41 research outputs found
Rasmea Odeh: The Case of an Indomitable Woman
No full textIn this profile of Rasmea Odeh, JPS examines the case of a Palestinian woman who has been incarcerated in both Israel and the United States. After a decade of confinement in Israel, Odeh was freed in a prisoner exchange in 1979. Following deportation from the occupied Palestinian territories, she became a noted social justice and women's rights organizer, first in Lebanon and Jordan, and later in the U.S., where she built the now over 800-strong Arab Women's Committee of Chicago. In April 2017, Odeh accepted a plea bargain that would lead to her deportation from the United States after a years-long legal battle to overturn a devastating conviction on charges of immigration fraud. Observers, legal experts, and supporters consider the case to “reek of political payback,” in the words of longtime Palestine solidarity activist, author, and academic Angela Davis. Odeh's generosity of spirit, biting wit, and easy smile did not desert her throughout the years that she fought her case. To know Odeh is to be reminded that the work of organizing for social justice is about the collective rather than the individual, and that engagement, relationship building, and trust are the foundations of such work.</jats:p
qF3 Analysis Code
No full textProvided here:
-Scripts for Performing quantitative Fast FLIM FRET (qF3) Analysis. Organized into folders by steps (1-13) to run for each biological replicate (Step1_Replicate_Analysis) and then for all combined replicates (Step2_CombineReps_Analysis).
-script used to calculate G factor (for which our original data can be provided upon request)
-Example Master platemap.
-LICENSE file for all code here.
-Author: Nehad Hirmiz ([email protected])
Instructions:
-Download all files here and extract .Zip.
-Install MATLAB Version R2020a with toolboxes:
Signal Processing, Curve Fitting, Image Processing.
-IFF starting with INO FLIM Hyperspectral data * then contact lead for
INO software package including (Release_r10357 package):
INO FHS Acquisition,
INO_FHS_Analysis,
INO_FHS_Batch Analysis
-Follow instructions to run these codes:
See associated text at Protocol Exchange: Title: “Automated, quantitative Fast FLIM-FRET (qF3): A step-by-step protocol to measure dissociation constants for protein-protein interactions in live-cell screening applications.”
LINK
https://doi.org/10.21203/rs.3.pex-1354/v1
And
Instructional videos:
LINK
https://www.youtube.com/playlist?list=PLUiSJrzzg9voe5sjA57oIbfOLAGIrHXR
Erratum: A scientific report on heat transfer analysis in mixed convection flow of Maxwell fluid over an oscillating vertical plate
No full textScientific Reports 7: Article number: 40147; published online: 15 March 2017; updated: 17 May 2018 In the original version of this Article, the author L. C. C. Dennis was inadvertently omitted from the Author Contributions statement and the Supplementary Information. The Author Contributions statement,</jats:p
Negative Transcriptional Regulation of Human Colonic Smooth Muscle Cav1.2 Channels by p50 and p65 Subunits of Nuclear Factor-κB
No full textGene expression data analysis identifies multiple deregulated pathways in patients with asthma
No full text©2018 The Author(s).Peer reviewe
Author Correction: Convergence of TGFβ and BMP signaling in regulating human bone marrow stromal cell differentiation
No full textCorrection to: Scientific Reports, published online 21 March 2019 This Article contains errors. In Figure 6C the OS image for SCR siRNA is incorrectly duplicated as the Figure 8C OS image for CNT. The correct Figure 8 and its accompanying legend appear below. (Figure presented.) Effect of exogenous BMP4 on osteoblastic and adipocytic differentiation of hBMSC−Bone cells. (a) Quantification of cell viability of hBMSC–Bone cells in the presence or absence of recombinant BMP4. (b) qRT-PCR quantification for TAGLN, TPM1, and Col1A2 in hBMSC−Bone cells in the presence or absence of recombinant BMP4. The expression of each target gene was normalized to GAPDH. Data are presented as mean ± SD from three independent experiments, n = 9; ***p < 0.0005. (c) OsteoImage™ staining (20× magnification) of hBMSC−Bone cells which were induced into the osteoblast in the presence or absence of recombinant BMP4. The lower panel shows Alizarin Red S staining. The quantification of mineralized matrix formation for vehicle or recombinant BMP4-treated hBMSC−Bone cells is shown (right panel). Data are presented as relative mean mineralization ± SD from three independent experiments, n = 9; *p < 0.0005. (d) qRT-PCR quantification of ALPL, OCN, ON, and COL1A1 osteogenic markers in hBMSC−Bone cells in the presence or absence of recombinant BMP4 under osteogenic induction conditions. The expression of each target gene