251 research outputs found
Plumbing, electricity, acoustics : sustainable design methods for architecture / Norbert Lechner.
No full textIncludes index.xi, 289 pages :Discover sustainable methods for designing crucial building systems for architects.
This indispensable companion to Norbert Lechner's landmark volume Heating, Cooling, Lighting: Sustainable Design Methods for Architects, Third Edition completes the author's mission to coverall topics in the field of sustainable environmental control. It provides knowledge appropriate for the level of complexity needed at the schematic design stage and presents the most up-to-date information available in a concise, logical, accessible manner and arrangement. Although sustainability deals with many issues, those concerning energy and efficiency are the most critical, making an additional goal of this book one of providing architects with the skills and knowledge needed to create buildings that use electricity and water efficiently. Guidelines and rules-of-thumb are provided to help designers make their buildings use less energy, less water, and less of everything else to achieve their primary objectives.
In addition, this book:
Addresses ways to reduce electricity usage through more efficient lighting systems and appliances and by incorporating automatic switches and control systems that turn off systems not in use.
Covers the design of well-planned effluent treatment systems that protect against potential health hazards while also becoming a valuable source of reclaimed water and fertilizer
Provides coverage of fire protection and conveyance systems, including very efficient types of elevators and escalators and designs that encourage the use of stairs or ramps.
Complete with case studies that illustrate how these systems are incorporated into large-project plans, Plumbing, Electricity, Acoustics is an indispensable resource for any architect involved in a sustainable design project
Target deconvolution of the HDAC pharmacopoeia highlights MBLAC2 as a common off-target
No full textThis dataset contains the untargeted lipidomics data for the publication Lechner et al. 2022 "Target deconvolution of the HDAC pharmacopoeia highlights MBLAC2 as a common off-target". The dataset has also been submitted to MetaboLight repository with ID "MTBLS3557". Please refer to the MetaboLight repository for the most up-to-date datasets.
Publication abstract:
Histone deacetylase (HDAC) targeting drugs have entered the pharmacopoeia in the 2000s. However, some enigmatic phenotypes suggest off-target engagement. Here, we developed a quantitative chemical proteomics assay using immobilized HDAC inhibitors and mass spectrometry that we deployed to establish the target landscape of 53 drugs. The assay covers 9 of the 11 human zinc dependent HDACs, questions the reported selectivity of some widely-used molecules, notably for HDAC6, and delineates how the composition of HDAC complexes influences drug potency. Unexpectedly, metallo-beta-lactamase domain-containing protein 2 (MBLAC2) featured as a frequent off-target of hydroxamate drugs. This poorly characterized palmitoyl-CoA hydrolase is inhibited by 24 HDAC inhibitors at low nM potency. MBLAC2 enzymatic inhibition and knock down led to the accumulation of extracellular vesicles. Given the importance of extracellular vesicle biology in neurological diseases and cancer, this HDAC-independent drug effect may qualify MBLAC2 as a target for drug discovery
The competitiveness of entrepreneurial firms from a network perspective
No full textThis book sheds light on how the competitiveness of entrepreneurial firms can be understood from a relational perspective. The relational perspective complements internally focused approaches to explain firm competitiveness. Through the review of publications of the author, it will be shown how the relational view extends the classic notion of strategic management and how different types of networks matter in time for the competitiveness of firms but also how the spatial distribution of relationships matter for firms. The latter leads also to an investigation of the nature of clusters and how they are born and developed but most importantly how differential firm performance within clusters can be explained (allowing firms to develop a competitive advantage). If we consider that the network model is relevant for the development of entrepreneurial firms, the question arises what the limits of this model are and what the consequences are for firm development. Moreover, while research stretches the positive effects of networks, the negative effects are somehow under-researched. Research is presented that sheds some light on network liabilities. Understanding networks as an organizational configuration, the perspective is extended to other organizational configurations that drive firm competitiveness: they include research on teams as sub-units and small business groups. Concluding remarks will finally link the idea of competitive advantage to entrepreneurship
Forma y razón histórica del Estado en el pensamiento de Norbert Lechner
No full textThis article examines one of the central approaches
in Norbert Lechner’s theory, who was
one of the most emblematic intellectuals in
Latin America’s studies of political subjectivity.
Based on the diagnosis of a State crisis due to its
functioning as an instrument of domination, the
author conceives it as form and historical reason.
