361 research outputs found
Probing the Gate-Voltage-Dependent Surface Potential of Individual InAs Nanowires Using Random Telegraph Signals RID C-6303-2008
No full textWe report a novel methocl for probing the gate-voltage dependence of the surface potential of individual semiconductor nanowires. The statistics of electronic occupation of a single defect on the surface of the nanowire, determined from a random telegraph signal, is used as a. measure for the local potential. The method, is demonstrated for the case of one or two switching defects in indium arsenide (InAs) nanowire field effect transistors at temperatures T = 25-77 K. Comparison with a self consistent model shows that surface potential variation is retarded In the conducting regime due to screening by surface states with density D(ss) approximate to 10(12) cm(-2) ev(-1). Temperature-dependent dynamics of, electron capture and emission producing the random telegraph signals are also analyzed, and multiphonon emission is identified as the process responsible for capture and emission of electrons from the surface traps. Two defects studied in detail had capture activation energies of E(B) approximate to 50 meV and E(B) approximate to 110 meV and cross sections of sigma(infinity) approximate to 3 x 10(-19) cm(2) and sigma(infinity) approximate to 2 x 10(-17) cm(2), respectively. A lattice relaxation energy of s (h) over bar omega = 187 +/- 15 meV was found for the first defect
A Method to predict the Wave Resistance of Planing Hulls, from a moving Hull Pressure Distribution
No full textA method for estimating the wave resistance in planing and semi-planing hulls will be presented. This prediction method calculates the wave resistance from a distribution of surfaces pressures acting over the free water surface and uses the calculation methods, currently applied for the ACV (air-cushion vehicle). Starting from an original paper by G.E. Gadd [1], in which the Author calculated the far field wave pattern for fast boats, the wave resistance is calculated for high speed vehicles by assuming an appropriate hull pressure distribution; then a practical application is presented
Igor Germanovich Levichev (in connection with the 70th anniversary)
No full textOctober 6, 2015 Igor Germanovich Levichev, Ph. D., Senior Researcher of the Herbarium of the Komarov Botanical Institute of Russian Academy of Sciences, celebrated his 70th birthday. He is widely known monograph of the large genus Gagea and its related genera as well as the author of the original hypothesis in the evolution of morphological structures of monocots. His scientific career began with expeditions to Chukotka, Kamchatka, in the Trans-Baikal region, Kyzylkum (Uzbekistan), Badkhyz Nature Reserve (Turkmenistan, 1972). Since the autumn of 1972, I. G. Levichev worked in Chatkal nature reserve (Uzbekistan), where he created the basis for the monitoring of vegetation changes in two key areas of relatively little changed Uzbek part of the Western Tien Shan. He worked on the creation of “The Red Book of Uzbek SSR” (1984), “Guide to the Plants of Central Asia. Critical synopsis of Flora “(1987). In 1996 he defended his thesis on the topic “Genus Gagea Salisb. of Western Tien Shan “. In collaboration with colleges from German, Italian and other countries I. G. Levichev published a number of interesting results of molecular phylogenetic studies of the genus Gagea (and its related genera). He also described a new genus – Kharkevichia Levichev of Lloydia – Gagea relationship (the family Liliaceae.). Igor Germanovich is the author of over 120 scientific (scientific and popular) works, 53 of them are in fact of Gagea species.</p
Features of neuro-endocrine and immune reactions to various water-salt loads in female rats
No full textGozhenko Olena A, Zavidnyuk Yuriy V, Korda Mykhaylo M, Mysula Igor R, Klishch Ivan M, Zukow Walery, Popovych Igor L. FEATURES OF NEURO-ENDOCRINE AND IMMUNE REACTIONS TO VARIOUS WATER-SALT LOADS IN FEMALE RATS. Journal of Education, Health and Sport. 2018;8(9):11-31. eISSN 2391-8306. DOI http://dx.doi.org/10.5281/zenodo.1323491
http://ojs.ukw.edu.pl/index.php/johs/article/view/5729
https://pbn.nauka.gov.pl/sedno-webapp/works/872545
The journal has had 7 points in Ministry of Science and Higher Education parametric evaluation. Part b item 1223 (26/01/2017).
