19 research outputs found
Physical and Mental Effects of Different Radical Prostatectomy Techniques on Urologic Surgeons
No full textObjective In this web-based international survey study, we aimed to show an association between physical exhaustion and patient, relatives, and employer-related mental stress for surgeons performing open radical prostatectomy (ORP), laparoscopic radical prostatectomy (LRP), and robot-assisted laparoscopic prostatectomy (RALP). Additionally, we also aimed to compare the outcomes of three approaches. Methods We sent a ten-question survey to the urologists performing ORP, LRP, and RALP via e-mail and social media. Only fully completed surveys were included in the study analysis. We asked questions about age, the preferred surgical approach for radical prostatectomy, frequency of weekly exercise, and their possible associations with physical exhaustion and musculoskeletal complaints. Results A total of 160 urologists completed the survey. The RALP group showed a lower physical exhaustion rate and increased eye strain (p 0.05). Conclusion Compared to ORP and LRP, physical exhaustion was lower in the RALP technique. Although the number of participants was limited, regular exercise weakly improved physical exhaustion and musculoskeletal complaints. We believe that regular sports activities by urologists dealing with LRP and RALP will help relieve physical discomfort.Turkish Association of Urology, Turkish Endourology SocietyAs authors, we would like to thank the Turkish Association of Urology, Turkish Endourology Society, and Turkurolap Education and Research Group for their support in reaching out to members of urologists
Performance Analysis of a Combined Building Integrated PV/T Collector with a Liquid Desiccant Enhanced Dew Point Cooler
No full textAbstractThis study introduces a new concept on solar thermal energy driven liquid desiccant based dew point cooling system that integrates several green technologies; including photovoltaic modules, polyethylene heat exchanger loop and a combined liquid desiccant dehumidification-indirect evaporative air conditioning unit. A small scale experimental prototype was developed and tested to investigate the performance of the proposed system and influence of the various parameters such as weather condition, air flow and regeneration temperature. A cost effective, easy-to-make polyethylene heat exchanger loop was employed underneath PV panels for heat generation. In addition, a liquid desiccant enhanced dew point cooling unit was utilized to provide air conditioning through dehumidification of humid air and indirect evaporative cooling. The experimental results show that the proposed tri-generation system is capable of providing about 3kW of heating, 5kW of cooling power and 10 MWh/year power generation, respectively
Eczacılık mesleğinde profesyonellik: Türkiye ile Suudi Arabistan karşılaştırması
No full textThe pharmacy philosophy has changed from product-oriented to patient-oriented in the last three decades. And due to the evolution of the medical field and the profound changes in the health system, including the pharmacy profession, the need to value ethics is becoming a necessity through building a system that determines and supports professional ethics; thus, pharmacists become more proficient and aligned with code of ethics. This aim can be achieved by continuously updating the ethical codes, evaluating pharmacists' professionalism, and measuring and incorporating mandatory subjects in the curriculum of pharmacy schools. However, in Türkiye and some Arab countries, the educational and practicing system continued to be product oriented. The main objective of this master's thesis is to shed light on professionalism by discussing its dimensions and finding a tool to evaluate pharmacists' professionalism and compare multiple countries regarding their pharmacists' professionalism. The professionalism assessment tool PAT is used, a 33-item self-evaluation tool that evaluates professionalism through five main dimensions. The participating pharmacists were from fourteen countries, but only Türkiye and Saudi Arabia participants were incorporated for the results and discussion because both countries achieved the required sample size. A cross-sectional data collection method was used, which resulted in 440 pharmacists have accepted to participate in the study by pressing "agree" for the participation consent; only 38.18% of them completed the evaluation to the end, thus being included in the data analysis. According to the collected data, we considered seventy-five percent of our pharmacists are professional according to their score from the 33-item tool. Despite a lot of legal and cultural differences, the Independent