19 research outputs found
Conceptualizing dimensions and characteristics of urban resilience: Insights from a co-design process
Get PDFResilience is a multi-faceted concept frequently used across a wide range of disciplines, practices, and sectors. There is a growing recognition of the utility of resilience as a bridging concept that can facilitate inter-and transdisciplinary approaches to tackle complexities inherent in decision making under conditions of risk and uncertainty. Such conditions are common in urban planning, infrastructure planning, asset management, emergency planning, crisis management, and development processes where systemic interdependencies and interests at stake influence decisions and outcomes. A major challenge that can undermine the use of resilience for guiding planning activities is the value-laden and contested nature of the concept that can be interpreted in a variety of ways. Because resilience is context-specific and generally depends on local aspirations, this issue can be partially tackled by adopting participatory approaches for the conceptualization of resilience. This paper provides an example of how co-design methods can be employed for conceptualizing resilience. The Structured Interview Matrix was used as a technique to facilitate discussions among a diverse group of researchers and practitioners attending the International Workshop on Tools and Indicators for Assessing Urban Resilience. Participants deliberated on issues related to constituent elements of urban resilience, including its position vis-à-vis concepts such as adaptation and sustainability, institutional factors that can enable/constrain resilience building, and the challenges of conducting and operationalizing urban resilience assessment. This paper can be considered as an initial step towards further exploration of participatory approaches for clarifying the underlying dimensions of complex concepts such as resilience
Formulation of Nutritious Ready to Eat Food Products
No full textThis Dissertation / Report is the outcome of investigation carried out by the creator(s) / author(s) at the department/division of Central Food Technological Research Institute (CFTRI), Mysore mentioned below in this page
India's INDC for transport and 2 C stabilization target
Get PDFTransport sector accounted for 13 % of India's energy-related CO2 emissions. India's Intended Nationally Determined Contributions (INDC) specify an economy wide decarbonization target of 33 to 35 % between 2005 and 2030 and includes announcements for urban transport, intercity transportation infrastructures, sustainable logistics and inland waterways to achieve these reductions. The Paris agreement that followed the announcement of the INDC increased the global ambition to stabilize the greenhouse gases so that maximum temperature rise is limited to 2 ?C with an enhanced ambition for 1.5 ?C. The paper analyses how far INDC will reduce the emissions from transport and to what extent a 2 ?C temperature stabilization goal will decarbonize the transport sector. The analysis is carried out using ANSWER MARKAL model for evaluating the energy system in combination with a transport demand module to model future scenarios for India till year 2050. Three scenarios are explored in this paper: i) a business-As-usual scenario ii) an INDC scenario iii) implementation of INDC in a strong climate regime aiming for the 2 oC target. The assessment shows that CO2 reductions from transport would happen through a wide portfolio of options. The highest mitigation is achieved through sustainable mobility strategies, followed by fuel economy standards. Electric vehicles offer significant mitigation benefits, however these are more significant post 2030
Deficiency of macrophage-derived Dnase1L3 causes lupus-like phenotypes in mice
No full textFile under embargo until 06 October 2024. This is a pre-copyedited, author-produced version of an article accepted for publication in the Journal of Leukocyte Biology following peer review. The version of record is available online at: https://doi.org/10.1093/jleuko/qiad115.Systemic lupus erythematosus (SLE) is an autoimmune disease caused by environmental factors and loss of key proteins, including the endonuclease Dnase1L3. Dnase1L3 absence causes pediatric-onset lupus in humans, while reduced activity occurs in adult-onset SLE. The amount of Dnase1L3 that prevents lupus remains unknown. To genetically reduce Dnase1L3 levels, we developed a mouse model lacking Dnase1L3 in macrophages (conditional knockout [cKO]). Serum Dnase1L3 levels were reduced 67%, though Dnase1 activity remained constant. Homogeneous and peripheral antinuclear antibodies were detected in the sera by immunofluorescence, consistent with anti-double-stranded DNA (anti-dsDNA) antibodies. Total immunoglobulin M, total immunoglobulin G, and anti-dsDNA antibody levels increased in cKO mice with age. The cKO mice developed anti-Dnase1L3 antibodies. In contrast to global Dnase1L3−/− mice, anti-dsDNA antibodies were not elevated early in life. The cKO mice had minimal kidney pathology. Therefore, we conclude that an intermediate reduction in serum Dnase1L3 causes mild lupus phenotypes, and macrophage-derived DnaselL3 helps limit lupus
Corrigendum:Common genetic variation drives molecular heterogeneity in human iPSCs (Nature (2017) 546 (370-375) DOI: 10.1038/nature22403)
No full textIn this Article, the authors Fiona M. Watt and Richard Durbin should also have been included as 'jointly supervising' authors, and authors Oliver Stegle and Daniel J. Gaffney should also have been noted as 'equally contributing' authors. In addition, the Author Contributions section should have included the sentence: 'H.K. and A.G. contributed equally to this work; O.S. and D.J.G. contributed equally to this work', as further clarification. The original Article has been corrected online.</p
Avaliação em médio prazo da pressão intra-saco após correção endovascular de aneurisma de aorta abdominal com o uso de sensor sem fio
