247 research outputs found
Comparative analysis of the lambda-interferons IL-28A and IL-29 regarding their transcriptome and their antiviral properties against hepatitis C virus.
No full textSpecific differences in signaling and antiviral properties between the different Lambda-interferons, a novel group of interferons composed of IL-28A, IL-28B and IL-29, are currently unknown. This is the first study comparatively investigating the transcriptome and the antiviral properties of the Lambda-interferons IL-28A and IL-29. Expression studies were performed by microarray analysis, quantitative PCR (qPCR), reporter gene assays and immunoluminometric assays. Signaling was analyzed by Western blot. HCV replication was measured in Huh-7 cells expressing subgenomic HCV replicon. All hepatic cell lines investigated as well as primary hepatocytes expressed both IFN-λ receptor subunits IL-10R2 and IFN-λR1. Both, IL-28A and IL-29 activated STAT1 signaling. As revealed by microarray analysis, similar genes were induced by both cytokines in Huh-7 cells (IL-28A: 117 genes; IL-29: 111 genes), many of them playing a role in antiviral immunity. However, only IL-28A was able to significantly down-regulate gene expression (n = 272 down-regulated genes). Both cytokines significantly decreased HCV replication in Huh-7 cells. In comparison to liver biopsies of patients with non-viral liver disease, liver biopsies of patients with HCV showed significantly increased mRNA expression of IL-28A and IL-29. Moreover, IL-28A serum protein levels were elevated in HCV patients. In a murine model of viral hepatitis, IL-28 expression was significantly increased. IL-28A and IL-29 are up-regulated in HCV patients and are similarly effective in inducing antiviral genes and inhibiting HCV replication. In contrast to IL-29, IL-28A is a potent gene repressor. Both IFN-λs may have therapeutic potential in the treatment of chronic HCV
Study of the D(0)p amplitude in Lambda(0)(b) -> D(0)p pi(-) decays
No full textAn amplitude analysis of the decay Lambda(0)(b) -> D(0)p pi(-) is performed in the part of the phase space containing resonances in the D(0)p channel. The study is based on a data sample corresponding to an integrated luminosity of 3.0 fb(-1) of pp collisions recorded by the LHCb experiment. The spectrum of excited Lambda(+)(c) states that decay into D(0)p is studied. The masses, widths and quantum numbers of the Lambda(c)(2880)(+) and Lambda(c) (2940)(+) resonances are measured. The constraints on the spin and parity for the Lambda(c)(2940)(+) state are obtained for the first time. A near-threshold enhancement in the D(0)p amplitude is investigated and found to be consistent with a new resonance, denoted the Lambda(c) (2860)(+), of spin 3/2 and positive parity.LPHEThis article is licensed under a Creative Commons Attribution 4.0 International Licens
Observation of the Lambda(0)(b) -> Lambda+cK+K-pi(-) decay
No full textThe Lambda(0)(b) -> Lambda+cK+K-pi(-) decay is observed for the first time using a data sample of proton-proton collisions at centre-of-mass energies of root s = 7 and 8 TeV collected by the LHCb detector, corresponding to an integrated luminosity of 3fb(-1). The ratio of branching fractions between the Lambda(0)(b) -> Lambda K-+(c)+ K-pi(-) and the Lambda(0)(b) -> Lambda D-+(c)s(-) decays is measured to beB(Lambda(0)(b) -> Lambda+cK+K-pi(-))/B(Lambda(0)(b) -> Lambda D-+(c)s(-)) = (9.26 +/- 0.29 +/- 0.46 +/- 0.26) x 10(-2),where the first uncertainty is statistical, the second systematic and the third is due to the knowledge of the D-s(-) -> K+K-pi(-) branching fraction. No structure on the invariant mass distribution of the Lambda K-+(c)+ system is found, consistent with no open-charm pentaquark signature. (c) 2021 The Author(s). Published by Elsevier B.V. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).LPH
