1,829 research outputs found
Aye–ay: An Anglo-Frisian Parallel
No full textThe most widespread form for neutral “yes” in the Survey of English Dialects is not yea or yes, but aye. It is used not only in the North and Midlands, but also in areas of the South of England. It is a feature of Scottish English, and is familiar from government in many English-speaking countries. We also find the aye-like ayuh in Northeast America. “Aye” appears suddenly about 1575 and is “exceedingly common” around 1600; it is initially written I and its origin, like yes, is uncertain. Ay is also found in Old Frisian, as well as Sater Frisian today (öäi, a'äi etc.). This study reviews a number of proposed etymologies, examining which can account for the occurrence or development of ay(e) in both languages. Based on a wider study of change in forms of “yes” and “no” in English, the author argues that aye–ay is a parallel development of interjection + particle. The study also suggests functional and phonological overlap with the pronominal echo I in English, but not Frisian, with the vocalic form of the pronoun and diphthongisation in the “Great Vowel Shift”, accounting for the popularity and spelling I of “aye” around 1600.</jats:p
Fucoxanthin promotes translocation and induction of glucose transporter 4 in skeletal muscles of diabetic/obese KK-Ay mice
No full textFucoxanthin (Fx) isolated from Undaria pinnatifida suppresses the development of hyperglycemia and hyperinsulinemia of diabetic/obese KK-Ay mice after two weeks of feeding 0.2% Fx-containing diet. In the soleus muscle of KK-Ay mice that were fed Fx, glucose transporter 4 (GLUT4) translocation to plasma membranes from cytosol was promoted. On the other hand, Fx increased GLUT4 expression levels in the extensor digitorum longus (EDL) muscle, although GLUT4 translocation tended to increase. The expression levels of insulin receptor (IR) mRNA and phosphorylation of Akt, which are in upstream of the insulin signaling pathway regulating GLUT4 translocation, were also enhanced in the soleus and EDL muscles of the mice fed Fx. Furthermore, Fx induced peroxisome proliferator activated receptor γ coactivator-1α (PGC-1α), which has been reported to increase GLUT4 expression, in both soleus and EDL muscles. These results suggest that in diabetic/obese KK-Ay mice, Fx improves hyperglycemia by activating the insulin signaling pathway, including GLUT4 translocation, and inducing GLUT4 expression in the soleus and EDL muscles, respectively, of diabetic/obese KK-Ay mice
Fusogenicity and neutralization sensitivity of the SARS-CoV-2 Delta sublineage AY.4.2
No full textInternational audienceBackground: SARS-CoV-2 lineages are continuously evolving. As of December 2021, the AY.4.2 Delta sub-lineage represented 20 % of sequenced strains in the UK and had been detected in dozens of countries. It has since then been supplanted by Omicron. The AY.4.2 spike displays three additional mutations (T95I, Y145H and A222V) in the N-terminal domain when compared to the original Delta variant (B.1.617.2) and remains poorly characterized.Methods: We compared the Delta and the AY.4.2 spikes, by assessing their binding to antibodies and ACE2 and their fusogenicity. We studied the sensitivity of an authentic AY.4.2 viral isolate to neutralizing antibodies.Findings: The AY.4.2 spike exhibited similar binding to all the antibodies and sera tested, and similar fusogenicity and binding to ACE2 than the ancestral Delta spike. The AY.4.2 virus was slightly less sensitive than Delta to neutralization by a panel of monoclonal antibodies; noticeably, the anti-RBD Imdevimab showed incomplete neutralization. Sensitivity of AY.4.2 to sera from vaccinated individuals was reduced by 1.3 to 3-fold, when compared to Delta.Interpretation: Our results suggest that mutations in the NTD remotely impair the efficacy of anti-RBD antibodies. The spread of AY.4.2 was not due to major changes in spike fusogenicity or ACE2 binding, but more likely to a partially reduced neutralization sensitivity
Experimental method to quantify the efficiency of the first two operational stages of nanosecond dielectric barrier discharge plasma actuators
No full textA method to quantify the efficiency of the first two operational stages of a nanosecond dielectric barrier discharge (ns-DBD) plasma actuator is proposed. The method is based on the independent measurements of the energy of electrical pulses and the useful part of the energy which heats up the gas in the discharge region. Energy input is calculated via a back current shunt technique as the difference between the energy given and the energy reflected back. The ratio of the difference of the latter two quantities and the energy input gives the electrical efficiency (η E) of a ns-DBD. The extent of the energy deposited is estimated via Schlieren visualizations and infrared thermography measurements. Then, the ideal power flux obtained if all the inputted energy was converted into heat is calculated. Transient surface temperature was measured via infrared thermography and used to solve a 1D inverse heat transfer problem in a direction normal to the surface. It gives as output the actual power flux. The estimated ratio between the two power fluxes represents a quantification of the mechanical fluid efficiency (η FM) of a ns-DBD plasma actuator. Results show an inverse proportionality between η E, and η FM, and the thickness of the barrier. The efficiency of the first two operational stages of a ns-DBD is further defined as η = η E centerdot η FM
Tempo espagnol / le Capitol Symphony Orchestra dir. Carmen Dragon
