730 research outputs found
Efeitos fetotóxicos do aldrin em filhotes de 1. e 2. gerações de ratos.
No full textOs organoclorados absorvidos pela mãe podem encontrar-se no feto ou no neonato, através da passagem pela placenta e pelo leite. Assim, procurou-se verificar se a administração de aldrin prejudicaria o desenvolvimento de filhotes de 1. e 2. gerações quando jovens (1-26 dias de vida) e adultos (90 dias). Os filhotes de ratas tratadas com 1.0 mg/Kg de aldrin, s.c., durante a prenhez ou a lactação, tiveram seu desenvolvimento físico e neurocomportamental testado. Observou-se prejuízo em relação a descida dos testículos, erupção de dente incisivo e maturação neuromuscular (reflexos), mas não quanto ao peso. Não foram encontrados aldrin e/ou dieldrin no plasma dos filhotes aos 90 dias. Todavia, estes apresentavam maior locomoção e exploração em caixa de "hole-board"As femeaas expostas apresentavam diminuição da taxa de viabilidade ao desmame (prenhez) mas não quanto ao seu comportamento maternal. Desta forma, pode-se supor que ocorreram alterações que perdurariam pela vida dos animais
MALDI-TOF MS characterization of proanthocyanidins from cranberry fruit (Vaccinium macrocarpon) that inhibit tumor cell growth and matrix metalloproteinase expression in vitro
No full textProanthocyanidin-rich extracts were prepared by fractionation of the fruit of the North American cranberry (Vaccinium macrocarpon). In vitro growth inhibition assays in eight tumor cell lines showed that selected fractions inhibited the growth of H460 lung tumors, HT-29 colon and K562 leukemia cells at GI(50) values ranging from 20 to 80 mu g ml(-1). Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) of one of these fractions found it to be composed of polyflavan-3-ols, which are primarily tetramers through heptamers of epicatechin containing one or two A-type linkages. Whole cranberry extract and the proanthocyanidin fractions were screened for effect on the expression of matrix metalloproteinases in DU 145 prostate carcinoma cells. The expression of MMP-2 and MMP-9 was inhibited in response to whole cranberry extract and to a lesser degree by the proanthocyanidin fractions. (c) 2005 Society of Chemical Industry.PT: J; CR: BOMSER J, 1996, PLANTA MED, V62, P212 CHA HJ, 1996, CANCER RES, V56, P2281 CHA HJ, 1998, ONCOGENE, V16, P771 FERGUSON PJ, 2004, J NUTR, V134, P1529 FOO LY, 2000, J NAT PROD, V63, P1225 GUTHRIE N, 2000, P EXP BIOL C SAN DIE HOWELL AB, 1998, NEW ENGL J MED, V339, P1085 HOWELL AB, 2002, CRIT REV FOOD SCI S, V42, P273 KANDIL FE, 2002, J AGR FOOD CHEM, V50, P1063 KOLODZIEJ H, 1995, PHYTOTHER RES, V9, P410 KRUEGER CG, 2000, J AGR FOOD CHEM, V48, P1663 KRUEGER CG, 2003, J AGR FOOD CHEM, V51, P538 MORROW DMP, 2001, MUTAT RES-FUND MOL M, V480, P269 MURPHY BT, 2003, J AGR FOOD CHEM, V51, P3541 NETO CC, 2005, S SERIES PHENOLICS F, P271 PORTER ML, 2001, J SCI FOOD AGR, V81, P1306 PUPA SM, 2002, J CELL PHYSIOL, V192, P259 SAMUEL SK, 1992, EMBO J, V11, P1599 SEERAM NP, 2004, J AGR FOOD CHEM, V52, P2512 SKEHAN P, 1990, J NATL CANCER I, V82, P1107 VAYALIL PK, 2004, CARCINOGENESIS, V25, P987 VINSON JA, 2001, J AGR FOOD CHEM, V49, P5315 YAN X, 2002, J AGR FOOD CHEM, V20, P5844 YE X, 1999, MOL CELL BIOCHEM, V196, P99 ZHAO J, 1999, CARCINOGENESIS, V20, P1737; NR: 25; TC: 2; J9: J SCI FOOD AGR; PG: 8; GA: 994DQSource type: Prin
Coelho Neto Canibal: Pseudônimos shakespearianos e literatura licenciosa no Brasil (1890-1940) / Coelho Neto Cannibal: Shakespearean pseudonyms and licentious literature in Brazil (1890-1940)
No full textResumo: Este trabalho estuda a trajetória do pseudônimo shakespeariano Caliban, adotado pelo escritor Henrique Coelho Neto (1864-1934), em 1890, para veicular literatura licenciosa nos impressos. Acompanhamos o pseudônimo desde sua estreia até sua última aparição no mundo editorial na década de 1940. Para levar a cabo a tarefa, consultamos os livros publicados por Caliban e investigamos sua atuação na imprensa periódica por meio da consulta online dos jornais na Hemeroteca Digital Brasileira. Caliban foi um autor de sucesso e parte desse reconhecimento vinha da origem erudita de seu nome. O filtro shakespeariano era crucial para a aceitação dessa literatura nos circuitos letrados, mas muitos a consideravam como mera pornografia. A literatura de Caliban revela um Coelho Neto moderno, contestador e inovador que foi esquecido pela tradição crítica.Palavras-chave: Coelho Neto; William Shakespeare; Caliban; literatura licenciosa.Abstract: This work studies the