37 research outputs found
Isolation and HPLC quantitative analysis of new flavonoid tetraglycosides from Brazilian beverages (Maytenus ilicifolia and M. aquifolium).
No full textSupercritical Fluid Extraction Of A High-ash Brazilian Mineral Coal
No full textThe effects of extraction temperature, solvent density and addition of cosolvents on the conversion, liquid yield and also on the characteristics of the extracts and residues from SCFE with toluene of a high-ash Brazilian mineral coal were experimentally investigated (Rocha [1]). The experiments were performed in a semi-batch laboratory-scale unit in the coal pyrolysis region - 593 to 673 K and with pressures up to 11.5 MPa. It was observed a reduction in the total sulfur content up to 44%, whereas providing residues with maximum losses of 16% of the original heat-content. The extracts were characterized by a reliable, non-destructive Preparative Liquid Chromatography method - PLC-8 (Karam et al. [2]), providing eight discrete fractions with well defined chemical functionality. With the addition of 5 mol% tetralin 21.7% conversion was obtained, that means an increase of 15% when compared to pure toluene, while with n-methyl-2-pyrrolidone (NMP) and ethanol the conversion decreased. © 1996 Elsevier B.V. All rights reserved.12C185190Rocha, S.R.P., (1995) M.Sc. Thesis, Federal University of Santa Catarina, Brazil, , 161pKaram, H.S., McNair, H.M., Lanças, F.M., (1987) LC-GC, 5, p. 41Gangoli, N., Thodos, G., (1977) Ind. Eng. Chem. Prod. Res. Dev., 16, p. 208Lanças, F.M., Vilegas, J.H.Y., Martins, S., Gobato, E.A.F., (1994) J. of High Resolution Chromatography, 17, p. 237Peng, D.Y., Robinson, D.B., (1976) Ind. Eng. Chem. Fundam., 15, p. 59Sakaki, T., Shibata, M., Adachi, Y., Hirosue, H., (1994) Fuel, 73, p. 515Cahill, P., Harrison, G., Lawson, G.J., (1989) Fuel, 68, p. 1152Kershaw, J.R., Jezko, J., (1982) Separation Science and Technology, 17, p. 151Vasilakos, N.P., Dobbs, J.M., Parisi, A.S., (1985) Ind. Eng. Chem. Process Des. Dev., 64, p. 883Canel, M., Hedden, K., Wilhelm, A., (1990) Fuel, 69, p. 47
Supercritical Technology In Brazil: System Investigated (1994-2003)
No full textIn this work, a review of the Brazilian scientific production in the past 10 years in the field of supercritical fluid is presented. The historical facts associated with the previous edition of the Brazilian Meeting on Supercritical Fluids are discussed. Because of the importance of the other South America countries contribution to the filed, a summary of the research published in the past 5 years by all South America countries is also presented. In the past 5 years (1999-2003) 82 papers from South American countries were published in journals indexed in the Web of Science data base. Of these, 26 papers were related to the use of supercritical fluids as an analytical tool. Supercritical extraction from a variety of vegetable raw material contributed with 38 papers and the petroleum industry added 2 papers to the field. Reactions contributed with 3 publications while thermodynamics and fundamental studies were responsible for 13 publications. The Brazilian contribution represented 53-84% of the publications in the above areas. © 2004 Elsevier B.V. All rights reserved.342 SPEC. ISS.109117Sutter, L.E.D.N., Silva, M.F.F., Cassel, E., Extração supercrítica, uma nova tecnologia industrial (1994) Ciênc. Tecnol. Aliment., 14, p. 3Stuart, G.R., Oliveira, J.V., D'Avila, S.G., Extração de óleo essencial de alfavaca utilizando dióxido de carbono e altas pressões (1994) Ciênc. Tecnol. Aliment., 14, p. 11Franco, T.T., Marty, A., Condoret, J.S., Protein solubilization in reverse micelles using supercritical CO 2 (1994) Ciênc. Tecnol. Aliment., 14, p. 17Corrêa, N.C.F., Meireles, M.A.A., França, L.F., Araújo, M.E., Extração de óleo de semente de maracujá (Passiflora edulis) com CO2 supercrítico (1994) Ciênc. Tecnol. Aliment., 14, p. 29Cassel, E., Oliveira, J.V., Planejamento experimental aplicado à discriminação de modelos: Extração supercrítica na indústria alimentícia (1994) Ciênc. Tecnol. Aliment., 14, p. 38Lanças, F.M., Vilegas, J.H.Y., Queiroz, M.E.C., Marchi, E., Projeto, construção e aplicação de sistemas SFE "home-made". I. Aplicações de um sistema analítico no estudo de produtos naturais de origem vegetal (1994) Ciênc. Tecnol. Aliment., 14, p. 45Lanças, F.M., Vilegas, J.H.Y., Sargenti, S.R., Moraes, M.L.L., Nossack, A.C., Projeto, Construção e aplicação de sistemas