30,341 research outputs found

    Maria Bersani

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    La voce illustra la biografia e l'apporto letterario dato da Maria Bersani alla letteratura per l'infanziaThe headword explains the biography and the contribution of the author Maria Bersani to the children's literatur

    Gli scali ferroviari di Milano_oggi, prima di domani

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    documentazione dello stato degli scali ferroviari di milano dopo la dismissione degli anni 80 e la trasformazione delle aree limitrof

    Il recupero degli scali ferroviari a Milano. Un’opportunità per ripensare il ruolo del progetto urbano

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    Gli scali ferroviari dismessi costituiscono un’opportunità per ripensare intere parti di città. I modi del loro recupero rappresentano tuttavia un complesso banco di prova per le pubbliche amministrazioni: non solo per l’efficacia degli strumenti di governo necessari per la fattibilità delle operazioni ma anche per l’effettiva capacità di garantire la qualità dei progetti e degli spazi abitabili che generano. Alcune direzioni di lavoro appaiono rilevanti a tal proposito: evitare approcci progettuali introversi e quantitativi; considerare il progetto entro una visione strategica urbana e come opportunità per trattare bisogni locali; intendere il riuso come avvio di processi di trasformazione estesi, assumendo lo sviluppo incrementale come tema di progetto; rafforzare il ruolo della regia pubblica per bilanciare la valorizzazione economica delle aree con valutazioni qualitative utili a indirizzare lo sviluppo dei progetti. Percorrere tali direzioni di lavoro significa ripensare alla natura del progetto urbano e al suo ruolo entro il processo decisionale. Le vicende legate alla dismissione degli scali ferroviari milanesi rappresentano uno sfondo rispetto al quale osservare le questioni sopra accennate

    Co-localization of ribosomal and telomeric sequences in Leptynia (Insecta: Phasmatodea)

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    Stick insects have been studied mainly for non-conventional reproduction modes, such as parthenogenesis, hybridogenesis and androgenesis. Parallel karyological investigations have evidenced extensive numerical and structural chromosome re-patterning, particularly evident in hybrid parthenogenetic taxa. Chromosome sets of bisexual Leptynia (Pantel) species show an evolutionary trend from 40 to 36 chromosomes and are characterized by cytological atellites of variable size and localization. We performed fluorescence in situ hybridization (FISH) analysis using 45S ribosomal genes and pentameric (TTAGG)n telomere sequences as probes in two strictly related but karyotypically distinct species, L. montana Scali (2n = 38/37; XX/XO) and L. attenuata Pantel (2n = 36). L. attenuata has recently been split into three subspecies (L. attenuata attenuata, L. attenuata iberica and L. attenuata algarvica), and found to share an XX/XY sex chromosome formula, unusual for stick insects. FISH by 45S rDNA sequences consistently labelled the short arm of the 4th chromosome pair, often of a variable size. Silver staining showed that nucleolar organizer regions (NORs) are active. FISH of the telomeric repeats, besides ordinary telomeres, also labelled the short arm of this same pair. The use of both probes in double FISH analysis fully confirmed the co-localization of ribosomal and telomeric highly repeated sequences. Since it is increasingly emerging that the co-localization of NORs and telomeric sequences appears to be a feature shared by evolutionarily distant animals, its possible role is discussed

    Controversies in fractional flow reserve

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    Fractional flow reserve (FFR) has been identified as the optimal diagnostic tool to identify significant coronary lesion. However, current evidence does not support this role. The optimal diagnostic strategy should give highly sensitive and specific results with lowest cost and accomplishing this task has been made more difficult in the era following the COURAGE trial

    Variations on the Author

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    “Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship

    Introduction: Building an International Community of Research in Career Guidance and Counseling