That is, as an imaginary referent that mediates
the social relations between everyday praxis
and institutionality. For him, it is in the microphysical
spaces where the hegemonic struggle,
which must be represented by a general interest,
unfolds. Without this mediation and ethical
content, the State becomes a simple reproductive
device of capitalist relations. Therefore, we
propose that the search for a historical perspective
within the conceptualization of the State
constitutes one of the bases that support Norbert
Lechner’s theory of political subjectivity.El presente artículo revisa uno de los planteamientos
centrales en la teoría de Norbert
Lechner, quien fue uno de los intelectuales más
representativos de los estudios de subjetividad
política en América Latina. A partir del diagnóstico
de una crisis de Estado operada por
su funcionamiento como instrumento de dominación,
el autor formula una concepción
de éste como forma y razón histórica, es decir,
como un referente imaginario que medie las relaciones
sociales entre la praxis cotidiana y la
institucionalidad. Para Lechner, es en los espacios
microfísicos donde se despliega la lucha
hegemónica que debe ser representada por un
interés general. Sin esa mediación y sin contenido
ético, el Estado deviene en mero aparato
reproductor de relaciones capitalistas. Proponemos
que la búsqueda de una conceptualización
con perspectiva histórica, se constituye en una
de las bases que sustentan la teoría de la subjetividad
política de Norbert Lechner
O PENSAMENTO POLÍTICO DE NORBERT LECHNER E O PAPEL DA IDEIA DE UTOPIA DO CONSENSO COMO FUNDAMENTO DA DEMOCRACIA
No full textThis article analyzes the contributions of Norbert Lechner\u27s political thinking to the understanding of the democratic political order, its role in the constitutions of the symbolic sense of collective life and its fundament from the secularization of power by modernity. The text initially highlights the relevance of the theme of political order and its role in fixing the idea of certainty and security for collective coexistence. Then, it emphasizes the links established by the author\u27s thinking between democratic political order, pluralism and secularization of the world. Finally, it analyzes consensus as a possible utopia that fundament the democratic political order. For the realization this research, the hypothetical-deductive method and the bibliographic technique were used.O presente artigo analisa as contribuições do pensamento político de Norbert Lechner para a compreensão da ordem política democrática, seu papel nas constituições do sentido simbólico da vida coletiva e seu fundamento a partir da secularização do poder pela modernidade. O texto destaca inicialmente a relevância do tema da ordem política e seu papel na fixação da ideia de certeza e de segurança para a convivência coletiva. Em seguida, enfatiza os vínculos estabelecidos pelo pensamento do autor entre ordem política democrática, pluralismo e secularização do mundo. Por fim, analisa o consenso como uma utopia possível que fundamenta a ordem política democrática. Para a realização desta pesquisa, foram utilizados o método hipotético-dedutivo e a técnica de pesquisa bibliográfica
Author Response: Chemical Considerations Regarding the H-Value Methodology and Its Relation With Toxicity Determination
No full text
Meaningful lines : Social semiotic investigations of the graphical line, used as a connector in digital data visualizations
No full textThe paper III is not published yet.The dissertation investigates the graphical line, used as a connector in digital data visualizations (DVs), from a social semiotic perspective. It explores the semiotic functions of connecting lines in digital DVs, building empirically on two corpus analyses. These analyses are concerned with how two key semiotic functions are graphically realized in the selected lines and whether graphical conventions regulating these realizations can be identified.
In the dissertation the connecting line is researched as a central element of several different DV types – line graphs, timelines, route maps, connection maps, network diagrams, etc. Today, DVs are used in a broad range of social contexts and thus play an essential role in society. New digital technologies make it possible to apply other visual characteristics to graphical lines in DVs than was previously possible, for example, when they were hand-drawn or printed. This change may have influenced the DV design practice, a situation calling for updated research.
The dissertation is article-based, comprising three articles and an extended abstract. The extended abstract frames the three articles and includes an introduction, definitions of key terms, more comprehensive sections on the theoretical framework, earlier research and methodology, as well as ethical considerations, reflections on methodological decisions and a conclusion. The two overall research questions addressed in the dissertation are:
(1) What characterizes the graphical forms and semiotic functions of connecting lines in current, publicly available digital DVs?
(2) What conventions, regulating the relations between these forms and functions, can be observed in such DVs?publishedVersio
Business Model Innovation and the Impact of Globalization
No full textAuthor Astrid LechnerMasterarbeit Universität Linz 201
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