1,676 research outputs found
Hemoglobinopathies types and their peculiarities in Morocco
No full textThere are two forms of thalassemia – alpha- and beta-, though clinically thalassemia is divided into minor, intermediate and major. Beta-thalassemia rate is 6-7% in Morocco (S.S. Khandker, 2023) with prevalence in Casablanca 5% among all cities (S. El Kababi, 2019), alpha-thalassemia 0,96%, particularly in the North (A.Laghmich et al., 2019), minor form 1,2% in a whole country. Carriers rate is 6,5% on beta-thalassemia (N.Marzouki, 2022), alpha-thalassemia 0,30% (I.Belmokhtar et al., 2025) and 8% on both thalassemia types (A.Laghmich et al., 2019). Morocco East became thalassemia region after its North and West (I.Belmokhtar et al., 2022). In Rabat, there was a research set which results demonstrated beta-thalassemia major dependence on HLA antigens of both I and II class (S. Ouadghiri et al., 2024). Novel beta-thalassemia variants (C6(-G) and -83(A>G) as well as Hb structural variant D-Ouled Rabah have been discovered first in Morocco. Beta-thalassemia represents the most widely-distributed hemoglobinopathy in Morocco while hemoglobinosis C takes the second position, alpha-thalassemia the third, hemoglobinosis G-Philadelphia - the fourth, D-Ouled Rabah and O-Arab the fifth one (I.Belmokhtar et al., 2025). Morocco has hemoglobinosis C representing mutant Hb with glutaminic acid replacement into lysine in its beta-chain 6 th position. Moroccan people have not only softer heterozygous form with no anemy but also harder homozygous form with moderate hemolytic anemy and Hb crystals in blood smears. Hemoglobinosis C is distributed in Southern Morocco at a greater extent (N.Marzouki, 2022). A combination between these Hb types represents more difficult pathological condition by course than separate hemoglobinoses. There are the data according to which beta-thalassemia can be in a complex with hemoglobinoses C and S with especially hard form of the disease, met in Eastern Morocco mainly (I.Belmokhtar, 2022), except Southern part of the country. Northern Moroccan city Kenitra is distinguished by sickle cell syndromes or hemoglobinosis S in children. Sickle-cell anemy carriers rate is 6,5% and morbidity 80% in the North and 10,5% in other parts of the country (N.Marzouki, 2022)
The role of individual self-study students work in course VI medical university in the professional preparation of doctors.
No full textGrubnik V. V., Koshel Y. M., Tkachenko O. I. The role of individual self-study students work in course VI medical university in the professional preparation of doctors. Journal of Education, Health and Sport. 2017;7(1):503-510. eISSN 2391-8306. DOI http://dx.doi.org/10.5281/zenodo.376848
http://ojs.ukw.edu.pl/index.php/johs/article/view/4327
The journal has had 7 points in Ministry of Science and Higher Education parametric evaluation. Part B item 754 (09.12.2016).
754 Journal of Education, Health and Sport eISSN 2391-8306 7
© The Author (s) 2017;
This article is published with open access at Licensee Open Journal Systems of Kazimierz Wielki University in Bydgoszcz, Poland
Open Access. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited. This is an open access article licensed under the terms of the Creative Commons Attribution Non Commercial License
(http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited.
This is an open access article licensed under the terms of the Creative Commons Attribution Non Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited.
The authors declare that there is no conflict of interests regarding the publication of this paper.
Received: 02.01.2017. Revised 16.01.2017. Accepted: 24.01.2017.
UDK 338 (063)
THE ROLE OF INDIVIDUAL SELF-STUDY STUDENTS WORK IN COURSE VI MEDICAL UNIVERSITY IN THE PROFESSIONAL PREPARATION OF DOCTORS
V. V. Grubnik, Y. M. Koshel, O. I. Tkachenko
Odessa National Medical University, Odessa
Summary
Implementing algorithms of the organization and evaluation of individual self-study students work of VI course aims to acquire well educational material that was not included in the theme. According to the work program on surgical diseases it was allocated 119 (46%) hours of self-study work from 259 total hours for students of 6 course. To prepare for practical training was given 71 hours (60%) of that time, and 48 hours (40%) should be used so that the student study himself the curriculum issues that have not been put to practical training topics. Individual self-study students work allows to learn educational material that was not included in the themes of practical training, to learn practical skills (curation of patients, primary surgical treatment, assistance during operation, the registration of medical documentation), to learn modern methods of professional information from the internet, what is a contemporary form of knowledge acquisition during self-study.