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    The ECADOC program has brought together doctoral students working on topical issues in the field of CGC, using various theoretical references and meth- odologies. The aim of the current volume is to disseminate this research to stu- dents and researchers all over the word, as well as informing practitioners about this very current work to support them in developing innovative interventions. To prepare this compilation, a call for contributing authors was addressed to the teams of researchers (doctoral students, researchers, and academics) who have participated in one of the ECADOC summer schools. The objectives of the volume are: – to present the current questions and preoccupations of young researchers all around the world in the field of CGC; – to gradually develop a community of researchers who publish together; – to offer the opportunity to doctoral students and collaborators to present their research to a larger audience than that reached by scientific articles; and – to provide a concrete product that will persist beyond the end of ECADOC program. ECADOC researchers (doctoral students, scientists, and academics) were asked to make chapter proposals alone or as a team. Proposals could be related to doctoral research or to another study in which they participated, with or without the involve- ment of a doctoral supervisor. The editors of this book received many proposals leading to an initial selection based on a set of criteria, including the scientific qual- ity of the proposal and its empirical foundation. The selection was then refined to underline the diversity of student profiles and of the territories in which the research was conducted. We also wanted to show the diversity of the research topics, of the theoretical frameworks, and of the methods used by the doctoral students. At that point, each selected proposal was peer-reviewed by two experts in the field of career counseling and guidance, most of whom were involved in the ECADOC pro- gram. The final decision was made by the editors based on these reviews. The edi- tors of this book also asked some senior researchers to write a chapter to share their perception of the evolution of research in the field and to provide some direction for the future. Jean Guichard, as director of the UNESCO Chair on Life Long Guidance and Counseling and professor at Cnam-Inetop proposed one chapter, and Lea Ferrari, Teresa Maria Sgaramella, and Salvatore Soresi, as professors at the University of Padova and organization head of the ECADOC program proposed another. The seven members of the Scientific Committee worked together to contri- bute to the final chapter, which proposes a European Research Agenda for the future of career counseling and research. These three additional chapters were also thoroughly reviewed. As an ensemble, the book provides a broad overview of the research interests, theoretical frameworks, methodologies, and career counseling devices that are useful in analyzing the variety of career counseling and guidance situations for individuals living in different parts of the world

    Il diritto penale dell ‘ immigrazione

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    Il presente lavoro costituisce una riflessione sul rapporto fra la condizione dello straniero e il sistema penale, attraverso l’analisi delle norme di maggiore impatto sulla sua libertà personale: ovvero le disposizioni del decreto legislativo n. 286 del 1998 (il c.d. Testo unico sull'immigrazione) concernenti le espulsioni e quelle propriamente incriminatrici. Obiettivo di fondo del legislatore è stato -allora come oggi - quello di privilegiare l’istanza di sicurezza proveniente dalla collettività rispetto ad altre istanze di tutela giuridico-penale, quali la condizione dello straniero. Alle riforme legislative si sono aggiunti i numerosi interventi - demolitori o correttivi - effettuati dalla Corte costituzionale, che hanno colpito la normativa in molti suoi aspetti anche essenziali. La condizione di estraneità, intesa come difetto della cittadinanza dello Stato di riferimento, ha costituito da sempre la giustificazione di previsioni normative specifiche, di trattamenti giuridici particolari, di soluzioni politiche difformi rispetto a quanto stabilito per i possessori dello status di cittadino, in ragione dell'assenza di diritti e di doveri- in sintesi, di legami istituzionali giuridicamente rilevanti (soprattutto in senso tutorio) - fra l’individuo (straniero) e lo Stat

    The potential value of integrated natriuretic peptide and echo-guided heart failure management

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    There is increasing interest in guiding Heart Failure (HF) therapy with Brain Natriuretic Peptide (BNP) or N-terminal prohormone of Brain Natriuretic Peptide (NT-proBNP), with the goal of lowering concentrations of these markers (and maintaining their suppression) as part of the therapeutic approach in HF. However, recent European Society of Cardiology (ESC) and American Heart Association/American College of Cardiology (AHA/ACC) guidelines did not recommend biomarker-guided therapy in the management of HF patients. This has likely to do with the conceptual, methodological, and practical limitations of the Natriuretic Peptides (NP)-based approach, including biological variability, slow time-course, poor specificity, cost and venipuncture, as well as to the lack of conclusive scientific evidence after 15 years of intensive scientific work and industry investment in the field. An increase in NP can be associated with accumulation of extra-vascular lung water, which is a sign of impending acute heart failure. If this is the case, an higher dose of loop diuretics will improve symptoms. However, if no lung congestion is present, diuretics will show no benefit and even harm. It is only a combined clinical, bio-humoral (for instance with evaluation of renal function) and echocardiographic assessment which may unmask the pathophysiological (and possibly therapeutic) heterogeneity underlying the same clinical and NP picture. Increase in B-lines will trigger increase of loop diuretics (or dialysis); the marked increase in mitral insufficiency (at baseline or during exercise) will lead to increase in vasodilators and to consider mitral valve repair; the presence of substantial inotropic reserve during stress will give a substantially higher chance of benefit to beta-blocker or Cardiac Resynchronization Therapy (CRT). To each patient its own therapy, not with a "blind date" with symptoms and NP and carpet bombing with drugs, but with an open-eye targeted approach on the mechanism predominant in that individual patient. A monocular, specialistic, unidimensional approach to HF can miss its pathogenetic and clinical complexity, which only can be overcome with an integrated, versatile and tailored approach
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