5,394 research outputs found
Regular Exercise Training as a Principal Non-Pharmacological Method Affects Serum Leptin and Cardiovascular Risk Factors in Men with Metabolic Syndrome
No full textBackground and Aim: Regular exercise training is the principal non-pharmacological method for the prevention and treatment of metabolic syndrome or other obesity-related diseases. We investigated the effects of aerobic training on leptin and cardiovascular risk factors in middle-aged men with metabolic syndrome.
Methods: Twenty-six sedentary middle-aged males with metabolic syndrome aged 40 ± 5 years were randomly assigned to two groups as exercise (aerobic training, n =13) and control (no training, n =13). The exercise programs were performed 3 days a week for 10 weeks at 55-75% of HRmax. Fasting blood samples were taken before and after the training period for measuring serum leptin and triglyceride (TG), total cholesterol (TC), LDL, and HDL as cardiovascular risk factors.
Results: No significant differences were observed between groups concerning anthropometric and clinical markers at baseline (p>0.05). Aerobic intervention resulted in significant decrease in anthropometric markers (abdominal circumference, body mass index, body fat percentage; p < 0.05), serum leptin (p = 0.026), TG (p = 0.001) and HDL (p = 0.032) in exercise group, but significant changes were not found in TC (p = 0.522) and LDL (p = 0.546). There were no changes in all measured variables in the control group.
Conclusion: Based on our finding, it seems that regular aerobic exercise is associated with improved serum leptin and cardiovascular function in patients with metabolic syndrome.
*Corresponding Author: Mojtaba Eizadi; Email: [email protected]
Please cite this article as: Naseri Rad R, Eizadi M. Regular Exercise Training as a Principal Non-Pharmacological Method Affects Serum Leptin and Cardiovascular Risk Factors in Men with Metabolic Syndrome. Arch Med Lab Sci. 2020;6:1-8 (e1). https://doi.org/10.22037/amls.v6.3164
Antibacterial activity of some Lamiaceae species against Staphylococcus aureus in yoghurt-based drink (Doogh)
No full textDoogh is a dairy drinkable fermented product, whose shelf-life and quality is mostly affected by bacteria such as Staphylococcus spp. This study investigated the antibacterial activity of essential oils (EOs) from Thymus vulgaris L., Mentha piperita L. and Ziziphora tenuior L., alone or in combination, against Staphylococcus aureus in industrial doogh. A three-level and three-variable face centered central composite design experiment was used. Results showed that EOs significantly inhibited S. aureus growth after 1 and 7 days of storage. According to the model, the maximum inhibition was obtained in the presence of 0.2% of EO, independently of the type, and no synergistic or additive effects were observed. Slightly lower S. aureus survivals were observed at the maximum concentration of Z. tenuior EO. In spite of the antimicrobial activity of these EOs, further research is needed to assess their performance in food matrix and, in particular, in dairy product
Status prawny młodzieżowych rad powiatów
No full textSocial participation, which has its origin in the Constitution of the Republic of Poland (civil society principle), should also be seen on the self-government level. On the county level, citizens’ activity can be strengthened by a youth county council. The article first discusses the history of these bodies as well as their current popularity and condition. The author also tries to create their definition and outline the establishment procedure. While pointing to the legal basis of the establishment acts, the author gives several reasons why youth county councils are not legal in the current circumstances. Youth county councils and youth municipal councils are compared on the basis of their activity. In the final part of the article, the author points out why those bodies should have a legal basis on the national level.Partycypacja społeczna, wynikająca z konstytucyjnej zasady społeczeństwa obywatelskiego, powinna mieć silne oddziaływanie w ramach samorządu terytorialnego. Na poziomie powiatu jedną z form aktywności obywateli może być młodzieżowa rada powiatu. W artykule zarysowano historię tych podmiotów oraz przedstawiono ich obecne rozpowszechnienie. Podjęto próbę stworzenia definicji tych rad oraz omówiono procedury ich powstania. Wskazując na podstawy prawne aktów powołujących, przestawiono wątpliwości co do możliwości ich istnienia w obecnym stanie prawnym. Porównano także aktywność tych podmiotów i młodzieżowych rad gmin, posiadających umocowanie ustawowe. Na podstawie oceny działalności młodzieżowych rad powiatów zaprezentowano również powody, które przemawiają zdaniem autora za koniecznością nowelizacji ustawy o samorządzie powiatowym
A Study of the Factors Related to Cardiopulmonary Resuscitation Physical Fatigue and the Quality of Resuscitation
No full textEffective chest compression is an important factor playing a key role in the cardiac arrest patient survival. An understanding of the factors causing an early physical fatigue can help to improve the quality of CPR operations in hospitals. Therefore, this study aimed to assess the factors relevant to the onset time of physical fatigue and resuscitation quality during cardiopulmonary resuscitation (CPR) provision by Iranian nurses.
