79 research outputs found
Design and Detection of Underground Cable Fault Using Raspberry Pi and IoT System
No full textThis paper proposes fault location model for underground power cable using raspberry pi and the Internet of Things which is based on the internet, which means the information will be transferred through the internet access. The aim of this method is to determine the distance of underground cable fault from base station in kilometres and also find the location of that faulty place. This paper uses the simple concept of Current Transformer Theory CT Theory . When any fault like short circuit occurs, voltage drop will vary depending on the length of fault in cable since the current varies Current Transformer is used to calculate the varying current. The signal conditioner manipulates the change in voltage and a microcontroller is used to make the necessary calculations so that the fault distance is displayed by IOT devices. These fault details are after sent to any access point through the internet and displayed. Mr. M. Dinesh | Mr. K. Vairaperumal | Mr. P. Senthilkumar "Design and Detection of Underground Cable Fault Using Raspberry Pi & IoT System" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-3 | Issue-1 , December 2018, URL: https://www.ijtsrd.com/papers/ijtsrd19037.pd
SECURE COMMUNICATION BASED ON AUTHENTICATION TECHNIQUES USING NIDS
No full text<p>Network Security is a unique, efficient and beneficial part in the management of network. Mostly many organizations around the world spend millions of revenue in every year for the safety and provide security regarding valuable corporate form of data’s and information. Authentication is one of the primary and most commonly ways of ascertaining and ensuring security in the network. In this paper, an attempt has been made to analyze the various authentication techniques such as Knowledge-based, Token-based and Biometric-based etc. Furthermore, we consider multi-factor authentications by choosing a combination of above techniques and try to compare them. This paper gives a description ofthe available approaches for a network intrusion detection system (NIDS) in both software and hardware implementation.</p>
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Crystal growth, piezoelectric, non-linear optical and mechanical properties of lithium hydrogen oxalate monohydrate single crystal
No full textLenalidomide-based combined therapy induced alterations in serum proteins of multiple myeloma patient: a follow-up case report and overview of the literature
No full textAim : Multiple myeloma (MM) is a malignant neoplasm of plasma cells (PC) derived from the bone marrow (BM) origin. The present case report was aimed to monitor the efficiency of lenalidomide-based combined therapy (LBCT) induced alterations in serum proteins of 42-year-old female MM patient. Besides, in the context of case report we also present an overview of the literature describing LBCT. Study design: Serum protein electrophoresis (SPEP) was performed in three visits (V1-V3) to monitor the disease status of the patient and her treatment response to LBCT. Level of monoclonal protein (M-protein) was measured through cellulose acetate zone electrophoresis and quantified by densitometer in follow-up investigations after therapy intervals. Results: A significant reduction of M-protein in γ-globulin region was observed (P < 0.007) after receiving LBCT. However, the condition depicted hyper γ-globulinemia. β-globulin (P < 0.002) and α2-globulin(P < 0.047) was suppressed from the initial visit and subsequent follow-up also indicated the status of hypoglobulinaemia. Although, serum albumin level was found to be increased after therapy (P < 0.016), hypoalbuminaemia was also noticed before and after LBCT. Conclusion: On the basis of this case report and pertinent literature, we conclude that LBCT is more efficient in the treatment of MM and has significant role in serum protein alterations especially in the reduction of M-protein in the MM patients.The authors thank the management of JNCHRC
especially Chairman Mr. Madan Mohan Joshi, Institute
Director Dr. K.V. Pandya, Medical Director and Radiation
oncologist R. K. Pandey, Addt. Director Mr. Rakesh
Joshi, Research coordinator Mrs. Divya Parashar for
research support
Lenalidomide-based combined therapy induced alterations in serum proteins of multiple myeloma patient: a follow-up case report and overview of the literature
No full textAim : Multiple myeloma (MM) is a malignant neoplasm of plasma cells (PC) derived from the bone marrow (BM) origin. The present case report was aimed to monitor the efficiency of lenalidomide-based combined therapy (LBCT) induced alterations in serum proteins of 42-year-old female MM patient. Besides, in the context of case report we also present an overview of the literature describing LBCT. Study design: Serum protein electrophoresis (SPEP) was performed in three visits (V1-V3) to monitor the disease status of the patient and her treatment response to LBCT. Level of monoclonal protein (M-protein) was measured through cellulose acetate zone electrophoresis and quantified by densitometer in follow-up investigations after therapy intervals. Results: A significant reduction of M-protein in γ-globulin region was observed (P < 0.007) after receiving LBCT. However, the condition depicted hyper γ-globulinemia. β-globulin (P < 0.002) and α2-globulin(P < 0.047) was suppressed from the initial visit and subsequent follow-up also indicated the status of hypoglobulinaemia. Although, serum albumin level was found to be increased after therapy (P < 0.016), hypoalbuminaemia was also noticed before and after LBCT. Conclusion: On the basis of this case report and pertinent literature, we conclude that LBCT is more efficient in the treatment of MM and has significant role in serum protein alterations especially in the reduction of M-protein in the MM patients.The authors thank the management of JNCHRC
especially Chairman Mr. Madan Mohan Joshi, Institute
Director Dr. K.V. Pandya, Medical Director and Radiation
oncologist R. K. Pandey, Addt. Director Mr. Rakesh
Joshi, Research coordinator Mrs. Divya Parashar for
research support
Placental volume in pregnant women with opioid use: prenatal MRI assessment
No full textObjective: Opioid use in pregnant women is a growing public health concern and is shown to be associated with lower infant birth weights. Placental volume changes in prior studies correlated with various maternal and fetal conditions. We aimed to identify differences between placental volumes in pregnant women with opioid use, and control pregnant women without drug use.
