36 research outputs found
Synthesis and pharmacological activities of morpholine and coumarin derivatives / Muhammad Afifi Mohd Faridz
No full textPlant-based natural products have played a major role in the development of new drug candidates. Organic synthesis has overcome the limitation of the compounds from natural sources, which provide and develop new pharmaceutical products. In order to explore new therapeutic synthetic compounds, the morpholine scaffold had found to be an outstanding pharmacophore in medicinal chemistry and number of molecules having morpholine skeleton are the clinically a drug. Seventeen novel derivatives of morpholine were synthesised by different arylhydrazides and 5-morpholinothiophene2-carbaldehyde. All synthesised compounds (83-99) were evaluated for their in-vitro anticancer potential against two human cancer cell lines, HepG2 and MCF7. Seventeen coumarin-based derivatives (101-117) were screened for a-glucosidase inhibitor activity and 3-formylcoumarin (118-134) analogues were screened for thymidine phosphorylase inhibition. All compounds showed a variable degree of inhibitions when compared to the standard inhibitors. Molecular docking studies were carried out to understand the binding interaction of active compounds. Analogues 95 had similar substantial inhibition effects towards HepG2 with IC50 value 6.76±3.12 //M, when compared with the standard doxorubicin (IC50 value 6.59±0.45 JUM); while compounds 87, 90 and 91 showed potent cytotoxicity against MCF7 with IC50 value 7.08±0.42 fiM, 1.26±0.34 JUM and 11.22±0.22 JUM respectively, when compared with the standard tamoxifen (IC5o=9.53±0.40 JUM). Coumarin-based derivatives, analogue 105 inhibition seems effective towards HepG2 and MCF7 with IC50 values 0.02±1.78 juM and 10.23±1.7
Industrial training report: Nuri Driving Solution Sdn. Bhd. / Muhammad Faridz Azmil Abu Hassan
No full textThis is an attempt to know how the theories can be applied to practical situation. As a student of UiTM, it is a part of study for everyone in last semester to undergo an industrial training at a suitable institute or organization. So, for this purpose, I got the opportunity to do my industrial training at NURI Driving Solution Sdn Bhd under account department. This organization are among the preferred driving institution in Bagan Datuk area with a good customer service provided. There are eight branches available under this organization whereas one staff for each branch. For this report, I decided to use regression analysis to analyze the financial performance through profitability approach in this organization. The dependent variable in this study is profitability (measured through gross margin) and the independent variable are asset turnover, sales growth, current ratio, and leverage. The findings show that among the four independent variables choose, only two of it are significant with profitability which are asset turnover and current ratio. The other two independent variable shows no significant relationship with profitability. As the outcome results, only current ratio shows positive relationship with the profitability of the company. Furthermore, there are several recommendations in this study that was applied by several article from other researchers. As for NURI Driving Solution Sdn Bhd, to make their organization more sustainable in future, they need to identify the factors that contribute for their company to earn profitability during this downturn. Besides, it is suggested for the company to have financial planning that target on a long-term basis. Other than that, the next researchers were suggested to use other set of independent variables to get different result for the analysis of financial performance through the profitability approach. To sum up, this sector are truly affected during this pandemic of Covid-19 as each industry do not manage to run their business smoothly
Aplikasi teori Double Movement Fazlur Rahman pada QS.Adh-Dhuha
No full textSkripsi ini meneliti tentang aplikasi teori Double Movement Fazlur Rahman pada QS. Adh-Dhuha. Adapun tujuan penelitian ini adalah untuk mengetahui reinterpretasi QS. Adh-Dhuha melalui metodelogi yang ditawarkan Fazlur Rahman, dengan mengkaji QS. Adh-Dhuha tersebut dari sisi historis surat baik secara mikro maupun makro, guna ditemukan nilai ideal moral atau spirit yang terdapat dalam QS. Adh-Dhuha, untuk kemudian dikontekstualisasikan pada kehidupan masa kini.
Metode yang dilakukan dalam penelitian adalah jenis kualitatif dengan menggunakan data-data kepustakaan (Library Research) dan bersifat deskriptif analitis, karena yang menjadi objek penelitian adalah pembacaan atas Alquran. Dalam hal ini penulis menggunakan teori Double Movement Fazlur Rahman dalam menganalisis teks Alquran surat Adh-Dhuha.
