114,100 research outputs found
Dose- and time-dependent effects of recombinant human bone morphogenetic protein-2 on the osteogenic and adipogenic potentials of alveolar bone-derived stromal cells
No full textPark J-C, Kim J.C, Kim B-K, Cho K-S, Im G-I, Kim B-S, Kim C-S. Dose- and time-dependent effects of recombinant human bone morphogenetic protein-2 on the osteogenic and adipogenic potentials of alveolar bone-derived stromal cells. J Periodont Res 2012; 47: 645654. (C) 2012 John Wiley & Sons A/S Background and Objective: Recombinant human bone morphogenetic protein-2 (rhBMP-2) is a well-known growth factor that can induce robust bone formation, and recent studies have shown that rhBMP-2-induced osteogenesis is closely related to adipogenesis. The aim of the present study was to determine the dose- and time-dependent effects of rhBMP-2 on the osteogenic and adipogenic differentiation of human alveolar bone-derived stromal cells (hABCs) in vivo and in vitro. Material and Methods: hABCs were isolated and cultured, and then transplanted using a carrier treated either with or without rhBMP-2 (100 mu g/mL) into an ectopic subcutaneous mouse model. Comprehensive histologic and histometric analyses were performed after an 8-wk healing period. To further understand the dose-dependent (0, 10, 50, 200, 500 and 1000 ng/mL) and time-dependent (0, 3, 5, 7 and 14 d) effects of rhBMP-2 on osteogenic and adipogenic differentiation, in vitro osteogenic and adipogenic differentiation of hABCs were evaluated, and the expression of related mRNAs, including those for alkaline phosphatase, osteocalcin, bone sialoprotein, peroxisome-proliferator-activated receptor gamma-2 and lipoprotein lipase, were assessed using quantitative RT-PCR. Results: rhBMP-2 significantly promoted the osteogenic and adipogenic differentiation of hABCs in vivo, and gradually increased both the osteogenic and adipogenic potential in a dose- and time-dependent manner with minimal deviation in vitro. The expression of osteogenesis- and adipogenesis-associated mRNAs were concomitantly up-regulated by rhBMP-2. Conclusion: The findings of the present study showed that rhBMP-2 significantly enhanced the adipogenic as well as the osteogenic potential of hABCs in dose- and time-dependent manner. The control of adipogenic differentiation of hABCs should be considered when regenerating the alveolar bone using rhBMP-2.N
The dynamic healing profile of human periodontal ligament stem cells: histological and immunohistochemical analysis using an ectopic transplantation model
No full textKim Y-T, Park J-C, Choi S-H, Cho K-S, Im G-I, Kim B-S, Kim C-S. The dynamic healing profile of human periodontal ligament stem cells: histological and immunohistochemical analysis using an ectopic transplantation model. J Periodont Res 2012; 47: 514524. (c) 2012 John Wiley & Sons A/S Background and Objective: Human periodontal ligament stem cells (hPDLSCs) have been reported to play the pivotal role in periodontal regeneration. However, the dynamic cellular healing process initiated by hPDLSCs still remains to be elucidated. In the present study, the sequence of regeneration by hPDLSCs was assessed using histological and immunohistochemical observation in an ectopic transplantation model, which is a well-standardized assessment tool that excludes the innate healing factors from the animals. Material and Methods: Human periodontal ligament stem cells that were isolated and characterized from teeth (n = 12) extracted for the purpose of orthodontic treatment were transplanted with carriers into ectopic subcutaneous pouches in immunocompromised mice (n = 20). Animals were killed after several different healing periods: 3 d (n = 4), 1 (n = 4), 2 (n = 4), 4 (n = 4) and 8 wk (n = 4). Histological analysis for regenerated tissues formed by hPDLSCs was conducted using hematoxylin and eosin, Massons trichrome and picrosirius red staining. In addition, immunohistochemical staining was performed to observe the sequential expression of osteogenic/cementogenic and periodontal ligament tissue-specific markers associated with periodontal regeneration. Results: The whole healing process by transplanted hPDLSCs could be broadly divided into four distinctive phases. In the first phase, proliferated hPDLSCs migrated evenly all over the carrier, and collagenous tissues appeared in the form of amorphous collagen matrices. In the second phase, collagen fibers were well arranged among the carriers, and cementoid-like tissues were observed. In the third phase, the formation of mature collagen fibers, resembling Sharpeys fibers, was associated with active mineralization of cementum-like tissues, and in the fourth phase, the maturation of cementum-like tissues was observed on carrier surfaces. Various osteogenic/cementogenic markers related to the regeneration processes were expressed in a well-orchestrated time order. Interestingly, well-organized cementum-like and periodontal ligament fiber-like tissues and cells with early and late osteogenic/cementogenic markers were frequently observed in the secluded area of carrier surfaces. We termed this area the cell-rich zone. Conclusion: The results from this study clearly demonstrated the sequential histological changes during periodontal tissue regeneration by hPDLSCs. Understanding of this process would potentially enable us to develop better cell-based treatment techniques.N
Bio-vison 2016: The second national framework plan for biotechnology promotion in Korea
No full textThis research was funded by the Specific Research
and Development Project of the Ministry of Science
and Technology.This material is based on Bio-Vision
2016 and its Report [5, 6].We are very grateful to the
following members of the Biotechnology Policy Research
Center: Young-Cheol Kim, Dong-Sub Yoon,
Moo Woong Kim, Eun Jung Kim, Su Gil Kim, Mi jeong
Park, Seong-Hoon Park, Oh-Min Joung, and Seung-
Hoo Shin
Measurement of the ratio of branching fractions B(B0→K∗0γ )/B(B0s→φγ ) and the directCP asymmetry inB 0→K∗0γ
No full textThe ratio of branching fractions of the radiative B decays B0→K⁎0γ and B0s→ϕγ has been measured using an integrated luminosity of 1.0 fb−1 of pp collision data collected by the LHCb experiment at a centre-of-mass energy of s√=7TeV. The value obtained is
B(B0→K⁎0γ)B(B0s→ϕγ)=1.23±0.06(stat.)±0.04(syst.)±0.10(fs/fd),
where the first uncertainty is statistical, the second is the experimental systematic uncertainty and the third is associated with the ratio of fragmentation fractions fs/fd. Using the world average value for B(B0→K⁎0γ), the branching fraction B(B0s→ϕγ) is measured to be (3.5±0.4)×10−5.
The direct CP asymmetry in B0→K⁎0γ decays has also been measured with the same data and found to be
ACP(B0→K⁎0γ)=(0.8±1.7(stat.)±0.9(syst.))%.
Both measurements are the most precise to date and are in agreement with the previous experimental results and theoretical expectations
Symplocarpus koreanus J. S. Lee, S. H. Kim & S. C. Kim 2021