The present cross-sectional study was performed on 194 subjects selected based on a stratified random sampling procedure from different hospital wards. The participants were required to perform CPR operations on a manikin. As they were performing CPR, the time and the quality of compressions were measured by a chronometer and visual analogue fatigue scale, respectively. The rescuers themselves reported the onset time of physical fatigue.
Statistical analyses run on the collected data revealed that the majority of participants experienced extreme physical fatigue after a two-minute CPR operation. Moreover, about 71.2% of the participants managed to provide compressions over five centimeters deep. Finally, the physical fatigue experienced by the participants was meaningfully correlated with the body weight, sex, university degree, and work place of the participants (p < 0.05). Since the findings of the present study showed that various factors including the sex, weight, height, university degree, and the work place of the rescuer were significantly correlated with the onset time of physical fatigue experienced during CPR operation, it is recommended that male nurses with greater height and weight be employed in the rescue teams in ICU wards. Moreover, it seems mandatory for the nurses currently working in such teams in hospitals to improve their physical fitness through doing aerobics on a regular basis so that they may experience less fatigue during their CPR operations in future
A Study of the Factors Related to Cardiopulmonary Resuscitation Physical Fatigue and the Quality of Resuscitation
No full textSummary
Effective chest compression is an important factor playing a key role in the cardiac arrest patient survival. An understanding of the factors causing an early physical fatigue can help to improve the quality of CPR operations in hospitals. Therefore, this study aimed to assess the factors relevant to the onset time of physical fatigue and resuscitation quality during cardiopulmonary resuscitation (CPR) provision by Iranian nurses.
The present cross-sectional study was performed on 194 subjects selected based on a stratified random sampling procedure from different hospital wards. The participants were required to perform CPR operations on a manikin. As they were performing CPR, the time and the quality of compressions were measured by a chronometer and visual analogue fatigue scale, respectively. The rescuers themselves reported the onset time of physical fatigue.
Statistical analyses run on the collected data revealed that the majority of participants experienced extreme physical fatigue after a two-minute CPR operation. Moreover, about 71.2% of the participants managed to provide compressions over five centimeters deep. Finally, the physical fatigue experienced by the participants was meaningfully correlated with the body weight, sex, university degree, and work place of the participants (p < 0.05). Since the findings of the present study showed that various factors including the sex, weight, height, university degree, and the work place of the rescuer were significantly correlated with the onset time of physical fatigue experienced during CPR operation, it is recommended that male nurses with greater height and weight be employed in the rescue teams in ICU wards. Moreover, it seems mandatory for the nurses currently working in such teams in hospitals to improve their physical fitness through doing aerobics on a regular basis so that they may experience less fatigue during their CPR operations in future.</jats:p
Rad GTPase inhibits cardiac fibrosis through connective tissue growth factor
No full textAims Our previous studies documented that Rad (Ras associated with diabetes), a member of the RGK (Rad, Gem, and Kir) family of Ras-related small G protein, is significantly decreased in human failing hearts and plays an important role in attenuating cardiac hypertrophy. The goal of this study is to identify the effect of Rad on cardiac fibrosis and the underlying mechanisms. Methods and results Rad knockout (KO) mice showed more severe cardiac fibrosis compared with wild-type littermate controls as detected by Sirius Red staining. Western blot analyses demonstrated that the expression of connective tissue growth factor (CTGF), a key mediator of fibrosis, increased dramatically in Rad KO mice. Overexpression of Rad in cultured neonatal cardiomyocytes suppressed both basal and transforming growth factor-beta 1-induced CTGF expression. Elevated CTGF expression was observed in cardiomyocytes when Rad was reduced by RNA interference. Moreover, cardiac fibroblasts produced greater extracellular matrix (ECM) when stimulated with conditioned medium from Rad-knockdown cardiomyocytes. ECM production was completely abolished by adding a CTGF-neutralizing antibody into the medium. CCAAT/enhancer-binding protein delta(C/EBP-delta) was demonstrated to activate CTGF in cardiomyocytes. Chromatin immunoprecipitation assay and co-immunoprecipitation further demonstrated that Rad inhibited the binding of C/EBP-delta to the CTGF promoter via direct interaction with C/EBP-delta. Conclusion Our data reveal that Rad deficiency can lead to cardiac fibrosis. Rad inhibits CTGF expression through binding with C/EBP-delta, thus regulating ECM production in the heart. This study suggests a potential link between decreased Rad levels and increased cardiac fibrosis in human failing hearts.Cardiac & Cardiovascular SystemsSCI(E)PubMed13ARTICLE190-989
Platelet-derived growth factor induces Rad expression through Egr-1 in vascular smooth muscle cells.
