67 research outputs found
Harmonious architecture and adaptive reuse: Urban gastro-lounge in Prishtina
No full textThe city of Prishtina has constantly been changing in urban, architectural, and technological terms. This has political, ecological, economic, and cultural consequences, especially in the downtown area, where higher-density, taller office buildings and commercial spaces and even more congested residential areas are planned. In this study, the Urban Gastro-Lounge is taken as an example of an adaptive reuse strategy for a whole building or its interior. This example of adaptive reuse aims to revive urban and architectural areas as a way of promoting the sustainable development of the city in terms of its general formal architectural morphology. The Urban Gastro-Lounge is an excellent example of this approach and is worthy of being considered a particularly useful intervention
Lack of Storage Space for Dangerous Goods: Case Study of the Pristina International Airport "Adem Jashari"
No full textThe purpose of this paper is to define the dangerous goods classes and the lack of storage in Kosovo. The Pristine International Airport “Adem Jashari” (PIA) is the only airport that Kosovo has, and knowing that the number of flights in Kosovo is growing pushed me to analyze the current situation that is going on. The research method that is used in this paper covers an interview with professional people who are responsible for this issue. The research continued with empirical results from the questionnaire developed with a monkey survey covering 100 respondents. Further in the research paper, the author covers marking, labeling and the orientation of the packages that are used for dangerous goods during air transportation. In Kosovo, the Civil Aviation Authority (CAA) is responsible to firstly identify if the goods meet the condition asked from these authorities or not. Therefore, in case of any individuals or airlines wants to transport goods via air, they should ask for permission from CAA and after that, they might proceed with further application procedures. In the last part, the author gives some recommendations resulting from the findings of this research
The First and Second Hands Data in Doctoral Research Work
No full textIt is a matter of debate about what a scientific research is. But within this issue we often discuss about the data source. These issues have raised some dilemmas of ethical character on how datas shall be collected, who collects them, and who may use and the way they are used. No doubt those doctorates represent a research but the purpose of this paper is to stimulate debate on some essential criteria which it should have. The first question we put forth is that how much of the data presented by the candidate are of first hand- collected by the candidate himself, his team and how much data are used from other sources or are given from second hand (Mattews, Ross, 2012). From the direct analysis of the doctorate works in SEE University, it turns out that there is a mixed approach of using the data and their presentation. We can freely say that first-hand data are more in number but there is also a great numbers of dissertations without first-hand data, so without source data, collected directly by the author on the determined subject of his paper . So the permanent question that should afflict us is that whether a dissertation should always respect innovation and basic principles of Salzburg Principles? By reviewing of the literature, documents analyzing, statistical analyzing we will be able to give a clear picture of how the of primary and secondary sources in the dissertation work should be used.</jats:p
Left ventricular function in children with Coarctation of the Aorta
No full textSurgical repair of coarctation of the aorta (CoA) is a safe procedure in children, however the condition is known for its potential recurrence and other related complications. The available evidence shows abnormal intrinsic properties of the aorta in CoA, thus suggesting additional effect, even after CoA repair, on left ventricular (LV) function. Accordingly, we sought to obtain a better understanding of LV myocardial mechanics in very early-corrected CoA using two-dimensional STE. Methods and results: We retrospectively studied 21 patients with corrected CoA at a median age of 9 (2–53) days at three time points: 1) just before intervention, 2) at short-term follow-up (within 3 months after intervention) and 3) at medium-term follow-up after intervention (median 2.3 years) and compared them with normal values. Speckle tracking analysis was conducted via vendor independent software, Tomtec. After intervention, LV function significantly improved (from −12.8 ± 3.9 to −16.7 ± 1.7; p \u3c 0.001), however normal values were not reached even at medium-term follow-up (−18.3 ± 1.7 vs. −20 ± 1.6; p = 0.002). Medium-term longitudinal strain correlated with pre intervention EF (r = 0.58, p = 0.006). Moreover, medium-term subnormal values were more frequently associated with bicuspid aortic valve (33.3% vs. 66.6%; p \u3c 0.05). Conclusion: LV myocardial function in neonates with CoA can be feasibly evaluated and followed up by speckle tracking echocardiography. LV subendocardial dysfunction however, remains in early infancy coarctation long after repair. Long-term follow-up through adulthood using myocardial deformation measurements should shed light on the natural history and consequences of this anomaly