T-test and Multivariate analysis of variance MANOVA test have been carried out to reveal no difference between Türkiye's and Saudi Arabia's regarding the pharmacists' professionalism. At the end of the thesis, unprofessional observations in the pharmacy community in Türkiye were mentioned and discussed by the author in the discussion chapter. Recommendations and commentary for the pharmacy community, pharmacy schools, and researchers in the field have been pointed out in the last section of the discussion chapter.Eczacılık felsefesi son otuz yılda üründen hasta odaklıya doğru değişti. Tıp alanındaki evrim ve eczacılık mesleği de dahil olmak üzere sağlık sistemindeki köklü değişiklikler nedeniyle, meslek etiğini belirleyen ve destekleyen bir sistem inşa ederek etiğe değer verme ihtiyacı bir zorunluluk haline geliyor; böylece eczacılar daha yetkin hale gelir ve etik kurallarla uyumlu hale gelir. Bu amaca, etik kodların sürekli olarak güncellenmesi, eczacıların profesyonelliklerinin değerlendirilmesi ve zorunlu konuların ölçülmesi ve eczacılık fakültelerinin müfredatına dahil edilmesi ile ulaşılabilir. Ancak Türkiye'de ve bazı Arap ülkelerinde eğitim ve uygulama sistemi ürün odaklı olmaya devam etti. Bu yüksek lisans tezinin temel amacı, profesyonelliğin boyutlarını tartışarak ve eczacıların profesyonelliğini değerlendirmek için bir araç bularak ve birden fazla ülkeyi eczacılarının profesyonelliği açısından karşılaştırarak profesyonelliğe ışık tutmaktır. Profesyonelliği beş ana boyut üzerinden değerlendiren 33 maddelik bir öz değerlendirme aracı olan profesyonellik değerlendirme aracı PAT kullanılmaktadır. Katılan eczacılar on dört ülkedendi, ancak sonuçlar ve tartışma için yalnızca Türkiye ve Suudi Arabistan katılımcıları dahil edildi çünkü her iki ülke de gerekli örneklem büyüklüğünü elde etti. Kesitsel bir veri toplama yöntemi kullanılmış, 440 eczacı katılım onayı için "katılıyorum" düğmesine basarak çalışmaya katılmayı kabul etmiş; sadece %38,18'i değerlendirmeyi sonuna kadar tamamlayarak veri analizine dahil edilmiştir. Toplanan verilere göre eczacılarımızın yüzde yetmiş beşini 33 maddelik araçtan aldıkları puana göre profesyonel kabul ettik. Birçok yasal ve kültürel farklılığa rağmen, Türkiye ve Suudi Arabistan arasında eczacıların profesyonelliği açısından bir fark olmadığını ortaya koymak için Independent T-testi ve Multivariate varyans analizi MANOVA testi yapılmıştır. Tezin sonunda Türkiye'deki eczacılık camiasındaki profesyonel olmayan gözlemlere değinilmiş ve tartışma bölümünde yazar tarafından tartışılmıştır. Eczacılık camiası, eczacılık okulları ve alandaki araştırmacılar için öneriler ve yorumlar tartışma bölümünün son kısmında belirtilmiştir
FTIR STUDIES OF AMMONIA PHOTOCHEMISTRY IN SOLID PARAHYDROGEN
No full textAuthor Institution: Department of Chemistry, University of Wyoming, Laramie, WY 82071-3838It is believed that producing and trapping high concentrations of reactive species in solid molecular hydrogen will ultimately lead to the development of new high performance rocket fuels.\textbf{189}, 351-365 (1994).} We think the NH radical could be a viable candidate and try to produce it by photolyzing ammonia (NH) at low temperature in solid parahydrogen. Upon 193.3 nm photolysis of NH, we observe both NH and NH radical photoproducts. No significant changes in the NH radical concentration have been detected during a period of 3 hours at 1.8 K, even though the reaction NH + H \rightarrow NH is highly exothermic and can occur by quantum mechanical tunneling even at these low temperatures. In contrast, the NH radical is only observed in FTIR scans recorded during photolysis and rapidly decays once the 193.3 nm laser is turned off. We will discuss the possible fates of NH and how conditions can be optimized to produce high concentrations of NH radicals
INFRARED SPECTROSCOPY OF HNO AND NOH SUSPENDED IN SOLID PARAHYDROGEN
No full textAuthor Institution: Department of Chemistry, University of Wyoming, Laramie, WY 82071-3838The only report in the literature on the infrared spectroscopy of the parent oxynitrene NOH was performed using Ar matrix isolation spectroscopy at 10 K.\textbf{38}, 108-110 (1999).} In this previous study, the NOH is synthesized by co-deposition of NO/Ar and a H/Ar mixture that is passed through a microwave discharge to create H-atoms. The H-atoms recombine with NO in the Ar matrix to produce mostly HNO, but some NOH is produced as well. In this work we irradiate NO doped parahydrogen solids at 2 K using 193 nm radiation which is known to generate H-atoms as by-products.\textbf{29}, 740-743 (2003).} After the photolysis laser is stopped, we detect growth of HNO and NOH presumably due to reactions of H-atoms with NO analogous to the previous Ar matrix study. The higher energy NOH isomer is predicted by high-level calculations to be in a triplet ground electronic state.\textbf{136}, 164303 (2012).} Interestingly, the infrared absorptions of NOH for the two observed vibrational modes (bend and OH stretch) display fine structure; an intense central peak with smaller peaks spaced symmetrically to both lower and higher wavenumbers. Further, the spacing between the peaks is the same for both vibrational modes. We believe this fine structure reflects the zero-field splitting of the triplet ground state of NOH (magnetic dipole-dipole interaction) and our most current results and analysis will be presented
