocretin-1 cerebrospinal fluid concentration (CSF HCRT-1), sleep architecture or muscle activity. METHODS: laboratory polysomnographic studies were performed in 27 consecutive drug-naïve NT1 children or adolescents and in 19 matched controls. Nocturnal sleep architecture and submentalis (SM), tibialis anterior (TA), and hand extensor (HE) electromyographic (EMG) activity were analyzed. Cardiovascular autonomic function was assessed through the analysis of pulse transit time (PTT) and heart period (HP). RESULTS: PTT showed reduced lengthening during total sleep and REM sleep compared to nocturnal wakefulness in NT1 patients than in controls, whereas HP did not. NT1 patients had altered sleep architecture, higher SM EMG during REM sleep, and higher TA and HE EMG during N1-N3 and REM sleep when compared to controls. PTT alterations found in NT1 patients were more severe in subjects with lower CSF HRCT-1, but did not cluster or correlate with sleep architecture alterations or muscle overactivity during sleep. CONCLUSION: our results suggest that pediatric NT1 patients close to disease onset have impaired capability to modulate ABP as a function of nocturnal wake-sleep transitions, possibly as a direct consequence of hypocretin neuron loss. The relevance of this finding for cardiovascular risk later in life remains to be determined
THE "FIGHT TO BLAST" ITALIAN PROJECT: FROM RESEARCH TO PRACTICE"
No full textBlast (Pyricularia oryzae) and rice exist in an environment in which man’s actions play a key role in determining the diffusion and aggressiveness of the pathogen. Air-spores are the most important source of infection but meteorological conditions and intensive high-input rice cultivation can greatly affect the spread of this disease. As well as in the rest of the world, blast cannot be definitively eliminated from the Italian paddy fields; it can cause marginal losses (2012 and 2013 Italian growing season) or devastating outbreaks (2008).
In the large scenario of the Italian rice cultivation, “Fight to Blast” stands for being a Project in which knowledge gained in scientific studies have been transformed into practical solutions.
Started in 2009, supported by the Agricultural Department of Vercelli Province, it’s based on an over twenty years multidisciplinary study carried on by researchers of the Pavia University.
The Project is now applied to an about 110.000 ha production area and it runs in real-time from the half of June till the end of August, by means of the below listed information:
1. daily concentration and fluctuation of air-borne infective spores of P. oryzae;
2. meteorological parameters favouring the virulence of the pathogen;
3. phytosanitary situation of both experimental and cultivated fields;
4. simulations of the dynamic deterministic model “SiRBInt - Simulation of Rice-Blast Interaction”, appositely created for temperate rice growing areas.
The final output of the work are biweekly bulletins, one for each environmentally different monitored area, in which results of the actions are traduced in four risk levels, from “0 - no risk of disease” to “3 - high risk” (resistant rice varieties and/or unfavourable to blast field management included).
This disease-forecast is a free-service, every Monday and Thursday afternoon both on-line published and transmitted as SMSs. The feedback of technicians and farmers is positive and, year after year, the number of followers is increasing.
“Fight to Blast” can really facilitate in formulating tricky decision rules on the basis of the available biological knowledge. It’s a successful example of how even an extremely complex academic study can become a practice and useful action tool
Antropologia radicale: modelli di fisiologia edenica nelle opere teologiche di Alberto Magno
No full textLa tesi esamina la rielaborazione delle dottrine filosofico-naturali nella teologia sistematica di Alberto Magno concentrandosi sui modelli di fisiologia alternativa con cui il maestro domenicano spiega la condizione edenica all’interno del De homine, del Commento alle Sentenze e della Summa theologiae. Il lavoro si divide in due parti. Nella prima parte è analizzata l’immortalità dei progenitori in rapporto alla fisica degli elementi, alla disposizione umorale, e alla facoltà nutritiva, nonché l’interazione tra dinamiche fisiologiche e stato di grazia. Nella seconda, vengono affrontate questioni legate alla generazione dei progenitori quali la capacità riproduttiva nello stato d’innocenza e la produzione delle umidità atte al processo generativo
Progettazione di un impianto di climatizzazione per locali di ristorazione ubicati nella stazione di porta Garibaldi (MI)
No full textLa Tesi tratta di un progetto preliminare svolto durante il tirocinio all'interno dell'azienda R.E.N. Solution a Reggio Emilia, una società di piccole dimensioni che lavora nel campo della progettazione energetico - impiantistica.
Il progetto, commissionato dall'azienda Conclima s.r.l., ha come oggetto la stazione di Porta Garibaldi a Milano. È in corso, infatti, un finanziamento importante destinato alla ristrutturazione e al riammodernamento del complesso ferroviario, che consiste nella realizzazione di un Food-Quarter (letteralmente "quartiere del cibo") con la compresenza di diverse tipologie di ristorazione, quali fast food, ristoranti, pizzerie e chioschi in locali attualmente inutilizzati della stazione.
Il progetto di Tesi ha come obiettivo l'ideazione e il dimensionamento di un impianto energetico in grado di climatizzare i futuri locali del Food-Quarter durante tutto l'arco dell'anno.
Le difficoltà dell'impresa consistono nel riuscire a soddisfare i diversi fabbisogni energetici delle varie tipologie di ambienti come cucine, sale ristoro e servizi igienici, integrarli all'interno di un unico sistema energetico funzionale, individuare i macchinari appropriati che possano compensare le tante dispersioni termiche, caratteristiche degli ambienti in esame, e proporre una schema ottimale di distribuzione interna
La colonizzazione fungina delle varietà di Oryza sativa L. coltivate in Italia: indagini e aspetti applicativi.
No full textKi 67 immunohistochemical evaluation in colorectal cancer and normal colonic mucosa: possible clinical applications
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