ROLE OF THE HUMAN RESOURCES IN BANK DEVELOPMENT- STUDY CASE NLB BANK PRISHTINA
No full textMentor: Dr.Sc. Beslim LEKIQIAfter a long work, over a year, treating different materials from secondary resources and primary resources we can get concrete conclusions regarding the role of the department of human resources in bank, and also its impact in the development of the banking sector in our country. Master thesis is concretized in form of the important and exploratory project with the following title. The role of the human resources in the development of the bank- study case the NLB Prishtina bank. This paper approaches the research of a complex problem as it is the definition of the role of human resources in bank respectively in the department of human resources as a study case the NLB Prishtina bank. The methodology that is used in this research is the heuristic method. The research starts with the theoretical part where are included different theories of the management of human resources narrowing to the specific issues as it is the role and the impact of the human resources in NLB Prishtina bank. In this case the purpose of this research is to identify the role of human resources in bank. Empiric research is developed in that way that with questionnaires have been interviewed the general director of the human resources department in NLB Prishtina bank, and also the seven directors of the main centers of the NLB Prishtina bank, in the territory of the republic of Kosovo. The first part is provided from the literature and previous researches where is treated the issue of understanding, concepts, the role and importance of the management of human resources, also the process of the management of human resources has been treated. While the second part is provided through the research of the author which has been developed through the questionnaire that’s been directly submitted to the respondents. I think that the results of this study are a modest contribution regarding this wide field, as it is the management of human resources and they can help the managers of this bank (NLB Prishtina). We think that the results and arguments of this study, can and should be the subject of debates and further studies in this field. In conclusion of this research paper we can say that the journey that send us in a more effective use of methods of the management of human resources in the bank sector, are the conviction and the education of the leading managers of these bank branches, for the importance and necessity of this managerial function
A European study on decellularized homografts for pulmonary valve replacement: initial results from the prospective ESPOIR Trial and ESPOIR Registry data†
No full textOBJECTIVES: Decellularized pulmonary homografts (DPH) have shown excellent results for pulmonary valve replacement. However, controlled multicentre studies are lacking to date. METHODS: Prospective European multicentre trial evaluating DPH for pulmonary valve replacement. Matched comparison of DPH to bovine jugular vein (BJV) conduits and cryopreserved homografts (CH) considering patient age, type of heart defect and previous procedures. RESULTS: In total, 121 patients (59 female) were prospectively enrolled (August 2014-December 2016), age 21.3 ± 14.4 years, DPH diameter 24.4 ± 2.8 mm. No adverse events occurred with respect to surgical handling; there were 2 early deaths (30 + 59 years) due to myocardial failure after multi-valve procedures and no late mortality (1.7% mortality). After a mean follow-up of 2.2 ± 0.6 years, the primary efficacy end points mean peak gradient (16.1 ± 12.1 mmHg) and regurgitation (mean 0.25 ± 0.48, grade 0-3) were excellent. One reoperation was required for recurrent subvalvular stenosis caused by a pericardial patch and 1 balloon dilatation was performed on a previously stented LPA. 100% follow-up for DPH patients operated before or outside the trial (n = 114) included in the ESPOIR Registry, age 16.6 ± 10.4 years, diameter 24.1 ± 4.2 mm, follow-up 5.1 ± 3.0 years. The combined DPH cohort, n = 235, comprising both Trial and Registry data showed significantly better freedom from explantation (DPH 96.7 ± 2.1%, CH 84.4 ± 3.2%, P = 0.029 and BJV 82.7 ± 3.2%, P = 0.012) and less structural valve degeneration at 10 years when matched to CH, n = 235 and BJV, n = 235 (DPH 61.4 ± 6.6%, CH 39.9 ± 4.4%, n.s., BJV 47.5 ± 4.5%, P = 0.029).CONCLUSIONS: Initial results of the prospective multicentre ESPOIR Trial showed DPH to be safe and efficient. Current DPH results including Registry data were superior to BJV and CH.Trial registration clinicaltrials.gov identifier: NCT02035540.sponsorship: This study was supported by a grant from the European Union's Seventh Framework Programme for Research, Technological Development and Demonstration [Grant Agreement No. 278453]. (European Union's Seventh Framework Programme for Research, Technological Development and Demonstration|278453)status: Publishe
Net-Rrjet XI: Temporary intervention and future architectural practice
No full textThis innovative research adopts a comprehensive approach to delve into temporary intervention. It aims to gain a deeper and more accurate understanding of architectural decisions related to long-term interventions. The study is based on several compelling case studies, revealing that temporary interventions achieve a more sustainable outcome and showcase remarkable flexibility and adaptability.