Key words: individual self-study students work, educational program, practical training
Pedagogical innovation of I. G. Tkachenko in Bogdanivska to school
No full textУ статті висвітлено новаторські погляди видатного педагога Кіровоградщини І. Г. Ткаченка. Доведено, що Богданівська школа, яку впродовж 35 років очолював І. Г. Ткаченко була центрами новаторської педагогічної думки, творчого пошуку та високоефективної організації навчально-виховного процесу.The innovative looks of prominent teacher of Kirovograd I. G. Tkachenko’s are reflected in the article. It is well-proven that Bogdanivska school, which during 35 years was headed by I. G. Tkachenko's was the center of innovative pedagogical idea, creative search, high-efficiency organization of educational-educator process. A few decades school from Bogdanivka did not mount from the pages of the most popular by then editions. About school, her director was written by prominent scientists, known writers, journalists, statesmen. His activity was highly estimated by practices, light minds of ordinary teachers. Attracting force to ordinary rural school, which it was fated to become one of centers of pedagogical idea, by the center of accumulation, creation front-rank, new, effective, will go out never. An inheritance of Tkachenko I. G. is the inexhaustible source of innovation and methodical recommendations
Energy indicators of operation the heat pumping system heating of the energy efficient house
No full textEnergy indicators of operation the heat pumping system heating of the energy efficient house / B. I. Basok, O. M. Nedbailo, I. K. Bozhko, M. V. Tkachenko // Актуальні проблеми енергетики та екології : зб. наук. пр. за матеріалами XVIII Всеукр. наук.-техн. онлайн-конф., Одеса, 29-30 верес. 2020 р. / Одес. нац. акад. харч. технологій ; ред. О. С. Тітлов. – Одеса : Бондаренко М. О., 2020. – P. 4–5. – Ref.: 2 tit
Этиопатогенетические, психопатогенетические и клинические аспекты когнитивных нарушений при сахарном диабете 2-го типа = Etiopathogenic, psychopathogenetic and clinical aspects of cognitive disorders in type 2 diabetes
No full textTkachenko О. V. Этиопатогенетические, психопатогенетические и клинические аспекты когнитивных нарушений при сахарном диабете 2-го типа = Etiopathogenic, psychopathogenetic and clinical aspects of cognitive disorders in type 2 diabetes. Journal of Education, Health and Sport. 2015;5(11):279-288. ISSN 2391-8306. DOI http://dx.doi.org/10.5281/zenodo.34006
http://ojs.ukw.edu.pl/index.php/johs/article/view/2015%3B5%2811%29%3A279-288
https://pbn.nauka.gov.pl/works/670229
Formerly Journal of Health Sciences. ISSN 1429-9623 / 2300-665X. Archives 2011–2014 http://journal.rsw.edu.pl/index.php/JHS/issue/archive
Deklaracja.
Specyfika i zawartość merytoryczna czasopisma nie ulega zmianie.
Zgodnie z informacją MNiSW z dnia 2 czerwca 2014 r., że w roku 2014 nie będzie przeprowadzana ocena czasopism naukowych; czasopismo o zmienionym tytule otrzymuje tyle samo punktów co na wykazie czasopism naukowych z dnia 31 grudnia 2014 r.
The journal has had 5 points in Ministry of Science and Higher Education of Poland parametric evaluation. Part B item 1089. (31.12.2014).
© The Author (s) 2015;
This article is published with open access at Licensee Open Journal Systems of Kazimierz Wielki University in Bydgoszcz, Poland and Radom University in Radom, Poland
Open Access. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium,
provided the original author(s) and source are credited. This is an open access article licensed under the terms of the Creative Commons Attribution Non Commercial License
(http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited.
