118,888 research outputs found
On Creation, Cave Art and Perception : a Doxological Approach
No full textPresenting doxology as a post-phenomenological way of approaching epistemic and perceptual questions, this article draws on the problematic of "cave art" and contemporary cognitive science. Perception and cognition are not reflections of objective reality; they are forms of creative productivity, specific for man and depending on both biological and sociocultural factors. Departing from some of the main ideas of E. Cassirer, L. Fleck, P. Bourdieu and J. Derrida, the author shows the complexities of the interweaving of biological and social factors in the perception process. Analyzing the first attempts at understanding paleolithic mural cave art, the author tries to answer the question of how man creates new knowledge needed for living in our human world (see also [Rosengren 2012, 63-72]). A central tenet is that human knowledge has never been and will never be epistemic (in the Platonic sense), since man does not have direct unmediated access to reality itself. Defending this idea, the author gives a doxological interpretation of Protagoras' homo-mensura thesis (see also: [Rosengren 2014, 171-178]) and, in fact, speaks of the need to abandon the principles of traditional and, as it were, metaphysical theory of knowledge. Instead, he proposes to take a doxic point of departure and proceed from the observed situatedness and the variability of our knowledge.</p
Targeting the GH/IGF-1 axis with novel, small molecule inhibitors
No full textThe growth hormone (GH) / insulin-like growth factor (IGF) family of ligands, binding proteins and receptors play multiple roles in cell growth, metabolism and development. In addition, numerous studies have demonstrated the pathophysiological importance of the GH/IGF-1 axis. In particular, the impact of IGF-1 receptor (IGF-1R) in cancer has attracted increasing attention during the last decade. Several classes of pharmacological agents that inhibit GH/IGF-1 signaling at different levels have shown anticancer activity both in vitro and in vivo. GH receptor (GHR) antagonists have proven the most effective and safe way to pharmacologically treat overproduction of GH (acromegaly) and antibodies against the IGF-1R cause massive apoptosis in vitro and tumor regression in animal models. However, there is a need to develop low molecular weight compounds targeting the GH/IGF-1 axis which can be administered perorally and have increased bioavailability compared to protein drugs. In paper I, we present a new mRNA quantification method which was used to test a number of low molecular weight compounds for their ability to reduce GH-induced IGF-1 mRNA in primary hepatocytes. One such potential GHR antagonist, BVT-A, was selected, and in paper II its attenuating effect on several markers for GH/IGF-1 overactivity was verified in an animal model of acromegaly. Picropodophyllin (PPP) was discovered some years ago as an effective inhibitor of IGF-1R signaling in cell lines and tumor repressor in vivo. The mechanism by which PPP caused this effect has not been fully delineated. In paper III, we show that IGF-1R knockout cells at late passages can acquire IGF-1R expression and dependency and therefore become sensitive to PPP treatment. Paper IV describes the inhibitory effect of PPP on IGF-1 induced vascular endothelial growth factor (VEGF) production as well as on neovascularization of the choroid in a model of macular degeneration, the most common cause of blindness. In paper V we show that PPP induces downregulation of the IGF-1R. This effect is important since it is known that downregulation, not only deactivation of the receptor is necessary for induction of massive apoptosis. Finally, in paper VI we show that PPP recruits the E3 ligase Mdm2 and â-Arrestin1 to the IGF-1R. This action was found to be involved in receptor downregulation and inhibition of AKT signaling and suggests that PPP acts as a â-Arrestin1-biased IGF-1R agonist. Hopefully, the substances identified and