Projects curated by the author serve as practical research tools, providing a deeper and more accurate insight based on user experiences. The study concludes that the strategic use of temporary intervention is a proven and effective method in architectural design. It promotes community engagement and sustainable urban development and addresses the issue of abandoned permanent structures
The effect of pressure afterload due to aortic coarctation on left ventricular function in children
No full textBackground: Coarctation of the aorta (CoA) is a congenital heart disease which represents a narrowing of the proximal descending aorta, hence increasing pressure afterload to the left ventricle (LV). Conventional treatment of native CoA is surgical repair, however potential recurrence or other related complications e.g. aortic rupture, heart failure and cerebrovascular events are common. Thus, lifelong follow-up of these patients is required. Echocardiography is the most patient’s friendly method to evaluate CoA and in particular its effect on LV function. Moreover, the novel speckle tracking echocardiography (STE) is an important method to assess subclinical LV dysfunction, a technique that promises better evaluation of LV function in these patients. The aims of this thesis were to review the literature on LV function in children with CoA using myocardial deformation imaging technologies, hence, to better understand the current knowledge and vagueness of the scientific evidence. We also aimed to study the effect of early CoA repair on the structure and function of LV and ascending aorta. In addition, we wished to establish in a meta-analysis format normal values of speckle tracking derived strain and strain rate values. Methods: Study 1. We have systematically searched the PubMed, and studies that fulfilled the inclusion criteria were critically analyzed and presented on a narrative form. Study 2 and 3. In addition to conventional echocardiographic measures of LV and ascending aorta, we measured longitudinal strain and strain rate of the LV using a vendor independent software, TomTec. We have also measured the aorto-septal angle (AoSA). Data was compared with normal healthy controls. Study 4. Electronic databases were systematically searched and suitable studies were meta analyzed using Comprehensive meta-analysis version 3 software. Results: Study 1. In 7/4945 included articles, 123 and 76 patients with congenital aortic stenosis (CAS) and CoA were reported, respectively. Normal conventional LV function, with subclinical myocardial dysfunction were reported in all studies before intervention. After intervention, a consistent improvement of myocardial deformation parameters was documented, even though not reaching normal values. Study 2. In 21 patients with CoA, LV function significantly improved after intervention (p <0.001), however normal values were not reached even at medium-term follow-up (p = 0.002). Medium-term longitudinal strain correlated with pre intervention LV ejection faction (EF) (r = 0.58, p = 0.006). Medium-term subnormal values were more frequently associated with Bicuspid aortic valve (BAV) (33.3% vs. 66.6%; p <0.05). Study 3. AoSA was abnormally wide before intervention, in particular at peak ejection in the descending aorta (p <0.0001), and correlated with CoA pressure gradient. After intervention, AoSA normalized and significantly correlated with the increase of LV cavity function and overall LV deformation parameters. Study 4. In a meta-analysis of 28/282 studies including 1192 subjects, strain and strain rate values were established. Longitudinal strain normal mean values varied from -12.9 to -26.5 (mean, -20.5; 95 % CI, -20.0 to -21.0). Normal mean values of circumferential strain varied from -10.5 to -27.0 (mean, -22.06; 95 % CI, -21.5 to -22.5). Radial strain normal mean values varied from 24.9 to 62.1 (mean, 45.4; 95 % CI, 43.0 to 47.8). Meta-regression showed LV end-diastolic diameter as a significant determinant of variation of longitudinal strain. Longitudinal systolic strain rate was significantly determined by age and radial strain was influenced by the type of vendor used. Conclusion: The systematic review showed subclinical LV dysfunction in children with CoA before and after correction. However, since most of the patients were operated at an older age and had preserved LV EF, the effect of early intervention on LV function was only speculated. Our children with CoA who were operated at an earlier age showed LV subclinical dysfunction even at medium- term after intervention while the AoSA returned to normal shortly after intervention. Lower longitudinal strain values were found in patients with LV dysfunction (LV EF <50%) before intervention and BAV. Finally, normal range values for strain and strain rate have been established and seem to be influenced by patients’ age, LV end-diastolic diameter and vendor used
