9 research outputs found
The genetics of resistance to infectious pancreatic necrosis virus in rainbow trout unveiled through survival and virus load data
No full textInfectious Pancreatic Necrosis virus (IPNV) is one of the major threats to the animal welfare and economy of the rainbow trout farming industry. Previous research has demonstrated significant genetic variation for resistance against IPNV. The main objective of the study was to investigate the genetic architecture of resistance against IPNV in rainbow trout fry. To achieve this, 610 rainbow trout fry, from a full factorial mating between 5 sires and 5 dams, were bath challenged with the IPNV isolate (IPNV-AS) from Atlantic salmon reared at a commercial farm. The resistance against IPNV was accessed using three different phenotypes; binary survival (BS), total days survived (TDS) and virus load (VL) recorded on the fish throughout the 40-day challenge test. All fish were genotyped using a 57K Affymetrix SNP array. The IPNV-AS isolate resulted in an overall mortality of 62.1%. The heritability estimates for survival (BS h2 = 0.21 ± 0.06, TDS h2 = 0.25 ± 0.07) and VL traits (h2 = 0.23 ± 0.08) were moderate and indicative of potential use of selection for increased resistance to IPNV in rainbow trout selective breeding programs. The unity estimated genetic correlation between the two survival traits (BS and TDS) indicates that the traits can be considered the same trait. In contrast, a moderate favourable negative genetic correlation was found between VL and the two survival traits (−0.61 ± 0.22 to −0.70 ± 0.19). The GWAS of the traits with many QTLs crossing the chromosome-wide Bonferroni corrected threshold indicates the polygenic nature of the studied traits. Most of the 10 possible identified genes were found to be linked with immunity or viral pathogenesis, which could be potentially responsible for the significant genetic variation in survival against the IPNV-AS. The QTL validation analysis revealed no significant difference in the mortalities and VL among the three genotypes of the detected QTL. The VL trait showed larger variation among the dead fry and with a concordant pattern with the two survival phenotypes, but with no significant difference in the proportion of IPNV VL positive samples in the dead and the survived fry. Overall, the results indicate the polygenic nature of the studied traits and support the use of genomic selection to improve resistance against IPNV in rainbow trout breeding companies
Book review: Electropolishing
No full textThe book „Electropolishing“ by M. Buhlert is dealing with the electrolytic brightening, smoothing and deburring of technical materials like steel, copper, brass, aluminum, titanium and magnesium. The book content covers the basics and the main influencing parameters of the electropolishing process and provides detailed and application orientated procedure information for technical relevant materials.
After a brief introduction into the topic of electrolytic polishing in the first chapter, the author gives a detailed description of the basic electrochemical reaction mechanisms in the second chapter. The reader will also be informed about the physical and chemical parameters, which control the electrochemical removal process. Additionally, the author reports about the advantages and disadvantages of electropolishing.
The third chapter provides a detailed insight into the influencing manufacturing parameters affecting the results of the electropolishing process. Distinct aspects of the manufacturing e.g. workpiece preparation, electrolyte composition, polishing time, electrolyte temperature and alloy compositions will be discussed in detail by the author.
In the fourth and fifth chapter, the author gives useful hints and information about the parameter variation and the suitable handling of hull cells for the optimization of the removal process, followed by a particular overview about material specific electrolyte mixtures for common-used technical metals and alloys, like steel, aluminum, brass, magnesium, copper and titanium.
The sixth chapter of the book provides many selected manufacturing results and investigations on electropolishing of different metals and alloys, which allows the reader the opportunity to develop a systematic understanding of the topic and to adopt the knowledge on the optimization of his own electropolishing process.
Finally, the book concludes with a brief chapter about some remarks with respect to the work safety and environmental efforts.
