37 research outputs found
: A software platform for centralizing, enriching and spatializing heterogeneous data
No full textContributeurs : Violette Abergel, Marco Callieri, Isabelle Cao, Livio De Luca, Anaïs Guillem, Olivier Malavergne, Adeline Manuel, Ariane Néroulidis, Thomas Pouyet, Roxane Roussel, Miled Rousset, Sarah Tournon, Aurore Pfitzmann //Author contributions : Conceptualization: L.D.L.; Data curation: V.A., M.C., I.C., L.D.L., A.G., O.M., A.M., A.N., T.P., R.R., M.R., S.T.; Formal analysis: ; Funding acquisition: L.D.L.; Investigation: ; Methodology: ; Project administration: L.D.L., A.P.; Resources: ; Software: ; Supervision: L.D.L.; Validation: L.D.L.; Visualization: V.A., M.C., I.C., L.D.L., A.G., O.M., A.M., A.N., T.P., R.R., M.R., S.T.; Writing – original draft: V.A., M.C., I.C., L.D.L., A.G., O.M., A.M., A.N., T.P., R.R., M.R., S.T.; Writing – review & editing: L.D.L.International audiencePresentation of the tools making up the n-Dame ecosystem designed by members of the “Digital Data” Working Group of the Chantier Scientifique Notre-Dame.Présentation des outils composant l'écosystème n-Dame conçu par les membres du Groupe de Travail "Données numériques" du Chantier Scientifique Notre-Dame
Regulation of the RNA‐binding protein Smaug by the GPCR Smoothened via the kinase Fused
No full textFrom fly to mammals, the Smaug/Samd4 family of prion-like RNA-binding proteins control gene expression by destabilizing and/or repressing the translation of numerous target transcripts. However, the regulation of its activity remains poorly understood. We show that Smaug's protein levels and mRNA repressive activity are downregulated by Hedgehog signaling in tissue culture cells. These effects rely on the interaction of Smaug with the G-protein coupled receptor Smoothened, which promotes the phosphorylation of Smaug by recruiting the kinase Fused. The activation of Fused and its binding to Smaug are sufficient to suppress its ability to form cytosolic bodies and to antagonize its negative effects on endogenous targets. Importantly, we demonstrate in vivo that HH reduces the levels of smaug mRNA and increases the level of several mRNAs downregulated by Smaug. Finally, we show that Smaug acts as a positive regulator of Hedgehog signaling during wing morphogenesis. These data constitute the first evidence for a post-translational regulation of Smaug and reveal that the fate of several mRNAs bound to Smaug is modulated by a major signaling pathway.Fil: Bruzzone, Lucia. Centre National de la Recherche Scientifique; Francia. Universite de Paris; FranciaFil: Argüelles, Camilla. Centre National de la Recherche Scientifique; Francia. Universite de Paris; FranciaFil: Sanial, Matthieu. Universite de Paris; Francia. Centre National de la Recherche Scientifique; FranciaFil: Miled, Samia. Universite de Paris; Francia. Centre National de la Recherche Scientifique; FranciaFil: Alvisi, Giorgia. Universite de Paris; Francia. Centre National de la Recherche Scientifique; FranciaFil: Gonçalves Antunes, Marina. Universite de Paris; Francia. Centre National de la Recherche Scientifique; FranciaFil: Qasrawi, Fairouz. Universite de Paris; Francia. Centre National de la Recherche Scientifique; FranciaFil: Holmgren, Robert A.. Northwestern University; Estados UnidosFil: Smibert, Craig A. University of Toronto; CanadáFil: Lipshitz, Howard D.. University of Toronto; CanadáFil: Boccaccio, Graciela Lidia. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; ArgentinaFil: Plessis, Anne. Centre National de la Recherche Scientifique; Francia. Universite de Paris; FranciaFil: Bécam, Isabelle. Centre National de la Recherche Scientifique; Francia. Universite de Paris; Franci
: A software platform for centralizing, enriching and spatializing heterogeneous data
