66,584 research outputs found

    Small sample multiple testing with application to cDNA microarray data

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    Many tests have been developed for comparing means in a two-sample scenario. Microarray experiments lead to thousands of such comparisons in a single study. Several multiple testing procedures are available to control experiment-wise error or the false discovery rate. In this dissertation, individual two-sample tests are compared based on accuracy, correctness, and power. Four multiple testing procedures are compared via simulation, based on data from the lab of Dr. Rajesh Miranda. The effect of sample size on power is also carefully examined. The two sample t-test followed by the Benjamini and Hochberg (1995) false discovery rate controlling procedure result in the highest power

    Erratum to: Effect of moderate red wine intake on cardiac prognosis after recent acute myocardial infarction of subjects with Type 2 diabetes mellitus (Diabetic Medicine, (2006), 23, 9, (974-981), 10.1111/j.1464-5491.2006.01886.x)

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    In an article by Marfella et al, the author name C. Saron is incorrect and should be listed as C. Sardu. Therefore the correct author list is: R. Marfella, F. Cacciapuoti, M. Siniscalchi, F. C. Sasso, F. Marchese, F. Cinone, E. Musacchio, M. A. Marfella, L. Ruggiero, G. Chiorazzo, D. Liberti, G. Chiorazzo, G. F. Nicoletti, C. Sardu, F. D'Andrea, C. Ammendola, M. Verza and L. Coppola.In an article by Marfella et al, the author name C. Saron is incorrect and should be listed as C. Sardu. Therefore the correct author list is: R. Marfella, F. Cacciapuoti, M. Siniscalchi, F. C. Sasso, F. Marchese, F. Cinone, E. Musacchio, M. A. Marfella, L. Ruggiero, G. Chiorazzo, D. Liberti, G. Chiorazzo, G. F. Nicoletti, C. Sardu, F. D'Andrea, C. Ammendola, M. Verza and L. Coppola

    FIGURE 17. Microplitis similis Lyle, A in Taxonomic studies on Oriental Microplitis Foerster (Hymenoptera: Braconidae, Microgastrinae) with description of two new species from South India

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    FIGURE 17. Microplitis similis Lyle, A) Habitus, dorsal view, male, cotype; B) Metasoma, dorsal view, specimen from Indonesia; C) Head & mesosoma (in part), dorsal view, specimen from Indonesia; D) Propodeum & tergite 1, dorsal view, specimen from Indonesia; E) Mesosoma (in part), medio & latero tergite 1, specimen from Indonesia; F) Fore wing, specimen from Indonesia.Published as part of Ranjith, A. P., Rajesh, K. M. & Nasser, M., 2015, Taxonomic studies on Oriental Microplitis Foerster (Hymenoptera: Braconidae, Microgastrinae) with description of two new species from South India, pp. 369-415 in Zootaxa 3963 (3) on page 405, DOI: 10.11646/zootaxa.3963.3.4, http://zenodo.org/record/23526

    Assessing the Vasculature Changes in Murine Fetal Brain Upon Alcohol Exposure

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    Fetal Alcohol spectrum disorder (FASD) refers to a broad spectrum of abnormalities that arise due to prenatal alcohol exposure (PAE). The severity of the abnormality depends on the amount of alcohol consumed and period of consumption during gestation. A large number of women continue to consume alcohol even during the second trimester of pregnancy, a critical period for fetal neurogenesis and angiogenesis. OCT is an optical analog of ultrasound. 3D non-invasive imaging technique with high spatial resolution. OCT has shown to be extremely useful in embryonic imaging. Speckle variance OCT (SVOCT), is a functional extension of OCT that has been used to study vasculature development in embryos. We use SVOCT, to detect vasculature changes in the embryonic brain in utero, minutes after maternal alcohol consumption. The results show that there is a decrease in fetal vessel diameter within the first 10 minutes and it persisted for 45 minutes after maternal alcohol consumption, indicating that ethanol is a possible vasoconstrictor on the fetal brain. This project was completed with contributions from Rajesh C. Miranda from the Neuroscience and Experimental Therapeutics, Texas A&M Health Science Center.Biomedical Engineering, Department ofHonors Colleg

    Evaluating changes in murine fetal brain vasculature due to maternal nicotine exposure using in utero optical coherence tomography

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    Nicotine is a commonly used substance of abuse during pregnancy. Previous research has shown that prenatal nicotine exposure (PNE) is harmful to a fetus. PNE is known to cause intrauterine and postnatal growth restriction, decrease in head circumference and biparietal diameter, and perinatal mortality and morbidity. Evidence of negative influences of nicotine on brain development has been seen in humans too. It is unknown whether the relationship between maternal smoking and behavior problems is due to physical brain deficits caused by nicotine. In this study, we use optical coherence tomography (OCT), a noninvasive optical imaging modality with high spatial and temporal resolution to image the changes in fetal brain vasculature caused due to maternal nicotine exposure. We use a functional extension of OCT called correlation mapping optical coherence angiography (cm-OCA) to image microvasculature in the fetal brain, in utero. Pregnant mice at 14.5 days post coitum were anesthetized and placed on a heated surgical platform. Abdominal fur was removed, and a small incision was made to expose the uterine horn for imaging. After initial cm-OCA measurements, the mother was administered nicotine via intragastric gavage, at a dose of 1mg/kg. Subsequent measurements were taken for a period of 45 minutes at 5-minute intervals. A drastic decrease in parameters quantifying vasculature was seen within 45 minutes of maternal nicotine exposure during the second trimester equivalent period. This project was completed with contributions from Rajesh C. Miranda from Texas A & M University College of Medicine.Health and Human Performance, Department ofHonors Colleg

