70 research outputs found
Maktabat Al Muthanna Baghdad Feb-May 1962
No full textOn the same date, Ali Al-Mansouri issued an official financial statement confirming that the Al-Khanji Foundation owed a total of 11.375.أصدر علي المنصوري بيانًا ماليًا رسميًا بتاريخ 25 نيسان 1962 يُفيد بأن مؤسسة الخانجي مدينة بمبلغ إجمالي قدره 11,375
Legal documents
No full textA document includes the terms for printing the book 'Tārīkh Baghdād' by its author, Al-Hafiz Abu Bakr Al-Khatib Al-Baghdadi, in 1931. This was between Muhammad Amin Al-Khanji Al-Kutbi on behalf of Al-Khanji Library in Cairo, and Muhammad Effendi Ismail on behalf of Al-Saada Printing House as the first party, and the second party: Nauman Effendi Al-A'zami Al-Kutbi on behalf of the Arab Library in Baghdad.وثيقة تتضمن شروط طباعة كتاب 'تاريخ بغداد' لمؤلفه الحافظ أبو بكر الخطيب البغدادي سنة 1931م. وكان ذلك بين محمد أمين الخانجي الكتبي عن مكتبة الخانجي بالقاهرة، ومحمد أفندي إسماعيل عن دار السعادة للطباعة كطرف أول، والطرف الثاني: نعمان أفندي الأعظمي الكتبي عن المكتبة العربية ببغداد.وثيقة تتضمن شروط طباعة كتاب 'تاريخ بغداد' لمؤلفه الحافظ أبو بكر الخطيب البغدادي سنة 1931م. وكان ذلك بين محمد أمين الخانجي الكتبي عن مكتبة الخانجي بالقاهرة، ومحمد أفندي إسماعيل عن دار السعادة للطباعة كطرف أول، والطرف الثاني: نعمان أفندي الأعظمي الكتبي عن المكتبة العربية ببغداد
Cardiovascular magnetic resonance imaging volume criteria for arrhythmogenic right ventricular cardiomyopathy: need for update?
No full textThis is a pre-copyedited, author-produced version of an article accepted for publication in European Heart Journal, following peer review. The version of record: Mohammed Y Khanji, Anwar A Chahal, Luis R Lopes, Steffen E Petersen, Cardiovascular magnetic resonance imaging volume criteria for arrhythmogenic right ventricular cardiomyopathy: need for update?, European Heart Journal, ehz965, https://doi.org/10.1093/eurheartj/ehz965 is available online at: https://doi.org/10.1093/eurheartj/ehz965
Legal documents
No full textThe document includes the remaining conditions for printing the book 'Tārīkh Baghdād' by its author, Al-Hafiz Abu Bakr Al-Khatib Al-Baghdadi, in 1931.وتتضمن الوثيقة الشروط المتبقية لطباعة كتاب 'تاريخ بغداد' لمؤلفه الحافظ أبو بكر الخطيب البغدادي سنة 1931م
Legal documents
No full textThis document includes the remaining statement under three titles, and under each title the author and a summary of the book, which are as follows: 'Ḥilyat al-awliyāʼ wa-ṭabaqāt al-aṣfiyāʼ', 'al-Bidāyah wa-al-nihāyah', and 'al-Iḥkām fī uṣūl al-aḥkām'تتضمن هذه الوثيقة البيان المتبقي تحت ثلاثة عناوين، وتحت كل عنوان اسم المؤلف وملخص الكتاب، وهي كما يلي: 'حلية الأولياء وطبقات الأصحاء'، و'البداية والنهاية'، و'الإحكام في أصول الأحكام'
Abstract 3291: Development of a novel prognostic scoring system for patient selection in immune checkpoint inhibitor phase 1 clinical trials
No full textAbstract
Purpose: To develop a prognostic scoring system for selecting patients for immune checkpoint inhibitor (ICI) phase 1 clinical trials.
Background: The Royal Marsden Hospital (RMH) and MD Anderson (MDA) prognostic scoring systems have been validated for patients in phase 1 clinical trials treated with cytotoxic chemotherapy and targeted therapy, but no such scoring system has been validated to help select patients entering ICI clinical trials.
Methods: We analyzed clinical data from patients treated in phase 1 ICI clinical trials (with anti-CTLA4 and anti-PD1 antibody therapy) at the MD Anderson Center for Targeted Therapy. Sixteen clinical factors were studied. Recursive partitioning analysis identified cut-points for each clinical factor and a Cox proportional hazards regression model was used to identify factors independently affecting overall survival.
Results: Among 172 patients treated with ICI therapy (105 CTLA4-based and 67 PD1-based) between January 2013 and November 2015, the median age was 60 years (range: 19-86 years) and 87 (51%) were male. The most common tumor types treated included renal cell carcinoma (n = 25; 15%), non-small cell lung cancer (n = 21; 12%), melanoma (n = 17; 10%), sarcoma (n = 14; 8%), gastrointestinal stromal tumors (n = 10; 6%), prostate cancer (n = 6; 3%), and colorectal cancer (n = 6; 3%). Seven factors were independently associated with significantly worse overall survival: age >52 years (hazard ratio [HR] 1.59, 95% confidence interval [CI] 1.1-2.4), Eastern Cooperative Oncology Group performance status >1 (HR 2.81, 95% CI 1.3-6.3), lactate dehydrogenase >466 U/L (HR 2.1, 95% CI 1.4-3.2), platelet count >300 × 109/L (HR 1.8, 95% CI 1.2-2.8), absolute neutrophil count >4.9 × 109/L (HR 2.3, 95% CI 1.5-3.5), absolute lymphocyte count <1.8 × 109/L (HR 3.3, 95% CI 1.9-5.7), and liver metastases (HR 1.8, 95% CI 1.2-2.6). An index was created whereby the cohort was divided into four risk groups based on the number of factors present: 0-2, 3, 4, or 5-6. Median overall survival was 24.2 months (0-2), 11.6 months (3), 8.0 months (4), and 3.8 months (5-6); log rank test, p < 0.0001. The Harrell c-index of this scoring system was 0.72, indicating significant predictability.