Pembacaan teks Alquran melalui analisis sejarah QS. Adh-Dhuha, menghasilkan unsur-unsur spesifik dan premis-premis yang mengantarkan Nabi Muhammad pada potensi kerasulannya karena status Nabi Muhammad sebagai yatim, belum mendapatkan wahyu atau petunjuk dan kekurangan harta tidak membuat keluarga dekatnya mengabaikannya, Allah mengirimkan pertolongan melalui keluarga Halimah yang menyusui Nabi Muhammad, Abdul Muthalib, Abu Thalib, dan Khadijah. Mereka melindungi Nabi Muhammad, memberikan perlindungan dan kasih sayang dari Abdul Muthalib maupun Abu Thalib, serta memberikan kecukupan harta melalui Khadijah sebagai saudagar kaya sekaligus istri Nabi Muhammad. Surah adh-Dhuha memberikan gambaran status Nabi yang pernah mengalami fase tersebut hendaknya ia atau umatnya tidak mengabaikan tiga golongan ini; anak yatim, orang bodoh, dan fakir miskin. Serta tidak menghardik, berlaku sewenang-wenang terhadap mereka.
Dengan demikian nilai ideal moral dalam QS. Adh-Dhuha tersebut adalah bahwa setiap individu, keluarga, komunitas, atau bangsa akan mampu mengembangkan potensi besarnya, apabila mereka tidak mengabaikan tiga golongan ini; anak yatim, orang bodoh dan fakir miskin. Hendaknya anak yatim diberikan perlindungan seperti panti asuhan beserta fasilitas kesehariannya dan diberikan pendidikan hingga mereka mampu mandiri, orang bodoh hendaknya diberikan petunjuk dengan cara yang baik dan benar, fakir miskin hendaknya tidak dihardik melainkan diberikan harta secukupnya dan diberikan motivasi agar mampu memperbaiki diri dan meninggalkan pekerjaan meminta-minta, sehingga beralih kepada usaha kecil-kecilan. Indonesia telah memiliki pasal 31 dan 34 yang serasi dengan ideal moral adh-Dhuha. Namun secara praktek masih belum dikatakan sempurna dan tidak sesuai harapan dan tujuan, karena banyaknya pemanfaan seperti panti asuhan sebagi ladang bisnis
Factors affecting the success of bumiputera entrepreneurs in small and medium enterprise [SMES] in Malaysia / Muhammad Faridz Azmil Abu Hasssan
No full textHereby, I would like to make a review regarding on this article “Factors Affecting the Success of Bumiputera Entrepreneurs in Small and Medium Enterprises (SMEs) in Malaysia. I found that this article is good to review. As we know, entrepreneurs not only create a career for him/herself, but also creates jobs for others. Successful entrepreneurs able to increase per capita income of the local community and increase our national income. There are some reasons why I choose this article to be reviewed. Firstly, to know what was the factors that can affect the bumiputera entrepreneurs’s success in small and medium enterprises (SMEs). Nowadays, this sector makes a big contribution to the national income. Therefore, government should focus on attracting the indigenous communities to participate in SME sector. Next, this article also gives us a discussion regarding on how to make people to contribute their self in this SME sector. Most people in Malaysia are afraid to start a business due to some problem. Besides, this article also tells us on what kind of problem that occurs to several unsuccessful bumiputera entrepreneurs. Hence, the Malaysian should take the initiative to make changes and drastic transformation of all aspects, especially in terms of thinking and mentality to become entrepreneurs that can enhance the strength and stability of the economy for a healthy competition with other nations
Optimization of SC-CO2 Extraction OF Alpinia Galangal (L.) Wild and Estimation of Cost of Manufacturing (COM) Via SIMULATION Process
No full textIn this study, the rhizome of a ginger plant, Alpinia galangal (L.) Wild, was subjected to supercritical fluid carbon dioxide (SCCO2) extraction at 150-250 bar and 40-60°C. Influence of the operating parameters; temperature and pressure on the yield extract was investigated as well the evaluation of 1-acetoxy-chavicol acetate (1'ACA) content in the best extraction condition by Gas Chromatograph (GC) and Gas Chromatograph/Mass Spectrum (GC/MS). Density of CO2 (kg/L) was calculated using Bender correlation based on the pressure and temperature, therefore solubility of solute in SC-CO2 (g/L) can be determined. PRO/II® software was used to simulate the extraction process at large scale and to estimate the cost of manufacturing (COM) at the best extraction condition. For simulation process, correlation between solubility of solute in SC CO2 and SC CO2 density was calculated based on Chrastil correlation and Peng Robinson was used as the thermodynamic model. The aim of this work is to determine the best SC-CO2 extraction condition for A.galangal rhizome based on yield extract and perform the economical evaluation of the extraction via simulation process
Intermittent fasting vs Ramadhan fasting / Sharifah Maimunah Syed Mud Puad, Mohd Faridz Ahmad and Muhammad Wafi A.Rahman
