592 research outputs found
European EADV network on assessment of severity and burden of Pruritus (PruNet): first meeting on outcome tools
No full textItem does not contain fulltextBACKGROUND: Chronic pruritus is a frequently occurring symptom of various dermatoses that causes a high burden and impaired quality of life. An effective anti pruritic therapy is important for the patient, but its effectiveness is difficult to evaluate. Diverse methods and interpretations of pruritic metrics are utilized in clinical trials and the daily clinical practice in different countries, resulting in difficulties comparing collected data. METHODS: We founded a European Network on Assessment of Severity and Burden of Pruritus (PruNet) that is supported by the EADV. PruNet consists of 28 experts from 15 EU countries (21 dermatologists, 5 medical informaticists, 2 psychologists) and aims to unify the assessment of itch in routine dermatological care. Following a preliminary survey, a consensus conference was held in order to agree upon the prioritization of patient-reported outcome tools. RESULTS: Through utilizing the Delphi method, it was agreed that tools for measuring itch intensity (ex. the visual analogue scale) and quality of life (ex. ItchyQoL) are of primary importance and should urgently be foremost validated. CONCLUSION: The validation and harmonization of standards are needed for the improvement of quality care for patients suffering from pruritic dermatoses. This summer, the first validation studies in several EADV member countries already began
A formal verification framework and associated tools for enterprise modeling : application to UEML
No full textThe aim of this paper is to propose and apply a verification and validation approach to Enterprise Modeling that enables the user to improve the relevance and correctness, the suitability and coherence of a model by using properties specification and formal proof of properties
Humanistic burden of chronic pruritus in patients with inflammatory dermatoses: Results of the European Academy of Dermatology and Venereology Network on Assessment of Severity and Burden of Pruritus (PruNet) cross-sectional trial
No full textBackground: Chronic pruritus is a multifactorial, challenging symptom of global relevance. Objective: The European Academy of Dermatology and Venereology Network on Assessment of Severity and Burden of Pruritus (PruNet) investigation aimed to analyze the severity and humanistic burden of chronic pruritus in patients suffering from inflammatory dermatoses across Europe. Methods: Prospectively collected routine data on 552 patients (with atopic dermatitis, contact dermatitis, prurigo nodularis, psoriasis vulgaris, lichen planus, or mycosis fungoides [pruritus numeric rating scale score ≥3]) from 9 European centers (in Austria, France, Germany, Italy, Poland, Russia, Spain, Switzerland, and Turkey) were analyzed by univariate and multivariate variance analyses of various itch characteristics and quality of life (as measured by the Dermatology Life Quality Index and the ItchyQoL). Results: Duration, frequency, and intensity of pruritus (according to a numeric rating scale and visual analog scale) and related impairment of quality of life differed between European centers and dermatologic diagnoses (P <.05). The country in which the center was located had a greater impact on how patients evaluated pruritus intensity and quality of life than diagnosis did (P <.001). Limitations: One center per country was included. Conclusion: The humanistic burden of chronic pruritus in patients with inflammatory dermatoses is high. European cross-cultural factors may have a stronger influence than a specific dermatologic diagnosis on how patients rate intensity of pruritus and quality of life
Encircling the dark: constraining dark energy via cosmic density in spheres
No full textCodis S, Pichon C, Bernardeau F, Uhlemann C, Prunet S. Encircling the dark: constraining dark energy via cosmic density in spheres. Monthly Notices of the Royal Astronomical Society. 2016;460(2):1549-1554.The recently published analytic probability density function for the mildly non-linear cosmic density field within spherical cells is used to build a simple but accurate maximum likelihood estimate for the redshift evolution of the variance of the density, which, as expected, is shown to have smaller relative error than the sample variance. This estimator provides a competitive probe for the equation of state of dark energy, reaching a few per cent accuracy on wp and wa for a Euclid-like survey. The corresponding likelihood function can take into account the configuration of the cells via their relative separations. A code to compute one-cell-density probability density functions for arbitrary initial power spectrum, top-hat smoothing and various spherical-collapse dynamics is made available online, so as to provide straightforward means of testing the effect of alternative dark energy models and initial power spectra on the low-redshift matter distribution
Summary Of Original Papers
No full textProstacyclin Administration During Cardiopulmonary Bypass In Man
D.B. Longmore, J.Graeme Bennett, P.M. Hoyle, M.A. Smith, A.Gregory, T.Osivand, W.A.Jones
Impaired Immune Response Of Splenectomised Patient To Polyvalent Pneumococcal Vaccine
Stephen W. Hosea, Cynthia G. Burch, Eric J. Brown, Richard A.Berg, Michael M.Drank
Prophylactic Cefazolin Versus Placebo In Total Hip Replacement
C. Hill, F.Mazas, R.Flamant, J.Evrard
Randomised Placebo-Controlled Trial Of Hepatitis B Surface vaccine In French Haemodialysis Units:II, Haemodialysis Patients
Jean Crosnier, Paul Jungers, Anne Marie Courouce, Agnes Laplanche, Ellen Benhamou, Francoise Degos,Bernard Lacour, Paul Prunet, Yvannex Cerisier, Pierre Guesr
Flow chart of the algorithm.