This is an open access article licensed under the terms of the Creative Commons Attribution Non Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted, non commercial
use, distribution and reproduction in any medium, provided the work is properly cited.
The authors declare that there is no conflict of interests regarding the publication of this paper.
Received: 25.09.2015. Revised 25.10.2015. Accepted: 10.11.2015.
Этиопатогенетические, психопатогенетические и клинические аспекты когнитивных нарушений при сахарном диабете 2-го типа
ETIOPATHOGENIC, PSYCHOPATHOGENETIC AND CLINICAL ASPECTS OF COGNITIVE DISORDERS IN TYPE 2 DIABETES
О. В. Ткаченко
О. V. Tkachenko
Запорожская медицинская академия последипломного образования Министерства здравоохранения Украины
Medical Academy for Post-Diploma Training of Doctors of the Ministry of Health care of Ukraine, Zaporozhe
Summary
Etiopathogenetic, psychopathogenetic and clinical aspects of cognitive impairments in type 2 diabetes patients have been analyzed and systematized. Etiopathogenetic and psychopathologic classification of cognitive disorders in the group under study is presented. Comorbid cognitive mental disorders for which cognitive impairment is a factor of amplification are detached. Morphological phenomena associated with cognitive insufficiency in the patients under study has been marked. The main tactics for cognitive insufficiency prevention and therapy in type 2 diabetes patients are considered.
Key words: type 2 diabetes, cognitive impairment, mental pathology.
Реферат
В статье проанализированы и систематизированы этиопатогенетические, психопатогенетические и клинические аспекты когнитивных нарушений при СД 2-го типа. Приведена этиопатогенетическая и психопатологическая классификация когнитивных нарушений при СД 2-го типа. Рассмотрены коморбидные когнитивным психические расстройства, для которых когнитивные нарушения выступают фактором амплификации. Выделены ассоциированные с когнитивной недостаточностью морфологические феномены у пациентов с СД 2-го типа. Рассмотрены основные тактики профилактики и терапии когнитивной недостаточностью у пациентов с СД 2-го типа.
Ключевые слова: сахарный диабет 2-го типа, когнитивные нарушения, психическая патология
Pathomorphological changes in the large intestine of rabbits parasitised by Passalurus ambiguus (Nematoda, Oxyuridae). Regulatory Mechanisms in Biosystems
No full textMykhailiutenko S. M., Kruchynenko O. V., Klymenko O. S., Serdioucov J. K., Dmytrenko N. I., Tkachenko V. V. Pathomorphological changes in the large intestine of rabbits parasitised by Passalurus ambiguus (Nematoda, Oxyuridae). Regulatory Mechanisms in Biosystems. 2019. Vol. 10. (1). Р. 69–73.
Expression of vimentin, E-cadherin and TGF-β as markers of epithelial-mesenchymal transformation and criteria for the prognosis of the diseaseby epithelium in benign pathology and prostate gland cancer
No full textTkachenko P. V., Yakovtcova I. I., Dolgaya O. V., Ivakhno I. V. Expression of vimentin, E-cadherin and TGF-β as markers of epithelial-mesenchymal transformation and criteria for the prognosis of the diseaseby epithelium in benign pathology and prostate gland cancer. Journal of Education, Health and Sport. 2017;7(7):764-775. eISSN 2391-8306. DOI http://dx.doi.org/10.5281/zenodo.843519
http://ojs.ukw.edu.pl/index.php/johs/article/view/4700
The journal has had 7 points in Ministry of Science and Higher Education parametric evaluation. Part B item 1223 (26.01.2017).
1223 Journal of Education, Health and Sport eISSN 2391-8306 7
© The Authors 2017;
This article is published with open access at Licensee Open Journal Systems of Kazimierz Wielki University in Bydgoszcz, Poland
Open Access. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium,
provided the original author(s) and source are credited. This is an open access article licensed under the terms of the Creative Commons Attribution Non Commercial License
(http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited.