Methods: We prospectively recruited 27 healthy pregnant women and 17 pregnant women with opioid use disorder who were on medication-assisted treatment (MAT). All women underwent placenta/fetal MRI at 27-39 weeks gestation on a 3 Tesla MR scanner. Placental volumes were measured in a blinded fashion using a previously validated technique. Multiple linear regression was used to identify associations of placental volume with multiple maternal and fetal clinical factors. The significance threshold was set at p < .05.
Results: Placental volume was significantly associated with gestational age at MRI (p < .0001), fetal sex (p = .027), MAT with smoking (p = .0008), MAT with polysubstance use (p = .01), and maternal BMI (p = .032). Placental volume was not associated with opioid MAT alone in our cohort.
Conclusion: For pregnant women on medication-assisted treatment for opioid use disorder, there was no significant difference in placental volume compared to healthy pregnant women. However, concomitant smoking and polysubstance use in the setting of medication-assisted treatment may be detrimental to placental health. To our knowledge, this is the first study assessing placental volume in opioid use on prenatal MRI. These results support the benefit of medication-assisted treatment during pregnancy; however additional studies are needed to further elucidate the impact of opioid use on placental and fetal development and postnatal outcomes
Intriguing the significance of hydrophobic groove by the inhibitory mechanism of mineralocorticoid receptor bound with spironolactone through mutations using long-range molecular dynamics simulations.
No full textMineralocorticoid receptor (MR) inhibition using spironolactone has been well studied, highlighting the importance of crucial residues (N770, Q776 and R817) in the binding site. However, there have been no reports on the importance of hydrophobic groove lined by varied hydrophobic residues. Herein we report on the importance of the hydrophobic groove of the MR occupying the thioacetyl moiety of spironolactone using mutations. The MR-spironolactone complex was subjected to mutations in the hydrophobic groove by categorizing into three forms viz., 1) completely in its native form, 2) reducing its hydrophobicity and 3) replacing its hydrophobicity and simulated for 1 μs. Our analysis revealed that the residues M807, F829, M845, C849 and M852 at the hydrophobic groove of MR are important in anchoring the thioacetyl moiety of spironolactone along with the residue N770 by providing the conformational stability to spironolactone. The binding free energy calculations of the binding site, including the hydrophobic groove and only the groove alone show a greater impact on the importance of hydrophobicity along with crucial residues N770, Q776 and R817. The mechanism addressing the role of selected hydrophobic residues M845, C849 and M852 at the hydrophobic pocket through site-directed mutagenesis will shed light on designing novel leads or biomarkers with improved efficiency and potency
Proactive Indoor Air Quality Monitoring System
No full textIn recent times indoor air quality has attracted the attention of policy makers and researchers similar to that of external air pollution. The indoor environments are confined and closed compared to external environments providing less opportunity for the pollutants to dilute. Our everyday devices emit various solids and gases into the environment during their operation. These emissions contain many substances that are harmful to human health, when exposed to them for a prolonged period of time. Here we propose an air quality monitoring system that allows us to monitor and check live air quality in particular areas through IOT. The System uses air sensors to sense presence of harmful gases/compounds in the air and constantly transmit this data to microcontroller PIC16F877A. The sensors interact with microcontroller which processes this data and transmits it over internet. The gas levels can be viewed through a webpage from anywhere in the world. This allows authorities to monitor air pollution in different areas and take action against it
Effect of bacterial inoculation, plant genotype and developmental stage on root-associated and endophytic bacterial communities in potato (Solanum tuberosum)