was normalized to GAPDH. Data are presented as the means ± SD from three independent experiments, n = 9; *p < 0.05, **p < 0.005, ***p < 0.0005. (e) hBMSC−Bone cells were differentiated into adipocytes for 7 days under the indicated experimental conditions. Upper panel shows fluorescence Nile red staining of mature oil filled adipocytes (20× magnification), whilst the lower panel shows Oil red O staining for adipocytes (20× magnification). The lower panel shows the relative quantification of Nile red staining of mature oil-filled adipocytes. (f) qRT-PCR quantification for LPL and CEBPA adipocytic markers. The expression of each target gene was normalized to GAPDH. Data are presented as mean ± SD from three independent experiments, n = 9; **p < 0.005, ***p < 0.0005. (g) Schematic model illustrating the convergence of BMP and TGFβ in regulating hBMSC differentiation.</p
Is There a Role for Informal Caregivers in the Management of Diabetic Foot Ulcers? A Narrative Review
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Author Correction: Dual solution framework for mixed convection flow of Maxwell nanofluid instigated by exponentially shrinking surface with thermal radiation
No full textThe genomes of two key bumblebee species with primitive eusocial organization
No full textBackground The shift from solitary to social behavior is one of the major evolutionary transitions. Primitively eusocial bumblebees are uniquely placed to illuminate the evolution of highly eusocial insect societies. Bumblebees are also invaluable natural and agricultural pollinators, and there is widespread concern over recent population declines in some species. High-quality genomic data will inform key aspects of bumblebee biology, including susceptibility to implicated population viability threats. Results We report the high quality draft genome sequences of Bombus terrestris and Bombus impatiens, two ecologically dominant bumblebees and widely utilized study species. Comparing these new genomes to those of the highly eusocial honeybee Apis mellifera and other Hymenoptera, we identify deeply conserved similarities, as well as novelties key to the biology of these organisms. Some honeybee genome features thought to underpin advanced eusociality are also present in bumblebees, indicating an earlier evolution in the bee lineage. Xenobiotic detoxification and immune genes are similarly depauperate in bumblebees and honeybees, and multiple categories of genes linked to social organization, including development and behavior, show high conservation. Key differences identified include a bias in bumblebee chemoreception towards gustation from olfaction, and striking differences in microRNAs, potentially responsible for gene regulation underlying social and other traits. Conclusions These two bumblebee genomes provide a foundation for post-genomic research on these key pollinators and insect societies. Overall, gene repertoires suggest that the route to advanced eusociality in bees was mediated by many small changes in many genes and processes, and not by notable expansion or depauperation. </p
Comparison of the post-marketing safety profile between influenza and COVID-19 vaccines: An analysis of the vaccine adverse event reporting system
No full textThe global coronavirus disease (COVID-19) epidemic can be partially managed by vaccines; however, the public must be informed about the safety of COVID-19 vaccines to avoid hesitancy. Therefore, it is important to know the safety profile of the COVID-19 vaccine by comparison to that of a well-known vaccine, such as the influenza vaccine. Hence, this retrospective descriptive study was conducted to evaluate and compare the number of adverse effects (AEs) reported to the Vaccine Adverse Event Reporting System (VAERS) for both COVID-19 and influenza vaccines, identify the most common AEs of each vaccine, and compare the frequency and outcomes of using COVID-19 and influenza vaccines in the U.S. population. Surveillance reports from 1st December 2020 to 8th October 2021 of both vaccines were retrieved from the U.S. VAERS. A total of 544,025 and 15,871 reports of post-COVID-19 and - influenza vaccine AEs were reported to the VAERS, respectively. Females reported > 58% and nearly 70% of influenza - and COVID-19 vaccine-associated AEs, respectively. The estimated incidence rates of AEs associated with COVID-19 and influenza vaccines in the U.S. were 1.36 and 0.12 per 1,000 persons, respectively. The incidence of AEs was higher among COVID-19 vaccine recipients than that among influenza vaccine recipients. COVID-19 vaccine recipients have a two-fold higher risk of mortality and life-threatening events than influenza vaccine recipients. However, most of the reported AEs were similar between the two vaccines in terms of symptoms