evaluated in this thesis will function as lead compounds in the development of improved pharmaceutical agents against GH/IGF-1 dependent diseases.List of scientific papersI. Rosengren L, Simko H, Aryan L, Axelsson-Lendin P, Chmielewska J, Mode A, Parrow V (2005). "Antisense and sense RNA probe hybridization to immobilized crude cellular lysates: a tool to screen growth hormone antagonists." J Biomol Screen 10(3): 260-9. https://pubmed.ncbi.nlm.nih.gov/15809322 II. Rosengren L, Parrow V, Chmielewska J, Mode A, Fhölenhag K (2007). "In vivo evaluation of a novel, orally bioavailable, small molecule growth hormone receptor antagonist." Growth Horm IGF Res 17(1): 47-53. https://pubmed.ncbi.nlm.nih.gov/17161642 III. Rosengren L, Vasilcanu D, Vasilcanu R, Fickenscher S, Sehat B, Natalishvili N, Naughton S, Yin S, Girnita A, Girnita L, Axelson M, Larsson O (2006). "IGF-1R tyrosine kinase expression and dependency in clones of IGF-1R knockout cells (R-)." Biochem Biophys Res Commun 347(4): 1059-66. https://pubmed.ncbi.nlm.nih.gov/16857168 IV. Economou MA, Wu J, Vasilcanu D, Rosengren L, All-Ericsson C, Van der Ploeg I, Menu E, Girnita L, Axelson M, Larsson O, Seregard S, Kvanta A (2007). "Inhibition of VEGF secretion and choroidal neovascularization by picropodophyllin (PPP), an inhibitor of the insulin-like growth factor-1 receptor." Invest Ophtamol Vis Sci. [Accepted] https://pubmed.ncbi.nlm.nih.gov/18515591 V. Vasilcanu R, Vasilcanu D, Rosengren L, Natalishvili N, Sehat B, Yin S, Girnita A, Axelson M, Girnita L, Larsson O (2007). "Picropodophyllin induces downregulation of the insulin-like growth factor 1 receptor: potential mechanistic involvement of Mdm2 and beta-arrestin1." Oncogene Sep 10: Epub ahead of print https://pubmed.ncbi.nlm.nih.gov/17828296 VI. Rosengren L, Girnita L, Axelson M, Larsson O (2007). "Picropodophyllin (PPP) acts as a beta-Arrestin1-biased IGF-1R agonist." [Submitted]</p
Critical properties and phase diagram of the quantum anisotropic XY spin chain in a random magnetic field: a density-matrix renormalization-group analysis
No full textGoing Beyond Counting First Authors in Author Co-citation Analysis
No full textThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Square Dancing with the Stars to Enhance Dynamic Hirschman Linkages?
No full textIn this Presidential Address, the author takes the reader on a reconnaissance of his life and time as a regional scientist. He points out scenery he found scintillating along the way, hoping that some may pick up the banner and chew on a few of the ideas for a while. He suggests a revisit to Albert O. Hirschman’s notion of key sectors and more empirical analysis related to Marcus Berliant’s and Masahisa Fujita’s notion of knowledge creation and transfer.Presidential Address, San Antonio, Texas, March 29, 2014 (53rd Meetings of the Southern Regional Science Association
Appropriate Similarity Measures for Author Cocitation Analysis
No full textWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Letter from unknown writer to Jesse L. Boyce
No full textLetter to Jesse L. Boyce from unknown author (possibly Jack) about the investigation into the powder magazine located in the Grand Canyon. Some personal news is included in the letter such as the writer's marriage to the daughter of C.A. Taylor, former Supervisor of Cochise County
Dispelling the Myths Behind First-author Citation Counts
No full textWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
Sarah L. Blum Author Visit - Warrior Nurse: PTSD and Healing
No full textHear Sarah L. Blum, author of Women Under Fire: Abuse in the Military, discuss her newest book, Warrior Nurse: PTSD and Healing followed by a Q&A and book signing.
Sarah L. Blum is a decorated Vietnam veteran who served as an operating room nurse during the intense fighting of 1967. In recognition of her service, she was awarded the Army Commendation Medal.
Sponsored by CWU Veterans Center and CWU Libraries.https://digitalcommons.cwu.edu/libraryevents/1252/thumbnail.jp
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