1223 Journal of Education, Health and Sport eissn 2391-8306 7
© The Author(s) 2018;
This article is published with open access at Licensee Open Journal Systems of Kazimierz Wielki University in Bydgoszcz, Poland
Open Access. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author (s) and source are credited. This is an open access article licensed under the terms of the Creative Commons Attribution Non commercial license Share alike.
(http://creativecommons.org/licenses/by-nc-sa/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited.
The authors declare that there is no conflict of interests regarding the publication of this paper.
Received: 20.06.2018. Revised: 28.06.2018. Accepted: 30.07.2018.
FEATURES OF NEURO-ENDOCRINE AND IMMUNE REACTIONS TO VARIOUS WATER-SALT LOADS IN FEMALE RATS
Olena A Gozhenko1, Yuriy V Zavidnyuk1,2, Mykhaylo M Korda2, Igor R Mysula2,
Ivan M Klishch2, Walery Zukow3, Igor L Popovych4
1Ukrainian Scientific Research Institute of Transport Medicine, Odesa, Ukraine, [email protected]
2IY Horbachevs’kyi State Medical University, Ternopil’, Ukraine, [email protected]
3Nicolaus Copernicus University, Torun, Poland, [email protected]
4OO Bohomolets’ Institute of Physiology, Kyiv, Ukraine, [email protected]
Abstract
Background. Previously, we have shown that the weekly load of rats with water-salt solutions of different chemical compositions causes both general and specific reactions of the parameters of metabolism. The purpose of this study is to identify under these conditions specific neuroendocrine and immune responses. Materials and methods. Experiment was performed on 58 healthy female Wistar rats 240-290 g divided into 6 groups. Animals of the first group remained intact, using tap water from drinking ad libitum. Instead, the other rats received the same tap water as well as waters Sophiya, Naftussya, Gertsa and its artificial salt analogue through the probe at a dose of 1,5 mL/100 g of body mass for 6 days. The day after the completion of the drinking course in all rats some neuroendocrine and immune parameters were registered. Results. The method of discriminant analysis revealed 29 parameters of the neuroendocrine-immune complex (10 of them reflect the neuroendocrine regulation, 4 thymus mass and thymocytogram elements, 5 elements of splenocytogram, 10 elements of immunocytogram and leukocytogram of blood and parameters of phagocytosis), according to which the reaction on various water-salt loads are identified with an accuracy of 98.3%. Conclusion. The peculiarities of the reactions of the parameters of the neuroendocrine-immune complex are due to the content of water in sulfate, bicarbonate and magnesium, as well as organic carbon and nitrogen.
Key words. Water-salt loads, neuroendocrine and immune parameters, female rats.Gozhenko Olena A, Zavidnyuk Yuriy V, Korda Mykhaylo M, Mysula Igor R, Klishch Ivan M, Zukow Walery, Popovych Igor L. FEATURES OF NEURO-ENDOCRINE AND IMMUNE REACTIONS TO VARIOUS WATER-SALT LOADS IN FEMALE RATS. Journal of Education, Health and Sport. 2018;8(9):11-31. eISSN 2391-8306. DOI http://dx.doi.org/10.5281/zenodo.1323491
http://ojs.ukw.edu.pl/index.php/johs/article/view/5729
https://pbn.nauka.gov.pl/sedno-webapp/works/87254
Role of organic carbon and nitrogen of mineral waters in their immunomodulating effects at female rats
No full textPopovych Igor, Mysula Igor, Popovych Andriy, Mysula Yuriy, Sydliaruk Nataliya, Bilas Volodymyra, Zukow Walery. Role of organic carbon and nitrogen of mineral waters in their immunomodulating effects at female rats. Journal of Education, Health and Sport. 2021;11(9):886-894. eISSN 2391-8306. DOI http://dx.doi.org/10.12775/JEHS.2021.11.09.104
https://apcz.umk.pl/czasopisma/index.php/JEHS/article/view/JEHS.2021.11.09.104
https://zenodo.org/record/5856299
The journal has had 5 points in Ministry of Science and Higher Education parametric evaluation. § 8. 2) and § 12. 1. 2) 22.02.2019.