trajectory of the Shakespearean pseudonym “Caliban”, adopted by writer Henrique Coelho Neto (1864-1934) in the 1890s to convey licentious literature in print. We follow the pseudonym from its debut until its last appearance in the publishing world in the 1940s. To carry out the task, we consulted the books published by Caliban and investigated his performance in the periodic press through online consultation of newspapers in the Hemeroteca Digital Brasileira. Caliban was a successful author and part of that recognition came from the erudite origin of his name. The Shakespearean filter was crucial for the acceptance of this literature in literary circuits, but many considered it as mere pornography. Caliban’s literature reveals a modern, challenging and innovative Coelho Neto who has been overlooked by critical tradition.Keywords: Coelho Neto; William Shakespeare; Caliban; licentious literature
Finite Displacement Analysis Of Plates Subjected To Flexure And Compression Using The Boundary Element Method
No full textThe generalized plane stress problem is coupled with the classic bending model using the effect of the finite displacements to analyze plates under combined loads. The direct boundary integral equations are derived from the equilibrium equations. Continuous or discontinuous linear boundary elements can be employed according to the boundary value problem and constant domain elements are introduced to consider the effect of the finite displacements. Compressed plates problems are studied with the shortening introduced by a uniform displacement applied on both edges to approach the numerical model to that used in the laboratorial experimentation. Obtained results are compared to those available from the literature.161168Gospodinov, G., Ljutskanov, D., The boundary element method applied to plates (1982) Appl. Math.Modelling, 6, p. 237Morjaria, M., Mukherjee, S., Inelastic analysis of transverse deflection of plates by the boundary element method (1980) J. Appl. Mech., 47, p. 291Palermo Jr., L., Plate bending analysis using the classical or the Reissner-Mindlin models (2003) Engineering Analysis with Boundary Elements, 27, pp. 603-609Tanaka, M., Integral Equation Approach to Small and Large Displacement of Thin Elastic Plates (1982) Boundary Element Methods in Engineering, pp. 526-539. , Brebbia, C.A. (ed.), Berlin: Springer-VerlagAtluri, S.N., Pipkins, D.S., Large Deformation Analysis of Plates and Shells (1991) Boundary Element Analysis of Plates and Shells, pp. 141-166. , Beskos D. E. (ed.), Springer-VerlagTimoshenko, S.P., Woinowsky-Krieger, S., (1959) Theory of Plates and Shells, , McGraw-Hill Book Company, New York, 2nd EdBui, H.D., Some Remarks about the Formulation of Three-Dimensional Thermoelastic Problems by Integral Equations (1978) Int. J. Solids and Structures, 14, pp. 935-939Ye, T.Q., Liu, Y.J., Finite deflection analysis of elastic plate by the boundary element method (1985) Appl. Math. Modelling, 9, pp. 183-188Salmon, C.G., Johnson, J.E., (1996) Steel Structures - Design and Behavior, , 4th Edition, New York, Harper Collins College PublishersSimões, R., Palermo Jr., L., O Cálculo das Menores Cargas Críticas em Placas Finas Usando o Método dos Elementos de Contorno XXIX Jornadas Sudamericanas de Ingenieria Estructural, Punta del Este, Uruguay, 2000. (Portuguese)Levy, S., Bending of Retangular Plates with Large Deflections (1942) NACA Technical Report 737, pp. 139-15
Maternal separation effects on the behavior, innate immunity and tumor growth
No full textUm modelo de indução de estresse/ansiedade é a separação materna. Sabe-se, a este respeito, que o desenvolvimento do comportamento emocional normal em mamíferos jovens depende da interação entre a mãe e o filhote. Além disso, eventos estressantes na infância e interrupções no cuidado materno podem levar a efeitos deletérios na resposta imune e na resistência a doenças ao longo da vida. Buscamos neste trabalho estudar os efeitos da separação materna sobre o comportamento, imunidade inata e crescimento tumoral de uma prole de camundongos machos adultos. Nossos resultados mostraram que a separação materna, em camundongos A/J, (1) não produziu alterações robustas no comportamento e em parâmetros hematológicos (antes e após o crescimento tumoral), (2) aumentou a atividade de neutrófilos sanguíneos e macrófagos alveolares (antes e após o crescimento tumoral), (3) aumentou os níveis estriatais de serotonina, seu metabólito 5-HIAA e o turnover de dopamina, (4) diminuiu os níveis séricos