SFE "home-made". II. Aplicações de um sistema semi-preparativo no estudo de produtos de origem vegetal (1994) Ciênc. Tecnol. Aliment., 14, p. 56Lanças, F.M., Pereira, D.M., Andrade, R.M.B., Projeto, construção e aplicação de sistemas SFE "home-made". III. Aplicações de um sistema estático no estudo de derivados de cana-de-açúcar e combustíveis alternativos (1994) Ciênc. Tecnol. Aliment., 14, p. 66Lanças, F.M., Galhiane, M.S., Barbirato, M.A., Rissato, S.R., Ferreira, L.H., Peres, R.G., Projeto, construção e aplicação de sistemas SFE "home-made". IV. Aplicação de um sistema dinâmico no controle de qualidade de alimentos de origem vegetal (1994) Ciênc. Tecnol. Aliment., 14, p. 75Ferrua, F.Q., Marques, M.O.M., Meireles, M.A.A., Óleo essencial de capim-limão obtido por extração com dióxido de carbono líquido (1994) Ciênc. Tecnol. Aliment., 14, p. 83Ferrua, F.Q., Meireles, M.A.A., Cinética de extração de óleo essencial de capim-limão com dióxido de carbono líquido (1994) Ciênc. Tecnol. Aliment., 14, p. 93Lanças, F.M., Vilegas, J.H.Y., Vasconcelos, E.C., Caleghini, R.M.S., Novas aplicações de sistemas SFE "home made": I. Plantas medicinais brasileiras (1997) Ciênc. Tecnol. Aliment., 17, p. 413Lanças, F.M., Vilegas, J.H.Y., Nossack, A.C., Vasconcelos, E.C., Caleghini, R.M.S., Cappelaro, E.A., Von Baer, D., Hasegawa, M., Novas aplicações de sistemas SFE "home made": II. Plantas da América do Sul (1997) Ciênc. Tecnol. Aliment., 17, p. 418Lanças, F.M., Assis, L.M., Souza, A.J., Kampen, M.H.V., Basseto Filho, A., Novas aplicações de sistemas SFE "home made": III. Energia química e elétrica Ciênc (1997) Tecnol. Aliment., 17, p. 423Lanças, F.M., Dórea, H.S., Müller, R.A., Fagundes, C.B., Novas aplicações de sistemas SFE "home made": IV. Qualidade dos alimentos (1997) Ciênc. Tecnol. Aliment., 17, p. 432Lanças, F.M., Barbirato, M.A., Galhiane, M.S., Rissato, R.S., Novas aplicações de sistemas SFE "home made": VI. Controle de agrotóxicos em produtos alimentícios (1997) Ciênc. Tecnol. Aliment., 17, p. 437Mendes, M., Oliveira, J.V., Uller, A., Fracionamento de óleos de citros utilizando fluidos supercríticos (1997) Ciênc. Tecnol. Aliment., 17, p. 441Coelho, L.A.F., Oliveira, J.V., Pinto, J.C., Modelagem e simulação do processo de extração supercrítica do óleo essencial de alecrim (1997) Ciênc. Tecnol. Aliment., 17, p. 446Cardozo-Filho, L., Ferrua, F.Q., Meireles, M.A.A., Estudo do processo da extração supercrítica de óleos essenciais de produtos naturais (1997) Ciênc. Tecnol. Aliment., 17, p. 449Silva, G.F., Cabral, F.A., Estimativa das propriedades de carotenóides por métodos de contribuição de grupos (1997) Ciênc. Tecnol. Aliment., 17, p. 456Dariva, C., Coelho, L.A.F., Oliveira, J.V., Predicting diffusivities in dense fluids (1997) Ciênc. Tecnol. Aliment., 17, p. 461Jaffe, R., Diaz, D., Hajje, N., Chen, L., Eckardt, C., Furton, K.G., Hydrocarbon speciation in ancient sediments studied by stepwise high-temperature supercritical carbon dioxide extraction (1997) Org. Geochem., 26, p. 59Vieira De Melo, S.A.B., Uller, A.M.C., Pessoa, F.L.P., Análise termodinâmica da desterpenação do óleo da casca de laranja com CO2 supercrítico a partir de uma mistura sintética (1997) Ciênc. Tecnol. Aliment., 17, p. 467Vieira De Melo, S.A.B., Uller, A.M.C., Pessoa, F.L.P., Modelagem e simulação da desterpenação do óleo da casca de laranja com CO2 supercrítico em modo semi-contínuo (1997) Ciênc. Tecnol. Aliment., 17, p. 475Cardozo-Filho, L., Stragevitch, L., Wolff, F., Meireles, M.A.A., The generalized maximum likelihood method applied to high pressure phase equilibrium (1997) Ciênc. Tecnol. Aliment., 17, p. 481Cardozo-Filho, L., Wolff, F., Meireles, M.A.A., High pressure phase equilibrium: Prediction of essential oil solubility (1997) Ciênc. Tecnol. Aliment., 17, p. 485Oliveira, A.L., Cabral, F.A., Uso da equação de estado de Peng-Robinson com regra de mistura dependente da composição na predição do equilíbrio de fases do sistema ternário CO2-limoneno- citral (1997) Ciênc. Tecnol. Aliment., 17, p. 489Neves, G.B.M., Mohamed, R.S., Modelagem termodinâmica do fracionamento do óleo de manteiga com fluidos supercríticos (1997) Ciênc. Tecnol. Aliment., 17, p. 494Stuart, G., MacHado, R., Oliveira, J.V., Uller, A.C., Lima, E.L., Hybrid artificial neural network applied to modeling SCFE of basil and rosemary oils (1997) Ciênc. Tecnol. Aliment., 17, p. 501Souza, A.M., Oliveira, J.V., Tavares, F.W., Estudo da seletividade