169,837 research outputs found
the mystery of colour for the young Le Corbusier, chromatic memories from voyage d'orient to maison blanche
No full textIl bisogno di Le Corbusier di vincolare l’opera a principi di validità universale radicati nella cultura e nella storia, lo ha condotto a ricercare continue conferme nelle opere del passato.
Anche per questo la sua opera, pur nella sua eccezionalità, è emblematica della cultura occidentale per il lungo tratto che ne ha percorso.
Il rapporto con il colore è, in questo senso, paradigmatico.
Molta cultura occidentale ha combattuto l’inquietudine per il potere misterioso del colore, ha tentato di depotenziarne la minaccia, sminuendone il ruolo, relegando il colore al decorativo, al femminile, all’infantile o al primitivo.
Le Corbusier è stato attraversato sia dall’attrazione inebriata che dalla ripulsa quasi fobica per il colore, come le alterne e contraddittorie affermazioni in proposito dimostrano, cercando di risolvere questo dissidio elaborando quel complesso strumento di controllo che sono i Claviers de couleurs.
Si è cercato di ripercorrere alcuni momenti di questo intenso rapporto esaminando la casa in cui il giovane Jeanneret applica le memorie dei cromatismi descritti nei carnets del viaggio in Oriente, la Maison Blanche,
e poi la casa considerata “soglia” verso l’applicazione dei principi della nuova architettura, è la Maison La Roche. In entrambe l’esterno bianco racchiude elaborati esercizi di policromia architettonica
PG dei bitumi stradali per il territorio italiano
No full textL’ARTICOLO SINTETIZZA IL LAVORO DI RICERCA SVOLTO DALL’UNIVERSITÀ DI PALERMO PER DEFINIRE - SU BASE TERRITORIALE NAZIONALE -
LE TEMPERATURE CARATTERISTICHE DETERMINANTI PER LA QUALIFICAZIONE DEI BITUMI, CONFORMEMENTE ALLE SPECIFICHE SUPERPAVE. NE SONO DERIVATE CARTE TEMATICHE DELLE TEMPERATURE MASSIME E MINIME
DI PROGETTO DELLE PAVIMENTAZIONI STRADALI CHE I TECNICI POTRANNO UTILIZZARE PER LA SELEZIONE DEI LEGANTI BITUMINOSI
Explorando el uso de herramientas de sensores remotos y tecnologías geoespaciales aplicadas al problema multidimensional de la seguridad alimentaria
No full textEl objetivo de este estudio fue analizar qué papel pueden jugar las tecnologías de teledetección para estudiar los factores multidimensionales que influyen en la seguridad alimentaria y nutricional (SAN), en Córdoba Argentina. [Metodología] El área de estudio comprende la ciudad de Córdoba, Argentina. Se obtuvieron datos epidemiológicos de la prevalencia de bajo peso, sobrepeso y obesidad (malnutrición) durante el 2013 de 23 centros de atención primaria de la ciudad. Se exploraron las condiciones ambientales de los centros en un radio de 1000 m. Se clasificaron imágenes SPOT 5, se utilizaron características espectrales y espaciales y se evidencia cómo una clasificación no supervisada puede dar información para describir la dimensión social y el acceso económico a los alimentos. Se realizó una regresión lineal multivariante para examinar la relación entre la prevalencia de malnutrición y las variables ambientales y espaciales, derivadas de las imágenes SPOT. [Resultados] Los resultados de la clasificación no supervisada de imágenes muestran la diferencia en el patrón espectral-espacial de los barrios, evidencian cómo una simple clasificación de imágenes de satélite puede convertirse en una herramienta de discriminación útil. Se obtienen análisis de regresión múltiple con R2 ajustados de 0,70 y 0,6435 respectivamente para desnutrición, y sobrepeso y obesidad. A partir de los modelos obtenidos, se construyen mapas continuos de prevalencia. [Conclusiones] El método propuesto en este trabajo puede discriminar socialmente diferentes áreas relacionadas con la SAN. Es innovador y necesario aprovechar las herramientas de teledetección y las tecnologías geoespaciales, en nuestra región, aplicadas a la SAN.Di Fino, E., Scavuzzo, C., Campero, M., Scavuzzo, C., & Defagó, M. (2022). Exploring the use of remote sensing tools and geospatial technologies applied to the multidimensional food security problem. Uniciencia, 36(1), 1-15. https://doi.org/10.15359/ru.36-1.4
SPANX-B and SPANX-C (Xq27 region) gene dosage analysis in Down's syndrome subjects with undescended testes
No full textDown’s syndrome (DS) is one of the most common numer-
ical chromosomal aberrations, usually caused by trisomy of
chromosome 21, and is frequently complicated with congen-
ital heart defects, duodenal obs
truction and other conditions
including undescended testis (UDT) (Fonkalsrud 1970). The
incidence of undescended testes in DS was reported to be
6.52% (Chew and Hutson 2004) while the incidence of UDT
in the first year is approximately 0.2%–0.8% in the nor-
mal population (Benson
et al
. 1991; Ichiyanagi
et al
. 1998).