No full textIntermittent fasting (IF) is becoming more popular as a weight-loss strategy. Many manage to lose weight with this strategy when practicing significant calorie reduction with restricted eating periods while fasting. But, is intermittent fasting the same as Ramadhan fasting? The main similarity is the practice of abstinence from food and drink. However, the difference is in the purpose and goal of the fasting: one is for religious and spiritual reasons, while the other is to lose weight
Sistem Informasi Manajemen Kepegawaian (Simpeg) Dan Kualitas Sdm Pengaruhnya Terhadap Kinerja Pegawai Pada Kantor Imigrasi Kelas I Tpi Bandung
No full textPenelitian ini bertujuan untuk mengetahui gambaran sistem informasi manajemen kepegawaian (SIMPEG), kualitas SDM dan kinerja pegawai, juga untuk mengetahui ada tidaknya pengaruh sistem informasi manajemen kepegawaian (SIMPEG) dan kualitas SDM terhadap kinerja pegawai pada Kantor Imigrasi Kelas I TPI Bandung baik secara parsial maupun simultan. Metode dalam penelitian ini menggunakan deskriptif dan verifikatif dengan pendekatan kuantitatif. Sampel penelitian berjumlah 54 pegawai Kantor Imigrasi Kelas I TPI Bandung dengan menghitung setiap sampel untuk masing-masing seksi menggunakan teknik proportionate stratified random sampling. Teknik pengumpulan data menggunakan kuesioner dan wawancara sedangkan teknik analisis data dengan analisis regresi linier berganda, analisis korelasi pearson product moment, analisis koefisien determinasi dan uji hipotesis yang dihitung menggunakan aplikasi SPSS 27 For Windows
Hasil penelitian menunjukkan bahwa sistem informasi manajemen kepegawaian (SIMPEG) dan kualitas SDM pada Kantor Imigrasi Kelas I TPI Bandung tergolong sangat baik. Hasil pengujian hipotesis menunjukkan bahwa sistem informasi manajemen kepegawaian (SIMPEG) dan kualitas SDM berpengaruh positif signifikan terhadap kinerja pegawai secara parsial maupun simultan
Pembuktian Tindak Pidana Pencucian Uang Dalam Perkara Nomor: 459/PID.SUS/2019/PN.PBR
No full textThe process of proving money laundering is different from examining criminal cases in general, one form of extraordinary effort is in the context of proving money laundering cases in court which uses a limited and balanced mechanism of reversing the burden of proof or reversing the burden of proof. The main problem in this research is what is the process of proving money laundering in case number: 459/Pid.Sus/2019/PN.Pbr and what are the considerations of the panel of judges in deciding the case of money laundering in case number: 459/Pid.Sus/2019 /PN. Pbr The method used by the author in this study is the Normative legal research method, namely library law research, which is a method or method used in legal research conducted by examining existing library materials and linking it to the decision of the Pekanbaru District Court judge who decided Case Number: 459/ Pid.Sus/2019/PN.Pbr While the nature of this research is descriptive, that is, the author tries to provide a detailed description. Namely describing the problems that were found to be related to each other in a relevant and logical and juridical way to find out a clear and detailed description of the decision 459/Pid.Sus/2019/PN.Pbr case. Based on the results of research conducted by the author, the evidence for case number: 459/Pid.Sus/2019/PN.Pbr. using reverse evidence in accordance with Law Number 8 of 2010 concerning the Prevention and Eradication of Money Laundering Crimes, in Article 77 which confirms that: "For the purposes of examination at court hearings, the accused is required to prove that his assets are not the proceeds of a crime." As well as using evidence in Article 73 of the a quo regulation "Valid evidence in proving the crime of money laundering is evidence as referred to in the criminal procedural law and/or other evidence in the form of spoken information sent, received, or stored electronically with means optical or similar optical devices and documents”. The basis for the judge's consideration is based on facts and evidence at trial as well as the judge's belief in a case, based on evidence and evidence at trial, originating from the verification process carried out by both the public prosecutor and the defendant's legal counsel, and the defendant is proven to have fulfilled the provisions of Article 3 of the Law - Law Number 8 of 2010 TPPU, so that the panel of judges gave a verdict against the defendant by imposing a prison sentence of 14 (fourteen) years and a fine of 1 billion rupiah if not paid is replaced then replaced with imprisonment for 2 months
Gambaran Konformitas Pada Remaja Anggota Pramuka di Kecamatan Situbondo
No full textGerakan Pramuka memiliki peran penting dalam membentuk karakter
generasi muda di Indonesia. Namun, temuan awal di Kabupaten Situbondo
menunjukkan bahwa meskipun anggota Pramuka menerapkan nilai-nilai Dasa
Dharma seperti disiplin dan tanggung jawab, kekompakan kelompok tetap rendah.