No full textSymplocarpus koreanus J.S. Lee, S.H. Kim & S.C. Kim (2021: 2) Isotype: KOREA, Gangwon-do: Chuncheon-si, Sabuk-myeon, Goseong-ri, Mt. Yonghwasan, 21 March 2020, S. C. Kim 200321500 (NIBRVP815477; Fig. 1 -23). Paratypes: KOREA, Gyeonggi-do: Gapyeong-gun, Buk-myeon, Baekdun-ri, Mt. Yeoninsan, 3 May 2013, W. B . Lee s.n. (NIBRVP517078); Gapyeong-gun, Oeseo-myeon, Mt. Hwayasan, 26 June 2007, W. K. Paik VP-KB-377062-0173 (NIBRVP815507); Gapyeonggun, Sang-myeon, Haenghyeon-ri, Mt. Chungnyeongsan, 31 March 2012, J. H . Kim, Y. J. Kim & I. S. Yoon KIMJH12006 (3 sheets, NIBRVP355001); Gapyeong-gun, Sang-myeon, Haenghyeon-ri, Mt. Chungnyeongsan, 29 March 2016, G. H . Nam, J. H. Kim & J. K. Hong L 16001 (NIBRVP550794); Gapyeong-gun, Seorak-myeon, Mt. Yumyeongsan, 4 April 2008, B. K . Kwon 080404-375 (NIBRVP532404); Gapyeong-gun, Seorak-myeon, Mt. Yumyeongsan, 4 April 2008, G. Y . Chung ANH-en-080404- 001 (NIBRVP197125); Hanam-si, Baealmi-dong, Mt. Geomdansan, 3 April 2007, J. O . Hyun, H. K. Park & J. A. Eom VP-NAPI-377054-092 (NIBRVP111433); Namyangju-si, Hwado-eup, Mt. Cheonmasan, 15 April 2007, W. K . Paik VP-KB-377061-0133 (NIBRVP815506); Namyangju-si, Hwado-eup, Mt. Cheonmasan, 22 March 2013, Song et al. s.n. (NIBRVP464822); Namyangjusi, Onam-eup, Onam-ri, Mt. Cheonmasan, 6 April 2009, G. H . Nam, M. H. Kim & J. H. Lee VS 15 (NIBRVP206699); Namyangjusi, Onam-eup, Onam-ri, Mt. Cheonmasan, 6 April 2009, G. H . Nam, M. H. Kim & J. H. Lee VS16 (2 sheets, NIBRVP206700); Namyangju-si, Mt. Chungnyeongsan, 28 March 1999, S. P . Hong & K. W. Park 411 (NIBRVP102296). Gangwon-do: Cheorwon-gun, Geunnam-myeon, Mt. Gwangdeoksan, 12 May 1997, S. P . Hong & H. S. Choi 99 (NIBRVP102297); Donghae-si, Bugok-dong, Mita Temple, 26 April 2011, G. H . Nam & W. J. Jeong SHY2-34 (NIBRVP284290); Gangneung-si, Wangsan-myeon, Mt. Hwaranbong, 30 April 2009, J. H . Kim & H. J. Kim VP-KB-0904-0071 (NIBRVP318582); Hwacheon-gun, Mt. Baekjeoksan, 24 May 2000, K . Ch. Yang & J. D. Jung s.n. (NIBRVP102304, NIBRVP102305); Hwacheon-gun, Mt. Baekjeoksan, 3 August 2000, J. H . Kim & D. K. Kim 49 (NIBRVP102307); Hwacheon-gun, Sanae-myeon, Mt. Gwangdoeksan, 7 April 2009, G. H . Nam, M. H. Kim & J. H. Lee VS24 (2 sheets, NIBRVP206708); Hwacheon-gun, Sanae-myeon, Mt. Gwangdoeksan, 7 April 2009, G. H . Nam, M. H. Kim & J. H. Lee VS25 (2 sheets; NIBRVP206709). Chungcheongbuk-do: Danyang-gun, Gagok-myeon, Mt. Sobaecksan, 17 May 1999, C. W . Park, H. W. Lee & J. Koh 10315 (NIBRVP815505); Danyang-gun, Gagok-myeon, Mt. Sobaeksan, 20 April 2007, G. Y . Chung ANH-en-070420-013 (NIBRVP121631). Jeollabuk-do: Jangsu-gun, Gyenam-myeon, Jangan-ri, 21 September 1997, B. Y . Sun & C. H. Kim 10361 (NIBRVP815504); Jangsu-gun, Gyenam-myeon, Mt. Jangansan, 19 May 2007, B. Y . Sun 2271 (NIBRVP128343); Jangsu-gun, Gyenam-myeon, Mt. Jangansan, 19 June 2009, J. K . Ahn, S. J. Lee & Y. W. Lee CH 40006 (NIBRVP266477); Jangsu-gun, Gyenammyeon, Mt. Jangansan, 19 June 2009, J. K . Ahn, S. J. Lee & Y. W. Lee CH 40239 (NIBRVP266707); Jinan-gun, Jucheon-myeon, Daebul-ri, Mt. Unjangsan, without date, C. H . Kim & S. H. Lee 50051 (3 sheets, NIBRVP537859). Gyeongsangnam-do: Geochanggun, Buksang-myeon, Mt. Deogyusan hyangjeokbong-satgatgoljae, 31 May 2006, B. Y . Sun 1577 (4 sheets, NIBRVP119643). Note: The holotype is deposited in SKK.Published as part of Jang, Hyun-Do, Hyun, Chang-Woo, Ryu, Seah & Lee, Sang-Jun, 2022, Type specimens of vascular plants in the herbarium of the National Institute of Biological Resources (II), pp. 229-243 in Phytotaxa 539 (3) on page 237, DOI: 10.11646/phytotaxa.539.3.2, http://zenodo.org/record/636408
Evidence for the decay B0→J/ψω and measurement of the relative branching fractions of meson decays to J/ψη and J/ψη′