Rapley
et al
. (2000) provided evidence for a testicular germ-
cell tumours (TGCT) predisposition locus at Xq27; the au-
thors obtained an hlod score of 4.7 from families with at least
one bilateral case, corresponding to a genome-wide signifi-
cance level of
P
=
0
.
034. The proportion of families with
undescended testis linked to this locus was 74%.
SPANX
(sperm protein associated with the nucleus in the X chro-
mosome) gene family maps in the same chromosomal region
and seven highly homologous genes belonging to this fam-
ily have been described (
SPANX-A1, SPANX-A2, SPANX-B1,
SPANX-B2, SPANX-C, SPANX-D
and
SPANX-E
) according
to the human genome database build 36.2. These genes,
made up of two exons separated by a small intron of
≈
650
bp, are expressed in sperm cells (Westbrook
et al
. 2000) and
in many tumours (Wang
et al
. 2003; Zendman
et al
. 2003;
Westbrook
et al
. 2004). Moreover, expression of
SPANX genes has been demonstrated in TGCT (Salemi
et al
. 2006).
The function of
SPANX
gene-encoded proteins is currently
unknown, and it is also not known if all the members or
some of them are normally expressed in the testis (West-
brook
et al
. 2000). Evidence suggests that
CTp11
,which
is 100% homologous to
SPANX-C
, is expressed in tumours
such as melanoma (Zendman
et al
. 2003), and
SPANX-B
in
myeloma and other haematological malignancies (Wang
et
al
. 2003; Zendman
et al
. 2003).
SPANX-C
mRNA was found
expressed in normal tissues and in embryonal carcinomas of
the testis (Salemi
et al
. 2006). Further, it is very di
ffi
cult to
design primers adequate for gene-specific PCR amplification
within the SPANX locus. For this reason, we decided to fo-
cus our study on
SPANX-C
and
SPANX-B
genes. The aim of
this study is to evaluate the genetic variability of
SPANX-B
and
SPANX-C
in D.UDT (Down’s syndrom patients a
ff
ected
by undescended testis) compared with D (Down’s syndrom
patients without undescended testis) and Nm (normal popu-
lation)
Going Beyond Counting First Authors in Author Co-citation Analysis
No full textThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Abitare in fabbrica. riconversione al domestico di edifici industriali
No full textIl riuso di manufatti esistenti comporta un processo trasformativo che interessa particolarmente gli spazi interni. La fabbrica dismessa possiede caratteri tipologici, costruttivi, spaziali, evidenti ed evocativi - grandi silenziosi spazi vuoti ritmati dall’isotropia delle campate strutturali – e caratteri dormienti che nuovi valori iconici, forme e figure del progetto di riuso devono innescare e rendere “udibili”.
Tra i caratteri di una fabbrica, luogo di lavoro e di produzione, c’è quello di corrispondere al principio di necessità. Le forme di domesticità contemporanee tornano al tema della necessità, per la contingenza economica, per la coscienza critica nei confronti del consumismo, per corrispondere ai nuovi modi di intersecare lavoro e vita domestica. Lo spazio industriale vuoto, continuo, neutro, sembra disponibile a ospitare questa nuova domesticità quasi più di strutture dai caratteri distributivi pre-definiti da un’organizzazione domestica superata.
L’appropriazione di uno spazio industriale dismesso per sperimentare nuovi modelli abitativi ha vari precedenti, dalle case atelier dei primi del ‘900, alle sperimentazioni delle comuni, ai loft.
Rimane un’altra necessità, costruire, sulle macerie della “stanza tutta per sé” convenzionale, un interno che sia luogo di definizione dell’identità di chi lo abita, necessità tanto più forte quanto più labile è il contesto in cui questa identità si colloca
Mitomycin C in highly myopic eyes - Author reply
No full textOphthalmology. 2005 Feb;112(2):208-18; discussion 219.
Mitomycin C modulation of corneal wound healing after photorefractive keratectomy in highly myopic eyes.
Gambato C, Ghirlando A, Moretto E, Busato F, Midena E.
SourceRefractive Surgery Service and Antimetabolite Therapy Research Unit, Department of Ophthalmology, University of Padova, Padova, Italy.