In summary, this book contains a very detailed and clear arranged overview about the electropolishing method for the surface optimization process. For this reason, it is a suitable and useful lecture for people, which want to take an in depth look into the topic in order to start using this method or are interested in optimize their existing electropolishing processes
Genealogia rodziny Jędryckich z Biskupca
No full textIn 1986. Janusz Jasinski gave print of diary of Franiszek Lieder under the title „Warmia my young years”, in which, among others - in connection with the work of his father Jan Lieder as a teacher in Biesowo - appears silhouette of his successor in the local school, Józef Jędrycki, derived from Biskupiec. The figure of Jędrycki gave rise to the presentation of relationships of Jędrycki family from Biskupiec (persons with this name we meet in other cities of Warmia). After years - through access to Warmia vital records, brought in 2002 from Regensburg to the Archives of the Archdiocese of Warmia in Olsztyn - you can confront the arguments of the diarist and publisher with the genealogical information contained in these valuable sources. An important data complement to the article topic from the oldest surviving book of baptisms and the oldest books of the dead from parish Biesowo stored in Sächsisches Staatsarchiv. Staatsarchiv Leipzig (this information was obtained thanks to the kindness and courtesy of the Leipzig archivist Dr. Thoralf Handke, whom the author would like to thank for understanding and the effort to carry out the query source), and the oldest book of the parish Biesowo marriages and other vital records, stored in the Archives of the Archdiocese of Warmia in Olsztyn
Author Correction: A consensus protocol for functional connectivity analysis in the rat brain
No full textAuthor Correction: A consensus protocol for functional connectivity analysis in the rat brai
Author Correction: A consensus protocol for functional connectivity analysis in the rat brain (Nature Neuroscience, (2023), 26, 4, (673-681), 10.1038/s41593-023-01286-8)
No full textIn the version of this article initially published, Clément M. Garin was presented in the author list without a middle initial. The name has been amended in the HTML and PDF versions of the article
Genealogia przodków i krewnych Franciszka Liedera (1791-1867), pamiętnikarza i pedagoga rodem z Biesowa
No full textIn 1986 Janusz Jasinski published the diary given by Franciszek Lieder (born April 2, 1791 in Biesowo, died on May 28, 1867 in Warsaw) under the title “Warmia of my young years”. Source was preceded by a comprehensive outline of the history of the parish and family Lieder from Biesowo, focusing on Franciszek’s parents and the diarist. But some problems in the publisher sketch, as well as with the text of diary are not entirely clear. After years - through access to vital records Warmia, imported in 2002 from Regensburg to the Archives of the Archdiocese of Warmia in Olsztyn – you can confront the findings of the publisher and the diarist arguments of genealogical information contained in these valuable resources. An important complement to the article topic data from the oldest surviving book of baptisms and the oldest books of the dead parish Biesowo stored in Sächsisches Staatsarchiv. Staatsarchiv Leipzig (this information was obtained thanks to the kindness and courtesy of the Leipzig archivist Dr. Thoralf Mr. Handke, that author would like to thank you for your understanding and effort to carry out the source query), and the oldest book of the parish Biesowo marriages and other vital records, located in the Archives of the Archdiocese of Warmia in Olsztyn. The article presents as completely as possible, which is permitted by the state of preservation of archival sources, the history of his grandfather Michał Lieder, parents Jan and Barbara from home Gralki and siblings diarist (recording for posterity the memory also listed his two older brothers and a sister, who died at the truth in infancy, but still not mentioned them by Franciszek Lieder in his diary is a bit of a surprise to the reader). Franiszek fullest captures the fate of his eldest sister, who lived to adulthood, Ludwika, her husband and children (not found any information about his younger brother, Józrf, and the date is set for the birth and death of the youngest brother, Marcin). In the second part of the article is given the fate of his father’s successor diarist, Jan Lieder, a teacher at a school in Biesowo – Józef Jędryckiego native of Biskupiec, and his descendants. Warmia maintained registry books also made it possible to verify and supplement or correction given by the publisher of the diary in the footnotes birthdays and death of several priests of Warmia mentioned by the author of memories, which was devoted to the third part of the article. Diary of Francis Lieder, in an interesting way which approximates the first decades of the nineteenth century everyday Warmia, but in some cases may not be a reliable source in relation to those presented in his memory of events and evaluations, as the author of this article tried to present and, if possible, offered preserved archival sources, correc
