3,141 research outputs found
Os paratextos das antologias brasileiras de contos de Edgar Allan Poe no século XXI
Get PDFTese (doutorado) - Universidade Federal de Santa Catarina, Centro de Comunicação e Expressão, Programa de Pós-Graduação em Estudos da Tradução, Florianópolis, 2014.Esta tese analisa elementos paratextuais em antologias brasileiras de contos de Edgar Allan Poe lançados ou reeditados nos doze primeiros anos do século XXI, verificando de que forma o autor e sua obra são apresentados ao leitor através desses paratextos. Para tanto, analiso quartas capas, orelhas, prefácios, posfácios e notas. O nível de participação do tradutor na utilização desses elementos é também examinado, para que se possa averiguar até que ponto esse intermediador de culturas teve visibilidade nas publicações. A referida análise é norteada, principalmente, pelos fundamentos teóricos de Gérard Genette, sobretudo em seu livro intitulado Paratextos Editoriais (2009), do original Seuils (1987).Abstract : This thesis analyzes paratextual elements in Edgar Allan Poe's Brazilian anthologies of short stories published or reprinted in the first twelve years of the 21st century, observing how the author and his fictional writings are presented to the reader through those paratexts. Thus, I analyze back pages, flaps, forewords, afterwords, and notes. The use the translator made of those elements is examined in order to assess the translator's visibility in the published editions. The referred analysis is grounded mainly on Gérard Genette's theory, especially in his book entitled Editorial Paratexts (2009) from the original Seuils (1987)
The Author of Waverley
No full textMedium: engravingprintssigned and dated."The Author of Waverley" [2017.0032.000.000], Goodall, Edward, Allan, WilliamArtist and Role: Goodall, Edward,Artist and Role: Allan, William, ArtistExtent: shee
Insights into the activation mechanism of PopA, a cyclic di-GMP effector protein involved in cell cycle and development of "Caulobacter Crescentus"
Get PDFIn Caulobacter crescentus, a complex network integrating cyclic di-GMP and Phosphorylation-dependent signals controls the proteolysis of key regulatory proteins to drive cell cycle and polar morphogenesis. The c-di-GMP input is processed by the effector protein PopA. Upon binding of c-di-GMP, PopA is sequestered to the old cell pole where it recruits the replication and cell division inhibitors CtrA and KidO and mediates their destruction by the polar ClpXP protease prior to entry into S-phase. In addition to its role at the stalked cell pole, PopA localizes to the opposite cell pole in dependence of the general topology factor PodJ where it exerts a yet unknown function.
Here we address the activation and polar sequestration mechanism of PopA guided by an existing activation model for the highly homologous c-di-GMP signaling protein PleD. PopA and PleD do not only share an identical domain organization (Rec1-Rec2-GGDEF), but also show similar spatio-temporal behavior during the cell cycle. While PleD is activated and targeted to the old cell pole via phosphorylation-induced dimerization, we show that PopA stalked pole function is phosphorylation-independent and requires c-di-GMP binding as a primary input signal for activation and polar localization. c-di-GMP binds to conserved primary and secondary I-sites within the PopA GGDEF domain and we show that intact binding sites are required for PopA positioning and function. This suggests that c-di-GMP-dependent crosslinking of adjacent GGDEF domains contributes to the localization of an active PopA dimer to the cell pole. Consistent with this, we demonstrate that the GGDEF domain encodes the polar localization signal(s), while the N-terminal receiver domains serve as interaction platform for downstream components that are actively recruited by PopA.
