12 research outputs found
Máscaras, burla y juego onomástico en la “Epístola [de Amarilis] a Belardo”: del poeta y marqués de Montesclaros, Juan Manuel de Mendoza y Luna, a Félix Lope de Vega y Carpio
No full textThis study identifies the author of the “Epistle to Belardo”. It is the Marquis
of Montesclaros, Juan Manuel de Mendoza y Luna, Viceroy of Peru and supporter of
the Academia Antártica, a lover of poetry and a good friend of Lope de Vega, whom he
had known for several years at the court of the Duke of Alba in his youth. Hidden under
the mask of a nun –Amarilis–, he nevertheless offers some clues in his composition to
identify him, including a reference to his brother–in–law, the Count of Palma,
mentioned in the play as the husband of “Belisa”, his sister Francisca de Mendoza. Lope
responded with another poetic epistle in which he identifies him, albeit in a hidden way:
one of the most beautiful texts written throughout his life by the Phoenix of Wit – the
wpistle “Belardo a Amarilis” – in which he confesses to his good friend and to his
readers in a profound and sincere way.Este estudio identifica al probable autor de la “Epístola a Belardo”. Se trata
del marqués de Montesclaros, Juan Manuel de Mendoza y Luna, virrey del Perú y
mantenedor de la Academia Antártica, aficionado a la poesía y buen amigo de Lope de
Vega al que trató durante varios años en la corte del duque de Alba en sus años de
juventud. Escondido bajo la máscara de una monja –”Amarilis”–, ofrece sin embargo en
su composición algunas pistas para descubrirlo, entre ellas una referencia a su cuñado,
el conde de Palma, citado en la obra como esposo de “Belisa”, su hermana Francisca de
Mendoza. Lope respondió con otra epístola poética en que lo identifica, aunque de
forma oculta: uno de los más bellos textos que escribió a lo largo de su vida el Fénix de
los Ingenios –”Belardo a Amarilis”–, en el que se confiesa ante su buen amigo y ante
los lectores de un modo profundo y sincer
Produksi dan Kualitas Umbi Beberapa Genotipe Kentang (Solanum tuberosum L.) Koleksi IPB untuk Olahan Keripik Kentang
No full textKebutuhan akan varietas kentang untuk industri olahan keripik kentang terus meningkat, namun ketersediaan varietas yang menghasilkan umbi yang memenuhi kriteria untuk keripik kentang masih terbatas. Penelitian ini bertujuan melakukan karakterisasi kualitas umbi kentang dari beberapa genotipe unggul koleksi IPB yang sesuai bagi kebutuhan industri olahan keripik kentang. Karakter kualitas tersebut meliputi diameter umbi, berat jenis, bahan kering, dan organoleptik keripik. Penelitian dilaksanakan pada Januari-Mei 2020 di Desa Margamulya, Kecamatan Cikajang, Kabupaten Garut. Sebanyak delapan genotipe yang terdiri atas PKHT-2019-010, PKHT-2019-011, PKHT-2019-012, PKHT-2019-013, PKHT-2019-014, PKHT-2019-015, PKHT-2019-016, PKHT-2019-017 dan dua varietas pembanding yaitu Medians dan Intan. Rancangan percobaan yang digunakan pada penelitian ini adalah rancangan kelompok lengkap teracak faktor tunggal yaitu genotipe dengan 4 ulangan. Penelitian dimulai dari persiapan lahan, penanaman, pemeliharaan, dan pemanenan, serta pengolahan keripik. Hasil penelitian menunjukkan bahwa genotipe PKHT-2019-010, PKHT-2019-012, dan PKHT-2019-017 memiliki potensi sebagai genotipe yang dapat dikembangkan sebagai varietas kentang untuk bahan baku industri keripik kentang berdasarkan berat jenis, kandungan gula, bentuk, penampilan dan warna keripik yang baik. Genotipe PKHT-2019-015 memiliki produktivitas, bobot umbi dan diameter umbi yang sangat baik dan memenuhi kriteria industri, namun memiliki kadar gula yang tinggi sehingga lebih cocok dikembangkan sebagai kentang sayur. Namun demikian masih diperlukan penelitian lanjutan untuk meningkatkan bobot dan ukuran ketiga genotipe tersebut untuk mencapai standard industri.
