162,051 research outputs found
Colorectal cancer : aspects of multidisciplinary treatment, metastatic disease and sexual function
No full textMore than 6000 people in Sweden are diagnosed with colorectal cancer annually. One out of five patients already has metastases at diagnosis. However, the occurrences of metastases at specific locations, e.g. peritoneal carcinomatosis and ovarian metastases, are not well known. The development of surgical and oncological treatment strategies for primary tumours and metastatic disease has led to a need to discuss colorectal cancer patients in a multidisciplinary team (MDT). Although oncologic cure and overall survival are the main goals of treatment, quality of life and functional results are becoming increasingly important with the prolonged survival. While male sexual dysfunction after rectal cancer treatment has been well described, considerably less data have been published about the impact on women. In addition to surgical trauma, female androgen insufficiency could be a contributing factor to sexual dysfunction. Radiotherapy for rectal cancer may increase the risk of reduced ovarian androgen production, but there is scant information on this in the literature.Papers I-III are large population-based cohort studies reporting on the effects of the development and implementation of MDT-conferences in patients with metastatic disease (Paper I) and the epidemiology of peritoneal carcinomatosis and ovarian metastases in colorectal cancer patients (Papers II–III). MDT assessment and metastasis surgery were more common in rectal cancer patients than in colon cancer patients, and the proportion increased over time. Peritoneal carcinomatosis was common, and risk factors were colon cancer, advanced tumour and nodal stage, fewer than 12 examined lymph nodes, emergency surgery, and a non-radical resection of the primary tumour. Ovarian metastases were uncommon, especially in rectal cancer patients. Paper IV assesses feasibility and internal and external validity in a prospective, observational cohort study on sexual function and androgen levels in women with rectal cancer. The methods were workable and the patients’ compliance was good. Comparison of clinical data from the study cohort with that of women who were eligible for inclusion but not included revealed a selection bias. Having a partner and sexual activity was more common among women who answered all questions in the questionnaires about sexual function compared with those who did not. A power calculation based on data from the first included patients showed that a larger sample size than initially planned for was needed.In conclusion, an increasing proportion of patients with metastatic colorectal cancer were discussed by the MDT. Predictors for and the occurrence of peritoneal carcinomatosis and ovarian metastases were defined, which may help to decide on individual treatment and follow-up regimens. The analysis of baseline data from the study on sexual function and androgen levels in women with rectal cancer indicates feasible methods but a selection bias. Inclusion of new patients in the study continues.List of scientific papersI. Differences in multidisciplinary team assessment and treatment between patients with stage IV colon and rectal cancer. J. Segelman, T. Singnomklao, H. Hellborg, A. Martling. Colorectal Disease. 2009; 11: 768-74. https://doi.org/10.1111/j.1463-1318.2008.01648.x II. Incidence, prevalence and risk factors for peritoneal carcinomatosis from colorectal cancer – a population based study. J. Segelman, F. Granath, T. Holm, M. Machado, H. Mahteme, A. Martling. British Journal of Surgery. 2012. https://doi.org/10.1002/bjs.8679 III. Epidemiology and prognosis of ovarian metastases in colorectal cancer. J. Segelman, A. Flöter-Rådestad, H. Hellborg, A. Sjövall, A. Martling. British Journal of Surgery. 2010; 97: 1704-9. https://doi.org/10.1002/bjs.7196 IV. Potential selection bias in a prospective study on sexual function and androgen levels in women with rectal cancer. J. Segelman, A. Martling, M. Machado, T. Holm, K. Bergmark, A. Flöter-Rådestad. [Manuscript]</p
[Report to Chief J. E. Curry, by an unknown author #1]
No full textReport to Chief J. E. Curry, by an unknown author. The report contains a list of officers who gave depositions to the United States Attorney
[Report to Chief J. E. Curry, by an unknown author #2]
No full textReport to Chief J. E. Curry, by an unknown author. The report contains a list of officers who gave depositions to the United States Attorney
Supplemental Material - Implementation of a CMS Nursing Facility Initiative: Differences by Racial Minority Resident Population
No full textSupplemental Material for Implementation of a CMS Nursing Facility Initiative: Differences by Racial Minority Resident Population by Lawren E. Bercaw, Angela Gasdaska, Micah Segelman, Helena Voltmer, Jessica M. Jones, Zhanlian Feng, Galina Khatutsky, and Melvin J. Ingber in Journal of Applied Gerontology</p
Murder on the mountain: author talk with Peter J. Wosh
No full textAuthor talk by Peter J. Wosh on May 5th, 2022, on his book, "Murder on the Mountain: crime, passion, and punishment in gilded age New Jersey.