Among these downstream factors is RcdA, a small mediator protein that interacts with the first PopA receiver domain and helps to recruit and degrade CtrA and KidO. In a screen for additional components of the PopA pathway we identify two novel proteins that directly interact with PopA, CC1462 and CC2616. CC1462 is a ClpXP substrate that requires PopA for polar positioning and subsequent degradation during swarmer-to-stalked cell transition. Although located in a flagellar gene cluster, deletion of CC1462 did not affect flagellar assembly and function. Its cellular role as well as the significance of its cell cycle-dependent degradation requires further studies. CC2616, the second PopA interaction partner, is not proteolytically processed and thus belongs to another class of PopA-dependent substrates. CC2616 is annotated as guanine deaminase, which is predicted to catalyze the conversion from guanine to xanthine thereby irreversibly removing guanine based nucleotides from a cellular pool. A CC2616 deletion leads to increased attachment and decreased motility, a phenocopy of strains with elevated c-di-GMP levels. It is not clear whether CC2616 indeed has deaminase activity or whether it has adopted a novel function.
Taken together, this work provides insight into the activation mechanism of a c-di-GMP effector protein. We propose that PopA has evolved through gene duplication from its ancestor, the catalytic PleD response regulator but has lost catalytic activity of the diguanylate cyclase domain. Moreover, PopA has adopted an inverse intra-molecular information transfer originating through c-di-GMP binding at the C-terminal GGDEF domain, which in turn activates the N-terminal receiver stem to serve as platform for downstream partner recruitment
Allan, Jonathan A.
No full textcurrentDr. Allan is a Canada Research Chair in Men and Masculinities and Professor in the Faculty of Arts at Brandon University. He is the author of Reading from Behind: A Cultural Analysis of the Anus (University of Regina Press, 2016; Zed Books, 2016; Japanese translation, Ohta-Shuppan, 2018), Men, Masculinities, and Popular Romance (Routledge 2019); and Men, Masculinities, and Infertilities (Routledge 2022). He is also one of the editors of Virgin Envy: The Cultural (In)Significance of the Hymen (University of Regina Press, 2016; Zed Books, 2016).
During his Canada Research Chair, Dr. Allan is working on the critical study of men and masculinities in a variety of spaces in the social sciences and the humanities. Dr. Allan is interested in the ways in which masculinity is lived, enacted, and embodied in everyday life.
His current research project is called, Men, Masculinity, and the Procreative Realm, for which he received a SSHRC Insight Grant. One of the research outcomes from this project, Men, Masculinities, and Infertility (Routledge 2022), is a book-length study of cultural representations of men’s infertility. Drawing on ideas of storytelling, this book explores how stories of infertility are told across popular fiction, canonical fiction, men’s memoirs of infertility, and film and television. A second project coming out of this research is a cultural study of vasectomy. Snip Snap will be an interdisciplinary study of the vasectomy, how it is represented in popular culture, and what the vasectomy means for sexuality and masculinity. This book will consider the history and the mainstreaming of vasectomy, as well as vasectomy reversal and post-vasectomy pain syndrome.
Dr. Allan is Series Editor of The Exquisite Corpse Series at University of Regina Press and he is one of the editors of Journal of Bodies, Sexualities, and Masculinities
Letter from Allan R. Bosworth, Captain, U.S. Navy, to Michi Weglyn
No full textA letter from Allan R. Bosworth to Michi Weglyn in which Bosworth states that he will not read Weglyn's book "Years of Infamy: the Untold Story of America's Concentration Camps" because he believes that story has already been told.These materials are from box 73 and 74 of the Frank Chin Papers. The Frank Chin Papers contain personal and professional correspondence between Frank Chin and Michi Weglyn relating to particular projects on which either author was working as well as files related to the Day of Remembrance Tribute to Michi Weglyn
To what extent may the unfavorable viewpoints of critics on E. A. Poe's use of horror and social satire in his stories be refuted by examples from and analysis of the author's eight short stories?
Get PDFWith numerous short stories and poems, Edgar Allan Poe is considered to be the piquant and
astounding milestone of the American Literature. Yet, his style and achievements have always
been interpreted antagonistically by large numbers of critics. This study analyzes the features
unique to Edgar Allan Poe in his short stories “Murders In The Rue Morgue”, “The Fall of
The House of Usher”, “A Tale of Jerusalem”, “The Pit and The Pendulum”, “The System of
Doctor Tarr and Professor Fether”, “A Cask Of Amonillado”, “The Masque of Red Death”
and “The Man That Was Used Up” while refuting to chosen examples of negative reviews
about Edgar Allan Poe.