Kata kunci: genotipe, kerenyahan, produktivitas, kandungan gulaThe need for potato varieties for the potato chip processing industry continues to increase; however, the availability of varieties that produce tubers that meet the criteria for potato chips is still limited. The study aimed to characterize the quality of potato tubers from several superior genotypes of IPB collections that are suitable for the potato chip processing industry’s needs. These quality characters included tuber diameter, specific gravity, dry matter, and organoleptic chips. This research was conducted in January-May 2020 at the Margamulya village, Cikajang, Garut. Eight genotypes, PKHT-2019-010, PKHT-2019-011, PKHT-2019-012, PKHT-2019-013, PKHT-2019-014, PKHT-2019-015, PKHT-2019-016, PKHT-2019-017 with two control varieties, Medians and Intan were used in this study as material plant. The genotype was used as a single factor in a randomized complete block design with four replications. The study begins with preparing the land, planting, maintenance, harvesting, and processing of chips. The results showed that the PKHT-2019-010, PKHT-2019-012, and PKHT-2019-017 genotypes had potential as genotypes that could be developed as potato varieties for raw materials for the potato chip industry based on density, sugar content, shape, appearance, and good color chips. The PKHT-2019-015 genotype has excellent productivity, tuber weight, and tuber diameter and meets industrial criteria, but has high sugar content, so it is more suitable to be developed as vegetable potatoes. However, further research is still needed to increase the three genotypes’ weight and size to reach industry standards.
Keywords: genotype, crispness, productivity, sugar conten
[en] THE MAN WHO COUNTED, BY MALBA TAHAN: A PSEUDOTRANSLATION WHERE BOTH AUTHOR AND TRANSLATOR ARE FICTITIOUS
No full textPengaruh Larutan Pulsing terhadap Daya Simpan Bunga Matahari Potong
No full textBunga matahari sebagai tanaman hias yang dapat dimanfaatkan sebagai bunga potong, namun proses respirasi dan transpirasi yang tinggi dapat menyebabkan penurunan daya simpan dan mutu bunga. Teknologi pasca panen seperti pemberian larutan pulsing yang tepat diperlukan agar kualitas dan daya simpan tetap terjaga. Penelitian ini bertujuan mengetahui jenis larutan pulsing terbaik untuk mempertahankan kesegaran dan mutu bunga potong bunga matahari. Percobaan menggunakan Rancangan Acak Lengkap dengan faktor komposisi larutan pulsing sebanyak 8 taraf, yaitu akuades (P1), akuades + gula 3% (P2), akuades + bayclin 0.25% (P3), akuades + gula 3% + bayclin 0.25% (P4), akuades + gula 3% + asam salisilat 50 ppm (P5), akuades + gula 3% + bayclin 0.25% + asam salisilat 50 ppm (P6), akuades + gula 3% + asam salisilat 75 ppm (P7), dan akuades + gula 3% + bayclin 0.25% + asam salisilat 75 ppm (P8). Setiap perlakuan terdiri dari 4 ulangan dengan satu tangkai bunga per ulangan, sehingga terdapat 32 tangkai bunga sebagai unit percobaan. Hasil penelitian menunjukkan bahwa larutan pulsing yang mengandung akuades + gula 3% + bayclin 0.25% + asam salisilat 75 ppm cenderung lebih dapat mempertahankan kesegaran bunga potong bunga matahari dan mengefektifkan penyerapan air hingga 6 HSP.