© The Authors 2021;
This article is published with open access at Licensee Open Journal Systems of Nicolaus Copernicus University in Torun, PolandOpen Access. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium,provided the original author (s) and source are credited. This is an open access article licensed under the terms of the Creative Commons Attribution Non commercial license Share alike.(http://creativecommons.org/licenses/by-nc-sa/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited.The authors declare that there is no conflict of interests regarding the publication of this paper.
Received: 10.09.2021. Revised: 20.09.2021. Accepted: 30.09.2021.
ROLE OF ORGANIC CARBON AND NITROGEN OF MINERAL WATERS IN THEIR IMMUNOMODULATING EFFECTS AT FEMALE RATS
Igor Popovych1, Igor Mysula2, Andriy Popovych1, Yuriy Mysula2, Nataliya Sydliaruk2, Volodymyra Bilas1, Walery Zukow3*
1OO Bohomolets’ Institute of Physiology, Kyїv, Ukraine
2IY Horbachevs’kyi National Medical University, Ternopil’, Ukraine
3Nicolaus Copernicus University, Torun, Poland
*[email protected]
Abstract
Background. Drinking mineral water is one of the ethnopharmacologic factors. Organic substances, despite their presence in all drinking mineral waters, are still considered to be active only in the water of Naftussya type (which, due to mineralization less than 1 g/L, are not formally mineral), whereas the physiological activity of true mineral waters (which mineralization is greater than 1-2 g/L) are associated with electrolytes and trace elements. Previously, we identified the role of organic carbon and nitrogen of mineral waters in their effects on certain metabolic and neuro-endocrine parameters. The purpose of this study is to clarify the role of organic substances of same mineral waters in their effects on immunity parameters. Material and methods. Experiment was performed on 48 healthy female Wistar rats 240-290 g divided into 5 groups. Animals of the first group for 6 days administered a single tap water through the tube at a dose of 1,5 mL/100 g of body mass. In the second group we administered the water Naftussya from the Truskavets’ layer (Galychyna, Ukraine), in the third group the water Sophiya of the Truskavets’ field. The rats of the fourth group received the native water from the Hertsa (Bucovyna, Ukraine) field, and the last group received its artificial salt analogue. The day after the completion of the drinking course in all rats immunne parameters were registered. Results. On the basis of the correlation analysis with step-by-step exclusion, 9 immune parameters (Endotheliocytes of Thymus, Spleen Mass Index, Entropy of Splenocytogram, Natural Killers, B- and 0-Lymphocytes, Rod-shaped Neutrophils, Phagocytic Index and Microbian Count of Monocytes of Blood) are included in the regressive model for organic nitrogen (R=0,818) and 6 parameters (Endotheliocytes of Thymus, Fibroblastes and Reticulocytes of Spleen, Pan-Lymphocytes, Microbian Count of Neutrophils and Phagocytic Index of Monocytes of Blood) for organic carbon (R=0,690). Together, the organic components of the chemical composition of loading fluids determine their effect on the immune parameters by 77%. Conclusion. Organic substances of mineral waters play an essential role in their effects on the immune parameters of female rats.
Key words: Mineral waters, organic carbon and nitrogen, female rats, immunity
Public spending and outcomes : does governance matter?