capacidade em sistemas sólido-gás (1997) Ciênc. Tecnol. Aliment., 17, p. 506Dariva, C., Oliveira, J.V., Pinto, J.C., Vale, M.G., Caramão, E.B., Statistical analysis of the SCFE of a Brazilian mineral coal (1997) Ciênc. Tecnol. Aliment., 17, p. 512Saldaña, M.D.A., Mohamed, R.S., Mazzafera, P., Supercritical carbon dioxide extraction of methylxanthines from mate tea leaves (2000) Braz. J. Chem. Eng., 17, p. 251Lanças, F.M., Barbirato, M.A., Galhiane, M.S., Rissato, S.R., Extraction of fluazinan residues from fruits by CO2 in the supercritical state (1997) HRC - J. High Res. Chromatogr., 20, p. 569Gerszt, R., Pessoa, F.L.P., Mendes, M.F., Phase behavior of sterols and vitamins in supercritical CO2 (2000) Braz. J. Chem. Eng., 17, p. 261Pasquel, A., Meireles, M.A.A., Marques, M.O.M., Petenate, A.J., Extraction of stevia glycosides with CO2 + water, CO 2 + ethanol, and CO2 + water + ethanol (2000) Braz. J. Chem. Eng., 17, p. 271Silva, E.A., Cardozo-Filho, L., Wolff, F., Meireles, M.A.A., Modeling the supercritical desorption of orange essential oil from a silica-gel bed (2000) Braz. J. Chem. Eng., 17, p. 283Araujo, M.E., MacHado, N.T., França, L.F., Meireles, M.A.A., Supercritical extraction of pupunha (Guilielma speciosa) oil in a fixed bed using carbon dioxide (2000) Braz. J. Chem. Eng., 17, p. 297Mizutani, F.T., Costa, A.L.H., Pessoa, F.L.P., Stochastic simulation of supercritical fluid extraction processes (2000) Braz. J. Chem. Eng., 17, p. 307Chassagnez-Mendez, A.L., Correa, N.C.F., França, L.F., MacHado, N.T., Araújo, M.E., A mass transfer model applied to the supercritical extraction with CO2 of curcumins from turmeric rhizomes (Curcuma longa L) (2000) Braz. J. Chem. Eng., 17, p. 315Baumann, W., Rodrigues, S.V., Viana, L.M., Pigments and their solubility in and extractability by supercritical CO2 - I: The case of curcumin (2000) Braz. J. Chem. Eng., 17, p. 323Eggers, R., Ambrogi, A., Von Schnitzler, J., Special features of SCF solid extraction of natural products: Deoiling of wheat gluten and extraction of rose hip oil (2000) Braz. J. Chem. Eng., 17, p. 329Del Valle, J.M., Bello, S., Thiel, J., Allen, A., Chordia, L., Comparison of conventional and supercritical CO2-extracted rosehip oil (2000) Braz. J. Chem. Eng., 17, p. 335Costa, A.L.H., Da Silva, F.P.T., Pessoa, F.L.P., Parameter estimation of thermodynamic models for high-pressure systems employing a stochastic method of global optimization (2000) Braz. J. Chem. Eng., 17, p. 349Lanças, F.M., Galhiane, M.S., Rissato, S.R., Barbirato, M.A., Effect of temperature, collection mode, and modifier on the supercritical CO2 extraction of Dicofol residues from fish samples (1997) HRC - J. High Res. Chromatogr., 20, p. 369Waintraub, S., Fonseca, C.N., Soares, G.M.G., Campagnolo, E.A., Conversion of a deasphalting unit for use in the process of supercritical solvent recovery (2000) Braz. J. Chem. Eng., 17, p. 355Martins, E.P., Aranda, D.A.G., Pessoa, F.L.P., Zotin, J.L., Hydrogenation of diesel aromatic compounds in supercritical solvent environment (2000) Braz. J. Chem. Eng., 17, p. 361De Melo, S.A.B.V., Costa, G.M.N., Garau, R., Casula, A., Pittau, B., Supercritical CO2 extraction of essential oils from Thymus vulgaris (2000) Braz. J. Chem. Eng., 17, p. 367Augusto, F., Lopes, A.L.E., Zini, C.A., Sampling and sample preparation for analysis of aromas and fragrances (2003) Trac-Trend Anal. Chem., 22, p. 160Arancibia, V., Valderrama, M., Silva, K., Tapia, T., Determination of chromium in urine samples by complexation-supercritical fluid extraction and liquid or gas chromatography (2003) J. Chromatogr. B, 785, p. 303Olenka, L., Nogueiran, E.S., Medina, A.N., Baesso, M.L., Bento, A.C., Muniz, E.C., Rubira, A.F., Photoacoustic study of PET films and fibers dyed in supercritical CO 2 reactor (2003) Rev. Sci. Instrum., 74, p. 328Zuin, V.G., Yariwake, J.H., Bicchi, C., Fast supercritical fluid extraction and high-resolution gas chromatography with electron-capture and flame photometric detection for multiresidue screening of organochlorine and organophosphorus pesticides in Brazil's medicinal plants (2003) J. Chromatogr. a, 985, p. 159Ibanez, E., Benavides, A.M.H., Senorans, F.J., Reglero, G., Concentration of sterols and tocopherols from olive oil with supercritical carbon dioxide (2002) J. Am. Oil Chem. Soc., 79, p. 1255Nunes, G.S., Santos, T.C.R., Barcelo, D., Pimenta, A.S., Ribeiro, M.L., Supercritical fluid extraction for some carbamate