12 research outputs found
Phosphorus-calcium metabolism in postmenopausal women with diabetes mellitus = Фосфорно-кальцієвий обмін у постменопаузальних жінок, хворих на цукровий діабет
No full textKyryliuk M. L., Atanova Ya. O. Phosphorus-calcium metabolism in postmenopausal women with diabetes mellitus = Фосфорно-кальцієвий обмін у постменопаузальних жінок, хворих на цукровий діабет. Journal of Education, Health and Sport. 2015;5(12):544-554. eISSN 2391-8306. DOI http://dx.doi.org/10.5281/zenodo.42478
http://ojs.ukw.edu.pl/index.php/johs/article/view/2015%3B5%2812%29%3A544-554
http://pbn.nauka.gov.pl/works/686447
Formerly Journal of Health Sciences. ISSN 1429-9623 / 2300-665X. Archives 2011–2014 http://journal.rsw.edu.pl/index.php/JHS/issue/archive
The journal has had 7 points in Ministry of Science and Higher Education parametric evaluation. Part B item 755 (23.12.2015). 755 Journal of Education, Health and Sport (null) 2391-8306 7
© The Author (s) 2015;
This article is published with open access at Licensee Open Journal Systems of Kazimierz Wielki University in Bydgoszcz, Poland and Radom University in Radom, Poland
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provided the original author(s) and source are credited. This is an open access article licensed under the terms of the Creative Commons Attribution Non Commercial License
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This is an open access article licensed under the terms of the Creative Commons Attribution Non Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted, non commercial
use, distribution and reproduction in any medium, provided the work is properly cited.
The authors declare that there is no conflict of interests regarding the publication of this paper.
Received: 10.12.2015. Revised 15.12.2015. Accepted: 29.12.2015.
PHOSPHORUS-CALCIUM METABOLISM IN POSTMENOPAUSAL WOMEN WITH DIABETES MELLITUS
ФОСФОРНО-КАЛЬЦІЄВИЙ ОБМІН У ПОСТМЕНОПАУЗАЛЬНИХ ЖІНОК, ХВОРИХ НА ЦУКРОВИЙ ДІАБЕТ
1Kyryliuk M. L., 2Atanova Ya. O.
Кирилюк М. Л., Атанова Я. О.
Український науково-практичний центр ендокринної хірургії, трансплантації ендокринних органів і тканин МОЗ України
(Україна, 01021 Київ, Кловський узвіз 13А)
01021 Ukraine Kyiv, Klovskyi uzviz 13A
Ukrainian Scientific and Practical Center of Endocrine surgery, Transplantation of Endocrine Organs and Tissues of Health of Ministry of Public Health of Ukraine, Kyiv
www.endosurg.com.ua, [email protected], [email protected], [email protected]
РЕЗЮМЕ
Кирилюк М. Л., Атанова Я. О.
ФОСФОРНО-КАЛЬЦІЄВИЙ ОБМІН У ПОСТМЕНОПАУЗАЛЬНИХ ЖІНОК, ХВОРИХ НА ЦУКРОВИЙ ДІАБЕТ
В роботі досліджено стан фосфорно-кальцієвого обміну у постменопаузальних жінок, хворих на цукровий діабет, в залежності від типу цукрового діабету, стажу менопаузи, стажу діабету, маси тіла, типу цукрознижуючої терапії. Показано, що концентрація іонізованого кальцію в крові, загального кальцію та неорганічного фосфору не може слугувати головними маркерами стану мінеральної щільності кісткової тканини у постменопаузальних жінок, хворих на на цукровий діабет 2-го типу, за умов відсутності тяжкої хронічної ниркової недостатності та відповідної коморбідної патології. Виявлено, що препарати сульфонілсечовини та інсулінотерапія у сполученні із бігуанідами не впливають на показники фосфорно-кальцієвого обміну у постменопаузальних жінок із цукровим діабетом 2-го типу.
Ключові слова: фосфорно-кальцієвий обмін, цукровий діабет, менопауза.
RESUME
Kyryliuk M. L., Atanova Ya. O.
