30,982 research outputs found
Maria Bersani
No full textLa voce illustra la biografia e l'apporto letterario dato da Maria Bersani alla letteratura per l'infanziaThe headword explains the biography and the contribution of the author Maria Bersani to the children's literatur
Variations on the Author
Get PDF“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
O curso de licenciatura em educação física da Universidade Federal de Santa Catarina: suas concepções de ensino e de educação física
Get PDFDissertação (mestrado) - Universidade Federal de Santa Maria. Centro de Educação Fisica e Desporto
Erratum: Lack of immunity against rubella among Italian young adults. [BMC Infect Dis., 17, (2017) (199)] Doi: 10.1186/s12879-017-2295-y
No full textAfter publication of this article [1], the authors noted that the given names and family names of all authors had been inverted, and are therefore incorrect in the original article. In the original article, the author names appear as the following: Gallone Maria Serena, Gallone Maria Filomena, Larocca Angela Maria Vittoria, Germinario Cinzia and Tafuri Silvio. However, this is incorrect, and the author names should appear as per the below: Maria Serena Gallone, Maria Filomena Gallone, Angela Maria Vittoria Larocca, Cinzia Germinario, Silvio Tafuri. The author names have been corrected in the author list and the citation for this Erratum
Imagens de Otto Maria Carpeaux: esboço de biografia
Get PDFTese (doutorado) - Universidade Federal de Santa Catarina, Centro de Filosofia e Ciências Humanas, Programa de Pós-Graduação em História, Florianópolis, 2015.Este esboço de biografia procura citar algumas imagens de Otto Maria Carpeaux: construções biográficas de naturezas múltiplas, elaboradas em contextos, por atores e sob condições igualmente díspares. Está constituído a partir de uma visão crítica da História, o que permite que ?outras imagens?, fragmentárias e não monumentais, também tenham espaço. Em diálogo com o princípio da montagem, este esboço apresenta-se em duas partes. Na primeira, Imagens possíveis, estão citadas as imagens elaboradas em vida e post mortem acerca do austríaco-brasileiro que nasceu em Viena em 1900, se exilou no Brasil em 1939 e morreu no Rio de Janeiro, em 1978. Na segunda, Montagens possíveis, apresentam-se duas possibilidades de exercício biográfico: pela leitura alegórica do documentário O velho e o Novo (Otto Maria Carpeaux), entendido como instrumento de intervenção no contexto ditatorial brasileiro e de uma reelaboração biográfica concernentes às suas experiências europeias; e pelo Caderno de imagens críticas, registro dos encontros em Carpeaux pelo meio de imagens críticas produzidas a partir da cesura do presente.Abstract : This biographical sketch attempts to quote some images of Otto Maria Carpeaux: various types of biographical constructions, carried out in different contexts by disparate authors under conditions just as distinct. It stems from a critical view of history, allowing for ?other images? fragmented and non-monumental ? to share the space.In dialogue with the montage principle, this sketch has two parts. The first, Possible Images, quotes the images produced during and after the life of the Austrian-Brazilian, who was born in Vienna in 1900, went to Brazil in exile in 1939 and died in Rio de Janeiro in 1978. The second part, Possible Montages, presents two possibilities of a biographical exercise: through the allegorical reading of documentary O Velho e o Novo (Otto Maria Carpeaux), understood as an instrument of intervention in the Brazilian dictatorship context and as a biographical retelling of the author?s European experiences; and through my Scrapbook of Critical Images, a record of the encounters in Carpeaux through critical images produced from the caesura of the present
Analysis of cell type-specific adverse effects in ovaries
No full textThe global rise in infertility, coupled with an increasing reliance on assisted reproductive technologies (ART), highlights the growing concern over environmental exposures that are associated with negative impacts on fertility. As the ovary's finite pool of oocytes determines female fertility, it is crucial to study the effects of chemicals on ovarian function.The overarching aim of this thesis was to identify key molecular targets and processes affected by chemical exposure in human ovaries, with the ultimate goal of generating novel information that could improve future risk assessment. This aim was approached through two complementary strategies: experimental studies and the development of AOPs. DEHP was chosen as a model compound. In the experimental studies, its primary