111 research outputs found
Adjuvant treatment with thyrotropin alpha for remnant ablation in thyroid cancer
No full textBernadette Biondi, Melania Pulcrano, Loredana Pagano, Gaetano LombardiDepartment of Clinical and Molecular Endocrinology and Oncology, University of Naples Federico II, Naples, ItalyAbstract: Various studies have demonstrated the safety and efficacy of recombinant human thyroid-stimulating hormone (rhTSH) for radioiodine remnant ablation. On this basis, rhTSH was approved in Europe for the radioiodine ablation of low-risk differentiated thyroid cancer (DTC) during thyroid hormone therapy with L-thyroxine (L-T4). Moreover, in December 2007, the US Federal Drug Administration approved the use of rhTSH for adjuvant treatment with radioiodine in patients with DTC without evidence of metastatic thyroid cancer. Quality of life was found to be better with rhTSH preparation than with L-thyroxine withdrawal, thereby resulting in benefits for society as a whole. Furthermore, rhTSH for radioiodine remnant ablation results in a longer effective radioiodine half-life within remnant thyroid tissue and a lower specific absorbed dose in the blood and exposure of bone marrow to X-rays. More studies are required to establish the amount of radioiodine to be administered especially in high-risk patients. Keywords: thyroid cancer, thyrotropin, radioiodine (131I) remnant ablation (RRA), quality of life, ray exposur
POORLY DIFFERENTIATED FOLLICULAR THYROID CARCINOMA: PROGNOSTIC FACTORS AND RELEVANCE OF HISTOLOGICAL CLASSIFICATION
No full textBackground. Poorly differentiated follicular carcinomas (PDFC) of the thyroid represent an heterogeneous but distinct group of tumors, clinically and histopathogenetically intermediate between follicular-derived well-differentiated and anaplastic carcinomas. The existence of this group of tumors was first proposed independently by Sakamoto et al. in 1983 and Carcangiu et al. in 1984 according to substantially different diagnostic criteria. Indeed, although the number of articles written on the subject of PD carcinoma has grown exponentially during the last decade, at the present the diagnostic criteria differ between various authors. Moreover, there is no clear definition of the histological, immunohistochemical and genetic characteristics of PDFC. Furthermore, although the majority of studies show the aggressiveness of PDFC with a high propensity for local recurrence and distant metastasis, there is no consensus regarding the prognostic indicators for these tumors.
Objective: The work performed during my Doctorate thesis in France contributes to clarify the histological definition and to identify clinical, histological, immunohistochemical characteristics of PDFC. For this purpose, parallel clinical, histological and immunohistochemical investigations have been performed.
Methods: Forty patients affected by PDFC were identified on the basis of a trabecular, insular, or solid (TIS) growth pattern, and their clinical outcome was correlated with histological architecture, cytological characteristics and expression of various markers of cell proliferation and differentiation such as cyclin A, B1, D1 and E, Ki67, TPO, galectin 3, Duox, VEGF, EGFR, P53.
Results: The mean survival was 5.2 5 years. At 5 years,the survival rate was 63% and the metastasis-free survival rate was 57%. An older age at the time of diagnosis and a larger tumor size were associated with an increased risk of distant metastases and of cancer related death whereas a high expression of Duox was associated with a reduced risk of death. In these patients with PDFC, no histological features or marker expression was prognostic. Conclusion: this study confirmed that PDFC has a more aggressive behavior than well differentiated carcinoma (WDC); prognosis is related to indicators that are relevant in patients with WDC, advanced age and larger tumor size
“Ruolo della PET (tomografia ad emissione di positroni) con 2-(18F)Fluoro-2-Desossiglucosio (FDG) nel carcinoma differenziato della tiroide”
No full text“Evaluation of coronary flow riserve (CFR) after cold pressor test in patient with subclinical hypothyroidism”
No full textMelania Trump – The First Lady of the United States
No full textკონფერენცია ეძღვნება მეიფლაუერის ხელშეკრულების დადების მე-400 წლისთავს/ The 2020 Annual conference of the American Studies is dedicated to the 400th Anniversary of the Signing of the Mayflower CompactIn the paper, the author tries to answer the question what role does Melania Trump play as the
First Lady of the United States in the Trump administration and the life of the country and how
she differs from her predecessors in this. Based on the original sources, it is concluded that in
the early years Melania Trump, unlike the other First Ladies, felt insecure, showed her
inexperience, was shy of her pronunciation of the English language, which was not native to
her. She also did not have her own program, but later she appeared under the name “Be Best”,
although it was criticized.
The coronavirus pandemic gave the First Lady the opportunity to find her new place in the
Trump administration's coronavirus response. Melania is one of several administration and
public health officials who will appear in new nationwide public service announcements, which
will educate Americans on how to protect themselves and others against Covid-19.