Kata kunci: asam salisilat, bayclin, bunga potong, gula, pasca panenSunflower is one of the ornamental plants that can be used as cut flowers. However, the ongoing processes of respiration and transpiration can lead to a decline in the quality of these cut flowers. Suitable postharvest technology, such as pulsing treatment, is necessary to maintain the quality and vase life of these cut flowers.. This research aimed to determine the most effective pulsing solution for preserving the freshness and quality of cut sunflowers.. The experiment used a Completely Randomized Design with pulsing solution types as the factor. There were 8 variations of pulsing solutions: aquades (P1), aquades + 3% sucrose (P2), aquades + 0.25% bayclin (P3), aquades + 3% sucrose + 0.25% bayclin (P4), aquades + 3% sucrose + 50 ppm salicylic acid (P5), aquades + 3% sucrose + 0.25% bayclin + 50 ppm salicylic acid (P6), aquades + sucrose 3% + 75 ppm salicylic acid (P7), dan aquades + 3% sucrose + 0.25% bayclin + 75 ppm salicylic acid (P8). Each treatment consisted of 4 replications with one cut flower per replication. Thus there were 32 cut sunflowers as the experimental units. The results revealed that pulsing with aquades + 3% sucrose + 0.25% bayclin + 75 ppm salicylic acid tended to maintain the freshness of the cut sunflowers and optimized the water absorption up to 6 days after the pulsing treatment.
Keywords: bayclin, cut flowers, salicylic acid, sucrose, postharves
Instrumentos musicales cotidianos en el desarrollo de la inteligencia musical en el inicial 2 de la Unidad Educativa Capitán Edmundo Chiriboga, Cantón Riobamba
No full textThis research deals with the subject of everyday musical instruments in the development of musical intelligence of children in kindergarten 2 of the Unidad Educativa Capitán Edmundo Chiriboga, in which the general objective is based on determining the importance of the use of everyday musical instruments in the development of musical intelligence in children. For this purpose, a quantitative methodology was used, which allowed the collection of relevant data to obtain the basic ideas within the research. The design of the classroom card was the instrument used for the application of the surveys applied to 20 children of initial 2 who are around 4 and 5 years old. In addition, a descriptive, non-experimental research design was chosen since there was no manipulation of variables in the research. The results obtained are presented in the respective tables and statistical diagrams that are clearly explained by the author. According to the analysis and the results found, it can be summarized that within the institution, activities related to music are developed, but it is notable that several of them are not reaching the level of learning that is needed, that is, the stage of acquired, although most of the children are in the stage of “in process” and in the stage of “acquired” there is still evidence of children who in some activities present a low level of integral development. In addition, the need to carry out and adapt activities that encourage the social, emotional, motor, auditory and creative development of children to improve their integration into the environment is emphasized. To this end, a proposal of activities related to the development of musical intelligence in children is promoted. In conjunction with this, active learning is promoted through the intellectual and playful activities of the children of the Institution, focusing on the learning, development and evolution of skills and abilities of the children.Esta investigación abordo la temática de los instrumentos musicales cotidianos en el desarrollo de la inteligencia musical de los niños de inicial 2 de la Unidad Educativa “Capitán Edmundo Chiriboga”, en el cual el objetivo general se basa en determinar la importancia del uso de los instrumentos musicales cotidianos en el desarrollo de la inteligencia musical de los niños. Para ello se utilizó una metodología cuantitativa la cual permitió recopilar datos relevantes para obtener las ideas bases dentro de la investigación. El diseño de la ficha áulica fue el instrumento utilizado para la aplicación de las encuestas aplicadas a 20 niños de inicial 2 quienes comprenden alrededor de 4 y 5 años. Además, se optó por el diseño de investigación descriptiva no experimental ya que dentro de la investigación no existió manipulación alguna de variables. Los resultados obtenidos se presentan en las respectivas tablas y diagramas estadísticos que son explicados claramente por el autor. De acuerdo al análisis y los resultados encontrados se sintetiza que dentro de la institución se desarrollan actividades relacionadas a la música, pero es notable que varias de ellas no están alcanzando el nivel de aprendizaje que se necesita, es decir la etapa de adquirido, aunque la mayoría de los niños se encuentre en la etapa de “en proceso” y en la etapa de “adquirido” aún se evidencia niños que en algunas actividades presentan un nivel bajo de desarrollo integral. Además, se enfatiza la necesidad de realizar y adaptar actividades que incentiven el desarrollo social, emocional, motriz, auditivo y creativo de los niños para mejorar su integración en el entorno. Para ello, se fomenta una propuesta de actividades relacionadas al desarrollo de la inteligencia musical en los niños. conjuntamente con ello se promueve un aprendizaje activo a través de las actividades intelectuales lúdicas de los niños y niñas de la Institución enfocándose en el aprendizaje, desarrollo y evolución de destrezas y habilidades propias de los niños.UNACH, Ecuado
Recomendaciones para el tratamiento epistemológico y praxeológico del proceso de formación de una cultura ambiental en los educandos (Original).