No full textBeneficial bacteria interact with plants by colonizing the rhizosphere and roots followed by further spread through the inner tissues, resulting in endophytic colonization. The major factors contributing to these interactions are not always well understood for most bacterial and plant species. It is believed that specific bacterial functions are required for plant colonization, but also from the plant side specific features are needed, such as plant genotype (cultivar) and developmental stage. Via multivariate analysis we present a quantification of the roles of these components on the composition of root-associated and endophytic bacterial communities in potato plants, by weighing the effects of bacterial inoculation, plant genotype and developmental stage. Spontaneous rifampicin resistant mutants of two bacterial endophytes, Paenibacillus sp. strain E119 and Methylobacterium mesophilicum strain SR1.6/6, were introduced into potato plants of three different cultivars (Eersteling, Robijn and Karnico). Densities of both strains in, or attached to potato plants were measured by selective plating, while the effects of bacterial inoculation, plant genotype and developmental stage on the composition of bacterial, Alphaproteobacterial and Paenibacillus species were determined by PCR-denaturing gradient gel-electrophoresis (DGGE). Multivariate analyses revealed that the composition of bacterial communities was mainly driven by cultivar type and plant developmental stage, while Alphaproteobacterial and Paenibacillus communities were mainly influenced by bacterial inoculation. These results are important for better understanding the effects of bacterial inoculations to plants and their possible effects on the indigenous bacterial communities in relation with other plant factors such as genotype and growth stage
Efeito antibiofilme de soluções de hipoclorito de sódio e de nanopartículas de prata
No full textTCC (graduação) - Universidade Federal de Santa Catarina, Centro de Ciências da Saúde, Odontologia.O objetivo deste estudo foi avaliar e comparar a efetividade das soluções de hipoclorito de sódio (NaOCl) e de nanopartículas de prata (Np Ag) contra um biofilme de Enterococcus faecalis (ATCC 29212) estabelecido no canal radicular. Para a execução do experimento foram obtidos 42 segmentos radiculares de 12 mm de comprimento a partir de dentes humanos unirradiculados hígidos. Os canais foram modelados pela técnica escalonada sob irrigação constante com NaOCl 1%. Após o preparo, uma suspensão de E. faecalis foi inoculada e renovada diariamente por 7 dias. Uma análise realizada por meio de microscopia eletrônica de varredura em dois segmentos radiculares confirmou a presença do biofilme. Os 40 segmentos radiculares remanescentes foram divididos aleatoriamente em 4 grupos (n=10), de acordo com a solução irrigadora empregada: G1) solução salina 0,85% (controle), G2) NaOCl 1%, G3) NaOCl 5%, G4) solução de Np Ag 1%. Concluída a irrigação, foram coletadas as bactérias remanescentes do interior dos canais com cones estéreis de papel absorvente. A partir de diluições da suspensão bacteriana, alíquotas de 100 µL foram plaqueadas em ágar Mueller-Hinton e as placas incubadas a 37ºC por 24 h. O conjunto de dados representados pelos valores médios de unidades formadoras de colônias (UFC) para cada grupo foi analisado estatisticamente pelos testes Kruskall-Wallis e Tukey (p<0,05). A efetividade das soluções de NaOCl 1% e 5% e Np Ag 1% contra o biofilme de E. faecalis foi semelhante e significativamente superior à solução salina 0,85%.The aim of this study was to evaluate and compare the effectiveness of sodium hypochlorite (NaOCl) solutions and silver nanoparticles (Np Ag) against E. faecalis biofilm (ATCC 29212) established at the root canal. To perform the experiment, 42 root segments with 12 mm were obtained from higid single root human teeth. The root canals were prepared by step back technique under irrigation with 1% NaOCl. After, the root canals were inoculated with a E. faecalis suspension, which was renewed daily for 7 days. Analysis in two root segments by scanning electron microscopy confirmed biofilm presence. The other 40 segments were divided into 4 groups, according to the solution used: G1) 0.85% saline solution (control group), G2) 1% NaOCl, G3) 5% NaOCl, G4) 1% Np Ag solution. After completing the irrigation protocol, collection of remaining bacteria was performed using absorbent paper cones. Aliquots of 100 µL were plated in Muller-Hinton agar from dilutions of bacterial suspensions, and plates were incubated at 37o C for 24 hours. The data were represented by the mean values of colony forming units (CFU) of each group and it was statistically analyzed by Kruskall-Wallis and Tukey tests (p<0.05). The solutions of 1% and 5% NaOCl and 1% Np Ag showed similar antibiofilm capacity and significantly higher than 0.85% saline
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