This is an open access article licensed under the terms of the Creative Commons Attribution Non Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted, non commercial
use, distribution and reproduction in any medium, provided the work is properly cited.
The authors declare that there is no conflict of interests regarding the publication of this paper.
Received: 01.07.2017. Revised: 02.07.2017. Accepted: 31.07.2017.
Expression of vimentin, E-cadherin and TGF-β as markers
of epithelial-mesenchymal transformation and criteria
for the prognosis of the diseaseby epithelium in benign pathology and prostate gland cancer
P. V. Tkachenko, I. I. Yakovtcova, O. V. Dolgaya, I. V. Ivakhno
Kharkiv medical academy of postgraduate education
Abstract
Epithelial-mesenchymal transformation in prostate gland cancer is a criterion of aggressive biological behavior of the tumor, but the clinical material is not sufficiently studied. The objective of the research was to study epithelial-mesenchymal transformation and its prognostic significance in benign pathology and prostate gland cancer. The absence of vimentin expression and the evident reaction of E-cadherin in the epithelium in benign pathology of the prostate glandwere revealed. The change in the expression of these markers in prostate gland canceroccur at the expense of low-differentiated forms and is characteristic of the high-risk group (p <0.05 and p <0.01, respectively). An inverse dependence between the reaction of vimentin and E-cadherin (p <0.05) and their correlation withTGFβ (p <0.05) was detected. Conclusion: community of the molecular-biological manifestations of the epithelial-mesenchymal transformation in prostate gland cancer and involvement of TGFβ into its process has been proved. Epithelial-mesenchymal transformation maybe a prognostic criterionof the disease.
Key words: prostate gland cancer, vimentin, E-cadherin, TGFβ, epithelial-mesenchymal transformation
Static properties of a warm dense uniform electron gas
No full textCopyright 2021 American Institute of Physics. This article may be downloaded for personal use only. Any other use requires prior permission of the author and the American Institute of Physics. The following article appeared in J. Ara, Ll. Coloma, and I. M. Tkachenko , "Static properties of a warm dense uniform electron gas", Physics of Plasmas 28, 112704 (2021) https://doi.org/10.1063/5.0062259[EN] We show how the static dielectric function and other static characteristics of dense warm charged Fermi liquids can be obtained exclusively from the system static structure factor. The non-perturbative self-consistent method of moments is employed to extend onto quantum fluids, a similar reduction stemming from the fluctuation-dissipation theorem and other exact relations for classical one-component plasmas. The results are compared to and complement the numerical data obtained recently by the path-integral Monte Carlo method. Alternative theoretical approaches are discussed and employed as well.I.M.T. is grateful to M. Bonitz and T. Dornheim for several valuable discussions. The authors appreciate that M. Bonitz and T. Dornheim provided accurate path integral Monte Carlo simulation results. I.M.T. also acknowledges fruitful discussions with Yu. V. Arkhipov and L. Conde and the financial support provided by the Committee of Science of the Ministry of Education and Science of the Republic of Kazakhstan (Project No. AP09260349).Ara-Bernad, J.; Coloma, L.; Tkachenko Gorski, IM. (2021). Static properties of a warm dense uniform electron gas. Physics of Plasmas. 28(11):1-17. https://doi.org/10.1063/5.0062259S117281
The significance of angiogenesis in tumorigenesis and prognosis of prostate cancer
No full textYakovtcova I. I., Tkachenko P. V., Ivakhno I. V. The significance of angiogenesis in tumorigenesis and prognosis of prostate cancer. Journal of Education, Health and Sport. 2017;7(8):415-422. eISSN 2391-8306. DOI http://dx.doi.org/10.5281/zenodo.852570
http://ojs.ukw.edu.pl/index.php/johs/article/view/4754
The journal has had 7 points in Ministry of Science and Higher Education parametric evaluation. Part B item 1223 (26.01.2017).