Perbedaan pribadi, komunikasi yang tidak efektif, dan tingkat komitmen yang
bervariasi menjadi penyebab utama ketidakseimbangan dalam kerjasama.
Tekanan dari luar dan kurangnya variasi kegiatan juga mengurangi partisipasi
aktif. Penelitian ini menggunakan metode kuantitatif deskriptif, dengan metode
pengambilan data menggunakan Skala konformitas yang disusun oleh Sears.
Populasi dalam penelitian ini remaja SMA bersekolah di daerah kecamatan
Situbondo dan pengurus aktif mengikuti pramuka minimal satu tahun. Penelitian
kuantitatif ini menggunakan kuesioner dengan skala Likert untuk mengukur
konformitas 458 siswa Pramuka di Kabupaten Situbondo, dengan sampel 213
siswa menggunakan rumus Slovin dan teknik non-probability sampling yaitu
kuota sampling. Metode analisa yang digunakan meliputi uji validitas, uji
reliabilitas, uji normalitas dan uji deskriptif. Hasil penelitian menunjukkan
validitas dan reliabilitas tinggi dengan koefisien Cronbach's Alpha sebesar 0,844.
Hasil penelitian menunjukkan bahwa 52% dari populasi memiliki skor
konformitas yang tinggi, dengan skor lebih dari 86. Sementara itu, 48% dari
populasi memiliki skor konformitas rendah, dengan skor kurang dari 86. Dengan
demikian, dapat disimpulkan bahwa mayoritas populasi memiliki tingkat
konformitas yang tinggi, dengan sekitar separuh populasi lainnya memiliki tingkat
konformitas yang rendah
ANALISIS TINGKAT RISIKO KERJA PEGAWAI DENGAN METODE RAPID OFFICE STRAIN ASSESSMENT DI UPT PUSKESMAS SEKELOA
No full textPenelitian ini dilakukan di UPT Puskesmas Sekeloa yang dalam kegiatannya bertugas untuk melakukan pelayanan kepada masyarakat dalam wilayah kerjanya. Pegawai yang melakukan layanan kepada masyarakat di UPT Puskesmas Sekeloa bekerja selama 7 jam setiap harinya, dan sebagian besar pegawai menggunakan komputer untuk menjalankan pekerjaannya. Berdasarkan hasil observasi didapatkan bahwa posisi kerja pegawai kurang ergonomis, yaitu seringnya posisi membungkuk dan leher yang menekuk karena posisi monitor yang tidak sejajar dengan mata. Posisi kerja yang kurang ergonomis dan dilakukan dengan jangka waktu yang lama secara berulang membuat pekerja merasakan rasa sakit pada beberapa anggota tubuh dan menyebabkan risiko terkena Musculoskeletal Disorders (MSDs). Berdasarkan hal tersebut, maka tujuan penelitian ini adalah untuk mengetahui tingkat risiko terkena MSDs dan faktor yang menyebabkan risiko MSDs pada saat bekerja. Pada penelitian ini, proses pengumpulan data digunakan kuesioner Nordic Body Map (NBM) dan mengisi lembar penilaian metode ROSA. Penelitian awal dilakukan dengan menyebarkan kuesioner NBM untuk melihat anggota badan yang terasa sakit pada saat bekerja. Hasil yang didapatkan dari kuesioner NBM menunjukkan bahwa sebagian besar pegawai merasakan rasa sakit pada bagian leher atas sebesar 53,8%, punggung sebesar 69,2%, dan pantat (buttock) sebesar 53,8%. Berdasarkan hasil yang didapatkan dari kuesioner NBM diketahui bahwa terdapat pegawai yang memiliki risiko terkena MSDs. Berdasarkan hasil tersebut, maka penelitian dilanjutkan dengan menggunakan metode ROSA untuk mengetahui faktor penyebab risiko terkena MSDS. Berdasarkan hasil metode ROSA, diketahui bahwa 11 pegawai memiliki risiko terkena MSDs dan 2 pegawai tidak memiliki risiko terkena MSDs. Hasil yang didapatkan dari metode ROSA kemudian dibandingkan antara hasil skor (Bagian A) dengan skor (Monitor dan Periferal), dan diketahui faktor risiko pegawai untuk terkena MSDs berasal dari pemilihan kursi yang salah. Usulan kursi yang digunakan untuk mengurangi risiko MSDs berdasarkan metode ROSA yaitu memiliki sandaran tangan yang adjustable, sandaran punggung yang adjustable dengan sudut 95° sampai 110°, ketinggian kursi yang adjustable, dan kedalaman kursi yang adjustable