No full textEducational systems in general and higher education in particular, have insisted on the incorporation of environmental content in the comprehensive training of students. The relationship between science, environment and profession is essential during the environmental training process at the university. Recommendations are proposed that could condition the professional training process based on the protagonist participation of students in the educational institution, in the community where they work and in their work performance. The author considers: proposing recommendations for the epistemological and praxeological treatment of the students' environmental training process. It took 82 students from the Municipal University Center and deepened with 3 3 students from the first and second year of the Primary Education career, from the Teacher Training School of the Buey Arriba municipality. Dialectical materialism was used as a general method and with a very objective character that emanates from the current demands related to the environmental culture of the students. The partial results showed that it is possible from the different subjects of the study plan to contribute to the development of environmental education. The author considers the research important and is very current, it is inserted within the main lines of research established by the Ministry of Education, specifically thematic line # 7. The proposal contributes to the development of environmental education, taking into account the current historical moment. The protection of the environment is urgent and necessary for the preservation of the human species.Los sistemas educativos en general y la educación superior en particular, han insistido en la incorporación del contenido ambiental en la formación integral de los estudiantes. La relación entre ciencia, medio ambiente y profesión resulta esencial durante el proceso de formación ambiental en la universidad. Se proponen recomendaciones que pudieran condicionar el proceso de formación profesional en función de la participación protagónica de los estudiantes en la institución educativa, en la comunidad donde actúan y en su desempeño laboral. La autora se plantea proponer recomendaciones para el tratamiento epistemológico y praxeológico del proceso de formación de una cultura ambiental en los educandos. Se utilizó como método general el materialismo dialéctico y con un carácter muy objetivo que emana de las exigencias actuales relacionadas con la cultura ambiental de los estudiantes. La propuesta contribuye al desarrollo de la educación ambiental, teniendo en cuenta el momento histórico que se vive. Es urgente y necesaria la protección del medio ambiente para la preservación de la especie human
Representações da diáspora na escrita de Orlanda Amarílis
No full textEste ensaio contempla as representações identitárias caboverdianas presentes nos contos da escritora Orlanda Amarílis e como tais representações se inserem em um projeto crítico da autora. Os movimentos diaspóricos das personagens transformam suas configurações identitárias, e o modo como elas são construídas revela um profundo questionamento a respeito do lugar que os cabo-verdianos e a literatura proveniente de Cabo Verde ocupam no cenário mundial. This paper contemplates the Cape Verde representations of identities present in the short stories of the writer Orlanda Amarilis, and in which ways these representations are introduced in a critical project of the author. The diasporic movements of the characters turn their identities’ configurations, and the way they are built reveals a profound questioning about the place in which the Cape Verdeans and the literature from Cape Verde occupy the world scenery
SEGURANÇA DO PACIENTE NA ATENÇÃO PRIMÁRIA EM SAÚDE: SABERES E PRÁTICAS DO PROFISSIONAL ENFERMEIRO