No full textContributeurs : Violette Abergel, Marco Callieri, Isabelle Cao, Livio De Luca, Anaïs Guillem, Olivier Malavergne, Adeline Manuel, Ariane Néroulidis, Thomas Pouyet, Roxane Roussel, Miled Rousset, Sarah Tournon, Aurore Pfitzmann //Author contributions : Conceptualization: L.D.L.; Data curation: V.A., M.C., I.C., L.D.L., A.G., O.M., A.M., A.N., T.P., R.R., M.R., S.T.; Formal analysis: ; Funding acquisition: L.D.L.; Investigation: ; Methodology: ; Project administration: L.D.L., A.P.; Resources: ; Software: ; Supervision: L.D.L.; Validation: L.D.L.; Visualization: V.A., M.C., I.C., L.D.L., A.G., O.M., A.M., A.N., T.P., R.R., M.R., S.T.; Writing – original draft: V.A., M.C., I.C., L.D.L., A.G., O.M., A.M., A.N., T.P., R.R., M.R., S.T.; Writing – review & editing: L.D.L.International audiencePresentation of the tools making up the n-Dame ecosystem designed by members of the “Digital Data” Working Group of the Chantier Scientifique Notre-Dame.Présentation des outils composant l'écosystème n-Dame conçu par les membres du Groupe de Travail "Données numériques" du Chantier Scientifique Notre-Dame
: A software platform for centralizing, enriching and spatializing heterogeneous data
No full textContributeurs : Violette Abergel, Marco Callieri, Isabelle Cao, Livio De Luca, Anaïs Guillem, Olivier Malavergne, Adeline Manuel, Ariane Néroulidis, Thomas Pouyet, Roxane Roussel, Miled Rousset, Sarah Tournon, Aurore Pfitzmann //Author contributions : Conceptualization: L.D.L.; Data curation: V.A., M.C., I.C., L.D.L., A.G., O.M., A.M., A.N., T.P., R.R., M.R., S.T.; Formal analysis: ; Funding acquisition: L.D.L.; Investigation: ; Methodology: ; Project administration: L.D.L., A.P.; Resources: ; Software: ; Supervision: L.D.L.; Validation: L.D.L.; Visualization: V.A., M.C., I.C., L.D.L., A.G., O.M., A.M., A.N., T.P., R.R., M.R., S.T.; Writing – original draft: V.A., M.C., I.C., L.D.L., A.G., O.M., A.M., A.N., T.P., R.R., M.R., S.T.; Writing – review & editing: L.D.L.International audiencePresentation of the tools making up the n-Dame ecosystem designed by members of the “Digital Data” Working Group of the Chantier Scientifique Notre-Dame.Présentation des outils composant l'écosystème n-Dame conçu par les membres du Groupe de Travail "Données numériques" du Chantier Scientifique Notre-Dame
: A software platform for centralizing, enriching and spatializing heterogeneous data
No full textContributeurs : Violette Abergel, Marco Callieri, Isabelle Cao, Livio De Luca, Anaïs Guillem, Olivier Malavergne, Adeline Manuel, Ariane Néroulidis, Thomas Pouyet, Roxane Roussel, Miled Rousset, Sarah Tournon, Aurore Pfitzmann //Author contributions : Conceptualization: L.D.L.; Data curation: V.A., M.C., I.C., L.D.L., A.G., O.M., A.M., A.N., T.P., R.R., M.R., S.T.; Formal analysis: ; Funding acquisition: L.D.L.; Investigation: ; Methodology: ; Project administration: L.D.L., A.P.; Resources: ; Software: ; Supervision: L.D.L.; Validation: L.D.L.; Visualization: V.A., M.C., I.C., L.D.L., A.G., O.M., A.M., A.N., T.P., R.R., M.R., S.T.; Writing – original draft: V.A., M.C., I.C., L.D.L., A.G., O.M., A.M., A.N., T.P., R.R., M.R., S.T.; Writing – review & editing: L.D.L.International audiencePresentation of the tools making up the n-Dame ecosystem designed by members of the “Digital Data” Working Group of the Chantier Scientifique Notre-Dame.Présentation des outils composant l'écosystème n-Dame conçu par les membres du Groupe de Travail "Données numériques" du Chantier Scientifique Notre-Dame
: A software platform for centralizing, enriching and spatializing heterogeneous data
No full textContributeurs : Violette Abergel, Marco Callieri, Isabelle Cao, Livio De Luca, Anaïs Guillem, Olivier Malavergne, Adeline Manuel, Ariane Néroulidis, Thomas Pouyet, Roxane Roussel, Miled Rousset, Sarah Tournon, Aurore Pfitzmann //Author contributions : Conceptualization: L.D.L.; Data curation: V.A., M.C., I.C., L.D.L., A.G., O.M., A.M., A.N., T.P., R.R., M.R., S.T.; Formal analysis: ; Funding acquisition: L.D.L.; Investigation: ; Methodology: ; Project administration: L.D.L., A.P.; Resources: ; Software: ; Supervision: L.D.L.; Validation: L.D.L.; Visualization: V.A., M.C., I.C., L.D.L., A.G., O.M., A.M., A.N., T.P., R.R., M.R., S.T.; Writing – original draft: V.A., M.C., I.C., L.D.L., A.G., O.M., A.M., A.N., T.P., R.R., M.R., S.T.; Writing – review & editing: L.D.L.International audiencePresentation of the tools making up the n-Dame ecosystem designed by members of the “Digital Data” Working Group of the Chantier Scientifique Notre-Dame.Présentation des outils composant l'écosystème n-Dame conçu par les membres du Groupe de Travail "Données numériques" du Chantier Scientifique Notre-Dame