Assessing the climate impact of the AHEAD multi-fuel blended wing body
No full textAir traffic is important to our society and guarantees mobility especially for long distances. Air traffic is also
contributing to climate warming via emissions of CO2 and various non-CO2 effects, such as contrail-cirrus or
increase in ozone concentrations. Here we investigate the climate impact of a future aircraft design, a multi
fuel blended wing body (MF-BWB), conceptually designed within the EU-project AHEAD. We re-calculate
the parameters for the contrail formation criterion, since this aircraft has very different characteristics
compared to conventional technologies and show that contrail formation potentially already occurs at lower
altitudes than for conventional aircraft. The geometry of the contrails, however, is similar to conventional
aircraft, as detailed Large-Eddy-Simulations show. The global contrail-cirrus coverage and related radiative
forcing is investigated with a climate model including a contrail-cirrus parameterisation and shows an increase
in contrail-cirrus radiative forcing compared to conventional technologies, if the number of emitted particles
is equal to conventional technologies. However, there are strong indications that the AHEAD engines would
have a substantial reduction in the emission of soot particles and there are strong indications that this leads
to a substantial reduction in the contrail-cirrus radiative forcing. An overall climate impact assessment with
a climate-chemistry response model shows that the climate impact is likely to be reduced by 20% to 25%
compared to a future aircraft with conventional technologies. We further tested the sensitivity of this result
with respect to different future scenarios for the use of bio fuels, improvements of the fuel efficiency for
conventional aircraft and the impact of the number of emitted soot particles on the radiative forcing. Only the
latter has the potential to significantly impact our findings and needs further investigation. Our findings show
that the development of new and climate compatible aircraft designs requires the inclusion of climate impact
assessments already at an early stage, i.e. pre-design level
Author Correction:A consensus protocol for functional connectivity analysis in the rat brain
No full textInternational audienceNo abstract availabl
Segmenting Whole-Body MRI and CT for Multiorgan Anatomic Structure Delineation.
No full textContains fulltext :
324382.pdf (Publisher’s version ) (Open Access)Purpose To develop and validate MRSegmentator, a retrospective cross-modality deep learning model for multiorgan segmentation of MRI scans. Materials and Methods This retrospective study trained MRSegmentator on 1200 manually annotated UK Biobank Dixon MRI sequences (50 participants), 221 in-house abdominal MRI sequences (177 patients), and 1228 CT scans from the TotalSegmentator CT dataset. A human-in-the-loop annotation workflow used cross-modality transfer learning from an existing CT segmentation model to segment 40 anatomic structures. The model's performance was evaluated on 900 MRI sequences from 50 participants in the German National Cohort (NAKO), 60 MRI sequences from the Multi-Modality Abdominal Multi-Organ Segmentation Challenge 2022 dataset, and 29 MRI sequences from TotalSegmentator MRI. Reference standard manual annotations were used for comparison. Metrics to assess segmentation quality included Dice similarity coefficient (DSC). Statistical analyses included organ- and sequence-specific means ± SDs reporting and two-sided t tests for demographic effects. Results One-hundred thirty-nine participants were evaluated; demographic information was available for 70 (mean age, 52.7 years ± 14.0 [SD], 36 female participants). Across all test datasets, MRSegmentator demonstrated high class-wise DSC for well-defined organs (lungs: 0.81-0.96, heart: 0.81-0.94) and organs with anatomic variability (liver: 0.82-0.96, kidneys: 0.77-0.95). Smaller structures showed lower DSC (portal or splenic veins: 0.64-0.78, adrenal glands: 0.56-0.69). The average DSC on the external testing using NAKO data ranged from 0.85 ± 0.08 for T2-weighted half-Fourier acquisition single-shot turbo spin echo to 0.91 ± 0.05 for in-phase sequences. The model generalized well to CT, achieving a mean DSC of 0.84 ± 0.12 on abdominal multiorgan segmentation CT data. Conclusion MRSegmentator accurately segmented 40 anatomic structures on MRI and generalized to CT, outperforming existing open-source tools. Keywords: MR-Imaging, Segmentation, Vision, Application Domain, Supervised Learning, Type of Machine Learning © The Author(s) 2025. Published by the Radiological Society of North America under a CC BY 4.0 license. See also commentary by Tao in this issue.01 november 202
