172 research outputs found
Recensione a G. Comandè, Medical Law in Italy,Wolters Kluwer, 2014
No full textThe review analyses G. Comandè's work Medical Law in Italy focusing on the main issues analysed by the Author under a criminal law perspectiv
Müller Deutschland 1979-1989. L'istituzione Heiner Müller nella Repubblica Federale Tedesca attraverso l'esempio di Berlino Ovest
No full textObject of this essay is role of the GDR author and dramatist Heiner Müller in West Berlin between 1979 and 1989, contextualizing him in the specific and peculiar artistic and intellectual scenario of the so called "two hearted city"
Los apuntes autobiográficos de un morisco expulsado: algunas reflexiones sobre el prólogo del Ms. S2 de la Colección Gayangos de la Biblioteca de la Real Academia de la Historia de Madrid
No full textThis paper aims to study some details, concerning style and themes, that the anonymous Moorish author determined to provide in the prologue of the manuscript S2 of the Gayangos Collection of the Library of the Real Academia de la Historia in Madrid [ff. 2r-16v]. Particularly, the attention is focused on the autobiographical notes inserted in the prologue, important narrative sequences in which the author tells the tough conditions suffered as a crypto-Muslim in Seventeenth-century Spain.El presente trabajo procura realizar una observación sobre algunos detalles estilísticos y temáticos que el autor morisco anónimo determina brindar en la sección del prólogo del manuscrito S2 perteneciente a la Colección Gayangos de la Biblioteca de la Real Academia de la Historia de Madrid [ff. 2r-16v]. De manera particular, la atención se focaliza en los apuntes autobiográficos intercalados en el mismo prefacio, importantes secuencias narrativas en las que el autor relata la durísima condición que sufrió como criptomusulmán en la España del siglo XVII
Per un teatro che crede nella storia. Pier Paolo Pasolini nell'opera di Heiner Müller
No full textAim of this essay is to analyse the role of Pier Paolo Pasolini in the work and poetics of the GDR-author Heiner Müller. After an analysis of the reception of Pasolini’s works and persona in Germany and in the specific context of the GDR, the current work focuses on the influence of PPP in Müller’s approach to language, identity and history
The cobordism ring: the perspective of characteristic classes
No full textThis written work, by Benedetta Andina, discusses ``The cobordism ring: the prospective of characteristic classes''. After providing sufficient preliminaries to make this thesis accessible to any graduate student, it clearly highlights how both the oriented and unoriented cobordism rings can be studied using characteristic classes, which are usually easily computable. To demonstrate this relationship in the unoriented case (as presented by Pontrjagin and Thom), the author unveils an explicit structure of the unoriented cobordism ring. This structure provides a clear classification of smooth closed manifolds
Book review: Lobbying in the European Union: interest groups, lobbying coalitions, and policy change
No full text"Lobbying in the European Union: Interest Groups, Lobbying Coalitions, and Policy Change." Heike Klüver. Oxford University Press. February 2013. --- Why can some interest groups influence policy-making while others cannot? Even though this question is central to the study of politics, we know little about the factors explaining interest group influence. This book aims to shed light on the impact of interest groups on European policy-making, with author Heike Klüver developing a comprehensive theoretical model for understanding lobbying success. Reviewed by Benedetta Voltolini
Nota a Cass. pen., sez. IV, n. 11136, 4 febbraio 2015
No full textThe Italian Supreme Court Judgment commented by the Author dealt with a case, where the director of a nursing home had been convicted of manslaughter. More specifically, the director was accused of having failed to put in place a proper alarm system linked to the doors' opening, which would have allegedly been able to prevent one of the old guests to access the stairs and to fall down, dying. The comment provides the reader with the relevant references to scholars' opinions and case law, focusing on causation in omission and on issues arising when a legal duty to prevent a specific event lies on more than one person
«Que es gente que come arroz, / pasas, higos y alcuzcuz» : la construcción de la imagen esterotipada del morisco en nueve comedias de Lope de Vega
No full textNueve son las comedias de Lope de Vega en las que se puede considerar el morisco como figura activa de los enredos dramáticos. En ellas, el Fénix presenta al público un personaje que corresponde básicamente a una imagen deformada del sujeto real: el autor parece valerse, efectivamente, de los rasgos del distorsionado «monigote» concebido por algunos estratos del ambiente político-social de la época para ajustarlos a su propia lógica teatral y proporcionar una figura teatral en clave esencialmente cómica. Lope realizaría su propósito dramático a través del empleo de cuatro parámetros: la elección del nombre de origen árabe, el proceso de conversión al cristianismo, las referencias al consumo de vino y tocino y el uso de la jerga morisca. El presente trabajo se centra, por tanto, en la observación de los atributos estereotipados que constituyen la columna vertebral de cada figura examinada, y reflexiona asimismo acerca del significado del procedimiento cómico que el autor maneja sutilmente en todas las obras del corpus analizado.Nine are the plays by Lope de Vega in which the Moorish figure can be considered as an active dramatic character. In them, the Fénix presents to the audience a character which is basically a distorted image of the real social subject: the author seems to rely on the features of a disfigured «puppet», conceived by some levels of the socio-political environment of the time, in order to adjust the character to his own theatrical logic and present it from a comical perspective. Lope carries out his dramatic purpose through the use of four parameters: the choice of Arabic names, the process of conversion to Christianity, the references to drinking wine and eating pork and, finally, the use of the Moorish jargon. This paper focuses therefore on the observation of the stereotyped attributes that constitute the backbone of each of those figures, and reflects also about the meaning of the comical procedure that Lope manages in all the works of the analysed corpus
Development of PROTACs Targeting the Moonlighting Enzyme Nicotinamide Phosphoribosyltransferase (NAMPT) for Breast Cancer Therapy
No full text: PROTACs (proteolysis-targeting chimeras) enable selective protein degradation through the ubiquitin-proteasome system and offer opportunities to target moonlighting proteins with nonenzymatic functions. We report the design, synthesis, and biological evaluation of NAMPT-directed PROTACs derived from our previously described inhibitor MV78 (7). A modular click chemistry strategy facilitated rapid assembly of a focused library by varying linker architectures and E3 ligase recruiters, with emphasis on the impact of a triazole unit. Structure-activity relationship studies revealed that eliminating the triazole from the linker and introducing an (S)-methyl group on the VHL ligand markedly enhanced degradation. The optimized degrader, U42, exhibited low nanomolar antiproliferative activity, robust intracellular and extracellular NAMPT degradation, excellent metabolic stability, favorable pharmacokinetics, and sustained efficacy in mammosphere models, three-dimensional breast cancer cultures not previously explored with NAMPT degraders. These findings highlight U42 as a lead compound and provide strong rationale for advancing NAMPT-directed PROTACs as a therapeutic strategy in breast cancer
Inautenticità del sistema della responsabilità degli enti e giudizio di colpevolezza
No full textThe text is a translation into Italian of Professor Laufer's article titled Corporate Inauthenticity and the Finding of Fault, where the Author provides insight into the main issues arising from the current US legislation concerning corporate criminal liability and presents its Constructive Fault model for the ascertainment of organizational fault
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