First quantitative dosages: Strong correlations between non-5-HT2Rs serotonin receptors on normal human heart valves
No full textInternational audienceObjectives Although critical in animal and human development and pathology, a measurement of the quantitative expression of 5-HTR serotonin receptors on animal or human valvular tissues has never been performed.Methods Quantification of the most frequent 5-HTRs reported as being present in human peripheral tissue was performed using radiolabeled agonists/antagonists. A membrane protein extract from normal human valves (aortic/mitral/tricuspid and some pulmonary) and associated diseased left myocardium, all unusable in clinics, were obtained from the Homograft bank.Results We analyzed 5-HT 1A R/5-HT 1B/D R/5-HT 2A R/5-HT 2B R/5-HT 2C R/5-HT 4 R/5-HT 7 R from 28 hearts. We confirmed the presence of tissue and measured the quantitative content for respective proteins in femtomol/mg of protein extracts: for 5-HT 2A R (35.9+/−0.7), 5-HT 2B R (28.8+/−1.3) but also a newly observed and robust expression for 5-HT 4 R (38+/−4.2). We identified one, 5-HT 1A Rs (4.9+/−0.3), and the possible expression, but at a very low level, of previously reported 5-HT 1B/D Rs (1.3+/−0.5) as well as the new 5-HT 7 Rs (3.5+/0.1) and 5-HT 2C Rs (1.2+/−0.1). Interestingly, by using univariate analysis, we were able to observe many correlations between the different 5-HTR levels of expression especially between 5-HT 1A R/5-HT 1B/D R and also between 5-HT 4 R/5-HT 7 R, but none were observed between 5-HT 2A R and 5-HT 2B R. Using multivariate analyses for a specific 5-HTR level of expression, after adjustment for implantation sites and other 5-HTRs, we found that 5-HT 1A R was correlated with 5-HT 1B/D R;5-HT 4 R with 5-HT 7 R and 5-HT 1A R;5-HT 2B R with 5-HT 2A R only. For 5-HT 2 C, no correlation was observed.Conclusion 5-HT 2A R/5-HT 2B R and 5-HT 4 R were all observed to have a high and equal level of expression on human valves, but that of 5-HT 1A R was more limited. Since these non-5-HT 2 Rs are coupled with different G-proteins, with specific signaling, theoretically they may control the main 5-HT 2 R signaling (i.e., PLC/DAG-PKC-ERK/Ras/Src signaling) involved in valvular fibrosis and degeneration
The Antimicrobial Resistance of the Bacterium Salmonella Enteritidis Isolated from Poultry for the Production of Eggs in Kosovo
No full textSalmonella Enteritidis represents a group of bacteria known to cause typhoid fever, food poisoning, gastroenteritis, enteric fever, and other diseases in humans. People are mainly infected with contaminated water or foods, especially meat, chicken meat and eggs. Salmonella gender includes over 2300 bacterial serotypes. Salmonella enteritidis and Salmonella typhimurium are responsible for over 50% of all infections caused in people anywhere in the world. The purpose of the study is to determine the sensitivity and resistance to antibiotics of some isolated strains of Salmonella enteritidis in private farms and eggs for egg production in several parts of Kosovo. Isolation and identification is done according to ISO 6579: 2002. The antibiotic test was performed on 13 strains of Salmonella enteritidis with the Kirby-Bauer method. Disk diffusion test method must be in compliance with the standard of CLSI clinical institutes and laboratories. Mueller Hinton agar was used with antibiotic disks of various groups where we obtained these results in sensitivity and resistance: Gentamicin 10mcg-S / 66.2%, I / 12.4% and R / 21.4%, Trimethoprim-sulfamethoxazoleSxt 25 mcg - S / 33.4, I / 48.3% and R / 18.3% Ampicillin Amp 2 mcg S / 15.6%, I / 23.5 And R- 60.9% and Cephalexin CL 30mg-S / 16.4, I / 77 and R / 6.6%
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