418 research outputs found
Can we simply infer mitochondrial function from PCr resynthesis after exercise in skeletal muscle?
No full textRatel, Sebastien Martin, Vincent Tonson, Anne Cozzone, Patrick J Bendahan, David Comment Letter United States Pediatric research Pediatr Res. 2012 Aug;72(2):221. doi: 10.1038/pr.2012.67
Skeletal muscle mitochondrial function cannot be properly inferred from PCr resynthesis without taking pH changes into account
No full textRatel, Sebastien Martin, Vincent Tonson, Anne Cozzone, Patrick J Bendahan, David Comment Letter Netherlands Magnetic resonance imaging Magn Reson Imaging. 2012 Dec;30(10):1542-3. doi: 10.1016/j.mri.2012.06.017. Epub 2012 Aug 13
Sebastien Rale vs. New England: A Case Study of Frontier Conflict
No full textAuthor\u27s original abstract: A study was made of the Jesuit missionary, Sebastien Rale, and his role in New England-New France relations. French and English primary and secondary materials were examined to give the broadest possible view of the man and to place him in historical context.
It was found that Sebastien Rale was not an agent of New France. The conflicting opinions surrounding the mission of Norridgewock and the border war of the 1720\u27s were traced to the problems of Massachusetts-Abnaki relations. Rale\u27s frequent and testy letters to the government of the Bay Colony were blunt reactions to what he viewed as religious and territorial threats against his mission.
The frontier conflict between 1713 and 1722 was not the result of French Imperial policy. The French insisted that the Abnakis were allies but refused active participation in the Indians\u27 quarrel with New England. Policy was developed in Maine by the Jesuits. The missionaries were only secondarily interested in Quebec\u27s desire to prevent Massachusetts\u27 settlement of the Kennebec. With the declaration of war in July, 1722, however, the Jesuits left the Abnakis in the hands of the governor and the intendant of New France on whom the Indians relied for vital war supplies.
Finally, the controversial attack on Norridgewock was appraised. It was found that no secondary account had fully evaluated the sources. Examination led to the discovery of crucial inconsistencies in the primary accounts of New England. The French sources were found to be based on the understandably confused impressions of the fleeing Indians. In large measure the English sources present the more valid picture: the sudden attack, the panicked confusion, and Sebastien Rale dying with gun in hand. After Rale\u27s death the war drew to a close. Without Sebastien Rale\u27s persuasion and determination, the Abnakis were not able to present a united front against colonial expansion
Steve J. Chavez recital thesis 2012
No full textThesis (M.M.)
California State University, Los Angeles, 2012Committee members: Sebastien Vallee, Jeffrey Benedict, John KennedyThe musical selections from this Master recital were not chosen with a specific theme in mind, rather each selection was carefully selected to represent the requisite musical styles stemming from the 18th to 20th century.All the literature was selected based on the requirements of the music department representing the technical skill level worthy of a graduate student from the institution of California State University, Los Angeles. This written project is the presentation of historical and musical research gathered by this author in preparation for this recital. The selections of Bach, Handel, Beethoven, Schubert, Faure, Menotti, Hoiby, and Barber are discussed in turn
Considerations sur l'ordre de Cincinnatus, [electronic resource] : ou imitation d'un pamphlet anglo-americain. Par le comte de Mirabeau. Suivies de plusieurs pieces relatives a cette institution; ... d'un pamphlet du Docteur Price, intitule: Observations on the importance of the American Revolution, ...
No full textSebastien Roch Nicholas Chamfort is given as joint author by Querard and Barbier.A reissue of the 1784 Londres edition, with a different title-page.Sig. H1 is a cancel - The 'Avis' is dated: Londres, 20 septembre, 1784.Printer's name from colophon.Electronic reproduction.English Short Title Catalog,Reproduction of original from British Library
Limit Theorem for a Modified Leland Hedging Strategy under Constant Transaction Costs rate
No full textWe study the Leland model for hedging portfolios in the presence of a constant proportional transaction costs coefficient. The modified Leland's strategy recently defined by the second author, contrarily to the classical one, ensures the asymptotic replication of a large class of payoff. In this setting, we prove a limit theorem for the deviation between the real portfolio and the payoff. As Pergamenshchikov did in the framework of the usual Leland's strategy, we identify the rate of convergence and the associated limit distribution. This rate turns out to be improved using the modified strategy and non periodic revision dates.Asymptotic hedging ; Leland-Lott strategy ; Transaction costs ; Martingale limit theorem.
Going Serverless with Knative on Kubernetes
No full textAbstract:
After reviewing some of the latest evolutions in Kubernetes we will discuss the serverless computing paradigm and highlight a few application use-cases. We will then introduce Knative, a system built on top of Kubernetes which provides components to build and serve applications as well as manage events. Through quick demos will demonstrate several key capabilities like scaling to zero and also highlight future directions with service mesh technologies.