DETECTING HYDROGEN ATOMS IN SOLID PARAHYDROGEN USING FTIR SPECTROSCOPY
No full textAuthor Institution: Department of Chemistry, University of Wyoming, Laramie, WY 82071-3838Our group is currently studying the 193.3 nm photochemistry of a number of precursor molecules isolated in solid parahydrogen (pH) using high-resolution FTIR spectroscopy. In photochemical studies of formic acid\textbf{3}, 342-347 (2012).} and ammonia, right after the photolysis laser is turned off, we observe metastable satellite peaks in close proximity to the strong rovibrational transition out of the ground state of the respective monomer photoproducts HO and NH. In both cases, there are two satellite peaks near the R(0) monomer transition. We have assigned these satellite features to H-HO and H-NH radical clusters that form via reactions of the photoproduct with the pH host. We will present IR spectroscopic studies of these two H-atom cluster systems that we hope to use in future photochemical studies to measure the concentration of H-atoms in our sample using FTIR spectroscopy
Okullarda sosyal sermaye ile yenileşme iklimi arasındaki ilişki
No full textBu araştırmada, ortaöğretim kurumlarında (liseler) sosyal sermaye ile yenileşmeiklimi arasındaki ilişkinin incelenmesi amaçlanmıştır. Bu kapsamda lise öğretmenlerininsosyal sermaye ve yenileşme iklimine ilişkin görüşlerinin düzeyleri belirlenmiştir.Araştırmada nicel araştırma yöntemlerinden “ilişkisel tarama” ve “nedenselkarşılaştırma” modelleri birlikte kullanılmıştır. Araştırmanın evrenini 2015-2016eğitim-öğretim yılında Ankara İli merkez ilçelerinde görev yapan lise öğretmenlerioluşturmaktadır. Araştırmaya tabakalı örnekleme yöntemiyle seçilen 700 lise öğretmenikatılmıştır. Araştırmanın verileri araştırmacı tarafından geliştirilen “Kişisel BilgiFormu”, “Okullarda Sosyal Sermaye Ölçeği” ve “Okullarda Yenileşme İklimi Ölçeği”ile toplanmıştır. Veriler; betimsel istatistikler (aritmetik ortalama, standart sapma bağıldeğişim katsayısı), anlam çıkarıcı istatistikler [t-testi (cinsiyet, eğitim durumu), tekyönlü varyans analizi (okul türü, okuldaki çalışma süresi, yaş), Pearson korelasyon veçoklu regresyon analizi] ile çözümlenmiştir.Araştırma sonucunda öğretmenlerin görüşlerine göre, okullarda sosyal sermayeve yenileşme iklimi puanlarının orta düzeyde olduğu saptanmıştır. Kadın öğretmenlerinsosyal sermaye toplam puanları, erkek öğretmenlere göre daha yüksektir. Cinsiyete göreokullardaki yenileşme iklimi toplam puanları birbirine benzerlik göstermektedir. Eğitimdurumu lisans olan öğretmenlerin hem sosyal sermaye hem de yenileşme iklimi toplampuanlarının, lisansüstü dereceye sahip olanlara göre daha yüksektir. Okul türüdeğişkenine göre, fen lisesi ve imam hatip lisesinde çalışan öğretmenlerin sosyalsermaye puanlarının, anadolu teknik ve meslek lisesinde çalışan öğretmenlere görepuanları daha yüksek olduğu görülmüştür. Benzer şekilde fen lisesinde çalışanöğretmenlerin yenileşme puanlarının ortalamaları anadolu teknik ve meslek lisesindevçalışan öğretmenlere göre daha yüksek olduğu gözlemlenmiştir. Görece göreve yenibaşlayanların hem sosyal sermaye hem de yenileşme iklimi puanı toplamları, daha fazlaçalışma süresine sahip öğretmenlere göre daha yüksek bulunmuştur. Okullarda sosyalsermaye ve yenileşme iklimi toplam puanları öğretmenlerin yaşlarına göre istatistikselolarak anlamlı bir farklılık göstermemiştir. Okulda çalışmaya yeni başlayanöğretmenlerin yenileşme iklimi toplam puanları, okulda daha uzun süre çalışanöğretmenlere göre daha yüksek bulunurken sosyal sermaye toplam puanları bakımındanistatistiksel olarak anlamlı bir farklılık bulunamamıştır.Kavramlar arasındaki ilişki sonuçlarına göre okullardaki sosyal sermaye ileyenileşme iklimi arasında pozitif yüksek düzeyde anlamlı ilişki olduğu tespit edilmiştir.Sosyal sermayenin boyutları ile yenileşme ikliminin (yenileşemeye açıklık dışında)boyutları arasında pozitif orta ve yüksek düzeyde anlamlı ilişkiler saptanmıştır. Sonolarak sosyal sermaye boyutlarının, yenileşme ikliminin önemli bir yordayıcısı olduğusonucuna ulaşılmıştır. Araştırma bulguları ilgili alan yazınla