Observation of the decay Lambda(0)(b) -> Lambda(+)(c)p(p)over-bar pi(-)
No full textThe decay Lambda(0)(b) -> Lambda(+)(c)p (p) over bar pi(-) is observed using pp collision data collected with the LHCb detector at centre-of-mass energies of root s = 7 and 8 Tev, corresponding to an integrated luminosity of 3 fb(-1). The ratio of branching fractions between Lambda(0)(b) -> Lambda(+)(c)p (p) over bar pi(-) and Lambda(0)(b) -> Lambda(+)(c)pi(-) decays is measured to be B(Lambda(0)(b) -> Lambda(+)(c)p (p) over bar pi(-))/B(Lambda(0)(b) -> Lambda(+)(c)pi(-) = 0.0540 +/- 0.0023 +/- 0.0032. Two resonant structures are observed in the Lambda(+)(c)pi(-) mass spectrum of the Lambda(0)(b) -> Lambda(+)(c)pp pi(-) decays, corresponding to the Xc(2455) and X (2520) states. The ratios of branching fractions with respect to the decay Lambda(0)(b) -> Lambda(+)(c)p (p) over bar pi(-) are B(Lambda(0)(b) -> Sigma(0)(c)p (p) over bar x B(Sigma(0)(b) -> Lambda(+)(c)pi(-))/B(Lambda(0)(b) -> Lambda(+)(c)p (p) over bar pi(-)) = 0.089 +/- 0.015 +/- 0.006, B(Lambda(0)(b) -> Sigma(c)*(0)p (p) over bar x B(Sigma(c)*(0) -> Lambda(+)(c)pi(-))/B(Lambda(0)(b) -> Lambda(+)(c)p (p) over bar pi(-)) = 0.119 +/- 0.020 +/- 0.014. In all of the above results, the first uncertainty is statistical and the second is systematic. The phase space is also examined for the presence of dibaryon resonances. No evidence for such resonances is found. (C) 2018 The Author(s). Published by Elsevier B.V
On conservativity of concurrent Haskell
No full textThe calculus CHF models Concurrent Haskell extended by concurrent, implicit futures. It is a process calculus with concurrent threads, monadic concurrent evaluation, and includes a pure functional lambda-calculus which comprises data constructors, case-expressions, letrec-expressions, and Haskell’s seq. Futures can be implemented in Concurrent Haskell using the primitive unsafeInterleaveIO, which is available in most implementations of Haskell. Our main result is conservativity of CHF, that is, all equivalences of pure functional expressions are also valid in CHF. This implies that compiler optimizations and transformations from pure Haskell remain valid in Concurrent Haskell even if it is extended by futures. We also show that this is no longer valid if Concurrent Haskell is extended by the arbitrary use of unsafeInterleaveIO
A contextual semantics for concurrent Haskell with futures
No full textIn this paper we analyze the semantics of a higher-order functional language with concurrent threads, monadic IO and synchronizing variables as in Concurrent Haskell. To assure declarativeness of concurrent programming we extend the language by implicit, monadic, and concurrent futures. As semantic model we introduce and analyze the process calculus CHF, which represents a typed core language of Concurrent Haskell extended by concurrent futures. Evaluation in CHF is defined by a small-step reduction relation. Using contextual equivalence based on may- and should-convergence as program equivalence, we show that various transformations preserve program equivalence. We establish a context lemma easing those correctness proofs. An important result is that call-by-need and call-by-name evaluation are equivalent in CHF, since they induce the same program equivalence. Finally we show that the monad laws hold in CHF under mild restrictions on Haskell’s seq-operator, which for instance justifies the use of the do-notation
Measurement of the Lambda(0)(b) lifetime and mass in the ATLAS experiment