    Figure 3 in A new species of the enigmatic genus Chiromachetes Pocock, 1899 (Scorpiones: Hormuridae) from Western Ghats, India, with a key to the genus

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    Figure 3: Chiromachetes sahyadriensis sp. nov. holotype male NCBS AG-873. (A) chelicerae; (B) lateral eyes; (C), dentition on movable finger, (D) tarsi IV.Published as part of Mirza, Zeeshan A., Sanap, Rajesh V. & Zambre, Amod M., 2015, A new species of the enigmatic genus Chiromachetes Pocock, 1899 (Scorpiones: Hormuridae) from Western Ghats, India, with a key to the genus, pp. 1-10 in Euscorpius 212 on page 5, DOI: 10.18590/euscorpius.2015.vol2015.iss212.1, http://zenodo.org/record/550810

    Chiloscyphus chinnarensis Manju, K. P. Rajesh et Madhus., Acta Bot. Hung.

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    Chiloscyphus chinnarensis Manju, K.P.Rajesh et Madhus., Acta Bot. Hung. 53 (1–2): 152, 2011 (see Manju et al. 2011). TYPE: “ India, Kerala, Idukki district, Chinnar Wildlife Sanctuary, Kariveppin shola, alt.: 1,850 m, on trunk of trees. Coll.: Manju, C. N. and Rajesh, K. P. (87425c), 19 January 2003. Holotype: CALI, isotypes: CALI, EGR ”.Published as part of Söderström, Lars, Hagborg, Anders & Konrat, Matt Von, 2014, Early Land Plants Today: Index of Liverworts & Hornworts 2011 - 2012, pp. 61-85 in Phytotaxa 170 (2) on page 64, DOI: 10.11646/phytotaxa.170.2.1, http://zenodo.org/record/477961

    Figure 8 in A new species of the enigmatic genus Chiromachetes Pocock, 1899 (Scorpiones: Hormuridae) from Western Ghats, India, with a key to the genus

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    Figure 8: Map showing type locality of the new scorpion species. (A) Distribution of the genus Chiromachetes in peninsular India: black, C. sahyadriensis; red, C. tirupati; yellow, C. fergusoni; (B) The type locality of C. sahyadriensis near Mulshi Dam (black circle).Published as part of Mirza, Zeeshan A., Sanap, Rajesh V. & Zambre, Amod M., 2015, A new species of the enigmatic genus Chiromachetes Pocock, 1899 (Scorpiones: Hormuridae) from Western Ghats, India, with a key to the genus, pp. 1-10 in Euscorpius 212 on page 9, DOI: 10.18590/euscorpius.2015.vol2015.iss212.1, http://zenodo.org/record/550810

    Measurement of the ratio of prompt χ c to J / ψ production in pp collisions at √s = 7 TeV

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    The prompt production of charmonium χ c and J / ψ states is studied in proton-proton collisions at a centre-of-mass energy of √s = 7 TeV at the Large Hadron Collider. The χ c and J / ψ mesons are identified through their decays χ c → J / ψ γ and J / ψ → μ + μ - using 36 pb - 1 of data collected by the LHCb detector in 2010. The ratio of the prompt production cross-sections for χ c and J / ψ, σ (χ c → J / ψ γ) / σ (J / ψ), is determined as a function of the J / ψ transverse momentum in the range 2 < p T J / ψ < 15 GeV / c. The results are in excellent agreement with next-to-leading order non-relativistic expectations and show a significant discrepancy compared with the colour singlet model prediction at leading order, especially in the low p T J / ψ region

    Faust : Romance Of The Secret Tribunals / By George W. M. Reynolds, Author Of "The Mysteries Of London", "Pickwick Abroad", &c. Illustrated In The First Style Of The Art

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    FAUST : ROMANCE OF THE SECRET TRIBUNALS / BY GEORGE W. M. REYNOLDS, AUTHOR OF "THE MYSTERIES OF LONDON", "PICKWICK ABROAD", &C. ILLUSTRATED IN THE FIRST STYLE OF THE ART Faust : Romance Of The Secret Tribunals / By George W. M. Reynolds, Author Of "The Mysteries Of London", "Pickwick Abroad", &c. Illustrated In The First Style Of The Art (1) Cover (1) Umschlagtitel (8) Titelseite (9) Contents (10) Illustrations / Prologue (11) Prologue (12) Chapter I.-XCV. (14) Epilogue (119
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