insecticides in potatoes samples, with HPLC/fluorescence determination and HPLC/mass spectrometry confirmation (2002) Quim. Nova., 25, p. 214Paroul, N., Cassel, E., Rota, L., Atti-Santos, A.C., Moyna, P., Grower, A.E., Serafini, L.A., Chemical composition of the volatiles of angelica root obtained by hydrodistillation and supercritical CO2 extraction (2002) J. Essent. Oil Res., 14, p. 282Moraes, M.D.L.L., Vilegas, J.H.Y., Lanças, F.M., Supercritical fluid extraction of glycosylated flavonoids from Passiflora leaves (1997) Phytochem. Anal., 8, p. 257Rostagno, M.A., Araújo, J.M.A., Sandi, D., Supercritical fluid extraction of isoflavones from soybean flour (2002) Food Chem., 78, p. 111Bauza, R., Rios, A., Valcarcel, M., Supercritical fluid extraction with in situ chiral derivatization for the enantiospecific determination of ibuprofen in urine samples (2001) Anal. Chim. Acta, 450, p. 1Celeghini, R.M.S., Vilegas, J.H.Y., Lancas, F.M., Extraction and quantitative HPLC analysis of coumarin in hydroalcoholic extracts of Mikania glomerata Spreng ("guaco") leaves (2001) J. Braz. Chem. Soc., 12, p. 706Granados, D.L., Jimenez, A., Cuadrado, T.R., Assessment of parameters associated to the risk of PVC catheter reuse (2001) J. Biomed. Mater. Res., 58, p. 505Maraschin, M., Sugui, J.A., Wood, K.V., Bonham, C., Lanças, F.M., Araújo, P.S., Yunes, R.A., Verpoorte, R., J. D. Fontana Supercritical CO2 extraction of velutinol a from Mandevilla velutina (Apocynaceae) cultured cells and MALDI-TOF MS analysis (2001) Biotechnol. Lett., 23, p. 77Pinto, J.S.S., Cappelaro, E.A., Lanças, F.M., Design and construction of an on-line SPE-SFE-CGC system (2001) J. Braz. Chem. Soc., 12, p. 192Tavares, M.C.H., Vilegas, J.H.Y., Lanças, F.M., Separation of underivatised triterpene acids by capillary supercritical fluid chromatography (2001) Phytochem. Anal., 12, p. 134Arancibia, V., Segura, R., Leiva, J.C., Contreras, R., Valderrama, M., Supercritical fluid extraction and gas chromatography or electroanalysis of metal chelates from different sample matrices (2000) J. Chromatogr. 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Food Chem., 51, p. 2520Martinez, J., Monteiro, A.R., Rosa, P.T.V., Marques, M.O.M., Meireles, M.A.A., Multicomponent model to describe extraction of ginger oleoresin with supercritical carbon dioxide (2003) Ind. Eng. Chem. Res., 42, p. 1057Rodrigues, M.R.A., Caramão, E.B., Dos Santos, J.G., Dariva, C., Oliveira, J.V., The effects of temperature and pressure on the characteristics of t
Indigofera Suffruticosa Mill As New Source Of Healing Agent: Involvement Of Prostaglandin And Mucus And Heat Shock Proteins
No full textEthnopharmacological relevance: Indigofera suffruticosa is specie typical of the "Cerrado" or Brazilian savannah; it is a member of the Fabaceae family - in folkmedicine is used for gastric disorders, infection and inflammation. Aim of the study: Ethyl acetate fraction (AcF) and aqueous fraction (AqF) of the methanolic extract of I. suffruticosa leaves were evaluated against acute gastric ulcer. The AcF fraction was selected to assess its activity in ulcer healing and its gastroprotective effects via mucus and gastric secretion. Materials and methods: The gastroprotective action of AcF and AqF fractions were evaluated in a rodent experimental model. The action mechanisms, involvements of the antisecretory action, mucus and prostaglandin production, toxicological and healing activity of the AcF (100 mg/kg, p.o.) were evaluated. We also used histological analysis (HE and PAS) and immunohistochemical (PCNA and HSP-70) assays to evaluate the effects of I. suffruticosa. Results: AcF significantly inhibited the gastric mucosal damage caused by ethanol. This effect was statistically significant in 100 mg/kg group compared vehicle. AcF did not interfered with gastric secretion, significantly increased the PGE 2 and mucus production (validated in PAS technique). The gastroprotection was attenuated by pretreatment with N-ethylmaleimide, but not L-NAME. In acid-acetic-induced ulcer model AcF accelerated ulcer healing. Immunohistochemistry analysis showed induction of proliferating cell (PCNA) and heat shock protein (HSP 70). Conclusions: These results showed that AcF acted as gastroprotective agent stimulating prostaglandin, mucus and HSP70. © 2011 Elsevier Ireland Ltd All rights reserved.1371192198Arrieta, J., Benitez, J., Flores, E., Castillo, C., Navarrete, A., Purification of Gastroprotective