No full textBACKGROUND: Ras associated with diabetes (Rad) inhibits vascular lesion formation by reducing the attachment and migration of vascular smooth muscle cells (VSMCs). However, the transcriptional regulation of Rad in VSMCs is unclear. METHODOLOGY AND PRINCIPAL FINDINGS: We found that Platelet-Derived Growth Factor (PDGF)induced Rad expression in a time- and dose-dependent manner in rat aortic smooth muscle cells (RASMCs) using quantitative real-time PCR. By serial deletion analysis of the Rad promoter, we identified that two GC-rich early growth response-1 (Egr-1) binding sites are essential for PDGF-induced Rad promoter activation. Overexpression of Egr-1 in RASMCs strongly stimulated Rad expression while the Egr-1 corepressor, NGFI-A binding protein 2 (NAB2), repressed PDGF-induced Rad up-regulation in a dose-dependent manner. Direct binding of Egr-1 to the Rad promoter region was further confirmed by chromatin immunoprecipitation assays. CONCLUSIONS: Our results demonstrate that Rad is regulated by PDGF through the transcriptional factor Egr-1 in RASMCs
Hochbegabte kinder - das unterdrückte genie -- was treibt Hans Giebenrath unter das rad?: eine neuere perspektive zu Herman Hesses Unterm Rad, in bezug auf die idee ,das lernen als strafe'
No full text2013 Fall.Includes bibliographical references.Text in German; title and abstract in English and German.The current discussion on Hermann Hesse's 1906 book, Unterm Rad, leaves many open-ended questions. Because the storyline so closely follows Hermann Hesse's personal biography, it obfuscates his authorial intentions and makes it difficult for scholars to differentiate between the two. Many critics also claim that the correlations between Unterm Rad's protagonist, Hans Giebenrath, and Hesse's personal life have actually stagnated later research about the book, as discussions always circle back to Hesse's personal struggles in the Prussian school system. This thesis, although acknowledging the similarities to Hesse's personal timeline, aims to frame the book in historical context in order to discuss its importance in a literary context. This thesis begins by analyzing the norm of educational methods in the early nineteenth century, and establishes that they are strongly based on a long tradition of child rearing by using force. This can be traced back to some accounts from 1752, and are based on a history of bourgeois childrearing. The headmaster and pastor's treatment of Hans in Unterm Rad clearly demonstrate the force and suppression of new ideas, used as modes of teaching to ensure students conformed to societal norms: this is historically reconcilable. Hesse's fictional story is thus the ideal basis for an analysis of childrearing methods used during that time. In order to effectively introduce a new perspective on the discussion, this paper uses the New Historicism approach and begins with Roland Barthes's theory of authorial intention. It analyses the text within the constraints of The Death of the Author, and continues with Michel Foucault's What is an Author? The goal is to evaluate what Unterm Rad says about the child rearing at the turn of the century in southern Germany, particularly for gifted children, and how it can be applied to what is already known from a historical standpoint. This idea is then applied from Hans Giebenrath's point of view to German psychologist Katharina Rutschky's concept of "Schwarze Pädagogik" or "Black Pedagogy" and her theories of suppression. This idea is further supplemented by Alice Millers research on childrearing, in relation to Hans's experience at the school in Maulbronn
Role rad społecznych we współrządzeniu miastem