ilişkili bir biçimdetartışılmış ve araştırma sonuçlarına ilişkin bazı öneriler sunulmuştur.AbsrtactThe purpose of the study was to explore the relationship between social capitaland innovative climate in secondary education institutions (high schools). In thiscontext, levels of high school teachers’ views about social capital and innovativeclimate were determined. The study employed corretional research under quantitativeresearch methods. The population of the research included high school teachersemployed in high schools in central districts of Ankara Province in the 2015-2016academic year. The sample of the study consisted of 700 high school teachers chosenthrough stratified sampling method. The research data were gathered by incorporate useof “Personal Data Form”, the “Social Capital in Schools Scale” and the “InnovativeClimate in Schools Scale”, developed by the author. The data were analysed bydescriptive statistics (arithmetic mean, standard deviation relative change coefficient)and inferential statics [t-test (gender, educational background), one-way varianceanalysis (school type, term of school employment, age), Pearson correlation andmultiple regression analysis].Results revealed that the scores of social capital and those of innovative climatein schools were at a moderate level in teachers’ views. The total scores of social capitalof the female participant teachers were found higher than those of the male teachers.The scores of innovative climate in schools were similar according to gender. It wasfound that the total scores of both social capital and innovative climate of the graduateteachers were higher than those of the postgraduates. According to the school typevariable, the social capital scores of the teachers employed in science high schools andreligious vocational high schools were found higher than those of the teachers employedviiin vocational and technical Anatolian high schools. It was clear from the results that theinnovative climate scores of the teachers employed in science high schools were higherthan those of the teachers employed in vocational and technical Anatolian high schools.The scores of both social capital and innovative climate of those with short terms ofschool employment were found higher than the scores of the teachers with longer termsof school employment. The total scores of social capital and innovative climate inschools did not vary according to the teachers’ ages. The innovative climate scores ofthe new teachers in schools were found higher than those of the ones who workedlonger in those schools while there was no difference in the social capital scores.As a result of the relationship between the study concepts, it was seen that therewas a high, significant positive correlation between social capital in schools andinnovative climate. There were also positive, moderately and highly significantcorrelations between the social capital factors and those of innovative climate (exceptfor openness to innovation). Finally, it was concluded that the factors of social capitalwere significant predictors of innovative climate
Periostin alters transcriptional profile in a rat model of isoproterenol-induced cardiotoxicity
No full textSozmen, Mahmut/0000-0001-7976-4051Periostin is an extracellular matrix protein from the fasciclin family that guides cellular trafficking and extracellular matrix organization. Periostin stimulates mature cardiomyocytes to reenter the cell cycle. The molecular mechanism behind such stimulation remains to be explored. A DNA microarray technology constituting 30,429 gene-level probe sets was utilized to investigate effects of recombinant murine periostin peptide on the gene expression pattern in a rat model of isoproterenol (ISO)-induced myocardial injury. The experiment was performed on 84 adult male Sprague-Dawley rats in four groups (n = 21): (1) control group, (2) only periostin applied group, (3) ISO cardiotoxicity group, and (4) ISO + periostin group. The experiment was continued for 28 days, and rats were killed on days 1, 7, and 28 (n = 7). Microarray analyses revealed that periostin significantly altered the expression of at least +/- 2-fold of 2474 genes in the ISO + periostin group compared to the ISO cardiotoxicity group of which 521 genes altered out of 30,429 gene-level probe sets. Ingenuity pathway analysis indicated that multiple pathway networks were affected by periostin, with predominant changes occurring in the expression of genes involved in oxidative phosphorylation, oxidative stress, fatty acid metabolism, and TNF-alpha NF-kappa B signaling pathways. These findings indicate that periostin alters gene expression profile in the ISO-induced myocardial injury and modulates local myocardial inflammation, possibly mitigating inflammation through TNF-alpha NF-kappa B signaling pathway along with a decreased Casp7 activity and apoptotic cell death.Ondokuz Mayis University Scientific Research and Development Support Program, Samsun [PYO.VET.1901.13]; Turkish Scientific Research Council (TUBITAK-TOVAG), Ankara, Turkey [114O734]The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This project was financially supported by Ondokuz Mayis University Scientific Research and Development Support Program (Project No.: PYO.VET.1901.13), Samsun, and Turkish Scientific Research Council (TUBITAK-TOVAG; Project No.: 114O734), Ankara, Turkey
