117,725 research outputs found
Relative socioeconomic characteristics of the three IPCC SRES scenarios used in this assessment.
No full text<p>See Nakicenovic et al. (2000) for additional information on SRES characteristics and Sohl et al. (2014) for how these characteristics were interpreted to create the LULC projections used in this assessment.</p><p>Relative socioeconomic characteristics of the three IPCC SRES scenarios used in this assessment.</p
KMF-006
No full textThis is a book entitled "Kitail Lokaiahn Pohnpei: Introductory Lessons in Ponapean," which was published in November 1969. It was funded by the United States Peace Corps and developed by Kenneth L. Rehg with the assistance of Damian Sohl. The book was designed for training volunteers in the Ponape District, and it contains both a long and a short course of instruction. The book's preface indicates that it has accompanying audio materials, including dialgogues and listening comprehension exercises.Pohnpei, Federated States of Micronesi
Hypoxia in arterial and venous specification during vascular development
No full textA developing embryo needs a constant supply of oxygen and nutrients in order to survive and grow into a functioning organism. During the earliest embryonic stages passive diffusion is enough to sustain the embryo. At later embryonic stages however, a system for delivering the necessary oxygen and nutrients to all parts of the embryo is needed. As a consequence, the vasculature is the earliest functional organ to form during embryonic development. The area of interest for my research has been vascular development, with a specific aim to uncover mechanisms of arterial and venous specification during embryogenesis. This research could be important for understanding underlying mechanisms behind several severe pathologies such as cancer, diabetes and atherosclerosis.In the first study we developed a system for generating endothelial cells with arterial or venous characteristics from ESC (Embryonic stem cells). We showed that VEGF play a critical role in determining both arterial and venous fate. Differentiation of ESCs to endothelial cells using high levels of VEGF promoted arterial specification, while low levels of VEGF induced venous fate. In addition we could show that the VEGF signaling was dependent on Notch signaling for driving arterial fate.In the second paper we characterized the promoter region of ephrinB2, a gene specifically expressed in arteries but not in veins, in order to identify transcription factors involved in arterial specification. In this study we identified the minimal promoter region of ephrinB2 and proved that the transcription factors MAZ, Meis1 and NFY bind to the promoter and induce EphrinB2 expression in MAE cells. In addition, a TATA-box necessary for ephrinB2 expression was identified.In the third paper we showed that ephrinB2 is up regulated in response to hypoxia in mouse arterial endothelial (MAE) cells, and aimed to reveal the mechanism for hypoxic regulation of ephrinB2. We proved that neither hypoxia inducible factor (Hif) 1a nor Hif- 2a was responsible for inducing ephrinB2 expression in MAE cells. Instead we showed that Sp1 binds to the promoter during hypoxic conditions but not in normoxia, while the opposite is true for MAZ. Also, knocking down Sp1 proved to reduce ephrinB2 expression in hypoxic MAE cells.In the fourth manuscript we used the in vitro ESC differentiation system developed in the first study to investigate how hypoxia affects arterial/venous differentiation of vascular progenitor cells. We showed that hypoxia activates an arterial transcriptional program and that this response is not driven by classic VEGF signaling, but rather by Notch and Adrenomedullin signaling.List of scientific papersI. Lanner F, Sohl M, Farnebo F (2007). Functional arterial and venous fate is determined by graded VEGF signaling and notch status during embryonic stem cell differentiation. Arterioscler Thromb Vasc Biol. 27(3): 487-93. Epub 2006 Dec 21 https://pubmed.ncbi.nlm.nih.gov/17185616II. Sohl M, Lanner F, Farnebo F (2009). Characterization of the murine Ephrin-B2 promoter. Gene. 437(1-2): 54-9. Epub 2009 Mar 5 https://pubmed.ncbi.nlm.nih.gov/19268698III. Sohl M, Lanner F, Farnebo F (2009). Hypoxia induced expression of ephrinB2 is independent of Hif-1. [Manuscript]IV. Lanner F, Sohl M, Hansson E, Carmeliet P, Poellinger L, Lendahl U, Farnebo F (2009). Hypoxic induction of Adrenomedullin and Notch signaling promotes arterial differentiation of embryonic stem cells. [Manuscript]</p
Going Beyond Counting First Authors in Author Co-citation Analysis
No full textThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Square Dancing with the Stars to Enhance Dynamic Hirschman Linkages?
No full textIn this Presidential Address, the author takes the reader on a reconnaissance of his life and time as a regional scientist. He points out scenery he found scintillating along the way, hoping that some may pick up the banner and chew on a few of the ideas for a while. He suggests a revisit to Albert O. Hirschman’s notion of key sectors and more empirical analysis related to Marcus Berliant’s and Masahisa Fujita’s notion of knowledge creation and transfer.Presidential Address, San Antonio, Texas, March 29, 2014 (53rd Meetings of the Southern Regional Science Association
Appropriate Similarity Measures for Author Cocitation Analysis
No full textWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Letter from unknown writer to Jesse L. Boyce
No full textLetter to Jesse L. Boyce from unknown author (possibly Jack) about the investigation into the powder magazine located in the Grand Canyon. Some personal news is included in the letter such as the writer's marriage to the daughter of C.A. Taylor, former Supervisor of Cochise County
Dispelling the Myths Behind First-author Citation Counts
No full textWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
Pro Region C-Terminus:Protease Active Site Interactions Are Critical in Catalyzing
No full textR-Lytic protease is encoded with a large (166 amino acid) N-terminal pro region that is required transiently both in vivo and in vitro for the correct folding of the protease domain [Silen, J. L., and Agard, D. A. (1989) Nature 341, 462-464; Baker, D., et al. (1992) Nature 356, 263-265]. The pro region also acts as a potent inhibitor of the mature enzyme [Baker, D., et al. (1992) Proteins: Struct., Funct., Genet. 12, 339-344]. This inhibition is mediated through direct steric occlusion of the active site by the C-terminal residues of the pro region [Sohl, J. L., et al. (1997) Biochemistry 36, 3894-3904]
Sarah L. Blum Author Visit - Warrior Nurse: PTSD and Healing
No full textHear Sarah L. Blum, author of Women Under Fire: Abuse in the Military, discuss her newest book, Warrior Nurse: PTSD and Healing followed by a Q&A and book signing.
Sarah L. Blum is a decorated Vietnam veteran who served as an operating room nurse during the intense fighting of 1967. In recognition of her service, she was awarded the Army Commendation Medal.
Sponsored by CWU Veterans Center and CWU Libraries.https://digitalcommons.cwu.edu/libraryevents/1252/thumbnail.jp
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