No full textTitre uniforme : [Valencia]Titre uniforme : [La Cumparsita]Titre uniforme : [Le Cid. Acte 2. Ballet]. ExtraitTitre uniforme : [Jalousie]Titre uniforme : [La vida breve]. Extr. adapt.Titre uniforme : [Carmen (Suites. No 1 et 2)]. ExtraitComprend : LADY OF SPAIN / Evans - Jalousie / Gade - VALENCIA / José Padilla - Castillane du "Cid" / Jules Massenet - LA CUMPARSITA / Rodriguez - JESUSITA EN CHIHUAHUA : Air populaire - AY, AY, AY : air populaire - Danse Espagnol N ° 1 de "La vie brève" / Manuel de Falla - INTERMEZZO de la Suite N ° 1 de Carmen / Georges BizetBnF-Partenariats, Collection sonore - BelieveContient une table des matière
LATIN RHYTHMS / Kurt MAIER et ses rythmes
No full textTitre uniforme : [Carioca]Titre uniforme : [España. Op. 236]Titre uniforme : [Adios Muchachos]Titre uniforme : [Misirlou]Titre uniforme : [Ay, ay, ay]Titre uniforme : [La Violetera]Titre uniforme : [La Cumparsita]Titre uniforme : [Siboney]Titre uniforme : [Granada]Titre uniforme : [El Cumbanchero]Comprend : GRANADA / Agustin LARA - LA CUMPARSITA / RODRIGUEZ - LA CHANSON DU BONHEUR : du film "Les trois Caballeros" / A. LARA et GILBERT - QUIZAS, QUIZAS, QUIZAS / FARES - SI VOUS M'AIMIEZ AUTANT / FARES - AY, AY, AY / O. PEREZ et FREIRE - SIBONEY / LECUONA - ADIOS MUCHACHOS / SANDERS - EL CUBANCHERO / Raphael HERNANDEZ - TICO, TICO / ABREU - CARIOCA / Vincent YOUMANS - MAMA YO QUIERO UN NOVIO / COLAZO - ESPANA / WALDTEUFEL - SOUTH AMERICAN JOE / CAESAR et FRIEND - PLEGARIA / BIANCO - MISIRLOU / N. ROUBANIS - LA VIOLETERRA / PADILLA - MY SHAWL / Xavier CUGAT - FILLES D'ESPAGNE / EVANSBnF-Partenariats, Collection sonore - BelieveContient une table des matière
Population health and status of epidemiology: WHO European Region I
No full textBackground This article of the International Epidemiological Association commissioned paper series stocktakes the population health and status of epidemiology in 21 of the 53 countries of the WHO European Region. By United Nations geographical classification, these countries belong to Eastern Europe, Western Asia and South-Central Asia. Methods Published data were used to describe population health indicators and risk factors. Epidemiological training and research was assessed based on author knowledge, information searches and E-mail survey of experts. Bibliometric analyses determined epidemiological publication outputs. Results Between-country differences in life expectancy, amount and profile of disease burden and prevalence of risk factors are marked. Epidemiological training is affected by ongoing structural reforms of educational systems. Training is advanced in Israel and several Eastern European countries. Epidemiological research is mainly university-based in most countries, but predominantly conducted by governmental research institutes in several countries of the former Soviet Union. Funding is generally external and limited, partially due to competition from and prioritization of biomedical research. Multiple relevant professional societies exist, especially in Poland, the Czech Republic and Hungary. Few of the region's 39 epidemiological academic journals have international currency. The number of epidemiological publications per population is highest for Israel and lowest for South-Central Asian countries. Conclusions Epidemiological capacity will continue to be heterogeneous across the region and depend more on countries' individual historical, social, political and economic conditions and contexts than their epidemiologists' successive efforts. National and international research funding, and within- and between-country collaborations should be enhanced, especially for South-Central Asian countries
Sequence effects in categorization of simple perceptual stimuli
No full textCategorization research typically assumes that the cognitive system has access to a (more or less noisy) representation of the absolute magnitudes of the properties of stimuli and that this information is used in reaching a categorization decision. However, research on identification of simple perceptual stimuli suggests that people have very poor representations of absolute magnitude information and that judgments about absolute magnitude are strongly influenced by preceding material. The experiments presented here investigate such sequence effects in categorization tasks. Strong sequence effects were found. Classification of a borderline stimulus was more accurate when preceded by a distant member of the opposite category than by a distant member of the same category. It is argued that this category contrast effect cannot be accounted for by extant exemplar or decision-bound models of categorization. The effect suggests the use of relative magnitude information in categorization. A memory and contrast model illustrates how relative magnitude information may be used in categorization
14 JUILLET / EMILE DECOTTY et son orchestre Musette
No full textComprend : VALENCIA : One-step / PADILLA - FIESTA CATALANE : Paso-doble / E. DECOTTY - CREPE DE CHINE : Valse / A. HUARD - POT POURRI DE VALSES : "TIPITIN" / MARIA GREVER - FANDANGO DU PAYS BASQUE / F. LOPEZ - VALSE DES ORGUEILLEUX / P. MISRAKI - AY ! AY ! AY ! / FREIMAN, FREIRE - CUMPARSITA : Tango / RODRIGUEZ - LEON : Tango / GAZE - ANDALUCIA : Boléro / LECUONA - LA FETE DU TABAC : Baiao / DENONCIN - LA MUSIQUE A PAPA : Guaracha / JIMENEZ - LES DOUANIERS DU CLAIR DE LUNE : Marche / FRAGNA - POT POURRI DE MARCHES : "LES CASQUETTES" / Folklore - AUPRES DE MA BLONDE / CHAUMETTE - LES FRAISES ET LES FRAMBOISES / G. MATHIS - P'TIT QUINQUIN / DESROUSSEAUX - MONT'LA D'SSUS / BOREL-CLERCBnF-Partenariats, Collection sonore - BelieveContient une table des matière
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