No full textThe authors examine the role of governance-measured by level of corruption and quality of bureaucracy-and ask how it affects the relationship between public spending and outcomes. Their main innovation is to see if differences in efficacy of public spending can be explained by quality of governance. The authors find that public health spending lowers child and infantmortality rates in countries with good governance. The results also indicate that as countries improve their governance, public spending on primary education becomes effective in increasing primary education attainment. These findings have important implications for enhancing the development effectiveness of public spending. The lessons are particularly relevant for developing countries, where public spending on education and health is relatively low, and the state of governance is often poor.Health Systems Development&Reform,Public Health Promotion,Public Sector Economics&Finance,Decentralization,Health Monitoring&Evaluation,Health Economics&Finance,National Governance,Governance Indicators,Health Monitoring&Evaluation,Public Sector Economics&Finance
The impact of new digital tools on journalistic routines: a case study of Instagram at Val 202
No full textMagistrska naloga raziskuje, kako so se s pojavom internetnih družbenih omrežij in njihovim vključevanjem v novinarsko delo spremenile rutine v novinarskih uredništvih. Osredotoča se na primer Instagrama na II. programu Radia Slovenija – Valu 202. Avtor skozi epistemološki pogled proučuje novinarske rutine, za kar mu kot podlaga služi model tipizacije Gaye Tuchman. Skozi novejše študije proučuje razmerje novinarskih rutin in internetnih družbenih omrežij. Študije primera se loteva skozi opazovanje z udeležbo ter s poglobljenimi intervjuji in tako prepoznava spremembe novinarskih rutin v Dnevno-aktualnem uredništvu Vala 202 v povezavi z internetnimi družbenimi omrežji. Ob tem raziskava ponuja dognanja, da tipizacija na primeru Vala 202 v večji meri sloni na nerutinskih modelih, obenem pa sama organiziranost dela vseeno kaže znake rutinskih vzorcev. Medtem Instagram kot internetno družbeno omrežje ne zavzema posebnega mesta ter ni ključen dejavnik sprememb novinarskih rutin. Magistrsko delo ugotavlja, da internetna družbena omrežja niso postala dejavnik, ki prinaša jasen in enoznačen vpliv na uveljavljene novinarske rutine, temveč gre za vzajemen odnos, pri čemer si v uredništvu težko predstavljajo novinarski delovni proces brez njih.This master\u27s thesis explores how the emergence of social media and their integration into journalistic work has changed the routines in newsrooms. It focuses on the example of Instagram at the II. programme of Radia Slovenia – Val 202. The author examines journalistic routines through an epistemological perspective, using Gaye Tuchman\u27s typification model as a basic foundation. Through recent studies, the relationship between journalistic routines and social media is investigated. The case study is conducted through participant observation and in-depth interviews, identifying changes in journalistic routines in the newsroom of Val 202 in relation to social media. The research suggests that typification, in the case of Val 202, relies more on non-routine models, while the organization of work still exhibits signs of routine patterns. Meanwhile, Instagram as a social media does not hold a special place and is not a key factor in changing journalistic routines. The master\u27s thesis concludes that social media have not become a factor that brings a clear and unambiguous impact on established journalistic routines, but rather represents a mutual relationship, and it\u27s challenging to envision the journalistic workflow in the editorial office without them
Genetic association study of QT interval highlights role for calcium signaling pathways in myocardial repolarization.