de corticosterona e (5) não influenciou a incidência tumoral. Em camundongos C57BL/6, a separação materna produziu um comportamento ansioso e um aumento na atividade de neutrófilos sanguíneos. Tomados em seu conjunto, parece-nos possível afirmar que a separação materna tenha produzido alterações na atividade neuroimune dos animais, modificando, nos mesmos a atividade do eixo HPA e essas alterações foram influenciadas pelas características individuais das linhagens.Maternal separation is one model of stress/anxiety induction. We know about it that the mammals normal emotional behavior development depends on the interaction between mother and younglet. Beside this, early life stressed events can induce deletery effects in immune response and to illness resistance for all life long. In this work we searched for the maternal separation effects on the behavior, innate immunity and tumor growth in an adult male mice offspring. Our results showed that the maternal separation, in A/J mice (1) had no big effects in the behavior and in the hematological parameters (before and after the tumor growth), (2) increased the neutrophil and alveolar macrophages activity (before and after the tumor growth), (3) increased the serotonin striatum levels, the 5-HIAA metabolite and the dopamine turnover (4) decreased the corticosterone serum levels and (5) had no effects on tumor incidence. In the C57BL/6 mice, the maternal separation induced an anxiety behavior and increased the neutrophil activity. These results suggest that the maternal separation could have produced alterations in neuroimmune activity, modifying the HPA axis activity and these alterations could be influenced by individual strains characteristics
Tropical ginsberg: the resonance of Allen Ginsberg on the Tropicália
No full textDissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Comunicação e Expressão, Programa de Pós-graduação em Letras/Inglês e Literatura Correspondente, Florianópolis, 2010Through a dialogical relation between poems and song lyrics, and the socio-political contexts which surrounded these texts, this research discusses the resonance that North American poet, Allen Ginsberg, had over the Brazilian musical movement, the Tropicália. The corpora are the poems "Howl" (1956), "America" (1956), "Supermarket in California" (1955), "Sunflower Sutra" (1955), "Song" (1954), and "Wild Orphan" (1952), written by Allen Ginsberg, and the songs "Batmacumba" (1968), composed by Caetano Veloso, and Gilberto Gil, "Baby" (1968), composed by Caetano Veloso, "Geléia Geral" (1968), composed by Gilberto Gil and Torquato Neto, "Alegria, Alegria" (1967), composed by Caetano Veloso, and "Domingo no Parque" (1967), composed by Gilberto Gil. The main theoretical and critical parameters of this research include: Mikhail Bakhtin and his reflections on intertextuality; James J. Farrell, who believes that the American counterculture began with the Beats; Claudio Willer, who stresses the importance of Allen Ginsberg to the Beat movement, as well as to the birth of the American counterculture; Christopher Dunn, who emphasizes the historical, social, and political relevance of the Tropicália; and Celso Favaretto, who discusses in depth the complexity of most of the Tropicália songs. Based on such parameters, this research suggests that the life and work of Allen Ginsberg had great resonance over the creation of the Tropicália.Através de uma relação dialógica entre poesia e letras de música e o contexto sócio-político que circundava tais textos, este estudo discute a ressonância que o poeta Norte Americano, Allen Ginsberg, teve sobre o movimento musical Brasileiro, a Tropicália. A corpora são os poemas "Howl" (1956), "America" (1956), "Supermarket in California" (1955), "Sunflower Sutra" (1955), "Song" (1954), e "Wild Orphan" (1952), escritos por Allen Ginsberg, e as músicas "Batmacumba" (1968), composta por Caetano Veloso, e Gilberto Gil, "Baby" (1968), composta por Caetano Veloso, "Geléia Geral" (1968), composta por Gilberto Gil e Torquato Neto, "Alegria, Alegria" (1967), composta por Caetano Veloso, e "Domingo no Parque" (1967), composta por Gilberto Gil. Os principais parâmetros teóricos e críticos desta pesquisa incluem: Mikhail Bakhtin e suas reflexões sobre intertextualidade; James J. Farrell, que acredita que a contracultura Americana começou com os Beats; também em Claudio Willer, que salienta a importância de Allen Ginsberg no movimento Beat e no nascimento da contracultura Americana; Christopher Dunn, que enfatiza a relevância histórica, social e política da Tropicália; e Celso Favaretto, que discute em profundidade a complexidade da grande maioria das músicas da Tropicália. Baseando-se em tais parâmetros identificados, esta dissertação sugere que a vida e obra de Allen Ginsberg tiveram grande ressonância sobre a criação da Tropicália