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Previous issue date: 2018-04-30Introduction: patient safety represents an important concern in the quality of health care and has an analogy with the prevention of errors in care. Adverse events take place wherever health care is provided and, in many circumstances, could be prevented through preventive measures. Objective: to identify the actions of the professional practice of nurses that indicate patient safety in primary health care, with a view of qualifying health care. Specific Objectives: to identify, in the literature the area, the scientific publications related to patient safety actions related to the nurses' performance in primary health care and to understand the conceptions of nurses working in the Family Health Strategy on safety knowledge and practices of the patient in primary health care. Methodology: This dissertation was developed in two stages, one consisting of a integrative review of literature in which scientific articles were found with the objective of the review. The second stage consisted of a descriptive-exploratory study with a qualitative approach, developed in Family Health Strategies located in the western region of Santa Maria - RS. The data were analyzed according to the thematic content analysis of Minayo. This research is approved by the Research Ethics Committee of the Franciscan University, and is registered under opinion nº 1.876.855. Results: The publications found in the review totaled 10 scientific articles presented in a synthesis table, in order to characterize the publications according to author / year, objectives, type of study, approach, results and conclusions. In field research, the analysis process resulted in the organization of three thematic categories: Patient safety meanings for the nurses of the Family Health Strategy; Barriers to safe care in the context of Primary Health Care and Strategies for safe care in the work of nurses of the Family Health Strategy. Discussion: the findings of the integrative literature review did not allow a more in-depth analysis of the topic, since the studies about nurses' work in primary care related to the subject are scarce and incipient, indicating the existence of spaces for new research to be carried out. Many articles, because they are international, have brought a primary health care organization that is very similar to the Family Health Strategy model and traditional Basic Health Units, which are characteristic models of Primary Care in Brazil. In the field research, it was noticed that the conception of the majority of the nurses regarding the safety of the patient are related to the safe care that avoids damages. Some participants highlighted the concern about infection prevention as one of the criteria for avoiding risk and harm. Some difficulties were also signaled both in the speeches and in the professional performance, through the observations. Although many difficulties have been mentioned and observed in nurses' work, it is important to highlight that they have been developing some strategies to promote safe care, even in adverse working conditions. Final Considerations: the integrative review made it possible to identify and ponder existing studies on nurses' performance in primary care pertinent to patient safety. The data allowed to address nurses' understanding of the patient's knowledge and safety practices in primary health care, as well as the main barriers and strategies for the development of safe care. It is necessary to explore in depth questions related to patient safety in the work of nurses, since this topic presents a strategic role in the planning and implementation of health team actions and in the direct supervision of the work of Community Health Agents. attributions are heavily included actions of health promotion and care management, which impacts on a role of articulation and leadership towards the team.Introdução: a segurança do paciente representa uma importante preocupação na qualidade do cuidado de saúde e tem analogia com a prevenção de erros no atendimento e ao cuidado. Eventos adversos acontecem em qualquer lugar onde se proporcionam cuidados de saúde e, em muitas circunstâncias, poderiam ser evitados por meio de medidas preventivas. Objetivo: identificar as ações da prática profissional do enfermeiro que indiquem a segurança do paciente na atenção primária em saúde, com vistas à qualificação do cuidado em saúde. Objetivos Específicos: identificar, na literatura da área, as publicações científicas referentes às ações de segurança do paciente relacionadas à atuação do enfermeiro na