metabolite, MEHP, was used to expose human ovarian tissue and cell cultures in vitro, followed by transcriptomic analyses to identify effects in an unbiased manner. For AOP development, the focus was on DEHP's hypothesized mode of action, androgen signaling, mapping its role in ovarian follicle biology through semi-systematic literature reviews.Paper I aimed to identify the effects of MEHP exposure on human ovarian tissue and ovarian cells in culture, utilizing RNA-sequencing and histological assessments. The findings highlighted significant effects on follicle survival and growth in vitro in human ovarian cortical cultures, along with gene expression changes related to cytoskeleton, adherens junctions and Hippo pathway in ovarian cells.Paper IV focused on cell type-specific responses, employing single-cell RNA sequencing to investigate the molecular effects of MEHP exposure on different ovarian cell types. This approach confirmed the disruption of cytoskeleton genes observed in Paper I in more cell types, and identified disruption of oxidative phosphorylation genes. Additionally, it revealed reduced cell interactions upon exposure and identified glial cells as the most sensitive cell types to the exposure.Paper II aimed to develop a Key Event Relationship (KER) that links androgen receptor antagonism to reduced granulosa cell proliferation, as part of an AOP on androgen antagonism leading to reduced female fertility (AOP345). The KER was developed through a systematic literature review, as it was non-canonical knowledge, and studies were collected and assessed for their quality.Paper III was built on Paper II, by continuing the development of the AOP, populating the information of all the included Key Events (KEs) and KERs. A similar systematic approach was followed to connect granulosa proliferation with ovarian cycle irregularities. A weight-of-evidence approach was followed, to inform the confidence in the complete AOP.Overall, this thesis provides new insights into the impact of chemical exposures on ovarian function, advancing understanding through both experimental and AOP-based approaches. In Papers I and IV processes including cytoskeleton organization and oxidative phosphorylation are identified through MEHP results, as potential targets for female fertility endpoints. Furthermore, the future perspective of expanding the assessment of chemical effects beyond follicles and onto ovarian cell types like glial cells is presented. Through Papers II and III a pragmatic way of developing KEs, KERs and whole AOPs is demonstrated. AOP345 highlights the importance of follicle counts as a key endpoint in toxicological assessments, an approach currently considered optional in test guidelines. However, as follicle counting is both subjective and time-consuming, these papers identify the possibility of developing granulosa cell proliferation as an alternative.List of scientific papersI. E.M. Panagiotou, A. Damdimopoulos, T. Li, E. Moussaud-Lamodière, M. Pedersen, F. Lebre, K. Pettersson, C. Arnelo, K. Papaikonomou, E. Alfaro-Moreno, C. Lindskog, T. Svingen, P. Damdimopoulou. Exposure to the phthalate metabolite MEHP impacts survival and growth of human ovarian follicles in vitro. Toxicology. 505 (2024). https://doi.org/10.1016/j.tox.2024.153815II. E.M. Panagiotou, M.K. Draskau, T. Li, A. Hirschberg, T. Svingen, P. Damdimopoulou. AOP key event relationship report: Linking decreased androgen receptor activation with decreased granulosa cell proliferation of gonadotropin-independent follicles. Reproductive Toxicology. 112 (2022) 136-147. https://doi.org/10.1016/j.reprotox.2022.07.004III. E.M. Panagiotou, H.K.L. Johansson, J. Zilliacus, A. Beronius, T. Svingen, P. Damdimopoulou. AOP report: Androgen receptor (AR) antagonism leading to decreased fertility in females via reduced granulosa cell proliferation. [Submitted]IV. E.M. Panagiotou*, L. Méar*, E. Moussaud-Lamodière, A. Kamposiora, N. Throumpari, C. Arnelo, K. Pettersson, K. Papaikonomou, C. Lindskog, P. Damdimopoulou. Single-cell insights on the effects of the phthalate metabolite MEHP on the human ovary in vitro. [Manuscript]* Equal contribution authors</p
Supplemental material for An objective and automated method for evaluating abdominal hyperalgesia in a rat model for endometriosis
No full textSupplemental Material for An objective and automated method for evaluating abdominal hyperalgesia in a rat model for endometriosis by Mieke AW van Aken, Patrick G Groothuis, Maria Panagiotou, Marcel van Duin, Annemiek W Nap, Tineke CM van Rijn, Tamas Kozicz, Didi DM Braat and Ard BWMM Peeters in Laboratory Animals</p
Maria José ao encontro de Tchekov