PHOSPHORUS-CALCIUM METABOLISM IN POSTMENOPAUSAL WOMEN WITH DIABETES MELLITUS
In this work it was investigated the state of phosphorus-calcium metabolism in postmenopausal women with diabetes mellitus depending on the type of diabetes, length of menopause and diabetes, body weight, type of hypoglycemic therapy. It is shown that the concentration of ionized calcium, general calcium and inorganic phosphorus in the blood can not serve as the main marker of the state of bone mineral density in postmenopausal women with diabetes mellitus type 2 in in cases of absence of severe chronic renal failure and related comorbid pathology. It was found that sulfonylureas drugs and insulin in combination with biguanide not affect on performance of phosphorous-calcium metabolism in postmenopausal women with diabetes mellitus type 2.
Keywords: phosphorus-calcium metabolism, diabetes mellitus, menopause.
Kyryliuk Mykhailo - Prof, MD, PhD, DMSci, Head the Department of Neuroendocrinology and General Endocrinology
http://lazarevich.at.ua/
Atanova Yana - MD, endocrinologis
Роль интерпретатора в актуализации прагматической модальности художественного текста
No full textВ данной работе выявляется необходимость и осуществляется попытка наметить новый подход к осмыслению искусства как культурного феномена. Искусство понимается в прагматическом ключе, в связи с его коммуникативной функцией. Проводится методологическое различение поняти художественного текста и произведения искусства. Выявляется, что интерпретатор, действуя на стороне художественного текста, актуализирует его прагматическую модальность, обеспечивая возможность коммуникации между произведением и рецепиентом.In this paper the need for a new approach to understanding art as a cultural phenomenon is revealed. The author makes an attempt to outline such an approach through exploring art in connection with it's communicative function. Methodological distinction between artistic text and work of art is made. In a conclusion the role of interpreter of the artistic text reveals
Measurement of the energy and time resolution of a undoped CsI + MPPC array for the Mu2e experiment
No full textMeasurement of the energy and time resolution of a undoped CsI + MPPC array for the Mu2e experiment
No full textUpconversion Nanoparticles Intercalated in Large Polymer Micelles for Tumor Imaging and Chemo/Photothermal Therapy
No full textFrontiers in theranostics are driving the demand for multifunctional nanoagents. Upconversion nanoparticle (UCNP)-based systems activated by near-infrared (NIR) light deeply penetrating biotissue are a powerful tool for the simultaneous diagnosis and therapy of cancer. The intercalation into large polymer micelles of poly(maleic anhydride-alt-1-octadecene) provided the creation of biocompatible UCNPs. The intrinsic properties of UCNPs (core@shell structure NaYF4:Yb3+/Tm3+@NaYF4) embedded in micelles delivered NIR-to-NIR visualization, photothermal therapy, and high drug capacity. Further surface modification of micelles with a thermosensitive polymer (poly-N-vinylcaprolactam) exhibiting a conformation transition provided gradual drug (doxorubicin) release. In addition, the decoration of UCNP micelles with Ag nanoparticles (Ag NPs) synthesized in situ by silver ion reduction enhanced the cytotoxicity of micelles at cell growth temperature. Cell viability assessment on Sk-Br-3, MDA-MB-231, and WI-26 cell lines confirmed this effect. The efficiency of the prepared UCNP complex was evaluated in vivo by Sk-Br-3 xenograft regression in mice for 25 days after peritumoral injection and photoactivation of the lesions with NIR light. The designed polymer micelles hold promise as a photoactivated theranostic agent with quattro-functionalities (NIR absorption, photothermal effect, Ag NP cytotoxicity, and Dox loading) that provides imaging along with chemo- and photothermal therapy enhanced with Ag NPs
Upconversion Nanoparticles Intercalated in Large Polymer Micelles for Tumor Imaging and Chemo/Photothermal Therapy