atenção primária em saúde e compreender as concepções de enfermeiros atuantes na Estratégia de Saúde da Família acerca dos saberes e práticas de segurança do paciente na atenção primária em saúde. Metodologia: esta dissertação foi desenvolvida em duas etapas, uma constituída de uma revisão integrativa de literatura na qual foram encontrados artigos científicos que atenderam ao objetivo da revisão. A segunda etapa constou de um estudo descritivo-exploratório com abordagem qualitativa, desenvolvido em Estratégias de Saúde da Família localizadas na região oeste de Santa Maria – RS. Os dados foram analisados segundo análise de conteúdo temática de Minayo. A pesquisa possui aprovação do Comitê de Ética em Pesquisa da Universidade Franciscana, estando registrada sob o parecer nº1.876.855. Resultados: As publicações encontradas na revisão totalizaram 10 artigos científicos apresentados em um quadro síntese, a fim de caracterizar as publicações segundo autor/ano, objetivos, tipo de estudo, abordagem, resultados e conclusões. Na pesquisa de campo, o processo de análise resultou na organização de três categorias temáticas: Significados de segurança do paciente para as enfermeiras da Estratégia de Saúde da Família; Barreiras para o cuidado seguro no contexto da Atenção Primária em Saúde e Estratégias para o cuidado seguro na atuação das enfermeiras da Estratégia de Saúde da Família. Discussão: os achados da revisão integrativa de literatura não permitiram uma análise mais aprofundada sobre o tema, pois os estudos acerca do trabalho do enfermeiro na atenção primária relacionados à temática são escassos e incipientes, o que indica a existência de espaços para que novas pesquisas sejam realizadas. Muitos artigos, por serem internacionais, trouxeram uma organização de atenção primária em saúde que pouco se assemelha com o modelo de Estratégia de Saúde da Família e Unidades Básicas de Saúde tradicionais, que são modelos característicos da Atenção Primária do Brasil. Na pesquisa de campo, percebeu-se que a concepção da maioria das enfermeiras quanto à segurança do paciente está relacionada com o cuidado seguro que evita danos. Algumas participantes elencaram a preocupação com a prevenção de infecções como um dos critérios para se evitar o risco e o dano. Algumas dificuldades também foram sinalizadas tanto nas falas como na atuação profissional, por meio das observações. Embora muitas dificuldades tenham sido referidas e observadas na atuação das enfermeiras, destaca-se que estas vêm desenvolvendo algumas estratégias para potencializar um cuidado seguro, mesmo que em condições de trabalho adversas. Considerações Finais: a revisão integrativa possibilitou identificar e ponderar sobre os estudos já existentes sobre a atuação do enfermeiro na atenção primária pertinentes à segurança do paciente. Os dados permitiram abordar a compreensão das enfermeiras sobre os saberes e práticas de segurança do paciente na atenção primária em saúde, assim como as principais barreiras e estratégias para o desenvolvimento do cuidado seguro. É necessário explorar em profundidade questões pertinentes à segurança do paciente no trabalho do enfermeiro, uma vez que este tema apresenta papel estratégico no planejamento e implementação das ações de equipe de saúde e na supervisão direta do trabalho dos Agentes Comunitários de Saúde. Ainda, dentre suas atribuições estão fortemente incluídas as ações de promoção da saúde e de gestão do cuidado, o que repercute em um papel de articulação e liderança perante a equipe
Efficacy and tolerability of fixed-combination bimatoprost/timolol versus fixed-combination dorzolamide/brimonidine/timolol in patients with primary open-angle glaucoma or ocular hypertension: A multicenter, prospective, crossover study