The new role of Melania Trump indicates that the First Lady was able to overcome the language
barrier, determined her place in the White House and is trying to play an active role in the
administration and, in general, in the life of the country
Fashion Leader Comparison: Michelle Obama and Melania Trump
No full textIn The Second Skin, author Marilyn Horn defines a fashion leader as someone who is admired, inspires fashion, and is important in society. Anyone in the public eye can be considered a fashion leader, especially the First Lady of the United States. The two most recent first ladies, Michelle Obama and Melania Trump, may be fashion leaders but their background and style varies greatly
Poorly differentiated follicular thyroid carcinoma (prognostic factors and relevance of histological classification)
No full textLE KREMLIN-B.- PARIS 11-BU Méd (940432101) / SudocSudocFranceF
Screening and Follow-up of Children Who Snore When Polysomnography Is Not Available
No full textWe read with great interest the article titled “The Role of Sleep Studies in Children Who Snore” by Ishman.1 In this article the author reaffirmed the importance of performing polysomnography in children with suspected sleep disordered breathing (SDB) before and especially after treatment because the risk of persistent obstructive sleep apnea (OSA) after surgery is high
Meanders of Fame. About Melania Burzyńska and More
No full textAutorka zastanawia się nad mechanizmami kariery twórcy ludowego w okresie PRL, biorąc pod uwagę przypadek Melanii Burzyńskiej. Przedmiotem namysłu jest zarówno dorobek, jak też biografia poetki z Podlasia. W artykule postawione zostaje pytanie, na ile aktywność literacka Burzyńskiej była autonomiczna, a w jakim stopniu zdeterminowana presją środowiska i miejskich elit, oczekujących od poetki, by realizowała „ludowy” model twórczości i życiorysu.The author reflects on the mechanisms of a folk artist’s career in the Polish People’s Republic, taking into account the case of Melania Burzyńska. The subject of reflection is both the output and the biography of the poet from Podlasie. The article poses the question to what extent was Burzyńska’s literary activity autonomous, and to what
extent was it determined by the pressure of the community and city elites, who expected the poet to follow the “folk” model of creativity and biography.Jolanta SZTACHELSKA, prof. dr hab., historyk literatury polskiej II połowy XIX wieku, związana z Uniwersytetem w Białymstoku, gdzie kieruje Katedrą Modernizmu Europejskiego i Badań Kulturowych. Sienkiewiczolog. Zajmuje się także formami dokumentarnymi (epistolografia, podróżopisarstwo, reportaż) oraz pisze o twórcach rodzinnego Podlasia. Wybrane publikacje książkowe: Reporteryje i reportaże (Białystok 1997), Czar i zaklęcie Sienkiewicza (Białystok 2003), Zabijanie klasyków (Białystok 2015), Mity sienkiewiczowskie (Warszawa 2017), Henryk Sienkiewicz. Życie na walizkach (Warszawa 2017).Uniwersytet w BiałymstokuAntologia poezji ludowej 1830–1980, oprac. i wstęp J. Szczawiej, Warszawa 1985.Antologia współczesnej poezji ludowej, oprac. i wstęp J. Szczawiej, Warszawa 1967, wydanie drugie: 1972.Bereza Henryk, Związki naturalne, Warszawa 1972.Burszta Jerzy, Kultura ludowa – kultura narodowa. Szkice i rozprawy, Warszawa 1974.Burzyńska Melania, Uśmiech krzywej gęby, Białystok 1991.Burzyńska Melania, I u nas jest świątek. Wiersze o treściach religijnych z rękopisów Melanii Burzyńskiej, Białystok 2013.Chłopska niepamięć. Dziedzictwo chłopskości w polskiej literaturze i kulturze, red. G.Wołowiec, D. Krawczyńska, G. Grochowski, Kraków 2019.Chmielowska Katarzyna, Lud w perspektywie, perspektywa ludu, „Teksty Drugie” 2021, nr 5.Clifford James, Kłopoty z kulturą, przeł. E. Dżurak i in., Warszawa 2000.Czapliński Przemysław, Śmierć, śmierć, inne życie, „Teksty Drugie” 2017, nr 6.Fiszerowa Maria, Piękno z „własnego podwórka”, „Gospodyni”, 1–15.06.1965.Janicki Kamil, Pańszczyzna, Poznań 2021.Klekot Ewa, Kłopoty ze sztuką. Gust, ideologie, nowoczesność, Gdańsk 2021.Kowalski Piotr, Folkloryzm nauk o kulturze ludowej, „Polska Sztuka Ludowa. Konteksty” 1992, nr 1.Leszczyński Adam, Ludowa historia Polski, Warszawa 2020.Mencwel Andrzej, Toast na progu, Kraków 2017.Myśliwski Wiesław, Kres kultury chłopskiej, „Twórczość” 2004, nr 4.Nesterowicz Piotr, Każdy został człowiekiem, Wołowiec 2016.Niedzielska Agnieszka, Poetka z Jaświł, „Tygodnik Kulturalny” 1981, nr 23.Pobłocki Kacper, Chamstwo, Wołowiec 2021.Redliński Edward, Poetka, w: E.Redliński, Ja w nerwowej sprawie, Warszawa 1969.Siemiatycka Krystyna, „Pozbieram w fartuch gwiazdy”, „Kobieta i Życie” 1981, nr 26.Sosnowski Jakub, Melania Burzyńska (1917–2003), „Twórczość Ludowa” 2017, nr 34.Sosnowski Jakub, Życie i twórczość Melanii Burzyńskiej, „Bibliotekarz Podlaski” 2008, nr 17, 2009, nr 18.Wieś tworząca. Antologia współczesnej poezji chłopskiej Lubelszczyzny, oprac. A. Aleksandrowicz, Lublin 1962.Wieś tworząca. Antologia współczesnej twórczości chłopskiej, oprac. E. i R.Rosiakowie, Lublin 1966, 1968, 1970, 1974.Zawadzka Danuta, „Szara przędza” Melanii Burzyńskiej – pamiętnik chłopki a idea „Kontrastów”, w: Białostockie „Kontrasty”: szkice i materiały, red. M.Roszczynialska,
K. Sawicka-Mierzyńska, Białystok 2018.13115
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