Triterpenoids from the Stem Bark of Amphipterygium adstringensRole of Prostaglandins, Sulfhydryls, Nitric Oxide and Capsaicin-Sensitive Neurons (2003) Planta Medica, 69 (10), pp. 905-909. , DOI 10.1055/s-2003-45098Behmer, O.A., Tolosa, E.M.C., Freitas Neto, A.G., (1976) Manual de Técnicas Para Histologia Normal e Patológica, pp. 80-195. , Editora da USP, São Paulo, SP, BrazilCalvo, T.R., Cardoso, C.R., Da Silva Moura, A.C., Dos Santos, L.C., Colus, I.M., Vilegas, W., Varanda, E.A., Mutagenic activity of Indigofera truxillensis and I. suffruticosa aerial parts (2009) Evidence-Based Complementary and Alternative Medicine, 20, pp. 1-8Cola-Miranda, M., Barbastefano, V., Hiruma-Lima, C.A., Calvo, T.R., Vilegas, W., Souza Brito, A.R.M., Antiulcerogenic activity of Indigofera truxillensis Kunth (2006) Biota Neotropica, 6, pp. 1-9Curtis, G.H., MacNaughton, W.K., Gall, D.G., Wallace, J.L., Intraluminal pH modulates gastric prostaglandin synthesis (1995) Canadian Journal of Physiology and Pharmacology, 73, pp. 130-134De Sousa Falcão, H., Leite, J.A., Barbosa-Filho, J.M., De Athayde-Filho, P.F., De Oliveira Chaves, M.C., Moura, M.D., Ferreira, A.L., Batista, L.M., Gastric and duodenal antiulcer activity of alkaloids: A review (2008) Molecules, 13, pp. 3198-3223Farias-Silva, E., Cola, M., Calvo, T.R., Barbastefano, V., Ferreira, A.L., Michelatto, D.D.P., De Almeida, A.C.A., Souza Brito, A.R.M., Antioxidant activity of indigo and its preventive effect against ethanol-induced DNA damage in rat gastric mucosa (2007) Planta Medica, 73 (12), pp. 1241-1246. , DOI 10.1055/s-2007-981613Grant, C.M., Role of the glutathione/glutaredoxin and thioredoxin systems in yeast growth and response to stress conditions (2001) Molecular Microbiology, 39 (3), pp. 533-541. , DOI 10.1046/j.1365-2958.2001.02283.xGrob, N.G., Peptic ulcer in twenty-century of America (2004) New Jersey Medicine, 101, pp. 19-28Jung, H.K., Lee, K.E., Chu, S.H., Yi, S.Y., Reactive oxygen species activity, mucosal lipoperoxidation and glutathione in Helicobacter pylori-infected gastric mucosa (2001) Journal of Gastroenterology and Hepatology, 16 (12), pp. 1336-1340. , DOI 10.1046/j.1440-1746.2001.02647.xKimura, M., Goto, S., Ihara, Y., Wada, A., Yahiro, K., Niidome, T., Aoyagi, H., Kondo, T., Impairment of glutathione metabolism in human gastric epithelial cells treated with vacuolating cytotoxin from Helicobacter pylori (2001) Microbial Pathogenesis, 31 (1), pp. 29-36. , DOI 10.1006/mpat.2001.0446Kvietys, P.R., Twohig, B., Danzell, J., Specian, R.D., Ethanol-induced injury to the rat gastric mucosa. Role of neutrophils and xanthine oxidase-derived radicals (1990) Gastroenterology, 98 (4), pp. 909-920Laine, L., Takeuchi, K., Tarnawski, A., Gastric Mucosal Defense and Cytoprotection: Bench to Bedside (2008) Gastroenterology, 135 (1), pp. 41-60. , DOI 10.1053/j.gastro.2008.05.030, PII S0016508508007944Malfertheiner, P., Chan, F.K., McColl, K.E., Peptic ulcer disease (2009) Lancet, 374, pp. 1449-1461Massignani, J., Lemos, M., Maistro, E.L., Schaphauser, H.P., Jorge, R.F., Sousa, J.P., Bastos, J.K., De Andrade, S.F., Antiulcerogenic activity of the essential oil of Baccharis dracunculifolia on different experimental models in rats (2009) Phytotherapy Research, 23, pp. 1355-1360Matos, F.J.A., (1999) Plantas da Medicina Popular Do Nordeste: Propriedades Atribuídas e Confirmadas, p. 78. , Editora UFC FortalezaMoreno, M.I.N., Isla, M.I., Sampietro, A.R., Vattuone, M.A., Comparison of the free radical-scavenging activity of propolis from several regions of Argentina (2000) Journal of Ethnopharmacology, 71 (1-2), pp. 109-114. , DOI 10.1016/S0378-8741(99)00189-0, PII S0378874199001890Morimoto, Y., Shimohara, K., Oshima, S., Sukamoto, T., Effects of the new anti-ulcer agent KB-5492 on experimental gastric mucosal lesions and gastric mucosal defensive factors, as compared to those of teprenone and cimetidine (1991) Japanese Journal of Pharmacology, 57, pp. 495-505Mota, K.S., Dias, G.E., Pinto, M.E., Luiz-Ferreira, A., Souza-Brito, A.R., Hiruma-Lima, C.A., Barbosa-Filho, J.M., Batista, L.M., Flavonoids with gastroprotective activity (2009) Molecules, 14, pp. 979-1012Naryzhny, S.N., Proliferating cell nuclear antigen: A proteomics view (2008) Cellular and Molecular Life Sciences, 65, pp. 3789-3808Okabe, S., Amagase, K., An overview of acetic acid ulcer models: The history and state of the art of peptic ulcer research (2005) Biological and