No full textThe QT interval, an electrocardiographic measure reflecting myocardial repolarization, is a heritable trait. QT prolongation is a risk factor for ventricular arrhythmias and sudden cardiac death (SCD) and could indicate the presence of the potentially lethal mendelian long-QT syndrome (LQTS). Using a genome-wide association and replication study in up to 100,000 individuals, we identified 35 common variant loci associated with QT interval that collectively explain ∼8-10% of QT-interval variation and highlight the importance of calcium regulation in myocardial repolarization. Rare variant analysis of 6 new QT interval-associated loci in 298 unrelated probands with LQTS identified coding variants not found in controls but of uncertain causality and therefore requiring validation. Several newly identified loci encode proteins that physically interact with other recognized repolarization proteins. Our integration of common variant association, expression and orthogonal protein-protein interaction screens provides new insights into cardiac electrophysiology and identifies new candidate genes for ventricular arrhythmias, LQTS and SCD
Crowd versus Experts Forecasting Technologies: Impact of Collective Diversity & Size on Collective Performance
No full textFor centuries, Homo sapiens have been trying to predict the future through supernatural or scientific methods. Since prehistory, this quality has been essential to humans (e.g., anticipate prey, then ambush it). Even in today’s society, predicting the future remains essential in many industries and research domains. Although, we are still far from producing flawless forecasts (e.g., weather) because future events are uncertain. When decisions contain uncertainty, governments, organizations, and individuals alike tend to be interested in the advice of others.One such case that was interesting is when predicting the outcome of a standard battle. Within such a battle, high-tech firms compete to obtain most customers in a given market through their technological inventions. To predict which technology will be the standard on the market, experts are independently interviewed to determine the importance of factors (e.g., weights) that can influence this battle. Were the second round of expert interviews need to assign a value for each of these factors for every competing technology—resulting in a performance grade used to make the prediction. This prediction indicates which firm/technology will likely have the upper hand in the market. The factors originate from the list of factors in combination with the Best-Worst Method (BWM), which allows evaluating the multiple-criteria decision-making (MCDM) problem (Rezaei, 2015a; v.d. Kaa, G., v.d. Ende, J., de Vries, H.J., van Heck, 2011).Multiple studies expressed concerns that it is challenging to persuade and find experts willing to participate in the interview. Instead of finding a better way to approach the experts, this study focused on another solution not applied before in predicting standard battles. Hence, the objective was to understand, test, and examine how the Collective Intelligence (CI) of the crowd (i.e., group of random individuals) performs compared to experts. The idea of CI is that it does not reside in any individual but emerges from the group. When people's opinions are combined, their advice should be more truthful or similar to a typical expert's. In other words, this quantitative exploratory study investigated if CI in comparison to experts differs when predicting standard battles. Hence, a literature review was required to provide deeper insights and factors that influence CI. This study explored the underlying mechanism of CI and established a conceptual model based on the theoretical background, which indicates the (moderating) relationship between ‘Diversity’ (DIV), ‘Group Size’ (GS), ‘Performance’ (PERF) of the crowd.The variable DIV was measured based on differences in gender, age, degree, job, and nationality and expressed by the Simpson’s index, reflecting the number of different species and distributions (SIMPSON, 1949). As for GS, the only attribute measured was the number of people in a contrived group. Further, the definition of the PERF of a collective is the quantifiable difference in their solution relative to the prediction proposed by the experts (Wagner et al., 2010). Hence, this was dubbed ‘Relative Performance’ (RP) for the rest of this paper.Prior research on standard battles was selected to test and validate the assertions in this study. This selection was based on several factors, such as the outcome of the battle was predicted by experts but where the ground truth is unknown. Doing so allowed validating if the crowd performs differently than experts in prediction tasks. The selected study involved the battle of two wind turbine technologies (WTT) dubbed ‘Gearbox’ (GB) and ‘Direct Drive’ (DD) (van de Kaa et al., 2020). Further, to interview the crowd, the traditional BWM questionnaire was converted into a cross-sectionally distributed online survey (i.e., MTurk) to obtain the data. Two hundred respondents completed the survey, but only 137 remained after pre-qualifications.In this research, ‘groups’ were contrived from the sample that completed the prediction task. Here, the group members employ their expertise to carry out the given task. In other words, all group members performed the same activity and then were randomly pooled based on varying group sizes. Next, simplified random sampling was carried out twice. The first time this resulted in six groups with a respective size of 5, 10, 20, 30, and 40. A second time was required