No full textFrontiers in theranostics are driving the demand for multifunctional nanoagents. Upconversion nanoparticle (UCNP)-based systems activated by near-infrared (NIR) light deeply penetrating biotissue are a powerful tool for the simultaneous diagnosis and therapy of cancer. The intercalation into large polymer micelles of poly(maleic anhydride-alt-1-octadecene) provided the creation of biocompatible UCNPs. The intrinsic properties of UCNPs (core@shell structure NaYF4:Yb3+/Tm3+@NaYF4) embedded in micelles delivered NIR-to-NIR visualization, photothermal therapy, and high drug capacity. Further surface modification of micelles with a thermosensitive polymer (poly-N-vinylcaprolactam) exhibiting a conformation transition provided gradual drug (doxorubicin) release. In addition, the decoration of UCNP micelles with Ag nanoparticles (Ag NPs) synthesized in situ by silver ion reduction enhanced the cytotoxicity of micelles at cell growth temperature. Cell viability assessment on Sk-Br-3, MDA-MB-231, and WI-26 cell lines confirmed this effect. The efficiency of the prepared UCNP complex was evaluated in vivo by Sk-Br-3 xenograft regression in mice for 25 days after peritumoral injection and photoactivation of the lesions with NIR light. The designed polymer micelles hold promise as a photoactivated theranostic agent with quattro-functionalities (NIR absorption, photothermal effect, Ag NP cytotoxicity, and Dox loading) that provides imaging along with chemo- and photothermal therapy enhanced with Ag NPs
Thermal Cycling Reliability of Hybrid Pixel Sensor Modules for The ATLAS High Granularity Timing Detector
No full textInternational audienceThe reliability of bump connection structures has become a critical aspect of future silicon detectors for particle physics. The High Granularity Timing Detector (HGTD) for the ATLAS experiment at the High-Luminosity Large Hadron Collider will require 8032 hybrid pixel sensor modules, composed of two Low Gain Avalanche Diode sensors bump-bonded to two readout ASICs and glued to a passive PCB. The detector will operate at low temperature (-30 degrees Celsius) to mitigate the impact of irradiation. The thermomechanical reliability of flip-chip bump connections in HGTD modules is a critical concern, particularly due to their characteristically lower bump density (pixel pitch dimensions of 1.3 mm by 1.3 mm). This paper elaborates on the challenges arising from this design characteristic. Finite element analysis and experimental testing were employed to investigate failure modes in the flip-chip bump structures under thermal cycling from -45 degrees Celsius to 40 degrees Celsius and to guide the module redesign. The optimized design demonstrates significantly enhanced robustness and is projected to fulfill the full lifetime requirements of the HGTD
Beam-test evaluation of pre-production Low Gain Avalanche Detectors for the ATLAS High Granularity Timing Detector
No full textInternational audienceThe High Granularity Timing Detector (HGTD) will be installed in the ATLAS experiment as part of the Phase-II upgrade for the High Luminosity-Large Hadron Collider (HL-LHC). It will mitigate pile-up effects in the forward region, and measure per bunch luminosity. The design of HGTD is based on Low Gain Avalanche Detector (LGAD) sensors. This paper presents the results of beam-test campaigns conducted at CERN and DESY in 2023 and 2024 on single LGADs from HGTD pre-production test structures, before and after neutron irradiation up to fluences of . The tested LGADs can meet HGTD requirements in terms of charge collection, time resolution, and hit efficiency, even under HL-LHC end-of-life conditions, supporting their deployment in the final detector
TCT-based monitoring of LGAD radiation hardness for ATLAS-HGTD production
No full textInternational audienceProduction of the High Granularity Timing Detector for the ATLAS experiment at High Luminosity LHC requires over 21000 silicon sensors based on Low Gain Avalanche Diode (LGAD) technology. Their radiation hardness is monitored as a part of the production quality control. Dedicated test structures from each wafer are irradiated with neutrons and a fast and comprehensive characterization is required. We introduce a new test method based on Transient Current Technique (TCT) performed in the interface region of two LGAD devices. The measurement enables extraction of numerous sensor performance parameters, such as LGAD gain layer depletion voltage, LGAD gain dependence on bias voltage, sensor leakage current and effective interpad distance. Complementary capacitance-voltage measurements and charge collection measurements with 90Sr on the same samples have been performed to calibrate the TCT results in terms of charge collection and define acceptance criteria for wafer radiation hardness in the ATLAS-HGTD project