Pharmaceutical Bulletin, 28 (8), pp. 1321-1341. , http://bpb.pharm.or.jp/bpb/200508/b08_1321.pdf, DOI 10.1248/bpb.28.1321Rafatullah, S., Tariq, M., Al-Yahya, M.A., Mossa, J.S., Ageel, A.M., Evaluation of turmeric (Curcuma longa) for gastric and duodenal antiulcer activity in rats (1990) Journal of Ethnopharmacology, 29 (1), pp. 25-34Roig, J.T., (1988) Plantas Medicinales, Aromaticas O Venenosas de Cuba, , Editorial Cientifica-Tecnica, La HavanaRokutan, K., Role of heat shock proteins in gastric mucosal protection (2000) Journal of Gastroenterology and Hepatology, 15, pp. 12-19Schmeda-Hirschmann, G., Yesilada, E., Traditional medicine and gastroprotective crude drugs (2005) Journal of Ethnopharmacology, 100 (1-2), pp. 61-66. , DOI 10.1016/j.jep.2005.06.002, PII S037887410500351X, Perspectives of EthnopharmacologyShay, H., Komarov, S.A., Fels, S.S., Meranze, D., Gruenstein, M., Siplet, H., A simple method for the uniform production of gastric ulceration in the rat (1945) Gastroenterology, 5, pp. 43-61Shichijo, K., Ihara, M., Matsuu, M., Ito, M., Okumura, Y., Sekine, I., Overexpression of heat shock protein 70 in stomach of stress-induced gastric ulcer-resistant rats (2003) Digestive Diseases and Sciences, 48 (2), pp. 340-348. , DOI 10.1023/A:1021939829515Sostres, C., Gargallo, C.J., Arroyo, M.T., Lanas, A., Adverse effects of non-steroidal anti-inflammatory drugs (NSAIDs, aspirin and coxibs) on upper gastrointestinal tract. 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Extração de compostos volateis de carvões minerais utilizando-se fluidos supercriticos
No full textDissertação (mestrado) - Universidade Federal de Santa Catarina, Centro Tecnologic
Estudo fitoquímico e biológico das partes aéreas da Mikania Lanuginosa DC (ASTERACEAE)
No full textDissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências Físicas e Matemáticas. Programa de Pós-Graduação em Química
Investigação química de Sorocea bonplandii (Baillon) Burger, Lanjouw e Boer (Moraceae)
No full textDissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências da Saúde. Programa de Pós-Graduação em Farmácia.Sorocea bonplandii (Baillon) Burger, Lanjow e Boer, devido à sua similaridade morfológica com Maytenus spp., é utilizada pela população com os mesmos fins medicinais desta. Ao contrário das espécies de Maytenus, que possuem inúmeros estudos químicos farmacológicos, as informações a respeito da espécie Sorocea bonplandii ainda são incipientes. Neste trabalho foram analisadas as frações éter de petróleo, clorofórmio e acetato de etila - obtidas de um extrato clorofórmico das folhas de S. bonplandii - quanto às suas atividades no bioensaio de letalidade para larvas de Artemia salina Leach. A fração com maior bioatividade neste ensaio foi a clorofórmica, da qual foram isolados e identificados, por ressonância magnética nuclear de 1H e 13C, um álcool primário saturado, o diterpeno fitol, um álcool vinílico de cadeia isoprenílica, uma mistura dos esteróides sitosterol e estigmasterol (sendo o primeiro a substância majoritária). Em outra etapa, após deslipidificação das folhas com éter de petróleo, foram preparados os extratos acetônico e metanólico. Deste foi isolado e identificado por espectrometria de massas e espectroscopia de infravermelho, o dissacarídeo sacarose. Os extratos metanólico e acetônico foram avaliados quanto a sua atividade anticoagulante in vitro. O extrato acetônico apresentou atividade anticoagulante nos testes de tempo de protrombina (TP) e tempo de tromboplastina parcial ativada (TTPa). O mesmo extrato não apresentou atividade sobre a agregação plaquetária induzida por ADP assim como, no teste de tempo de trombina (TT). O extrato metanólico não demonstrou atividade em nenhum dos ensaios anteriores. O efeito anticoagulante evidenciado neste trabalho, nunca descrito para esta espécie, abre novas perspectivas para futuras investigações químico-biológicas, visando o isolamento e identificação da(s) substância(s) responsável(eis) por esta bioatividade
Obtaining phenolic compounds from jatoba (hymenaea courbaril L.) bark by supercritical fluid extraction