Combined wind lidar and cloud radar for high-resolution wind profiling
No full textThis paper introduces an experimental setup for retrieving horizontal wind speed and direction profiles with a high temporal and vertical resolution for process studies and validation of convection-permitting model simulations. The CMTRACE (tracing convective momentum transport in complex cloudy atmospheres) campaign used collocated wind lidar and cloud radar measurements to retrieve seamless wind profiles from near the surface up to cloud tops. It took place in Cabauw, the Netherlands, between 13 September and 3 October 2021. The intermediate processing steps for generating the level 1 and level 2 data, such as second trip echoes filtering, offset correction, wind retrieval, re-gridding, and flagging, are described. In level 1 (https://doi.org/10.5281/zenodo.6926483, Dias Neto, 2022a), the data from lidar and radars are kept in the original spatial and temporal resolution, while in level 2 (https://doi.org/10.5281/zenodo.6926605, Dias Neto, 2022b), they are regridded to a common spatial and temporal resolution. Statistical analyses of the lidar's and radar's wind speed and direction profiles indicate a correlation higher than 0.95 for both variables. The bias of wind direction and speed calculated between radar's and lidar's observations are 0.24∘ and −0.16 m s−1, respectively. The foreseen initial application of the datasets includes the study of convective momentum transport and its validation in regional weather forecasts and large-eddy simulation hindcasts.Atmospheric Remote Sensin
Sevilha andando, com “A sevilhana que não se sabia” / Sevilha andando, with “A sevilhana que não se sabia”
No full textResumo: Em 1987, quando foi publicada a coleção de poemas de João Cabral de Melo Neto intitulada Crime na Calle Relator, “A sevilhana que não se sabia” era o segundo na ordem de exposição, logo após o poema homônimo ao livro. Aquele poema foi reproduzido como o primeiro da coleção seguinte do autor, intitulada Sevilha andando (1989), ao passo que deixou de figurar nas reedições do livro em que constara de início. Assim, o poema que era de um livro passou a compor outro, exclusivamente, por iniciativa do próprio autor, para quem importava a constituição do artefato estético que o livro vem a ser. Este traço diferencial na trajetória do autor incide retrospectivamente sobre toda sua obra, a partir desse evento marcante que interfere na compreensão do que constitui um livro, seja sua publicação ou a reunião de poemas que demanda uma apreciação particularizada, de caso a caso, dos poemas entrelaçados entre si. Acompanhando a repercussão do poema no contexto da obra poética em pauta, será feito um cotejo entre as edições disponíveis dos volumes implicados para se chegar a uma compreensão mais palpável do poema, perspectivado ao longo daquela produção poética.Palavras-chave: poesia brasileira moderna; João Cabral de Melo Neto; estilo; editoração.Abstract: In 1987, when the João Cabral de Melo Neto’s collection of poems was published under the title of Crime in Calle Relator (1987), “A sevilhana que não se sabia” was the second in the order of exhibition, shortly after the poem of the same name to the book. That poem was reproduced as the first of the author’s next collection, titled Sevilha andando (1989), while it ceased to appear in the reissues of the book in which it was initially listed. Thus, the poem that was from one book began to compose another, exclusively, at the initiative of the author himself, for whom it mattered the constitution of the aesthetic artifact that the book comes to be. This differential trait in the author’s trajectory focuses retrospectively on all his work, from this remarkable event that interferes with the understanding of what constitutes a book, be it its publication or the meeting of poems that demands an appreciation particularized, on a case-by-case basis, of the poems intertwined with each other. Following the repercussion of the poem in the context of the poetic work, it will be made a comparison between the available editions of the volumes involved, to reach a more palpable understanding of the poem, perspectived throughout that poetic production.Keywords: modern Brazilian poetry; João Cabral de Melo Neto; style; publishing