: A software platform for centralizing, enriching and spatializing heterogeneous data
No full textContributeurs : Violette Abergel, Marco Callieri, Isabelle Cao, Livio De Luca, Anaïs Guillem, Olivier Malavergne, Adeline Manuel, Ariane Néroulidis, Thomas Pouyet, Roxane Roussel, Miled Rousset, Sarah Tournon, Aurore Pfitzmann //Author contributions : Conceptualization: L.D.L.; Data curation: V.A., M.C., I.C., L.D.L., A.G., O.M., A.M., A.N., T.P., R.R., M.R., S.T.; Formal analysis: ; Funding acquisition: L.D.L.; Investigation: ; Methodology: ; Project administration: L.D.L., A.P.; Resources: ; Software: ; Supervision: L.D.L.; Validation: L.D.L.; Visualization: V.A., M.C., I.C., L.D.L., A.G., O.M., A.M., A.N., T.P., R.R., M.R., S.T.; Writing – original draft: V.A., M.C., I.C., L.D.L., A.G., O.M., A.M., A.N., T.P., R.R., M.R., S.T.; Writing – review & editing: L.D.L.International audiencePresentation of the tools making up the n-Dame ecosystem designed by members of the “Digital Data” Working Group of the Chantier Scientifique Notre-Dame.Présentation des outils composant l'écosystème n-Dame conçu par les membres du Groupe de Travail "Données numériques" du Chantier Scientifique Notre-Dame
: A software platform for centralizing, enriching and spatializing heterogeneous data
No full textContributeurs : Violette Abergel, Marco Callieri, Isabelle Cao, Livio De Luca, Anaïs Guillem, Olivier Malavergne, Adeline Manuel, Ariane Néroulidis, Thomas Pouyet, Roxane Roussel, Miled Rousset, Sarah Tournon, Aurore Pfitzmann //Author contributions : Conceptualization: L.D.L.; Data curation: V.A., M.C., I.C., L.D.L., A.G., O.M., A.M., A.N., T.P., R.R., M.R., S.T.; Formal analysis: ; Funding acquisition: L.D.L.; Investigation: ; Methodology: ; Project administration: L.D.L., A.P.; Resources: ; Software: ; Supervision: L.D.L.; Validation: L.D.L.; Visualization: V.A., M.C., I.C., L.D.L., A.G., O.M., A.M., A.N., T.P., R.R., M.R., S.T.; Writing – original draft: V.A., M.C., I.C., L.D.L., A.G., O.M., A.M., A.N., T.P., R.R., M.R., S.T.; Writing – review & editing: L.D.L.International audiencePresentation of the tools making up the n-Dame ecosystem designed by members of the “Digital Data” Working Group of the Chantier Scientifique Notre-Dame.Présentation des outils composant l'écosystème n-Dame conçu par les membres du Groupe de Travail "Données numériques" du Chantier Scientifique Notre-Dame
: A software platform for centralizing, enriching and spatializing heterogeneous data
No full textContributeurs : Violette Abergel, Marco Callieri, Isabelle Cao, Livio De Luca, Anaïs Guillem, Olivier Malavergne, Adeline Manuel, Ariane Néroulidis, Thomas Pouyet, Roxane Roussel, Miled Rousset, Sarah Tournon, Aurore Pfitzmann //Author contributions : Conceptualization: L.D.L.; Data curation: V.A., M.C., I.C., L.D.L., A.G., O.M., A.M., A.N., T.P., R.R., M.R., S.T.; Formal analysis: ; Funding acquisition: L.D.L.; Investigation: ; Methodology: ; Project administration: L.D.L., A.P.; Resources: ; Software: ; Supervision: L.D.L.; Validation: L.D.L.; Visualization: V.A., M.C., I.C., L.D.L., A.G., O.M., A.M., A.N., T.P., R.R., M.R., S.T.; Writing – original draft: V.A., M.C., I.C., L.D.L., A.G., O.M., A.M., A.N., T.P., R.R., M.R., S.T.; Writing – review & editing: L.D.L.International audiencePresentation of the tools making up the n-Dame ecosystem designed by members of the “Digital Data” Working Group of the Chantier Scientifique Notre-Dame.Présentation des outils composant l'écosystème n-Dame conçu par les membres du Groupe de Travail "Données numériques" du Chantier Scientifique Notre-Dame