Due to the fact that Edgar Allan Poe is well-known for his usage horror, satire, humor and
fiction in his short stories, these qualities have been criticized mostly by many writers and
philosophers as well. In this sense, the scope of the study will be sharpened on how these
techniques are used in his short stories to make them nonpareil and what was Edgar Allan
Poe’s authorial intention while utilizing these attributes in his works. At this point the analysis
of the characters, themes and plot will be prioritized compared to the language and style that
Edgar Allan Poe uses in his texts.
Since the criticism against Poe focus on the usefulness of such features in his short stories and
how they intimidate the reader from the text, the study proves that the gap between Poe and
the reader is a simple issue of reciprocal misunderstanding which is proven to be artificial and
bogus with examples and facts from his short stories
Activation and polar sequestration of PopA, a c-di-GMP effector protein involved in Caulobacter crescentus cell cycle control
Get PDFWhen Caulobacter crescentus enters S-phase the replication initiation inhibitor CtrA dynamically positions to the old cell pole to be degraded by the polar ClpXP protease. Polar delivery of CtrA requires PopA and the diguanylate cyclase PleD that positions to the same pole. Here we present evidence that PopA originated through gene duplication from its paralogue response regulator PleD and subsequent co-option as c-di-GMP effector protein. While the C-terminal catalytic domain (GGDEF) of PleD is activated by phosphorylation of the N-terminal receiver domain, functional adaptation has reversed signal transduction in PopA with the GGDEF domain adopting input function and the receiver domain serving as regulatory output. We show that the N-terminal receiver domain of PopA specifically interacts with RcdA, a component required for CtrA degradation. In contrast, the GGDEF domain serves to target PopA to the cell pole in response to c-di-GMP binding. In agreement with the divergent activation and targeting mechanisms, distinct markers sequester PleD and PopA to the old cell pole upon S-phase entry. Together these data indicate that PopA adopted a novel role as topology specificity factor to help recruit components of the CtrA degradation pathway to the protease specific old cell pole of C. crescentus
Popa Group: The International Presence of an Information Technology Family Business in Central America
No full textFamily businesses are present in all sectors and their participation in information technology (IT) is no exception. Honduras is a stereotypical Latin American context in terms of family influence and participation in business activities over time. The POPA Group was founded in Tegucigalpa, the capital of Honduras, in 1992 by Rene Portela and Gerardo Pacheco. The name POPA emerged out of the first two letters of the founders’ family names. Currently POPA imports and commercializes product lines mainly from Dell, Lexmark, SAP, and Oracle. The current top management team at POPA is composed of members of the founding and second generation of the Pacheco family. In 2013, POPA decided to expand its operations internationally. Nicaragua, a neighboring country, was chosen due to a growing client base outside of Honduras and the awareness that POPA needed to keep up with the globalization of the technological trends. © 2019 Taylor & Francis
Generalizing curriculum policy across boarders : crossing boundaries
No full text"This essay is a critique of the scientific and policy rationales for transnational standardization. It analyzes two examples of policy export: early childhood standards in one of North America’s oldest Indigenous communities and the ongoing development of international standards for university teaching. It examines calls for American education to look to Finland, Canada, and Singapore for models of reform and innovation, focusing on the complex historical, cultural, and political settlements at work in these countries. The author addresses two affiliated challenges: first, the possibility of a principled understanding of evidence and policy in cultural and political-economic context, and second, the possibility of a mediative educational science that might guide policy formation." -- EDUCATIONAL RESEARCHER November 2011 vol. 40 no. 8 367-37
In the red
No full textIN THE RED, a work of fiction, is a collection of 12 short stories. The characters in these stories are romantically bankrupt, and yet their falls help them discover who they really are as they pick up the pieces of their lives in Delaware’s strange suburbs and Connecticut’s rusting industrial cities.M.F.A.Short storiesby Dennis Allan Lawso
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