Get PDF“A Carta da Corcunda para o Serralheiro” (“Letter from the Hunchback Girl to the Metalworker”), signed by Maria José, was first performed in a theatre show in 1988 (by actress-director Maria do Céu Guerra), two years before the typescript was published in book form for the first time by Teresa Rita Lopes. The evidence upon which this article is built is that it was the theatre that revealed the dramatic destination of this singular epistle of the only female heteronym that Fernando Pessoa invented, which was also the last heteronym to be created by the author. The dramatic construction of Maria José can be approximated to the character-building strategies in Anton Chekhov’s realist dramaturgy, in a way that differs from Pessoa’s other dramaturgical experiences. The analysis of Chekhov’s ascendancy over Stanislavski’s research, as well as the importance of Schopenhauer’s conception of the tragicomic, which is simultaneously projected onto Chekhov’s theatre and Maria José’s profile, are favourable lines of reading for this rapprochement between Pessoa and the Russian fiction writer and playwright. Pessoa’s readings of Chekhov’s texts (such as the play Uncle Vania and the short story “Vanka”) provide relevant data for assessing the magnitude of this encounter.“A Carta da Corcunda para o Serralheiro”, assinada por Maria José, começou por ser difundida num espectáculo de teatro em 1988 (pela actriz-encenadora Maria do Céu Guerra) dois anos antes de o dactiloscrito se ver publicado em livro, pela primeira vez, por Teresa Rita Lopes. Parte-se da evidência de ter sido o teatro a revelar a destinação dramática da epístola singular do único heterónimo mulher que Fernando Pessoa inventou, que terá sido também o último a ser criado pelo autor. A construção dramática de Maria José pode ser aproximada às estratégias de construção de personagem na dramaturgia realista de Anton Tchekov, de um modo que se distingue de outras experiências dramatúrgicas de Pessoa. A análise do ascendente de Tchekov sobre as pesquisas de Stanislavski, bem como a importância da concepção de tragicómico em Schopenhauer, que se projecta em simultâneo sobre o teatro de Tchekov e sobre o perfil de Maria José, são linhas de leitura propícias para esta aproximação entre Pessoa e o ficcionista e dramaturgo russo. As leituras de textos de Tchekov por parte de Pessoa (como o caso da peça Tio Vânia e o conto “Vanka”) fornecem dados relevantes para avaliar a magnitude deste encontro
O negro como personagem na literatura infantil, na obra de Maria Rita Py
Get PDFTried to when analyzing the works of Coleção História da Vó Preta, of the Santa Mariense author Maria Rita Py, the representation of black people, showing how the issues surrounding it in society, his yearnings, sorrows, lived since last century , are present in contemporary children's literature. The literature has shown an increasing concern in presenting a cultural identity that expresses the relationship of social inclusion. The Brazilian reality shows that the black, after the liberations of slaves, and most recently with the growth of the black movement, assumed a new vision, creating a new discourse in this literature, when passing to be personage of the transformation of black spirit (sense). It is in this context that the black literature of Maria Rita Py inserts, dedicated to child audience, search for solutions to solve the problems of this personage such as frustration, rejection, desire to be white, doubts and anxieties of children black in society, affect self-esteem and identityProcurou-se ao analisar nas obras da Coleção História da Vó Preta, da autora santa-mariense Maria Rita Py, a representação do negro, demonstrando como as questões que o envolvem na sociedade, seus anseios, mágoas, vividas desde o século passado, estão presentes na literatura infantil contemporânea. A literatura tem evidenciado uma preocupação cada vez maior em apresentar uma identidade cultural que expresse as relações de inclusão social. A realidade brasileira mostra que o negro, após a libertação dos escravos, e mais recentemente com o crescimento do movimento negro assumiu uma nova visão, criando um novo discurso nessa literatura, quando passa a ser personagem da transformação da consciência negra. Neste contexto que se insere a literatura negra de Maria Rita, dedicadas ao público infantil, destaca-se a preocupação em buscar soluções para resolver os problemas dos seus personagens tais como: frustração, rejeição, desejo de ser branco, dúvidas e os anseios de crianças negras na sociedade, mas que afetam a auto-estima e a sua identidade
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