No full textUrban governance (UG) is a place-based network of cooperation between public and non-public actors where public authorities play a strategic role in deciding on city matters. A number of UG actors include advisory councils (ACs), characterized by a long tradition, universality, stability and objectives related to urban affairs. The article aims to identify AC roles in UG. In addition, the author hypothesizes a correlation between the number of official (statutory) and informal (not legally regulated) roles and differences between ACs in terms of the roles they play. The hypotheses were verified in qualitative research. 57 semi-structured interviews were conducted with members of the youth councils, senior citizen councils, sport councils, and councils for residents with disabilities in 16 Polish cities. The interview transcripts were uploaded to QDA Miner for encoding and analysis. It was found that all ACs, regardless of their official roles, play informal roles, and all these roles are related to UG. There is no correlation between the number of official and informal roles, which would make ACs very similar unless the mandatory character of the roles played by the council for residents with disabilities, which differs this AC from the other. The results of the study lead the author to recommend revisions to AC regulations in order to increase their participation in the UG.Współrządzenie miastem (WM) to związana z miejscem sieć współpracy między podmiotami publicznymi i niepublicznymi, w której władze publiczne odgrywają strategiczną rolę w podejmowaniu decyzji o sprawach miasta. Wśród aktorów WM są rady społeczne (RS), które charakteryzują się długą tradycją, powszechnością, stabilnością i celami związanymi z miastem. Artykuł ma na celu identyfikację ról RS w WM. Ponadto autorka stawia hipotezę o związku między liczbą ról oficjalnych (ustawowych) i nieformalnych (nieuregulowanych prawnie) oraz o różnicach między RS pod względem pełnionych ról. Hipotezy zweryfikowano w badaniach jakościowych. Przeprowadzono 57 wywiadów częściowo ustrukturyzowanych z członkami rad młodzieżowych, rad seniorów, rad sportu i rad ds. osób niepełnosprawnych w 16 polskich miastach. Transkrypcje wywiadów zostały wprowadzone do QDA Miner w celu zakodowania i analizy. Stwierdzono, że wszystkie RS, niezależnie od swoich ról oficjalnych, pełnią role nieformalne, a wszystkie te role są związane z WM. Nie ma związku między liczbą ról oficjalnych i nieformalnych, co sprawia, że RS wydałyby się bardzo podobne, gdyby nie role pełnione przez radę ds. osób niepełnosprawnych, które mają charakter obowiązku ustawowego, co istotnie różni tę radę od pozostałych. Wyniki badań skłoniły autorkę do zaproponowania zmian w przepisach dotyczących RS w kierunku zwiększenia ich udziału w UG
Rad na ulozi Sarah u predstavi "Ljubavnik"
No full textDjelo Harolda Pintera Ljubavnik zaživjelo je kao diplomska predstava Gordana Marijanovića i Matee Bublić pod mentorstvom doc. art. Jasmina Novljakovića na Akademiji za umjetnost i kulturu u Osijeku na odsjeku za kazališnu umjetnost, smjer gluma i lutkarstvo. U ovom diplomskom radu Matea opisuje proces rada na diplomskoj predstavi koji uključuje rad na tekstu, rad u prostoru te rad na ulozi. Na početku ukratko iznosi činjenice o autoru i djelu nakon čega kronološki navodi faze rada unutar kojih opisuje proces svojeg glumačkog istraživanja i spoznajne činjenice o utvrđenom znanju. Kroz sva poglavlja čitatelja upoznaje s režijskim konceptom predstave, opisuje mu scenografiju, kostimografiju i rekvizite te mu približava karakter predstave. Svoj diplomski rad Matea zaokružuje spoznajom i iznošenjem činjenica o stečenom znanju kroz petogodišnje studiranje te svojom idejom o karakteristikama koje čine kvalitetnog glumca.Drama „Lover“ by Harold Pinter was set on the scene as a final exam of Gordan Marijanović and Matea Bublić, mentored by assist. prof. art. Jasmin Novljaković and produced by Academy for art and culture in Osijek under the Department of Theatre Arts, study of acting and puppetry. In this written thesis Matea is describing the working process on the final exam which is consisted of chapters which are talking about: working on the text, working on the scene and creating a role. On the beginning she is writing about author and drama, chronologically describes the working phases and analyse process of acting reaserch. Through all chapters Matea introduces the reader to the concept of the play, describes the scenography, costumography and tries to bring the character of the play closer to the reader. She is concluding her written thesis by bringing the facts about acquired knowledge through the study and sharing her opinion about characteristics of a good actor
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