because the former did not provide a good range of DIV scores. Because of this limitation, the sample was sampled multiple times, which resulted in multiple subgroups with each a DIV score—resulting in five groups of size 5, 10, 20, 30, 40, and 137 with respectively 26, 13, 6, 4, 3, and 1 subgroup for comparison.After sampling the data, the variables were tested for normality and homoscedasticity. The results indicate that the independent variables (i.e., DIV, GS) do not satisfy the normality assumption. Hence, the variables are not suited for parametrical testing. However, both the non- and parametrical tests were applied. Because ANOVA seems not to be very susceptible to modest divergence from normality. Namely, various studies used a variation of non-normal distributions and concluded that the false positive rate is not affected much if the notion of normality is not satisfied (Glass et al., 1972; Harwell et al., 1992; Lix et al., 1996). In addition, it was required to compare more than two groups. Hence, the One-Way ANOVA test (OWAT) and the Kruskal-Wallis Test (KWT) were selected to investigate the relationship between the variables (DIV, GS, RP). More specifically, the effects that GS or DIV can have on the RP of the crowd. In addition, due to systematic limitations with simplified random sampling, Bootstrapping (BOOT) and Monte Carlo (MC) were also performed respectively for the OWAT and KWT to investigate the relationship between DIV and RP. Lastly, the moderation effect was tested based on the Linear Regression (LR) method. The results did not show any significant differences between DIV and RP, and any significant moderation effect. Hence, the initial hypothesis that a more diverse group of individuals would perform better was refuted. In addition, this research rejects the proposition that the relationship between GS and RP should be positively moderated by how diverse the crowd is. Consequently, this research was not able to conclude how these variables affected the PERF of the crowd. Nevertheless, the former results weaken the theory of (S. Krause et al., 2011; Nguyen et al., 2018; Surowiecki, 2005), who underlines the importance of DIV. In contrast, the results gave ample support to (Reynolds et al., 2017) and their claim that there is no correlation between DIV and PERF. However, their second assertion about an existing relationship between cognitive DIV was not tested. Hence, it is recommended that future studies investigate this relationship.The findings did show a significant difference between groups for the variable GS in the case of GB WTT. Namely, when the size of the group increases, the PERF also proportionately increases with an upper limit, dubbed ‘Optimal Group Size’ (OGS). A U-shape relationship defines this relation between the variables. However, both the OWAT and KWT provide contradicting findings. Namely, findings from the OWAT suggest that the OGS consists of 15 people and that there is indeed a U-shape relationship between GS and RP, which proves that the claim of (Hashmi, 2005) and our hypothesis is correct. In contrast, the KWT indicates a relatively linear relationship, where the group of 10 and 20 performed significantly better than 30. However, OWAT showed that the group of 30 performed significantly better than the group of 10 and 20 people. Whereas the OGS was 10 and not 15 individuals. The results from the (non) parametrical for the location of OGS indicate that a group of 10 or 15 outperforms the other groups of smaller and bigger sizes. Hence, supporting the claim of (Carvalho et al., 2016) and weakening (S. Krause et al., 2011). To conclude, how CI operated in this research depended on survey completion time, consistency ratio, selection of best and worst criteria, PERF grade, and the final prediction. Hence, this research concluded that the CI of the crowd did show differences in predicting the outcome of a standard battle compared to the expert pool. This was primarily based on the fact that the crowd had a PERF score that was two-thirds lower than that of the experts. Although, the crowd performed in some aspects in similar or better ways. This research only tested one case, limiting our insights if this happened due to chance or not. In addition, the main goal of this study was to investigate if the crowd could come up with the exact prediction. Meaning that the conclusion and the process (e.g., selection criteria and grading WTT) towards this conclusion should be similar to experts. However, this was not the case. In addition, the consistency ratio remains a matter of doubt since most of the results were initially unreliable, which required (logical) corrections to obtain reliable results. Making the comparison based on the consistency ratio rickety. To reiterate, the crowd performed differently than experts when predicting the outcome of the WTT battle. Despite various differences, the individual and groups would conclude a similar prediction like in the case of experts.Management of Technology (MoT
Cluster analysis of hormonal constellation at women and men with harmonious and disharmonious general adaptation reactions
No full textHrytsak Yaroslav L, Barylyak Liliya G, Zukow Walery, Popovych Igor L. Cluster analysis of hormonal constellation at women and men with harmonious and disharmonious general adaptation reactions. Journal of Education, Health and Sport. 2016;6(4):141-150. eISSN 2391-8306. DOI http://dx.doi.org/10.5281/zenodo.49942
http://ojs.ukw.edu.pl/index.php/johs/article/view/3461
The journal has had 7 points in Ministry of Science and Higher Education parametric evaluation. Part B item 755 (23.12.2015).
