291 research outputs found
Intervista a Claudio Neri (di Benedetta Pazzagli)
No full textUn'intervista composta da nove domande poste da Benedetta Pazzagli a Claudio Neri, inerenti principalmente la sua attività e la sua esperienza con i gruppi
Nella leucemia acuta mieloide una terapia induzione con dosi standard di citarabina è associata a una migliore qualità della risposta rispetto ad una terapia di induzione con alte dosi di citarabina
No full textLa leucemia mieloide acuta (LAM) è una malattia clonale caratterizzata dalla proliferazione e dall'accumulo di cellule progenitrici mieloidi nel midollo osseo, che in ultima analisi conduce al fallimento della proliferazione ematopoietica fisiologica. L'incidenza di LAM aumenta con l'età, ed i pazienti più anziani hanno in genere dei risultati peggiori in termini di risposta al trattamento rispetto ai pazienti più giovani.La molecola Citarabina (Ara-C) è la pietra angolare della terapia di induzione e di consolidamento per la LAM. Con questo studio abbiamo voluto dimostrare come l'utilizzo in induzione di schemi di trattamento contenenti dosi standard di citarabina (SDAC) sia associato ad una migliore qualità della risposta rispetto all'utilizzo di schemi di trattamento contenenti alte dosi di citarabina (HDAC). Il nostro lavoro si pone come scopo di verificare l'impatto sulla qualità della risposta di uno schema di trattamento con SDAC versus uno contenente HDAC, quantificando la malattia minima residua (MRD), una volta ottenuta la RC. Conseguentemente all'importanza dell'ottenimento di una cosiddetta “remissione citofluorimetrica”, abbiamo valutato la DFS in relazione alla dose di citarabina ed allo stato di MRD dopo il ciclo di consolidamento ed abbiamo evidenziato che i pazienti MRD negativi che abbiano ricevuto SDAC hanno una DFS significativamente migliore rispetto ai pazienti MRD positivi ed a quelli MRD negativi che abbiano ricevuto HDAC. (p: 0.0001).
Una valutazione analoga è stata ovviamente effettuata anche per la OS: il risultato è sovrapponibile al precedente e nettamente a favore dei pazienti MRD negativi che abbiano ricevuto SDAC (p:0.0014).Acute myeloid leukemia (AML) is a clonal disease characterized by the proliferation and accumulation of myeloid progenitor cells in the bone marrow, which ultimately leads to hematopoietic failure. The incidence of AML increases with age, and older patients typically have worse treatment outcomes than younger patients do.
Cytosine arabinoside (ARA-C) is the golden standard for induction and consolidation therapy in AML. With this study we want to demonstrate how the use of an induction chemotherapy schedule with Standard dose of ARA-C (SDAC) leads to a better quality of response, compared with a schedule containing High Dose of ARA-C (HDAC).
Our aim is to value the impact of the SDAC schedule on the quality of response to chemotherapy, monitoring minimal residual disease (MRD), once achieved RC. Basing on the importance of a so called “cytofluorimetric remission”, we have valued Disease Free Survival (DFS) according to ARA-C dose and to MRD status after consolidation: we found that MRD negative patients after SDAC schedule have a better DFS rate comparing to MRD positive and MRD negative patients who received HDAC schedule.(p: 0.0001).