Abstract
PURPOSE: To evaluate the role of topical mitomycin C in corneal wound healing (CWH) after photorefractive keratectomy (PRK) in highly myopic eyes.
DESIGN: Prospective, double-masked, randomized clinical trial.
PARTICIPANTS: Seventy-two eyes of 36 patients affected by high (>7 diopters) myopia.
METHODS: In each patient, one eye was randomly assigned to PRK with intraoperative topical 0.02% mitomycin C application, and the fellow eye was treated with a placebo. Postoperatively, mitomycin C-treated eyes received artificial tears (3 times daily, tapered in 3 months), whereas the fellow eye was treated with fluorometholone sodium 2% and artificial tears (3 times daily, tapered in 3 months).
MAIN OUTCOME MEASURES: Uncorrected visual acuity (UCVA) and best-corrected visual acuity (BCVA), contrast sensitivity, manifest refraction, and biomicroscopy. Contrast sensitivity was determined using the Pelli-Robson chart. Corneal confocal microscopy documented CWH.
RESULTS: Mean follow-up was 18 months (range, 12-36). No side effects or toxic effects were documented. At 12-month follow-up examination, UCVAs (logarithm of the minimum angle of resolution) were 0.4+/-0.48 and 0.5+/-0.53 (P = .03) in mitomycin C-treated eyes and corticosteroid-treated eyes, respectively. At 1 year, corneal haze developed in 20% of corticosteroid-treated eyes, versus 0% of mitomycin C-treated eyes. At 12, 24, and 36 months, corneal confocal microscopy showed activated keratocytes and extracellular matrix significantly more evident in untreated eyes (Ps = 0.004, 0.024, and 0.046, respectively).
CONCLUSION: Topical intraoperative application of 0.02% mitomycin C can reduce haze formation in highly myopic eyes undergoing PRK.
Comment in
Ophthalmology. 2006 Feb;113(2):357; author reply 357-8
Deep into the niche: Deciphering local endoderm-microenvironment interactions in development, homeostasis, and disease of pancreas and intestine
No full textThis is the Accepted Version of the following article: Szlachcic, W. J., Letai, K. C., Scavuzzo, M. A., & Borowiak, M. (2023). Deep into the niche: Deciphering local endoderm-microenvironment interactions in development, homeostasis, and disease of pancreas and intestine. BioEssays, 45, e2200186, which has been published at https://doi.org/10.1002/bies.202200186. This article may be used for non-commercial purposes in accordance with the Wiley Self-Archiving Policy [http://www.wileyauthors.com/self-archiving].
The read-only version of Final Published Version can be accessed here: https://onlinelibrary.wiley.com/share/author/3J48826BWNJ6KJPECKIR?target=10.1002/bies.202200186Unraveling molecular and functional heterogeneity of niche cells within the developing endoderm could resolve mechanisms of tissue formation and maturation. Here, we discuss current unknowns in molecular mechanisms underlying key developmental events in pancreatic islet and intestinal epithelial formation. Recent breakthroughs in single-cell and spatial transcriptomics, paralleled with functional studies in vitro, reveal that specialized mesenchymal subtypes drive the formation and maturation of pancreatic endocrine cells and islets via local interactions with epithelium, neurons and microvessels. Analogous to this, distinct intestinal niche cells regulate both epithelial development and homeostasis throughout life. We propose how this knowledge can be used to progress research in the human context using pluripotent stem cell-derived multilineage organoids. Overall, understanding the interactions between the multitude of microenvironmental cells and how they drive tissue development and function could help us make more therapeutically relevant in vitro models.Narodowe Centrum Nauki (OPUS UMO-2019/33/B/NZ3/01226, OPUS UMO-2020/37/B/NZ3/01917, OPUS UMO-2020/39/B/NZ3/01408 dla M.B., SONATA UMO-2021/43/D/NZ3/02294 dla W.J.Sz.), Fundacja na Rzecz Nauki Polskiej - Program TEAM (POIR.04.04.00-00-20C5/16-00) dla M.B., HHMI Hana Gray Fellowship i NYSCF Druckenmiller Fellowship dla M.A.S
Dispelling the Myths Behind First-author Citation Counts
No full textWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
A Multi-Language Comparison of Influences on Author Verification using Character N-Grams
No full textWe create a new multi-language corpus for author verification based on Wikipedia talkpages, and evaluate the influence that differences in topic and time have on character n-gram author profiles. Topic alignment between two texts is found to increase author verification precision, and an authors writing style is found to change over time, but not more significantly after 3 years than after 1 year.Information ArchitectureWISElectrical Engineering, Mathematics and Computer Scienc
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