Conclusion: We have developed a novel “MDA ICI” prognostic scoring system incorporating seven clinical parameters with prognostic significance for patients in phase 1 clinical trials treated with immune checkpoint inhibitors. Unlike in the RMH and MDA prognostic scoring systems, albumin level and number of metastatic sites did not independently correlate with overall survival. Prospective evaluation and external validation of our novel prognostic scoring system is warranted and may help better select patients for future clinical trials of checkpoint inhibitors.
Citation Format: Shiraj Sen, Kenneth Hess, David Hong, Aung Naing, Sarina Piha-Paul, Filip Janku, Siqing Fu, Holly Liu, Yunfang Jiang, Rahil Khanji, Daniel Karp, Apostolia Tsimberidou, Nizar Tannir, Funda Meric-Bernstam, Vivek Subbiah. Development of a novel prognostic scoring system for patient selection in immune checkpoint inhibitor phase 1 clinical trials [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2017; 2017 Apr 1-5; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2017;77(13 Suppl):Abstract nr 3291. doi:10.1158/1538-7445.AM2017-3291</jats:p
Maktabat Al Muthanna Correspondence 1948
No full textTelegram from Qasim Al-Rajab to Naguib, reporting a 50-pound folded bag to be registered, raising concern over a lawsuit by al-Rasafi’s author due to delays, and lamenting dependence on Naguib for timely work. He stresses prioritizing quality over cost, notes upcoming summer travel risking loss of an important client, and voices frustration with publication and notebook delays. He inquires about better coordination and requests a collection of books to restore their professional relationship.برقية من قاسم الرجب إلى نجيب يُبلغ فيها عن كيس مطوي يحتوي على ٥٠ جنيهاً يجب تسجيله، ويُعرب عن قلقه من دعوى قضائية محتملة من مؤلف كتاب الرصافي بسبب التأخيرات، كما يأسف لاعتماده على نجيب في إنجاز الأعمال في الوقت المناسب. يشدد على ضرورة إعطاء الأولوية للجودة على حساب الكلفة، ويشير إلى رحلته الصيفية القادمة التي قد تؤدي إلى خسارة عميل مهم، ويعبر عن استيائه من التأخير في النشرات والدفاتر. كما يستفسر عن تنسيق الجهود لتحسين الإدارة ويطلب مجموعة من الكتب لإصلاح العلاقة المهنية بينهما
Maktabat Al Muthanna Baghdad Feb-May 1962
No full textThe author writes to his uncle, Najeeb Al-Khanji, in Cairo, expressing heartfelt gratitude for his kind hospitality during his recent stay. He informs him of his safe arrival in Baghdad and underscores the importance of preparing and dispatching the books requested by the University of Khartoum. Special emphasis is placed on receiving timely updates regarding the Anglo publications and a critical text on geopolitics. The letter also mentions additional desirable titles, including Al-Wajdi’s commentary, and concludes with warm greetings extended to Uncle Najeeb’s family.يخاطب المؤلف عمه نجيب الخانجي في القاهرة معبرًا عن خالص شكره على حسن ضيافته خلال فترة إقامته هناك، ويخبره بوصوله سالمًا إلى بغداد. كما يشدد على ضرورة إعداد وشحن الكتب التي طلبتها جامعة الخرطوم، مع التأكيد على أهمية الحصول على تحديثات دقيقة حول هذه الشحنات، خاصة ما يتعلق بكتب الأنجلو ونص مهم جدًا في الجغرافيا السياسية. ويذكر المؤلف أيضًا عناوين إضافية مرغوبة، منها شرح الوجدي، ويختتم رسالته بإرسال أطيب التحيات إلى أسرة العم نجيب
Measurement of the inclusive φ cross-section in pp collisions at √s=7 TeV
No full textThe cross-section for inclusive φ meson production in pp collisions at a centre-of-mass energy of √s = 7 TeV has been measured with the LHCb detector at the Large Hadron Collider. The differential cross-section is measured as a function of the φ transverse momentum pT and rapidity y in the region 0.6< pT <5.0 GeV/c and 2.44< y <4.06. The cross-section for inclusive φ production in this kinematic range is σ(pp→φX)=1758±19(stat) +43−14(syst)±182(scale) μb, where the first systematic uncertainty depends on the pT and y region and the second is related to the overall scale. Predictions based on the Pythia 6.4 generator underestimate the cross-section
Observation of J/ψ-pair production in pp collisions at √s=7 TeV
No full textThe production of J/ψ pairs in proton–proton collisions at a centre-of-mass energy of 7 TeV has been observed using an integrated luminosity of 37.5 pb−1 collected with the LHCb detector. The production cross-section for pairs with both J/ψ in the rapidity range 2 < yJ/ψ < 4.5 and transverse momentum pJ/ψ T <10 GeV/c is σJ/ψJ/ψ =5.1±1.0±1.1 nb, where the first uncertainty is statistical and the second systematic
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