No full text<p>PRUNET takes as the input a prior knowledge gene regulatory network and a Booleanized representation of the gene expression profiles of stable phenotypes. After an iterative network pruning, PRUNET delivers as the output a single (or several) contextualized network(s) optimized to describe the phenotypes according to an adopted dynamical model (Boolean). The fitness function is based on the matching between the predicted (α) and the known gene states (φ) for specific phenotypes.</p
Detection of QTL with effects on osmoregulation capacities in the rainbow trout (Oncorhynchus mykiss)
No full textBackground
There is increasing evidence that the ability to adapt to seawater in teleost fish is modulated by genetic factors. Most studies have involved the comparison of species or strains and little is known about the genetic architecture of the trait. To address this question, we searched for
QTL affecting osmoregulation capacities after transfer to saline water in a nonmigratory captive-bred population of rainbow trout.
Results
A QTL design (5 full-sib families, about 200 F2 progeny each) was produced from a cross between F0 grand-parents previously selected during two generations for a high or a low cortisol response after a standardized confinement stress. When fish were about 18 months old (204 g body weight), individual progeny were submitted to two successive hyper-osmotic challenges (30g of salt/L) at a 14 d interval. Plasma chloride and sodium concentrations were
recorded 24h after each transfer. After the second challenge, fish were sacrificed and gill index (weight of total gill arches corrected for body weight) was recorded. The genome scan was performed using 200 microsatellites and 88 SNP markers. Unitrait and multitrait QTL analyses evidenced a total of 15 and 7 different QTL (P<0.10) for plasma ion concentrations and gill index respectively. Among the most significant QTL, three affected concentrations of both chloride and sodium during both challenges, two were specific to either chloride or
sodium concentrations, three QTL were specific to gill index, and three affected both gill index and ionic concentrations in plasma. Altogether, allelic effects were consistent for QTL affecting chloride and sodium concentrations but inconsistent for QTL affecting ionic
concentrations and gill morphology. There was no systematic lineage effect (grand-parental origin of QTL alleles) on the recorded traits.
Conclusions
For the first time, genomic loci associated with effects on major physiological components of osmotic adaptation to seawater in a nonmigratory fish were revealed. The results pave the way for further deciphering of the complex regulatory mechanisms underlying seawater adaptation
and genes involved in osmoregulatory physiology in rainbow trout and other euryhaline fishes
German experimental hepatitis B vaccine: influence of variation of dosage schedule, sex and age differences on immunogenicity in health care workers
No full textKrämer A, Sommer D, Hahn EG, Riecken E-O. German experimental hepatitis B vaccine: influence of variation of dosage schedule, sex and age differences on immunogenicity in health care workers. Klinische Wochenschrift. 1986;64(15):688-694
Domino Metathesis Reactions for the Synthesis of Fused Tricyclic Frameworks
No full text4 pagesA domino metathesis strategy has been successfully applied to the straightforward sterecontrolled construction of functionalized tricyclic systems of different ring sizes starting from readily available precursors
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