VDR gene FokI polymorphism as a poor prognostic factor for papillary thyroid cancer
No full textPubMed: 304867592-s2.0-85057533408This is the first study to investigate the effect of vitamin D receptor (VDR) gene single-nucleotide polymorphisms on the clinicopathologic features of papillary thyroid cancer in Turkey. A total of 165 patients with papillary thyroid cancer and 172 controls were included in this case–control study. VDR gene single-nucleotide polymorphisms FokI (rs2228570), BsmI (rs1544410), ApaI (rs7975232), and TaqI (rs731236) were evaluated using reverse-transcription polymerase chain reaction. VDR gene polymorphisms BsmI, ApaI, and TaqI did not differ between the papillary thyroid cancer group and control group (p > 0.05, each). BsmI, ApaI, and TaqI were not associated with papillary thyroid cancer risk. The VDR gene FokI CT/TT genotype was associated with an increased papillary thyroid cancer risk (CT vs CC: odds ratio = 1.71, 95% confidence interval = 1.15–2.76, p = 0.028; TT vs CC: odds ratio = 2.44, 95% confidence interval = 1.29–4.62, p = 0.005; CT/TT vs CC: odds ratio = 1.88, 95% confidence interval = 1.20–2.96, p = 0.006; CT/CC vs TT: odds ratio = 1.80, 95% confidence interval = 1.05–3.20, p = 0.041). VDR gene polymorphisms were not in linkage disequilibrium. The FokI TT genotype was associated with having T3 and T4, stage III/IV, extra-thyroidal invasion. The FokI CT/TT or TT genotype was associated with developing N1 status, multifocality, tumor size ?10 mm, and treatment with radioiodine therapy. Persistence/recurrence did not differ between the FokI genotypes. Carriers of the FokI T allele were at an increased risk of more advanced tumor-node-metastasis stage, greater tumor size, multifocality, and extra-thyroidal invasion of papillary thyroid cancer compared with the CC genotype. VDR gene FokI T allele and TT genotype correlated with aggressiveness of papillary thyroid cancer; thus, FokI could be useful as a poor prognostic factor to assess the high risk of papillary thyroid cancer. © The Author(s) 2018
Tyrosine kinase inhibitors in the treatment of metastatic renal cell cancer patients with early cytokine intolerance: TURCOS, a Turkish national, prospective observational study
No full textObjective Cytokines have been the mainstay of treatment in metastatic renal cell cancer (mRCC) for decades before the introduction of tyrosine kinase inhibitors (TKIs), which dramatically changed the therapeutic landscape in these patients. This observational study was designed to evaluate use of TKIs in the treatment of cytokine-intolerant mRCC patients. Methods A total of 151 cytokine-intolerant mRCC patients who were treated with TKIs (sunitinib, pazopanib and sorafenib) were enrolled in this prospective, non-interventional, multi-center observational study at 16 oncology centers across Turkey. Mean (SD) age was 61.3 (11.1) years and 74.8% were males. Data on duration of TKI treatment was the primary outcome measure. Additionally, overall response rate (ORR), progression free survival (PFS), overall survival (OS) and safety data were recorded. Results Median duration of treatment was 8.2 months at a median follow up of 17.9 months. ORR and disease control rate were 12.5% and 70.8%, respectively. Median PFS and OS were 7.5 months (95%CI: 6.4-10.4) and 27.3 months (95%CI: 17.6-27.3) with no significant difference among three TKI agents in terms of treatment duration, ORR, PFS and OS. The most common adverse events excluding progression-which was the protocol requirement were diarrhea (13.6%), asthenia (13.6%) and hand-foot syndrome (12.6%). Dose modifications were required in 30.5% of the patients and 15% discontinued TKIs because of toxicity. Conclusions Our findings confirm the efficacy and safety profile of TKIs in the first-line treatment of mRCC patients intolerant to cytokine treatment. There was no significant difference among three TKI agents in terms of treatment duration, ORR, PFS and OS.Bayer TurkThe author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This study was supported by Bayer Turk (ClinicalTrials.gov Identifier: NCT01585974)