Bio:
Sebastien is the co-founder of TriggerMesh (https://triggermesh.com) a serverless management platform built on Knative. He is the author of the Docker and Kubernetes O'Reilly cookbooks and was the CMS Tier-2 site lead at Purdue University more than 10 years ago
Determining the Muscle Voluntary Activation Characteristics in Children: A Methodological Challenge. Commentary on “Child-Adult Differences in Muscle Activation-A Review”
No full textInternational audienceIn a previously published review article, Dotan et al (10), proposed the hypothesis of a differential motor-unit (MU) activation in children to account for many observed child– adult differences (ie, maximal strength, rate of force development, fatigue resistance, metabolic profile, and responses to training). Specifically, these authors pointed to Type II MU utilization as " being the compromised portion of children's muscle function. " This review was previously commented on by Bassa et al (3) and O'Brien et al (25). In this comment, we propose to contribute to the ongoing debate on this topic. In particular, we will approach the question of MU recruitment from a method-ological point of view to sum up our current knowledge and to identify the methodological steps that must be done to move forward on this topic. Trying to infer MU utilization and recruitment from noninvasive investigation methods in children is challenging. Indeed, owing to obvious ethical considerations, the methodological approaches available to study MU recruitment and utilization noninvasively in children offer limited insights. Until now, the pediatric exercise physiologists have mainly used (1) the rate of force development, (2) surface electromyography (EMG), and (3) the twitch interpolation technique. (1) Some authors have focused on the time course of explosive maximal voluntary contractions to compare MU recruitment in children and adults. Specifically , these studies have examined the rate of rise in contractile force at the onset of contraction, ie, the rate of force development (RFD) exerted within the early phase of rising muscle force (30–200 ms). Among the physiological factors that can affect RFD are muscle fiber type and myosin heavy chain composition (16), muscle cross-sectional area (2), maximal muscle strength (26), viscoelastic properties of the muscle–tendon complex (6,33), and neural drive to the muscle (1,12). If the confounding effects of muscle cross-sectional area and muscle strength can be discarded using appropriate normalization procedures , the relative contributions of viscoelastic and neural properties to the differences in RFD between children and adults are difficult to determine. Nevertheless , Waugh et al (32) recently demonstrated that tendon stiffness and the rate of EMG increase (ie, muscle activation rate) accounted for 35% and 30% of the variability of RFD in children, respectively. The relative contributions of tendon stiffness and rate of EMG increase may nonetheless vary during the course of force rise. Indeed, the influence of muscle activation rate appeared more important than tendon stiffness in the early stages of development of force in children, whereas the opposite was true for adults (32). This is consistent with the recent suggestions of Dotan et al (9). Nevertheless, Waugh et al (32) also demonstrated that when tendon stiffness and rate of EMG increase were combined, they explained only 58% of RFD variability, suggesting that other (unknown) factors are involved. Thus, RFD cannot accurately and fully reflect the extent of MU utilization and recruitment. (2) The use of surface EMG to account for muscle activation is also debatable. Surface EMG quantifies muscle activity but does not determine the proportion of MU unrecruited or driven submaximally by the central nervous system (ie, muscle inactivation). As mentioned earlier, the ability of prepubertal children to maximally drive their MU is debated (3,5,10,20,25). If it holds true that children are not able to maximally recruit their MU, and especially the fastest (ie, Type II MU), peak EMG measured during voluntary contractions may represent a lower proportion of the maximal activation in children than in adults. In turn, this would bias the normalization of EMG activity used to determine the rate of muscle activation during explosive actions. Specifically, this could lead to an overestimation of the MU recruitment in Official Journal of NASPEM and the European Group of PWP www.PES-Journal.com COMMENTAR
GALDIERO is CO-FIRST AUTHOR. Phagocytes as Corrupted Policemen in Cancer-Related Inflammation
No full textInflammation is a key component of the tumor microenvironment. Tumor-associated macrophages (TAMs) and tumor-associated neutrophils (TANs) are prototypic inflammatory cells in cancer-related inflammation. Macrophages provide a first line of resistance against infectious agents but in the ecological niche of cancer behave as corrupted policemen. TAMs promote tumor growth and metastasis by direct interactions with cancer cells, including cancer stem cells, as well as by promoting angiogenesis and tissue remodeling and suppressing effective adaptive immunity. In addition, the efficacy of chemotherapy, radiotherapy, and checkpoint blockade inhibitors is profoundly affected by regulation of TAMs. In particular, TAMs can protect and rescue tumor cells from cytotoxic therapy by orchestrating a misguided tissue repair response. Following extensive preclinical studies, there is now proof of concept that targeting tumor-promoting macrophages by diverse strategies (e.g., Trabectedin, anti-colony-stimulating factor-1 receptor antibodies) can result in antitumor activity in human cancer and further studies are ongoing. Neutrophils have long been overlooked as a minor component of the tumor microenvironment, but there is evidence for an important role of TANs in tumor progression. Targeting phagocytes (TAMs and TANs) as corrupted policemen in cancer may pave the way to innovative therapeutic strategies complementing cytoreductive therapies and immunotherapy
Corrigendum to “Reliability assessment of generic geared wind turbines by GTST-MLD model and Monte Carlo simulation” (Renewable Energy (2015) 83 (222–233), (S0960148115003158), (10.1016/j.renene.2015.04.035))
No full textThe authors regret that the Order of Authors in this article published in November 2015 is incorrect. Thus, the objective of this Corrigendum is to re-establish the originally agreed Order of Authors, as described below. Order of Authors from published Article: Yan-Fu Li, PhD; Sebastien Valla; Enrico Zio, PhD. Corrected Order of Authors to implement with this Corrigendum: Sebastien Valla, Yan-Fu Li, PhD; Enrico Zio, PhD. The Corresponding author to contact for these changes are the Primary Author, Sebastien Valla (email below). The authors would like to apologise for any inconvenience caused
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