No full textObjectives: The efficacy and hepatic safety of the non-nucleoside reverse transcriptase inhibitors rilpivirine (TMC278) and efavirenz were compared in treatment-naive, HIV-infected adults with concurrent hepatitis B virus (HBV) and/or hepatitis C virus (HCV) infection in the pooled week 48 analysis of the Phase III, double-blind, randomized ECHO (NCT00540449) and THRIVE (NCT00543725) trials. Methods: Patients received 25 mg of rilpivirine once daily or 600 mg of efavirenz once daily, plus two nucleoside/nucleotide reverse transcriptase inhibitors. At screening, patients had alanine aminotransferase/aspartate aminotransferase levels 5 the upper limit of normal. HBV and HCV status was determined at baseline by HBV surface antigen, HCV antibody and HCV RNA testing. Results: HBV/HCV coinfection status was known for 670 patients in the rilpivirine group and 665 in the efavirenz group. At baseline, 49 rilpivirine and 63 efavirenz patients [112/1335 (8.4%)] were coinfected with either HBV [55/1357 (4.1%)] or HCV [57/1333 (4.3%)]. The safety analysis included all available data, including beyond week 48. Eight patients seroconverted during the study (rilpivirine: five; efavirenz: three). A higher proportion of patients achieved viral load <50 copies/mL (intent to treat, time to loss of virological response) in the subgroup without HBV/HCV coinfection (rilpivirine: 85.0%; efavirenz: 82.6%) than in the coinfected subgroup (rilpivirine: 73.5%; efavirenz: 79.4%) (rilpivirine, P = 0.04 and efavirenz, P = 0.49, Fisher's exact test). The incidence of hepatic adverse events (AEs) was low in both groups in the overall population (rilpivirine: 5.5% versus efavirenz: 6.6%) and was higher in HBV/HCV-coinfected patients than in those not coinfected (26.7% versus 4.1%, respectively). Conclusions: Hepatic AEs were more common and response rates lower in HBV/HCV-coinfected patients treated with rilpivirine or efavirenz than in those who were not coinfected. " The Author 2012. Published by Oxford University Press on behalf of the British Society for Antimicrobial Chemotherapy. All rights reserved.",,,,,,"10.1093/jac/dks130",,,"http://hdl.handle.net/20.500.12104/41161","http://www.scopus.com/inward/record.url?eid=2-s2.0-84864505008&partnerID=40&md5=bfab9b8f6f474d2558f7de2c5e9a2277",,,,,,"8",,"Journal of Antimicrobial Chemotherapy",,"202
Efficacy and safety of rilpivirine in treatment-naive, HIV-1-infected patients with hepatitis B virus/hepatitis C virus coinfection enrolled in the phase III randomized, double-blind ECHO and THRIVE trials
No full textObjectives: The efficacy and hepatic safety of the non-nucleoside reverse transcriptase inhibitors rilpivirine (TMC278) and efavirenz were compared in treatment-naive, HIV-infected adults with concurrent hepatitis B virus (HBV) and/or hepatitis C virus (HCV) infection in the pooled week 48 analysis of the Phase III, double-blind, randomized ECHO (NCT00540449) and THRIVE (NCT00543725) trials. Methods: Patients received 25 mg of rilpivirine once daily or 600 mg of efavirenz once daily, plus two nucleoside/nucleotide reverse transcriptase inhibitors. At screening, patients had alanine aminotransferase/aspartate aminotransferase levels ≤5× the upper limit of normal. HBV and HCV status was determined at baseline by HBV surface antigen, HCV antibody and HCV RNA testing. Results: HBV/HCV coinfection status was known for 670 patients in the rilpivirine group and 665 in the efavirenz group. At baseline, 49 rilpivirine and 63 efavirenz patients [112/1335 (8.4%)] were coinfected with either HBV [55/1357 (4.1%)] or HCV [57/1333 (4.3%)]. The safety analysis included all available data, including beyond week 48. Eight patients seroconverted during the study (rilpivirine: five; efavirenz: three). A higher proportion of patients achieved viral load <50 copies/mL (intent to treat, time to loss of virological response) in the subgroup without HBV/HCV coinfection (rilpivirine: 85.0%; efavirenz: 82.6%) than in the coinfected subgroup (rilpivirine: 73.5%; efavirenz: 79.4%) (rilpivirine, P = 0.04 and efavirenz, P = 0.49, Fisher's exact test). The incidence of hepatic adverse events (AEs) was low in both groups in the overall population (rilpivirine: 5.5% versus efavirenz: 6.6%) and was higher in HBV/HCV-coinfected patients than in those not coinfected (26.7% versus 4.1%, respectively). Conclusions: Hepatic AEs were more common and response rates lower in HBV/HCV-coinfected patients treated with rilpivirine or efavirenz than in those who were not coinfected. © The Author 2012. Published by Oxford University Press on behalf of the British Society for Antimicrobial Chemotherapy. All rights reserved.SCOPUS: ar.jinfo:eu-repo/semantics/publishe