No full textThe extraction of polyphenol compounds from jatoba (Hymenaea courbaril L. var stilbocarpa) bark using supercritical fluid extraction (SFE) with CO 2 and cosolvents has been investigated. Among the solvent systems studied, SFE using CO2 and water (9:1, v/v), at 323 K and 35 MPa, presented the best results, with extract yield of 24%, and with high antioxidant activity (IC50 of 0.2 mg/cm3). This solvent system was used to determine global yield isotherms, which were built at 323 and 333 K, and 15, 25, and 35 MPa, using a second lot of jatoba. The highest yield was 11.5% at 15 MPa and 323 K, with maximum total phenolic compounds (TPC) of 335.00 mg TAE/g extract (d.b.) and total tannins content of 1.8 g/100 g raw material. A kinetic experiment was performed using optimized conditions, yielding 18% extract, and the kinetic parameters were used to scale-up the process from laboratory to pilot scale. Chemical analyses showed high content of phenolic compounds in the extracts of jatoba bark mostly due to the presence of procyanidins. © 2014 Elsevier B.V.The extraction of polyphenol compounds from jatoba (Hymenaea courbaril L. var stilbocarpa) bark using supercritical fluid extraction (SFE) with CO2 and cosolvents has been investigated. Among the solvent systems studied, SFE using CO2 and water (9:1, v/v)896877FAPESP - FUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULOCNPQ - CONSELHO NACIONAL DE DESENVOLVIMENTO CIENTÍFICO E TECNOLÓGICO2008/10986-2301301/2010-7De Albuquerque, U.P., De Medeiros, P.M., De Almeida, A.L.S., Monteiro, J.M., De Freitas Lins Neto, E.M., De Melo, J.G., Dos Santos, J.P., Medicinal plants of the caatinga (semi-arid) vegetation of NE Brazil: A quantitative approach (2007) Journal of Ethnopharmacology, 114 (3), pp. 325-354. , DOI 10.1016/j.jep.2007.08.017, PII S0378874107004229Calixto, J.B., Twenty-five years of research on medicinal plants in Latin America: A personal view (2005) Journal of Ethnopharmacology, 100 (1-2), pp. 131-134. , DOI 10.1016/j.jep.2005.06.004, PII S0378874105003612, Perspectives of EthnopharmacologyFernandes, T.T., Santos, A.T.F., Pimenta, F.C., Antimicrobial activity of Plathymenia reticulata, Hymenaea courbaril and Guazuma ulmifolia plants (2005) Revista de Patologia Tropical, 34, pp. 113-122Lorenzi, H., Matos, F.J.A., Medicinal plants in Brazil (2002) Native and Exotics, , Plantarum Institute Nova Odessa, SP, BrazilNogueira, R.T., Shepherd, G.J., Laverde, Jr.A., Marsaioli, A.J., Imamura, P.M., Clerodane-type diterpenes from the seed pods of Hymenaea courbaril var. Stilbocarpa (2001) Phytochemistry, 58 (8), pp. 1153-1157. , DOI 10.1016/S0031-9422(01)00303-X, PII S003194220100303XAguiar, J.C., Santiago, G.M., Lavor, P.L., Veras, H.N., Ferreira, Y.S., Lima, M.A., Arriaga, A.M., Braz-Filho, R., Chemical constituents and larvicidal activity of Hymenaea courbaril fruit peel (2010) Natural Product Communications, 5, pp. 1977-1980Abdel-Kader, M., Berger, J.M., Slebodnick, C., Hoch, J., Malone, S., Wisse, J.H., Werkhoven, M.C.M., Kingston, D.G.I., Isolation and absolute configuration of ent-halimane diterpenoids from Hymenaea courbaril from the Suriname rain forest (2002) Journal of Natural Products, 65 (1), pp. 11-15. , DOI 10.1021/np0103261Orsi, P.R., Bonamin, F., Severi, J.A., Santos, R.C., Vilegas, W., Hiruma-Lima, C.A., Stasi, L.C.D., Hymenaea stigonocarpa Mart. Ex Hayne: A Brazilian medicinal plant with gastric and duodenal anti-ulcer and antidiarrheal effects in experimental rodent models (2012) J. Ethnopharmacology, 143, pp. 81-90Braga, F.C., Wagner, H., Lombardi, J.A., De Oliveira, A.B., Screening Brazilian plant species for in vitro inhibition of 5-lipoxygenase (2000) Phytomedicine, 6, pp. 447-452Pettit, G.R., Meng, Y., Stevenson, C.A., Doubek, D.L., Knight, J.C., Cichacz, Z., Pettit, R.K., Schmidt, J.M., Isolation and structure of palstatin from the amazon tree Hymeneae palustris (2003) Journal of Natural Products, 66 (2), pp. 259-262. , DOI 10.1021/np020231eDoménech-Carbó, M.T., De La Cruz-Cañizares, J., Osete-Cortina, L., Doménech-Carbó, A., David, H., Ageing behaviour and analytical characterization of the Jatobá resin collected from Hymenaea stigonocarpa Mart (2009) International J. Mass Spectrometry, 284, pp. 81-92Sasaki, K., Matsukura, Y., Shijima, K., Miyake, M., Fujiwara, D., Konishi, Y., High-performance liquid chromatographic purification of oligomeric procyanidins, trimers up to nonamers, derived from the bark of Jatoba (Hymenaea courbaril) (2009) Bioscience, Biotechnology, and Biochemistry, 73, pp. 1274-1279Scalbert, A., Antimicrobial properties of tannins (1991) Phytochemistry, 30, pp. 3875-3883Monteiro, J.M., De Albuquerque, U.P., Araújo, E.L., De Amorim, E.L.C., (2005) Tannins from Chemistry to Ecology, 28, p. 4De Bruyne, T., Pieters, L., Deelstra, H., Vlietinck, A., Condensed vegetable tannins: Biodiversity in structure and biological activities (1999) Biochemical Systematics and Ecology, 27 (4), pp. 445-459. , DOI 10.1016/S0305-1978(98)00101-X, PII S030519789800101XChung, K.