Get PDFDissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências da Saúde. Programa de Pós-Graduação em Ciências Médicas.Justificativa: O objetivo do tratamento endovascular do aneurisma de aorta abdominal é a exclusão do saco aneurismático da circulação sistêmica. Para acompanhar a eficácia do tratamento é necessária a realização de angiotomografias seriadas. A monitorização continuada da pressão poderia diagnosticar precocemente casos em que esteja ocorrendo falha desse tratamento, auxiliando ou substituindo a tomografia. Objetivo: Avaliar a eficácia em médio prazo da medida de pressão através de sensor sem fio implantado no saco aneurismático após tratamento endovascular de aneurisma de aorta abdominal (AAA). Desenho do Estudo: Quarenta pacientes submetidos a tratamento endovascular de aneurisma de aorta abdominal receberam implante de sensor sem fio para monitorização em médio prazo da pressão intra-saco. Os dados foram analisados no primeiro, sexto, décimo segundo meses e anualmente. A cada análise, uma angiotomografia informava o diâmetro do aneurisma, presença e tipo de vazamento. A pressão arterial sistêmica assim como todos os dados pressóricos obtidos através do sensor foram coletados. Resultados: No seguimento, dos 40 sensores implantados apenas em dois o sinal não pode ser detectado. A pressão de pulso obtida apresentou boa sensibilidade em afastar a presença de vazamento quando inferior a 25mmHg no primeiro ano. Após esse período, o Índice de Endotensão mostra-se como a variável que mais se aproxima dos dados tomográficos. Na presença de vazamantos tipo I ou III, o sensor é capaz de identificar sucesso ou falha após a correção do vazamento. Até o segundo ano de seguimento, resultados apresentados pelo sensor são concordantes com dados tomográficos, a partir daí, perdem acurácia. Conclusão: Na amostra estudada não foi possível obter sensibilidade suficiente para substituir a realização da tomografia no acompanhamento dos AAA tratados por técnica endovascular. Um maior número de pacientes é necessário para estabelecer o verdadeiro papel da monitorização pressórica sem fio no seguimento do tratamento endovascular do aneurisma de aorta abdominal.Racional: The objective of endovascular treatment of an abdo-minal aortic aneurysm is to exclude the aneurysm sac from systemic circulation. In order to assess treatment effectiveness it is necessary to perform serial computed tomography (CT). Continued pressure moni-toring could provide an early diagnosis of cases in which this treatment is failing, helping or replacing CT. Objective: Evaluation of medium-term effectiveness of pressure measurement using a wireless sensor implanted in the aneurysm sac after endovascular treatment of abdominal aortic aneurysm. Method: Forty patients undergoing endovascular treatment for abdominal aortic aneurysm had a wireless sensor implanted for medium-term monitoring of intrasac pressure. The data were analyzed in the first, sixth and twelfth month and annually. At each analysis, a CT scan in-formed the aneurysm diameter, presence and risk of endoleaks. System-ic arterial pressure was collected, as well as all pressure data obtained through the sensor. Results: Of the 40 sensors implanted, the signal could not be de-tected only in two. The pulse pressure obtained presented good sensitivi-ty to rule out the presence of leakage when it was less than 25mmHg during the first year. After this period, the Endotension Index is the variable that comes closest to the CT scan data. With type I or III endo-leaks, the sensor can identify success or failure after endoleak repair. Until the second year of follow up, the results presented by the sensor agree with CT data, and then become less accurate. Conclusions: In the sample studied sufficient sensitivity could not be achieved to replace the CT when following AAA treated by the en-dovascular technique. A larger number of patients is needed to deter-mine the true role of wireless pressure monitoring when following en-dovascular treatment of abdominal aortic aneurysm
Recommended from our members
Author Correction: Accelerated single cell seeding in relapsed multiple myeloma
No full text
Bridging the scale between the local particular and the global universal in climate change assessments of cities
No full textIdentifying gaps in urban climate change assessment is crucial for developing the new Intergovernmental Panel on Climate Change (IPCC) special report on cities. To bridge the gap between the understanding of local interventions and global climate goals, we call for the strengthening of assessment tools such as urban typologies, case study synthesis and big geospatial data studies. We sort research gaps into five overarching themes: (1) urban form, (2) data and artificial intelligence, (3) policies and governance, (4) system transformation and (5) potentials, costs and losses. Using these methods for categorizing and analyzing cities based on shared characteristics will enable the tailoring and scaling of local climate solutions to global contexts
What the latest science on climate change mitigation means for cities and urban areas.
Get PDFThe Summary for Urban Policymakers (SUP) initiative provides a distillation of the IPCC reports into accessible and targeted summaries that can help inform action at city and regional scales. Volume I in the series, What the Latest Physical Science of Climate Change Means for Cities, identified the ways in which human-induced climate change is affecting every region of the world, and the cities and urban areas therein. Volume II, Climate Change in Cities and Urban Areas: Impacts, Adaptation and Vulnerability, assessed the feasibility and effectiveness of different adaptation options. To achieve climate resilient development, synergies between policies and actions for climate change adaptation, mitigation and other development goals are needed.
This third volume in the series, What the Latest Science on Climate Change Mitigation Means for Cities and Urban Areas offers a concise and accessible distillation of the IPCC Working Group III Report for urban policymakers. The 21st century is characterized by a rapidly growing urban population, urban land expansion and associated rise in demand for resources, infrastructure and services. These trends are expected to drive the growth in emissions from urban consumption and production through 2100, although the rate of urban emissions growth will depend on the type of urbanisation and the speed and scale of mitigation action implemented. Aggressive and ambitious policies for transition towards net zero greenhouse gas emissions can be implemented in cities and urban areas, while contributing to sustainable development. Ultimately, mitigation action and adaptation are interdependent processes, and pursuing these actions together can promote sustainable development