A similar evaluation was done for Overall Survival (OS) as well :the result is similar to the previous and definitely better in MRD negative patients after SDAC schedule.(p:0.0014)
Recensione a G. Comandè, Medical Law in Italy,Wolters Kluwer, 2014
No full textThe review analyses G. Comandè's work Medical Law in Italy focusing on the main issues analysed by the Author under a criminal law perspectiv
Müller Deutschland 1979-1989. L'istituzione Heiner Müller nella Repubblica Federale Tedesca attraverso l'esempio di Berlino Ovest
No full textObject of this essay is role of the GDR author and dramatist Heiner Müller in West Berlin between 1979 and 1989, contextualizing him in the specific and peculiar artistic and intellectual scenario of the so called "two hearted city"
Los apuntes autobiográficos de un morisco expulsado: algunas reflexiones sobre el prólogo del Ms. S2 de la Colección Gayangos de la Biblioteca de la Real Academia de la Historia de Madrid
No full textThis paper aims to study some details, concerning style and themes, that the anonymous Moorish author determined to provide in the prologue of the manuscript S2 of the Gayangos Collection of the Library of the Real Academia de la Historia in Madrid [ff. 2r-16v]. Particularly, the attention is focused on the autobiographical notes inserted in the prologue, important narrative sequences in which the author tells the tough conditions suffered as a crypto-Muslim in Seventeenth-century Spain.El presente trabajo procura realizar una observación sobre algunos detalles estilísticos y temáticos que el autor morisco anónimo determina brindar en la sección del prólogo del manuscrito S2 perteneciente a la Colección Gayangos de la Biblioteca de la Real Academia de la Historia de Madrid [ff. 2r-16v]. De manera particular, la atención se focaliza en los apuntes autobiográficos intercalados en el mismo prefacio, importantes secuencias narrativas en las que el autor relata la durísima condición que sufrió como criptomusulmán en la España del siglo XVII
Per un teatro che crede nella storia. Pier Paolo Pasolini nell'opera di Heiner Müller
No full textAim of this essay is to analyse the role of Pier Paolo Pasolini in the work and poetics of the GDR-author Heiner Müller. After an analysis of the reception of Pasolini’s works and persona in Germany and in the specific context of the GDR, the current work focuses on the influence of PPP in Müller’s approach to language, identity and history
The cobordism ring: the perspective of characteristic classes
No full textThis written work, by Benedetta Andina, discusses ``The cobordism ring: the prospective of characteristic classes''. After providing sufficient preliminaries to make this thesis accessible to any graduate student, it clearly highlights how both the oriented and unoriented cobordism rings can be studied using characteristic classes, which are usually easily computable. To demonstrate this relationship in the unoriented case (as presented by Pontrjagin and Thom), the author unveils an explicit structure of the unoriented cobordism ring. This structure provides a clear classification of smooth closed manifolds
Book review: Lobbying in the European Union: interest groups, lobbying coalitions, and policy change
No full text"Lobbying in the European Union: Interest Groups, Lobbying Coalitions, and Policy Change." Heike Klüver. Oxford University Press. February 2013. --- Why can some interest groups influence policy-making while others cannot? Even though this question is central to the study of politics, we know little about the factors explaining interest group influence. This book aims to shed light on the impact of interest groups on European policy-making, with author Heike Klüver developing a comprehensive theoretical model for understanding lobbying success. Reviewed by Benedetta Voltolini
Nota a Cass. pen., sez. IV, n. 11136, 4 febbraio 2015
No full textThe Italian Supreme Court Judgment commented by the Author dealt with a case, where the director of a nursing home had been convicted of manslaughter. More specifically, the director was accused of having failed to put in place a proper alarm system linked to the doors' opening, which would have allegedly been able to prevent one of the old guests to access the stairs and to fall down, dying. The comment provides the reader with the relevant references to scholars' opinions and case law, focusing on causation in omission and on issues arising when a legal duty to prevent a specific event lies on more than one person
«Que es gente que come arroz, / pasas, higos y alcuzcuz» : la construcción de la imagen esterotipada del morisco en nueve comedias de Lope de Vega
No full textNueve son las comedias de Lope de Vega en las que se puede considerar el morisco como figura activa de los enredos dramáticos. En ellas, el Fénix presenta al público un personaje que corresponde básicamente a una imagen deformada del sujeto real: el autor parece valerse, efectivamente, de los rasgos del distorsionado «monigote» concebido por algunos estratos del ambiente político-social de la época para ajustarlos a su propia lógica teatral y proporcionar una figura teatral en clave esencialmente cómica. Lope realizaría su propósito dramático a través del empleo de cuatro parámetros: la elección del nombre de origen árabe, el proceso de conversión al cristianismo, las referencias al consumo de vino y tocino y el uso de la jerga morisca. El presente trabajo se centra, por tanto, en la observación de los atributos estereotipados que constituyen la columna vertebral de cada figura examinada, y reflexiona asimismo acerca del significado del procedimiento cómico que el autor maneja sutilmente en todas las obras del corpus analizado.Nine are the plays by Lope de Vega in which the Moorish figure can be considered as an active dramatic character. In them, the Fénix presents to the audience a character which is basically a distorted image of the real social subject: the author seems to rely on the features of a disfigured «puppet», conceived by some levels of the socio-political environment of the time, in order to adjust the character to his own theatrical logic and present it from a comical perspective. Lope carries out his dramatic purpose through the use of four parameters: the choice of Arabic names, the process of conversion to Christianity, the references to drinking wine and eating pork and, finally, the use of the Moorish jargon. This paper focuses therefore on the observation of the stereotyped attributes that constitute the backbone of each of those figures, and reflects also about the meaning of the comical procedure that Lope manages in all the works of the analysed corpus
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