1223 Journal of Education, Health and Sport eISSN 2391-8306 7
© The Authors 2017;
This article is published with open access at Licensee Open Journal Systems of Kazimierz Wielki University in Bydgoszcz, Poland
Open Access. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium,
provided the original author(s) and source are credited. This is an open access article licensed under the terms of the Creative Commons Attribution Non Commercial License
(http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited.
This is an open access article licensed under the terms of the Creative Commons Attribution Non Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted, non commercial
use, distribution and reproduction in any medium, provided the work is properly cited.
The authors declare that there is no conflict of interests regarding the publication of this paper.
Received: 01.08.2017. Revised: 27.08.2017. Accepted: 30.08.2017.
The significance of angiogenesis in tumorigenesis and prognosis of prostate cancer
I. I. Yakovtcova, P. V. Tkachenko, I. V. Ivakhno
Kharkiv medical academy of postgraduate education
Abstract
Angiogenesis is a key factor in tumor growth, invasion, and metastasis. The aim of the present study is to investigate the diagnostic and predictive value of prostatic cancer (PC) angiogenesis by immunohistochemically examination of CD34, VEGF and Ki-67 in 40 cases of PC, 8 cases of nodular hyperplasia and 8 cases of intraepithelial neoplasia. It was found that the density of microvessels and intensity data of stroma but not epithelium VEGF staining in PC more than in benign pathology, and increased with risk of recurrence and as the differentiation of cancer was reduced. Results indicate that the vascularization is a sign of growth and progression of PC and may be used as predictor of the disease.
Key words: prostatic cancer, angiogenesis, vascular endothelial growth factor, microvessel density
JETP Letters V. 80, I .09
No full textJETP Letters -- November 10, 2004
Volume 80, Issue 9, pp. 575-616
FIELDS, PARTICLES, AND NUCLEI
Redoubled Effect of a Neutron Spin Rotation in Deformed Noncentrosymmetric Crystal for the Bragg Diffraction Scheme
V. V. Fedorov, I. A. Kuznetsov, E. G. Lapin, S. Yu. Semenikhin, and V. V. Voronin
pp. 575-579 Full Text: PDF (93 kB)
CONDENSED MATTER
Manifestation of Geometric Effects in Temperature Behavior of AC Magnetic Response of Josephson Junction Arrays
S. Sergeenkov and F. M. Araujo-Moreira
pp. 580-583 Full Text: PDF (70 kB)
Zero-energy Andreev Surface Bound States in the Lattice Model
A. M. Bobkov
pp. 584-587 Full Text: PDF (54 kB)
Coherent Scattering in a Small Quantum Dot
V. A. Tkachenko, O. A. Tkachenko, Z. D. Kvon, D. G. Baksheev, A. L. Aseev, and J. C. Portal
pp. 588-592 Full Text: PDF (84 kB)
Anomalous Slowing Down of the Longitudinal Spin Relaxation near the Antiferromagnetic Phase Transition in LaMnO3 Manganite
V. A. Atsarkin, V. V. Demidov, and A. M. Balbashov
pp. 593-596 Full Text: PDF (50 kB)
Ultrasonic Study of the Phase Diagram of Methanol
E. L. Gromnitskaya, O. V. Stal'gorova, O. F. Yagafarov, V. V. Brazhkin, A. G. Lyapin, and S. V. Popova
pp. 597-601 Full Text: PDF (83 kB)
Stochastic Description of Phase Separation near the Spinodal Curve in Alloys
V. Yu. Dobretsov, I. R. Pankratov, and V. G. Vaks
pp. 602-607 Full Text: PDF (209 kB)
Electronic, Structural, and Thermal Properties of a Nanocable Consisting of Carbon and BN Nanotubes
A. N. Enyashin, G. Seifert, and A. L. Ivanovskii
pp. 608-611 Full Text: PDF (155 kB)
Observation of Hubbard Bands in gamma-Manganese
S. Biermann, A. Dallmeyer, C. Carbone, W. Eberhardt, C. Pampuch, O. Rader, M. I. Katsnelson, and A. I. Lichtenstein
pp. 612-616 Full Text: PDF (94 kB)Archived web conten
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