34,779 research outputs found
patel-saluja-kapadia-supplement – Affordable housing needs affordable transit
No full textSupplemental material, patel-saluja-kapadia-supplement for Affordable housing needs affordable transit by Shirish B Patel, Jasmine Saluja and Oormi Kapadia in Environment and Urbanization</p
Dynamics of a performance management system: performance information to performance knowledge
No full textIntroductionKaplan and Norton’s balanced scorecardThe NHS performance policy and issues Performance framework evaluationMental modelDefinition of a dynamical system model, steps and detailsSimulation of a model system, method, results and analysisEvaluation and knowledgeSummaryQ&
Measurement of the ratio of branching fractions B(B0→K∗0γ )/B(B0s→φγ ) and the directCP asymmetry inB 0→K∗0γ
No full textThe ratio of branching fractions of the radiative B decays B0→K⁎0γ and B0s→ϕγ has been measured using an integrated luminosity of 1.0 fb−1 of pp collision data collected by the LHCb experiment at a centre-of-mass energy of s√=7TeV. The value obtained is
B(B0→K⁎0γ)B(B0s→ϕγ)=1.23±0.06(stat.)±0.04(syst.)±0.10(fs/fd),
where the first uncertainty is statistical, the second is the experimental systematic uncertainty and the third is associated with the ratio of fragmentation fractions fs/fd. Using the world average value for B(B0→K⁎0γ), the branching fraction B(B0s→ϕγ) is measured to be (3.5±0.4)×10−5.
The direct CP asymmetry in B0→K⁎0γ decays has also been measured with the same data and found to be
ACP(B0→K⁎0γ)=(0.8±1.7(stat.)±0.9(syst.))%.
Both measurements are the most precise to date and are in agreement with the previous experimental results and theoretical expectations
Investigations of Streptomyces coelicolor A3(2) siderophore binding proteins
No full textSiderophores are small, high-affinity ferric iron chelators released by many microorganisms and some plants to solubilize iron. They are of great interest due to their clinical use to treat iron overload in humans, and also in relation to the development of novel antibiotics that target the biosynthetic and uptake pathways for iron in pathogens. Pathogens such as Bacillus anthracis excrete more than one type of siderophore. This is linked to increased pathogenicity. The Gram-positive soil bacterium Streptomyces coelicolor A3(2) excretes three siderophores: desferrioxamine B, desferrioxamine E and coelichelin. These displace iron from insoluble ferric hydroxides, and the resulting ferric complexes are transported into the cell via siderophore-binding proteins (lipoprotein receptors) associated with ATP-binding cassette (ABC) transporters. Previous studies showed that some of the genes in the biosynthetic clusters of the desferrioxamines (des) and coelichelin (cch) were required for efficient uptake of ferrioxamine E and ferri-coelichelin respectively and a third ABC transporter gene cluster (cdt), not associated with siderophore biosynthesis genes, was implicated in the import of ferrioxamine B. In this study, the lipoprotein receptors encoded within the des, cch and cdt clusters - DesE, CchF and CdtB – were recombinantly overproduced in E. coli and purified by immobilized metal affinity chromatography. Also, ferri-coelichelin was purified from cultures of S. coelicolor. The binding of the ferric complexes of the three cognate siderophores, as well as the xenosiderophores ferrichrome and ferrialbomycin, to the lipoprotein receptors was monitored by intrinsic fluorescence quenching. Dissociation constants of receptor-siderophore complexes were found to be in the nanomolar range, and a revised model of cognate siderophore transport in S. coelicolor was proposed. In collaboration with researchers at St. Andrews University, an X-ray crystal structure was solved for apo-DesE and DesE bound to ferrioxamine B, which demonstrated the similarity of DesE to other bacterial siderophore-binding proteins and the negligible conformational change on substrate binding. Ferrioxamine B also exhibited an unusual configuration not observed before in X-ray crystals of this ferri-siderophore. Also, a forcefield was constructed to model the structure and distortions ferric-tris-hydroxamate complexes, which could be used in the future to investigate the molecular basis of the tight and specific binding of ferri-siderophores to siderophore-binding proteins
Computational files for publication "Destabilizing evolutionary and eco-evolutionary feedbacks drive empirical eco-evolutionary cycles"
No full textMaple, Matlab, and R computational files for all analysis in "Destabilizing evolutionary and eco-evolutionary feedbacks drive eco-evo cycles in empirical systems" by Michael H. Cortez, Swati Patel, and Sebastian J. Schreiber (Proceedings B of the Royal Society: Biological Sciences, DOI: 10.1098/rspb.2019.2298). </p
Measurement of the branching fraction
No full textThe B
0
s
→ J/ψK
0
S
branching fraction is measured in a data sample corresponding to 0.41 fb−1
of integrated luminosity collected with the LHCb detector at the LHC. This channel is sensitive to
the penguin contributions affecting the sin 2β measurement from B
0
→ J/ψK
0
S
. The time-integrated
branching fraction is measured to be B(B
0
s
→ J/ψK
0
S
) = (1.83±0.28)×10−5
. This is the most precise
measurement to date
Balancing the NHS balanced scorecard!
No full textIn the UK, the split between opposition and supporters views of the National Health Service (NHS) performance ratings system is growing. Objective argument and consensus would be facilitated if a methodology was developed which showed the cause and effect relationships between the components of the performance rating system. The NHS hospital trust performance ratings data used in 2002 and 2003 were downloaded from the Department of Health performance rating website. Structural equation modelling was used to construct a causal-loop diagram showing the cause and effect relationships between the 16 common performance indicators in the two years. Scenario testing suggests that indicators of delayed transfer of care and of data quality are compromised if emergency readmissions performance is improved
Isolation of anaerobic, extremely thermophilic, sulphur metabolising archaebacteria from New Zealand hot springs
No full textEnrichments of New Zealand geo-thermal samples, initiated in anaerobic sulphur-containing media and incubated at temperatures above 85°C, yielded rod and coccal shaped organisms which possessed archaebacterial characteristics. Pure cultures were isolated and characterised. Five of the seven isolates, which were rod-shaped organisms and did not have an obligate requirement for sulphur respiration, were similar to Ther-moproteus sp. but had more neutral pH optima for growth. Three of these five Thermoproteus sp. were obligate heterotrophs, which has not previously been reported. The two coccal isolates had an obligate requirement for sulphur as an electron acceptor and were similar to Desulfurococcus sp. but again with more neutral pH optima for growth
Taxonomy of modelling and simulation methods in healthcare: emerging findings of Research Into Global Healthcare Tools (RIGHT)
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