No full textFirst evidence of the B 0 → J / ψ ω decay is found and the B s 0 → J / ψ η and B s 0 → J / ψ η ′ decays are studied using a dataset corresponding to an integrated luminosity of 1.0 fb -1 collected by the LHCb experiment in proton-proton collisions at a centre-of-mass energy of sqrt(s) = 7 TeV. The branching fractions of these decays are measured relative to that of the B 0 → J / ψ ρ 0 decay:frac(B (B 0 → J / ψ ω), B (B 0 → J / ψ ρ 0)) = 0.89 ± 0.19 (stat) - 0.13 + 0.07 (syst),frac(B (B s 0 → J / ψ η), B (B 0 → J / ψ ρ 0)) = 14.0 ± 1.2 (stat) - 1.5 + 1.1 (syst) - 1.0 + 1.1 (frac(f d, f s)),frac(B (B s 0 → J / ψ η ′), B (B 0 → J / ψ ρ 0)) = 12.7 ± 1.1 (stat) - 1.3 + 0.5 (syst) - 0.9 + 1.0 (frac(f d, f s)), where the last uncertainty is due to the knowledge of f d / f s, the ratio of b-quark hadronization factors that accounts for the different production rate of B 0 and B s 0 mesons. The ratio of the branching fractions of B s 0 → J / ψ η ′ and B s 0 → J / ψ η decays is measured to befrac(B (B s 0 → J / ψ η ′), B (B s 0 → J / ψ η)) = 0.90 ± 0.09 (stat) - 0.02 + 0.06 (syst)
Precise measurement of the branching fractions for B-s(0) -> D-s(()*()+) D-s(()*()-) and first measurement of the D-s*(+) D-s*(-) polarization using e(+)e(-) collisions
No full textWe have made a precise measurement of the absolute branching fractions of B-s(0) -> D-s(()*()+) D-s(()*()-) decays using 121.4 fb(-1) of data recorded by the Belle experiment running at the Upsilon(5S) resonance. The results are B(B-s(0) -> D-s(+) D-s(-)) = 0.58(-0.09)(+0.11) +/- 0.13)%, B(B-s(0) -> D-s*(+/-) D-s(-/+)) = (1.76(-0.22)(+0.23) +/- 0.40)%, and B(B-s(0) -> D-s*(+) D-s*(-)) = (1.98(-0.31-0.50)(+0.33+0.52))%; the sum is B(B-s(0) -> D-s(()*()+) D-s(()*()-)) = (4.32(-0.39-1.03)(+0.42+1.04))%. Assuming B-s(0) -> D-s(()*()+) D-s(()*()-) saturates decays to CP-even final states, the branching fraction constrains the ratio Delta Gamma(s)/cos phi(12), where Delta Gamma(s) is the difference in widths between the two B-s-(B) over bar (s) mass eigenstates, and phi(12) is the CP-violating phase in B-s-(B) over bar (s) mixing. We also measure for the first time the longitudinal polarization fraction of B-s(0) -> D-s*(+) D-s*(-); the result is 0.06(-0.17)(+0.18) +/- 0.03. DOI: 10.1103/PhysRevD.87.031101LPH
Integrated congestion-control mechanism in optical burst switching networks
No full textThis research has been conducted while Sungchang Kim was
visiting the Networks Research Lab. at UC Davis. This work
was supported by KOSEF through OIRC project, and also in
part by NSF Grant No. INT-03-23384
Study of B c + → J / ψ D s + and B c + → J / ψ D s ∗ + decays in pp collisions at s = 13 TeV with the ATLAS detector
No full textAbstract
A study of
B
c
+
→
J
/
ψ
D
s
+
and
B
c
+
→
J
/
ψ
D
s
∗
+
decays using 139 fb−1 of integrated luminosity collected with the ATLAS detector from
s
= 13 TeV pp collisions at the LHC is presented. The ratios of the branching fractions of the two decays to the branching fraction of the
B
c
+
→ J/ψπ+ decay are measured:
B
B
c
+
→
J
/
ψ
D
s
+
/
B
B
c
+
→
J
/
ψπ
+
= 2.76 ± 0.47 and
B
B
c
+
→
J
/
ψ
D
s
∗
+
/
B
B
c
+
→
J
/
ψπ
+
= 5.33 ± 0.96. The ratio of the branching fractions of the two decays is found to be
B
B
c
+
→
J
/
ψ
D
s
∗
+
/
B
B
c
+
→
J
/
ψ
D
s
∗
+
= 1.93 ± 0.26. For the
B
c
+
→
J
/
ψ
D
s
∗
+
decay, the transverse polarization fraction, Γ±±/Γ, is measured to be 0.70 ± 0.11. The reported uncertainties include both the statistical and systematic components added in quadrature. The precision of the measurements exceeds that in all previous studies of these decays. These results supersede those obtained in the earlier ATLAS study of the same decays with
s
= 7 and 8 TeV pp collision data. A comparison with available theoretical predictions for the measured quantities is presented
Measurement of the branching fraction
No full textThe B
0
s
→ J/ψK
0
S
branching fraction is measured in a data sample corresponding to 0.41 fb−1
of integrated luminosity collected with the LHCb detector at the LHC. This channel is sensitive to
the penguin contributions affecting the sin 2β measurement from B
0
→ J/ψK
0
S
. The time-integrated
branching fraction is measured to be B(B
0
s
→ J/ψK
0
S
) = (1.83±0.28)×10−5
. This is the most precise
measurement to date
- …