Mr. Melvin J. Collier, RWWL AUC, June 2011
No full textThis video is a conversation with Mr. Melvin J. Collier. Mr. Collier talks about his book, "From Mississippi to Africa: A Journey of Discovery". Daniel Le, AUC Woodruff Library, is the interviewer
A Tripartite Post-Recession Rebalancing
No full textIn this latest Advance & Rutgers Report, entitled “A Tripartite Post-Recession Rebalancing,” Dean James W. Hughes and Professor Joseph J. Seneca deliver an incisive assessment of the current market conditions and obstacles in the path of our economic recovery. They offer a statistical cautionary tale that the private and public sector need to hear and acknowledge in order for the economy to make continued progress.This report was published as Issue Paper Number 7, November 2011, in Advance & Rutgers Report
Evidence for the decay B0→J/ψω and measurement of the relative branching fractions of meson decays to J/ψη and J/ψη′
No full textFirst evidence of the B 0 → J / ψ ω decay is found and the B s 0 → J / ψ η and B s 0 → J / ψ η ′ decays are studied using a dataset corresponding to an integrated luminosity of 1.0 fb -1 collected by the LHCb experiment in proton-proton collisions at a centre-of-mass energy of sqrt(s) = 7 TeV. The branching fractions of these decays are measured relative to that of the B 0 → J / ψ ρ 0 decay:frac(B (B 0 → J / ψ ω), B (B 0 → J / ψ ρ 0)) = 0.89 ± 0.19 (stat) - 0.13 + 0.07 (syst),frac(B (B s 0 → J / ψ η), B (B 0 → J / ψ ρ 0)) = 14.0 ± 1.2 (stat) - 1.5 + 1.1 (syst) - 1.0 + 1.1 (frac(f d, f s)),frac(B (B s 0 → J / ψ η ′), B (B 0 → J / ψ ρ 0)) = 12.7 ± 1.1 (stat) - 1.3 + 0.5 (syst) - 0.9 + 1.0 (frac(f d, f s)), where the last uncertainty is due to the knowledge of f d / f s, the ratio of b-quark hadronization factors that accounts for the different production rate of B 0 and B s 0 mesons. The ratio of the branching fractions of B s 0 → J / ψ η ′ and B s 0 → J / ψ η decays is measured to befrac(B (B s 0 → J / ψ η ′), B (B s 0 → J / ψ η)) = 0.90 ± 0.09 (stat) - 0.02 + 0.06 (syst)
The vanishing author in computer-generated works: a critical analysis of recent Australian case law
No full textAbstract
The use of software is ubiquitous in the creation of many copyright works, yet the requirement in copyright law that every work have a human author who engages in independent intellectual effort means that its use may prevent copyright subsistence. Several recent Australian cases have refocused attention on authorship as an essential criterion of copyright subsistence, and these cases suggest that much computer-produced output may be authorless and thus lack copyright protection. This article, the first in a two-part series, analyses how each case deals with the question of authorship of computer-produced works and why the use of software diminishes copyright protection for a significant number of computer-generated works. The article critiques the application of conventional notions of human authorship developed in the pre-computer age to modern productions and suggests alternative approaches to authorship that satisfy both the major objectives of copyright policy and the need to adapt to the computer age. The article argues that, without a broader judicial approach to authorship of computer-generated works, Parliament must remedy the lacuna in protection for these ‘authorless’ works. Possible solutions for reform are suggested. In a forthcoming article, the author comprehensively examines those reform proposals
Appropriate Similarity Measures for Author Cocitation Analysis
No full textWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
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