755 Journal of Education, Health and Sport eISSN 2391-8306 7
© The Author (s) 2016;
This article is published with open access at Licensee Open Journal Systems of Kazimierz Wielki University in Bydgoszcz, Poland
Open Access. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium,
provided the original author(s) and source are credited. This is an open access article licensed under the terms of the Creative Commons Attribution Non Commercial License
(http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited.
This is an open access article licensed under the terms of the Creative Commons Attribution Non Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted, non commercial
use, distribution and reproduction in any medium, provided the work is properly cited.
The authors declare that there is no conflict of interests regarding the publication of this paper.
Received: 20.03.2016. Revised 17.04.2016. Accepted: 17.04.2016.
CLUSTER ANALYSIS OF HORMONAL CONSTELLATION AT WOMEN AND MEN WITH HARMONIOUS AND DISHARMONIOUS GENERAL ADAPTATION REACTIONS
Yaroslav L Hrytsak1, Liliya G Barylyak1,2,3, Walery Zukow4, Igor L Popovych3
1Hotel Spa Complex “Karpaty”, Truskavets’, Ukraine [email protected]
2JSC “Truskavets’kurort”, Truskavets’, Ukraine [email protected]
3Laboratory of Experimental Balneology, OO Bogomoletz Institute of Physiology NAS, Truskavets’-Kyiv, Ukraine [email protected]
4Faculty of Physical Education, Health and Tourism, Kazimierz Wielki University, Bydgoszcz, Poland [email protected]
Abstracts
Background. It is known that the nervous, endocrine and immune systems interact closely with each other to form a three-pronged neuro-endocrine-immune complex. On of manifest of causal neuroendocrine-immune relationships is Leukocytogram of peripheral blood that differ by various constellation of Principal Adaptation Hormones. Material and research methods. We determined twice at ten women and ten men aged 33-76 years without clinical diagnose serum levels of Cortisol, Aldosterone, Triiodothyronine, Testosterone and Calcitonin (ELISA) as well as Popovych’s Adaptation Index by Leukocytogram. Results. All case was distributed among four clusters. Cluster N1 contains 5 cases with drastically hypercortisolemia and moderately hypercalcitoninemia; 5 other cases characterized moderately hypercortisolemia and borderline level of Triiodothyronine, together reflected chronic stress. Majority of cases (Cluster N3) characterized upper borderline level of Cortisol and normal levels others hormones, while in 5 cases (Cluster N4) hormonal costellation is also normal but with lower borderline level of Cortisol. Estimation by Leukocytogram Popovych’s Adaptation Index shown that at 25 cases take place Harmonious General Adaptation Reactions (GAR) as markers of health while at 15 cases detected Disharmonious GAR as markers of premorbidic stage. Conclusion. Constellations of principal Adaptation Hormones displays widely variability representing different gradations of health and premobide states. Calcitonin may be considered as one of principal Adaptation Hormones.
Keywords: Cortisol, Aldosterone, Triiodothyronine, Testosterone, Calcitonin, General Adaptation Reactions
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