Gift Young Engineers: An Extra-Curricular Initiative for Updating Computer and Electrical Engineering Courses
No full textThe curricula of engineering courses are well defined by the central government for all Brazilian universities. Indeed, there are some mandatory determinations that must be fulfilled prior to the accreditation of any engineering course in Brazil. Modifications must be submitted for evaluation beforehand, resulting in a process that sometimes takes years to be approved. That is a secure way to guarantee that the fundamentals of each engineering program will be part of the students’ carrier all over the country, and at the same time a problem when you need to introduce new technological subjects. That poses a problem when you have new demands for technological curricular components that could express the actual state of the art of modern subjects. Trying to solve these issues some professors from the Federal University of Amazonas developed a flexible extra-curricular program for electrical and computer engineering courses, named Gift Young Engineers. This paper describes the philosophy of these extra-curricular programs. Some examples of successful particular partnerships are also discussed. Indeed the proposed training programs for Digital TV Systems (hardware and software) will be presented and analyzed in details. The obtained results will also be discussed in order to contribute to similar experiences worldwide
Avaliação da presença de guia de desoclusão lateral e protrusiva da mandíbula
No full textDissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências da Saúde, Programa de Pós-Graduação em Odontologia, Florianópolis, 2014.Neste estudo avaliou-se a presença de guias de lateralidade e protrusão em alunos do curso de Odontologia da Universidade Federal de Santa Catarina. Participaram da pesquisa, 187 voluntários, com idade média de 22 anos, de ambos os sexos. Os mesmos foram submetidos a questionamentos sobre tratamento ortodôntico prévio e disfunção têmporo-mandibular, ausência e/ou agenesia dentária, bem como foram submetidos ao exame clínico por um operador calibrado para observar a presença ou ausência das guias citadas, tanto do lado direito como do lado esquerdo. Os indivíduos foram classificados como guia de desoclusão oclusal do tipo canina, em grupo ou em outro tipo de guia. Do lado direito, possuíam guia em canino 43,3%; guia em grupo apenas 4,8% e o restante possuíam um outro dente como guia (41,2%). Já do lado esquerdo, 51,8% apresentavam guia em canino; 0,5% em grupo e o restante tinham outro dente como guia (34,8%). Guia lateral canina bilateral foi presente em 40,1%. Em relação à presença de guia anterior, 60,4% dos participantes a possuíam e esta obteve uma forte associação com a prévia realização de tratamento ortodôntico (pAbstract : In this study evaluated the presence of lateral and protrusive guidance in Dentistry students, from Federal University of Santa Catarina. The research involved 187 volunteers with an average age of 22 years, both gender. They were questioned about temporomandibular dysfunction and previous orthodontic treatment, absence and / or dental agenesis, and also underwent a clinical examination by a calibrated operator to observe the presence or absence of guidance, at both sides. The subjects were classified by their guidance occlusal protection type as canine, group or other type of guide . At the right side, canine guidance acquired 43,3%; guide group only 4,8% and another tooth as a guidance 41,2%. At the left side were found 51,8% with canine guidance , 0,5% group and another type of guide obtained 34,8%. Bilateral canine guidance was present in 40,1%. Regarding the presence of anterior guidance, 60,4% of participants leading a strong association with the prior execution of orthodontic treatment (p< 0,006) . No other association was found with types of orthodontic treatment and temporomandibular disorders, except for the presence of in the left canine guidance and make come true orthodontic treatment, which obtained a weak association (p<0,038 %). In addition, there was association between female gender and existence of any condition of dysfunction. Thus, there was no correlation between any type of guide and problems for patient, as well as presence of many different guides types in most of people surveyed
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