No full textA measurement of the Lambda(0)(b) lifetime and mass in the decay channel Lambda(0)(b) -> J/psi (mu(+) mu(-))Lambda(0)(p pi(-)) is presented. The analysis uses a signal sample of about 2200 Lambda(0)(b) and (Lambda) over bar (0)(b) decays that are reconstructed in 4.9 fb(-1) of ATLAS pp collision data collected in 2011 at the LHC center-of-mass energy of 7 TeV. A simultaneous mass and decay time maximum likelihood fit is used to extract the Lambda(0)(b) lifetime and mass. They are measured to be tau(Lambda b) = 1.449 +/- 0.036(stat) +/- 0.017(syst) ps and m(Lambda b) = 5619.7 +/- 0.7(stat) +/- 1.1(syst) MeV. DOI: 10.1103/PhysRevD.87.032002AuthorOverflow(2873
First observation of the decay Lambda(0)(b) -> eta(c) (1S)pK(-)
No full textThe decay Lambda(0)(b) -> eta(c) (1S)pK(- )is observed for the first time using a data sample of proton-proton collisions, corresponding to an integrated luminosity of 5.5 fb I, collected with the LHCb experiment at a center-of-mass energy of 13 TeV. The branching fraction of the decay is measured, using the Lambda(0)(b) -> J/psi pK(-) decay as a normalization mode, to be B(Lambda(0)(b) -> eta(c) (1S)pK(-)) = (1.06 +/- 0.16 +/- 0.06(-019)(+0.22)) x 10(-4), where the quoted uncertainties are statistical, systematic and due to external inputs, respectively. A study of the eta(c)(1S)p mass spectrum is performed to search for the P-c(4312)(+) pentaquark state. No evidence is B(Lambda(0)(b) -> P-c(4312)K-+(-))xB(P-c(4312)(+)-> eta(c)(1S)p)/B(Lambda(0)(b) -> eta(c) (1S)pK(-)) < 0.24( ) observed and an upper limit of < 0.24 is obtained at the 95% confidence level.LPH
First Observation of the Radiative Decay Lambda(0 )(b)-> Lambda gamma
No full textThe radiative decay Lambda(0 )(b)-> Lambda gamma is observed for the first time using a data sample of proton-proton collisions corresponding to an integrated luminosity of 1.7 fb(-1) collected by the LHCb experiment at a center-of-mass energy of 13 TeV. Its branching fraction is measured exploiting the B-0 -> K*(0)gamma decay as a normalization mode and is found to be B(Lambda(0 )(b)-> Lambda gamma) = (7.1 +/- 1.5 +/- 0.6 +/- 0.7) x 10(-6), where the quoted uncertainties arc statistical, systematic, and systematic from external inputs, respectively. This is the first observation of a radiative decay of a beauty baryon.The radiative decay Λb0→Λγ is observed for the first time using a data sample of proton-proton collisions corresponding to an integrated luminosity of 1.7 fb-1 collected by the LHCb experiment at a center-of-mass energy of 13 TeV. Its branching fraction is measured exploiting the B0→K∗0γ decay as a normalization mode and is found to be B(Λb0→Λγ)=(7.1±1.5±0.6±0.7)×10-6, where the quoted uncertainties are statistical, systematic, and systematic from external inputs, respectively. This is the first observation of a radiative decay of a beauty baryon
Measurement of the transverse polarization of Lambda and (Lambda)over-bar hyperons produced in proton-proton collisions at root s=7 TeV using the ATLAS detector [Elektronisk resurs]
No full textThe transverse polarization of Lambda and (Lambda) over bar hyperons produced in proton-proton collisions at a center-of-mass energy of 7 TeV is measured. The analysis uses 760 mu b(-1) of minimum bias data collected by the ATLAS detector at the LHC in the year 2010. The measured transverse polarization averaged over Feynman x(F) from 5 x 10(-5) to 0.01 and transverse momentum p(T) from 0.8 to 15 GeV is -0.010 +/- 0.005(stat) +/- 0.004(syst) for Lambda and 0.002 +/- 0.006(stat) +/- 0.004(syst) for (Lambda) over bar. It is also measured as a function of x(F) and p(T), but no significant dependence on these variables is observed. Prior to this measurement, the polarization was measured at fixed-target experiments with center-of-mass energies up to about 40 GeV. The ATLAS results are compatible with the extrapolation of a fit from previous measurements to the x(F) range covered by this measurement.AuthorOverflow(2875
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