-T., Wong, T.Y., Wei, C.-I., Huang, Y.-W., Lin, Y., Tannins and human health: A review (1998) Critical Reviews in Food Science and Nutrition, 38 (6), pp. 421-464Shad, M.A., Nawaz, H., Rehman, T., Ahmad, H.B., Hussain, M., Optimization of extraction efficiency of tannins from Cichorium intybus L.: Application of response surface methodology (2012) J. 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Galloylquinic acid derivatives from Byrsonima fagifolia leaf extract and potential antifungal activity.
No full textEthnopharmacological relevance: Byrsonima fagifolia Niedenzu (Malpighiaceae) and other Byrsonima species are popularly employed in Brazilian traditional medicine in the form of preparations as cicatrizing, antiinflammatory, and antimicrobial. Aim of the study: To characterize the phytochemical profile of the hydromethanolic extract obtained from B. fagifolia leaves (BF extract) and to evaluate the toxicity and the antifungal activity. based on extensive analyses of 1D and 2D NMR spectra (HMQC, HMBC and COSY) data. The antifungal effect was determined by the broth microdilution method and the toxicity was evaluated on erythrocytes from sheep?s blood and Galleria mellonella larvae. Results: Phytochemical investigation of the BF extract led to the isolation and characterization of pyrogallol, nbutyl gallate, 3,4-di-O-galloylquinic acid, 3,5-di-O-galloylquinic acid, 3,4,5-tri-O-galloylquinic acid, and 1,3,4,5-tetra-O-galloylquinic acid. The BF extract showed high content of galloylquinic acid derivatives reaching more than twenty-times the quercetin derivatives content, according to the quantification by HPLC. These galloylquinic acid derivatives, obtained during this study, and quercetin derivatives, previously isolated, were submitted to the antifungal assays. The BF extract inhibited yeast growth mainly against Cryptococcus spp., at concentrations of 1?16 ?g/mL, comparable to isolated compounds galloylquinic acid derivatives. However, the quercetin derivatives as well as quinic acid, gallic acid, and methyl gallate showed lower antifungal effect compared with galloylquinic derivatives. In addition, the BF extract had no hemolytic effect and no toxicity on G. mellonella
Supercritical Extraction Of Coumarin From Guaco (mikania Laevigata And Mikania Glomerata) For Pharmaceutical Applications
No full textGuaco has several applications in the chemical and pharmaceutical industries. This plant is a source of coumarin, a diterpene compound with expectorants properties. In Brazil, guaco extracts are used as medicinal products authorized by the National Health Surveillance Agency (ANVISA). Studies proved that guaco extracts are also effective against cancer, ulcers and infectious diseases. Supercritical extractions have been widely used to obtain highly pure natural extracts that do not contain organic solvents and have not lost their thermosensitive compounds and therefore are suitable for pharmaceutical applications. In this study, coumarin was obtained from guaco leaves extracts by supercritical extraction under different experimental conditions according to a central composite rotational design (CCRD) with two independent variables, temperature (T) and pressure (P). Lower values of T were used to maintain the stability of thermosensitive compounds and because coumarin is highly soluble in supercritical CO2 even at low T. The responses surface analyzes (RSA) acquired by fitting of linear and quadratic models to experimental extraction yields and coumarin concentrations showed similar conditions for improving yields from both plant species. Although the extract yield values were similar for both plant species, coumarin concentrations were higher in Mikania laevigata than Mikania glomerata. The greater extract yield of 4.20% coumarin, related to the higher coumarin concentration (0.43 g × 100 g-1 in guaco leaves), was obtained under extraction conditions of P above 175 bar and T above 45 C. © 2013 Elsevier B.V. All rights reserved.836571Bolina, R.C., Garcia, E.F., Duarte, M.G.R., Estudo comparativo da composição química das espécies vegetais Mikania glomerata Sprengel e Mikania laevigata Schultz Bip. 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